| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qing Lu, Sharon Round. Focal adhesion kinase and endothelial cell apoptosis. Microvascular research. vol 83. issue 1. 2012-04-03. PMID:21624380. |
growing evidence indicates that fak is important in maintenance of normal cell survival and that disruption of fak signaling results in loss of substrate adhesion and anoikis (apoptosis) of anchorage-dependent cells, such as endothelial cells. |
2012-04-03 |
2023-08-12 |
Not clear |
| Qing Lu, Sharon Round. Focal adhesion kinase and endothelial cell apoptosis. Microvascular research. vol 83. issue 1. 2012-04-03. PMID:21624380. |
this review summarizes the signaling pathways of fak in prevention of apoptosis and the role of fak in mediating adenosine and homocysteine-induced endothelial cell apoptosis and in cardiovascular diseases. |
2012-04-03 |
2023-08-12 |
Not clear |
| Patricia J Keel. Mechanisms by which the extracellular matrix and integrin signaling act to regulate the switch between tumor suppression and tumor promotion. Journal of mammary gland biology and neoplasia. vol 16. issue 3. 2012-02-07. PMID:21822945. |
signaling from fak moreover regulates p53 and mir-200 members, which control apoptosis and epithelial phenotype, such that a compliant matrix is predicted to promote normal mammary gland architecture and suppress tumor formation. |
2012-02-07 |
2023-08-12 |
Not clear |
| Lü-Hong Xu, Jian-Pei Fang, Wen-Jun Weng, Hong-Gui Xu, Ya-Ting Zhan. [Therapeutic effect of focal adhesion kinase gene silence on leukemia]. Zhongguo shi yan xue ye xue za zhi. vol 19. issue 3. 2012-01-19. PMID:21729532. |
the apoptosis of leukemia cells and survival of leukemic mice treated by fak shrna combined with drug sti571 were monitored. |
2012-01-19 |
2023-08-12 |
mouse |
| Lü-Hong Xu, Jian-Pei Fang, Wen-Jun Weng, Hong-Gui Xu, Ya-Ting Zhan. [Therapeutic effect of focal adhesion kinase gene silence on leukemia]. Zhongguo shi yan xue ye xue za zhi. vol 19. issue 3. 2012-01-19. PMID:21729532. |
the apoptosis test results showed that the percentages of annexin v(+) cells in vector control group and fak shrna group were (3.46 ± 0.56)% and (7.3 ± 0.79)%, respectively, and the difference was statistically significant (p < 0.05). |
2012-01-19 |
2023-08-12 |
mouse |
| Lü-Hong Xu, Jian-Pei Fang, Wen-Jun Weng, Hong-Gui Xu, Ya-Ting Zhan. [Therapeutic effect of focal adhesion kinase gene silence on leukemia]. Zhongguo shi yan xue ye xue za zhi. vol 19. issue 3. 2012-01-19. PMID:21729532. |
moreover, fak gene silence combined with drug sti571 could enhance the apoptosis of leukemia cells and prolong survival time of leukemic mice. |
2012-01-19 |
2023-08-12 |
mouse |
| Stéphanie P Häuselmann, Berit I Rosc-Schlüter, Vera Lorenz, Isabelle Plaisance, Marijke Brink, Otmar Pfister, Gabriela M Kuste. β1-Integrin is up-regulated via Rac1-dependent reactive oxygen species as part of the hypertrophic cardiomyocyte response. Free radical biology & medicine. vol 51. issue 3. 2011-12-05. PMID:21620958. |
et-1 also enhanced cell adhesion and fak phosphorylation and inhibited oxidative stress-induced cardiomyocyte apoptosis. |
2011-12-05 |
2023-08-12 |
Not clear |
| Bu Yi. Focal adhesion kinase as a target in the treatment of hematological malignancies. Leukemia research. vol 35. issue 10. 2011-11-23. PMID:21592572. |
during normal development, fak is a critical mediator of the integrin signaling cascade, which modulates cell proliferation, apoptosis, adhesion, spreading and migration. |
2011-11-23 |
2023-08-12 |
Not clear |
| Junyan An, Libo Zheng, Shurui Xie, Zhina Dun, Lisen Hao, Dongmei Yao, David Q Shih, Xiaolan Zhan. Down-regulation of focal adhesion kinase by short hairpin RNA increased apoptosis of rat hepatic stellate cells. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. vol 119. issue 6. 2011-08-15. PMID:21569089. |
the role of fak on proliferation and apoptosis of fibronectin (fn)-stimulated hsc was investigated using short hairpin rna (shrna)-mediated gene silencing technology. |
2011-08-15 |
2023-08-12 |
rat |
| Junyan An, Libo Zheng, Shurui Xie, Zhina Dun, Lisen Hao, Dongmei Yao, David Q Shih, Xiaolan Zhan. Down-regulation of focal adhesion kinase by short hairpin RNA increased apoptosis of rat hepatic stellate cells. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. vol 119. issue 6. 2011-08-15. PMID:21569089. |
together, these data show that fak regulates hsc proliferation and induces the apoptosis of hsc via the caspase-3 and bcl-2/bax pathway. |
2011-08-15 |
2023-08-12 |
rat |
| Bang-Jau You, Yang-Chang Wu, Bo-Ying Bao, Chi-Yu Wu, Ya-Win Yang, Yu-Hao Chang, Hong-Zin Le. Rottlerin Inhibits Lonicera japonica-Induced Photokilling in Human Lung Cancer Cells through Cytoskeleton-Related Signaling Cascade. Evidence-based complementary and alternative medicine : eCAM. vol 2011. 2011-07-14. PMID:21331326. |
