| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sabina Honisch, Saad Alkahtani, Michalis Kounenidakis, Guilai Liu, Saud Alarifi, Hamad Al-Yahya, Konstantinos Dimas, Abdullah A AlKahtane, Kyriakos C Prousis, Bader Al-Dahmash, Theodora Calogeropoulou, Konstantinos Alevizopoulos, Florian Lang, Christos Stournara. A steroidal Na+/K+ ATPase inhibitor triggers pro-apoptotic signaling and induces apoptosis in prostate and lung tumor cells. Anti-cancer agents in medicinal chemistry. vol 14. issue 8. 2015-05-12. PMID:24942548. |
our findings suggest that the steroidal na(+)/k(+) atpase inhibitor 3-r-pod induces apoptosis, paralleled by altered bcl-2 and c-fos gene transcription, inhibition of the pro-survival fak signalling, up-regulation of the pro-apoptotic p38 mapk pathway and stimulation of caspase-3 activity. |
2015-05-12 |
2023-08-13 |
Not clear |
| Gagan Deep, Rahul Kumar, Anil K Jain, Chapla Agarwal, Rajesh Agarwa. Silibinin inhibits fibronectin induced motility, invasiveness and survival in human prostate carcinoma PC3 cells via targeting integrin signaling. Mutation research. vol 768. 2015-05-11. PMID:25285031. |
molecular analyses revealed that silibinin treatment modulated the fibronectin-induced expression of integrins (α5, αv, β1 and β3), actin-remodeling (fak, src, gtpases, arp2 and cortactin), apoptosis (cparp and cleaved caspase 3), emt (e-cadherin and β-catenin), and cell survival (survivin and akt) related signaling molecules in pc3 cells. |
2015-05-11 |
2023-08-13 |
mouse |
| Haw-Young Kwon, Kyoung-Sook Kim, Ji-Sue Baik, Hyung-In Moon, Ji-Won Lee, Cheorl-Ho Kim, Young-Su Cho, Yong-Kee Jeong, Young-Choon Le. Triptolide-Mediated Apoptosis by Suppression of Focal Adhesion Kinase through Extrinsic and Intrinsic Pathways in Human Melanoma Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2015-05-06. PMID:25945102. |
moreover, tpl-induced apoptosis in sk-mel-2 cells was mediated through dephosphorylation of focal adhesion kinase (fak) and its cleavage by caspase-8-mediated caspase-3 activation via upregulation of fas expression. |
2015-05-06 |
2023-08-13 |
human |
| Haw-Young Kwon, Kyoung-Sook Kim, Ji-Sue Baik, Hyung-In Moon, Ji-Won Lee, Cheorl-Ho Kim, Young-Su Cho, Yong-Kee Jeong, Young-Choon Le. Triptolide-Mediated Apoptosis by Suppression of Focal Adhesion Kinase through Extrinsic and Intrinsic Pathways in Human Melanoma Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2015-05-06. PMID:25945102. |
in conclusion, our data firstly demonstrated that tpl induces apoptosis by both extrinsic and intrinsic apoptosis pathways in human melanoma cells and identified that rip shuttles between fas and fak to mediate apoptosis. |
2015-05-06 |
2023-08-13 |
human |
| Pavlo Sakhatskyy, Gustavo Andres Gabino Miranda, Julie Newton, Chun Geun Lee, Gaurav Choudhary, Alexander Vang, Sharon Rounds, Qing L. Cigarette smoke-induced lung endothelial apoptosis and emphysema are associated with impairment of FAK and eIF2α. Microvascular research. vol 94. 2015-04-21. PMID:24853558. |
cigarette smoke-induced lung endothelial apoptosis and emphysema are associated with impairment of fak and eif2α. |
2015-04-21 |
2023-08-13 |
mouse |
| Pavlo Sakhatskyy, Gustavo Andres Gabino Miranda, Julie Newton, Chun Geun Lee, Gaurav Choudhary, Alexander Vang, Sharon Rounds, Qing L. Cigarette smoke-induced lung endothelial apoptosis and emphysema are associated with impairment of FAK and eIF2α. Microvascular research. vol 94. 2015-04-21. PMID:24853558. |
correlated with increased lung ec apoptosis and early onset of emphysema, fak activity was reduced in the lungs of akr mice, but not of c57bl/6 mice. |
2015-04-21 |
2023-08-13 |
mouse |