furthermore, the promotion of the cytoskeleton-related signaling cascade following rottlerin by upregulation of cytoskeleton-related mediators (p38, hsp27, fak, paxillin, and tubulin) and molecules of downstream of f-actin (mitochondria-mediated apoptosis pathway) reduces ch27 cell death, indicating that cytoskeleton is the potential target in the photoactivated lonicera japonicaextract-induced photokilling of ch27 cells. |
2011-07-14 |
2023-08-12 |
human |
| Isabelle Tanjoni, Colin Walsh, Sean Uryu, Alok Tomar, Ju-Ock Nam, Ainhoa Mielgo, Ssang-Taek Lim, Congxin Liang, Marcel Koenig, Connie Sun, Neela Patel, Cheni Kwok, Gerald McMahon, Dwayne G Stupack, David D Schlaepfe. PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer biology & therapy. vol 9. issue 10. 2011-07-12. PMID:20234191. |
pnd-1186 fak inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. |
2011-07-12 |
2023-08-12 |
mouse |
| Isabelle Tanjoni, Colin Walsh, Sean Uryu, Alok Tomar, Ju-Ock Nam, Ainhoa Mielgo, Ssang-Taek Lim, Congxin Liang, Marcel Koenig, Connie Sun, Neela Patel, Cheni Kwok, Gerald McMahon, Dwayne G Stupack, David D Schlaepfe. PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer biology & therapy. vol 9. issue 10. 2011-07-12. PMID:20234191. |
however, under non-adherent conditions as spheroids and as colonies in soft agar, 0.1 µm pnd-1186 blocked fak and p130cas tyrosine phosphorylation, promoted caspase-3 activation, and triggered cell apoptosis. |
2011-07-12 |
2023-08-12 |
mouse |
| Michael D Schaller, Steven M Frisc. PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer biology & therapy. vol 9. issue 10. 2011-07-12. PMID:20364110. |
pnd-1186 fak inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. |
2011-07-12 |
2023-08-12 |
Not clear |
| Thorsten Jung, Wolfgang Gross, Margot Zölle. CD44v6 coordinates tumor matrix-triggered motility and apoptosis resistance. The Journal of biological chemistry. vol 286. issue 18. 2011-07-01. PMID:21372142. |
only the asml(wt)-matrix supports migration and apoptosis resistance, which both can be initiated via cd44v6, c-met, and α6β4 ligand binding and proceed via fak, pi3k/akt, and mapk activation, respectively. |
2011-07-01 |
2023-08-12 |
human |
| Hoang Anh Vu, Yuuichi Beppu, Hoang Thanh Chi, Kousuke Sasaki, Hideaki Yamamoto, Phan Thi Xinh, Takashi Tanii, Yukihiko Hara, Toshiki Watanabe, Yuko Sato, Iwao Ohdomar. Green tea epigallocatechin gallate exhibits anticancer effect in human pancreatic carcinoma cells via the inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor. Journal of biomedicine & biotechnology. vol 2010. 2011-05-20. PMID:21318151. |
at a dose of 100 μm which completely abolishes activations of fak and igf-1r, egcg suppresses more than 50% of cell proliferation without evidence of apoptosis analyzed by parp cleavage. |
2011-05-20 |
2023-08-12 |
human |
| Yongjie Ma, Bingbing Wang, Wenliang Li, Guoguang Ying, Li Fu, Ruifang Niu, Feng G. Reduction of intersectin1-s induced apoptosis of human glioblastoma cells. Brain research. vol 1351. 2011-05-17. PMID:20493827. |
our data demonstrate that several key proteins, including fak, akt, bcl-2, bad which are critical for cells apoptosis were probably involved in itsn1-s signaling pathways. |
2011-05-17 |
2023-08-12 |
human |
| Teresita Bellid. Antagonistic interplay between mechanical forces and glucocorticoids in bone: a tale of kinases. Journal of cellular biochemistry. vol 111. issue 1. 2011-02-14. PMID:20506204. |
recent evidence gained from studies on bone cell apoptosis has revealed that mechanical forces and gc exhibit converse effects on osteocyte and osteoblast survival resulting from divergent actions on the focal adhesion kinases fak and pyk2, molecules that regulate integrin-dependent interactions between bone cells and the extracellular matrix (ecm). |
2011-02-14 |
2023-08-12 |
Not clear |
| Bo Hu, Xiusheng He, Ao Li, Qingchao Qiu, Cunxi Li, Dan Liang, Ping Zhao, Jie Ma, Robert J Coffey, Qimin Zhan, Guanqing W. Cystogenesis in ARPKD results from increased apoptosis in collecting duct epithelial cells of Pkhd1 mutant kidneys. Experimental cell research. vol 317. issue 2. 2011-01-13. PMID:20875407. |
we demonstrated that the loss of pkhd1 disrupts multiple major phosphorylations of focal adhesion kinase (fak), and these disruptions either inhibit the ras/c-raf pathways to suppress mek/erk activity and ultimately reduce cell proliferation, or suppress pdk1/akt to upregulate bax/caspase-9/caspase-3 and promote apoptosis. |
2011-01-13 |
2023-08-12 |
mouse |
| Suyun Wang, Zhiyong Cheng, Xiaoyang Yang, Kai Deng, Yan Cao, Hao Chen, Ling Pa. Effect of wild type PTEN gene on proliferation and invasion of multiple myeloma. International journal of hematology. vol 92. issue 1. 2010-12-23. PMID:20582577. |
we explored the effect of the wild type pten gene on the proliferation, apoptosis and invasive ability of multiple myeloma (mm) cells from mm patients and rpmi 8226 cells (a human myeloma cell line), and the effect of the pten/focal adhesion kinase (fak)/mmp signaling pathway on the invasion activity of rpmi 8226 cells. |
2010-12-23 |
2023-08-12 |
human |