| Pavlo Sakhatskyy, Gustavo Andres Gabino Miranda, Julie Newton, Chun Geun Lee, Gaurav Choudhary, Alexander Vang, Sharon Rounds, Qing L. Cigarette smoke-induced lung endothelial apoptosis and emphysema are associated with impairment of FAK and eIF2α. Microvascular research. vol 94. 2015-04-21. PMID:24853558. |
additionally, inhibition of fak caused lung ec apoptosis, whereas over-expression of fak prevented cse-induced lung ec apoptosis. |
2015-04-21 |
2023-08-13 |
mouse |
| Pavlo Sakhatskyy, Gustavo Andres Gabino Miranda, Julie Newton, Chun Geun Lee, Gaurav Choudhary, Alexander Vang, Sharon Rounds, Qing L. Cigarette smoke-induced lung endothelial apoptosis and emphysema are associated with impairment of FAK and eIF2α. Microvascular research. vol 94. 2015-04-21. PMID:24853558. |
these results suggest that fak inhibition may contribute to cs-induced lung ec apoptosis and emphysema. |
2015-04-21 |
2023-08-13 |
mouse |
| Pavlo Sakhatskyy, Gustavo Andres Gabino Miranda, Julie Newton, Chun Geun Lee, Gaurav Choudhary, Alexander Vang, Sharon Rounds, Qing L. Cigarette smoke-induced lung endothelial apoptosis and emphysema are associated with impairment of FAK and eIF2α. Microvascular research. vol 94. 2015-04-21. PMID:24853558. |
taken together, our data suggest that inhibition of eif2α and fak signaling may play an important role in cs-induced lung ec apoptosis and emphysema. |
2015-04-21 |
2023-08-13 |
mouse |
| Na Shang, Maribel Arteaga, Ali Zaidi, Jimmy Stauffer, Scott J Cotler, Nancy J Zeleznik-Le, Jiwang Zhang, Wei Qi. FAK is required for c-Met/β-catenin-driven hepatocarcinogenesis. Hepatology (Baltimore, Md.). vol 61. issue 1. 2015-03-10. PMID:25163657. |
we found that deletion of fak in hepatocytes did not affect morphology, proliferation, or apoptosis. |
2015-03-10 |
2023-08-13 |
mouse |
| Michael L Megison, Lauren A Gillory, Jerry E Stewart, Hugh C Nabers, Elizabeth Mrozcek-Musulman, Elizabeth A Beierl. FAK inhibition abrogates the malignant phenotype in aggressive pediatric renal tumors. Molecular cancer research : MCR. vol 12. issue 4. 2015-02-19. PMID:24464916. |
fak inhibition resulted in decreased cellular survival, invasion and migration, and increased apoptosis. |
2015-02-19 |
2023-08-12 |
Not clear |
| Rui-Jun Ju, Xue-Tao Li, Ji-Feng Shi, Xiu-Ying Li, Meng-Ge Sun, Fan Zeng, Jia Zhou, Lei Liu, Cheng-Xiang Zhang, Wei-Yu Zhao, Wan-Liang L. Liposomes, modified with PTD(HIV-1) peptide, containing epirubicin and celecoxib, to target vasculogenic mimicry channels in invasive breast cancer. Biomaterials. vol 35. issue 26. 2015-02-02. PMID:24912818. |
in vitro results showed that the targeting liposomes exhibited strong transport ability across cell and nuclei membranes of invasive breast cancer, were able to penetrate and destruct the invasive breast cancer spheroids, initiated apoptosis via activating apoptotic enzymes (caspase 8, 3), and destroyed the vm channels via down-regulating the protein indicators (mmp-9, ve-cad, fak, epha2 and hif-1α) in invasive breast cancer cells. |
2015-02-02 |
2023-08-13 |
mouse |
| Yu-Jing Zhang, Zhi-Liang Tian, Xin-Yan Yu, Xia-Xia Zhao, Li Ya. Activation of integrin β1-focal adhesion kinase-RasGTP pathway plays a critical role in TGF beta1-induced podocyte injury. Cellular signalling. vol 25. issue 12. 2014-12-03. PMID:24036212. |
the fak inhibitor tae226 and the specific knockdown of grb2 remarkably alleviated tgfβ1-induced podocyte apoptosis. |
2014-12-03 |
2023-08-12 |
mouse |
| Meng Hou, Jinjin Cui, Jingjin Liu, Fang Liu, Rui Jiang, Kai Liu, Yongshun Wang, Li Yin, Wenhua Liu, Bo Y. Angiopoietin-like 4 confers resistance to hypoxia/serum deprivation-induced apoptosis through PI3K/Akt and ERK1/2 signaling pathways in mesenchymal stem cells. PloS one. vol 9. issue 1. 2014-10-29. PMID:24465718. |
angptl4 protects mscs from hypoxia/sd-induced apoptosis by interacting with integrins to stimulate fak complex, leading to downstream erk1/2 and pi3k/akt signaling pathways and mimicking the pathway in which mscs contact with the extracellular matrix. |
2014-10-29 |
2023-08-12 |
rat |
| Heejei Yoon, Yoon-La Choi, Ji-Young Song, Ingu Do, So Young Kang, Young-Hyeh Ko, Sangyong Song, Byoung-Gie Ki. Targeted inhibition of FAK, PYK2 and BCL-XL synergistically enhances apoptosis in ovarian clear cell carcinoma cell lines. PloS one. vol 9. issue 2. 2014-10-28. PMID:24523919. |
targeted inhibition of fak, pyk2 and bcl-xl synergistically enhances apoptosis in ovarian clear cell carcinoma cell lines. |
2014-10-28 |
2023-08-12 |
Not clear |
| Bernardo Tavora, Louise E Reynolds, Silvia Batista, Fevzi Demircioglu, Isabelle Fernandez, Tanguy Lechertier, Delphine M Lees, Ping-Pui Wong, Annika Alexopoulou, George Elia, Andrew Clear, Adeline Ledoux, Jill Hunter, Neil Perkins, John G Gribben, Kairbaan M Hodivala-Dilk. Endothelial-cell FAK targeting sensitizes tumours to DNA-damaging therapy. Nature. vol 514. issue 7520. 2014-10-23. PMID:25079333. |
our study shows that deletion of fak in endothelial cells has no apparent effect on blood vessel function per se, but induces increased apoptosis and decreased proliferation within perivascular tumour-cell compartments of doxorubicin- and radiotherapy-treated mice. |
2014-10-23 |
2023-08-13 |
mouse |
| Zhaokang Cheng, Laura A DiMichele, Mauricio Rojas, Cyrus Vaziri, Christopher P Mack, Joan M Taylo. Focal adhesion kinase antagonizes doxorubicin cardiotoxicity via p21(Cip1.). Journal of molecular and cellular cardiology. vol 67. 2014-10-22. PMID:24342076. |
fak depletion enhanced susceptibility to dox-induced myocyte apoptosis and cardiac dysfunction, while elevated fak activity provided remarkable cardioprotection. |
2014-10-22 |
2023-08-12 |
mouse |
| P Acedo, J C Stockert, M Cañete, A Villanuev. Two combined photosensitizers: a goal for more effective photodynamic therapy of cancer. Cell death & disease. vol 5. 2014-10-21. PMID:24625981. |
analysis of changes in cytoskeleton components (microtubules and f-actin), fak protein, as well as time-lapse video microscopy evidenced that hela cells were induced to undergo apoptosis, without losing adhesion to the substrate. |
2014-10-21 |
2023-08-12 |
mouse |
| Roxane Paulin, Jolyane Meloche, Audrey Courboulin, Caroline Lambert, Alois Haromy, Antony Courchesne, Pierre Bonnet, Steeve Provencher, Evangelos D Michelakis, Sébastien Bonne. Targeting cell motility in pulmonary arterial hypertension. The European respiratory journal. vol 43. issue 2. 2014-10-16. PMID:23845719. |
fak inhibition (sirna, pf-228 and pp2) in pah-pasmcs induced a fivefold increase in apoptosis (percentage of terminal deoxynucleotidyl transferase dutp nick end labelling), a 2.5-fold decrease in proliferation (%ki67), an 18% decrease in cell migration (colorimetric assay) and a 50% decrease in cell invasion (wound healing). |
2014-10-16 |
2023-08-12 |
human |
| Shao-Peng Zhou, Wei-Tao Liao, Lu-Kun Yang, Liao Su. Effects of sevoflurane pretreatment on renal Src and FAK expression in diabetic rats after renal ischemia/reperfusion injury. Molecular and cellular biochemistry. vol 384. issue 1-2. 2014-09-30. PMID:24002704. |
the aim of this study was to determine if sevoflurane pretreatment could help preserve renal function in rats with diabetes mellitus (dm) by altering non-receptor tyrosine kinases steroid receptor coactivator (src) and focal adhesion kinase (fak) expression (src and fak are mediators of cellular apoptosis and necrosis). |
2014-09-30 |
2023-08-12 |
rat |