| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Houjun Xia, Wei Wang, Joel Crespo, Ilona Kryczek, Wei Li, Shuang Wei, Zhaoqun Bian, Tomasz Maj, Mingxiao He, Rebecca J Liu, Youwen He, Ramandeep Rattan, Adnan Munkarah, Jun-Lin Guan, Weiping Zo. Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity. Science immunology. vol 2. issue 17. 2018-07-02. PMID:29150439. |
we report that naïve t cells are prone to undergo apoptosis due to a selective loss of fak family-interacting protein of 200 kda (fip200) in ovarian cancer patients and tumor-bearing mice. |
2018-07-02 |
2023-08-13 |
mouse |
| Yuan Jiang, Jinlu Dai, Zhi Yao, Greg Shelley, Evan T Kelle. Abituzumab Targeting of αV-Class Integrins Inhibits Prostate Cancer Progression. Molecular cancer research : MCR. vol 15. issue 7. 2018-04-02. PMID:28314844. |
to evaluate this, prostate cancer cells were treated with di17e6 and its effects on proliferation, apoptosis, cell-cycle, adhesion, detachment, migration, invasion and phosphorylation of downstream targets, including fak, akt, and erk, were determined. |
2018-04-02 |
2023-08-13 |
Not clear |
| Kan Yin, Rongjia Zhu, Shihua Wang, Robert Chunhua Zha. Low-Level Laser Effect on Proliferation, Migration, and Antiapoptosis of Mesenchymal Stem Cells. Stem cells and development. vol 26. issue 10. 2018-02-22. PMID:28178868. |
the mechanism of the effects included proliferation rate increase mediated by increased s phase proportion; mitochondrial biogenesis and function alteration mediated by fusion (mfn1, mfn2, and opa-1) and fission (fis1, drp-1, and mtp18)-related proteins, nrf1, tfam, pgc-1a, and upregulated intracellular ros and no concentration; migration acceleration through the erk1/2 and fak pathway and upregulation of growth factors such as hgf and pdgf; and resistance to apoptosis with increased bcl-2 and decreased bax, or through tunneling nanotube formation between lll-treated mscs and 5-fluorouracil-induced apoptotic mscs. |
2018-02-22 |
2023-08-13 |
human |
| Scott Walker, Fiona Foster, Amber Wood, Thomas Owens, Keith Brennan, Charles H Streuli, Andrew P Gilmor. Oncogenic activation of FAK drives apoptosis suppression in a 3D-culture model of breast cancer initiation. Oncotarget. vol 7. issue 43. 2018-02-21. PMID:27611942. |
oncogenic activation of fak drives apoptosis suppression in a 3d-culture model of breast cancer initiation. |
2018-02-21 |
2023-08-13 |
Not clear |
| Scott Walker, Fiona Foster, Amber Wood, Thomas Owens, Keith Brennan, Charles H Streuli, Andrew P Gilmor. Oncogenic activation of FAK drives apoptosis suppression in a 3D-culture model of breast cancer initiation. Oncotarget. vol 7. issue 43. 2018-02-21. PMID:27611942. |
however in 3d-cultures that better resemble normal tissue morphology, mammary cells largely respond to fak activation via suppression of apoptosis, promoting aberrant acinar morphogenesis. |
2018-02-21 |
2023-08-13 |
Not clear |
| Scott Walker, Fiona Foster, Amber Wood, Thomas Owens, Keith Brennan, Charles H Streuli, Andrew P Gilmor. Oncogenic activation of FAK drives apoptosis suppression in a 3D-culture model of breast cancer initiation. Oncotarget. vol 7. issue 43. 2018-02-21. PMID:27611942. |
thus, fak activation may facilitate tumour initiation by causing resistance to apoptosis. |
2018-02-21 |
2023-08-13 |
Not clear |
| Daniela Gnani, Ilaria Romito, Simona Artuso, Marco Chierici, Cristiano De Stefanis, Nadia Panera, Annalisa Crudele, Sara Ceccarelli, Elena Carcarino, Valentina D'Oria, Manuela Porru, Ezio Giorda, Karin Ferrari, Luca Miele, Erica Villa, Clara Balsano, Diego Pasini, Cesare Furlanello, Franco Locatelli, Valerio Nobili, Rossella Rota, Carlo Leonetti, Anna Alis. Focal adhesion kinase depletion reduces human hepatocellular carcinoma growth by repressing enhancer of zeste homolog 2. Cell death and differentiation. vol 24. issue 5. 2018-02-15. PMID:28338656. |
we found that fak depletion in hcc cells reduced in vitro and in vivo tumorigenicity, by inducing g2/m arrest and apoptosis, decreasing anchorage-independent growth, and modulating the expression of several cancer-related genes. |
2018-02-15 |
2023-08-13 |
human |
| Loriana Vitillo, Melissa Baxter, Banu Iskender, Paul Whiting, Susan J Kimbe. Integrin-Associated Focal Adhesion Kinase Protects Human Embryonic Stem Cells from Apoptosis, Detachment, and Differentiation. Stem cell reports. vol 7. issue 2. 2017-11-28. PMID:27509133. |
after inhibiting fak kinase activity we show that hescs undergo cell detachment-dependent apoptosis or differentiation. |
2017-11-28 |
2023-08-13 |
human |
| Nicole Tegtmeyer, Matthias Neddermann, Carmen Isabell Asche, Steffen Backer. Subversion of host kinases: a key network in cellular signaling hijacked by Helicobacter pylori CagA. Molecular microbiology. vol 105. issue 3. 2017-11-16. PMID:28508421. |
here we review the signal transmission by translocated caga on multiple receptor kinases (c-met and egfr) and non-receptor kinases (src, abl, csk, apkc, par1, pi3k, akt, fak, gsk-3, jak, pak1, pak2 and map kinases), manipulating a selection of fundamental processes in the human gastric epithelium such as cell adhesion, polarity, proliferation, motility, receptor endocytosis, cytoskeletal rearrangements, apoptosis, inflammation and cell cycle progression. |
2017-11-16 |
2023-08-13 |
human |
| Taylor J Zak, Yevgenia E Koshman, Allen M Samarel, Seth L Robi. Regulation of Focal Adhesion Kinase through a Direct Interaction with an Endogenous Inhibitor. Biochemistry. vol 56. issue 35. 2017-09-20. PMID:28782937. |
blocking phosphorylation by mutation (s217a) greatly increased frnk inhibitory potency, resulting in strong inhibition of fak autophosphorylation at y397 and induction of smooth muscle cell apoptosis. |
2017-09-20 |
2023-08-13 |
rat |
| Hiroki Kanazawa, Keisuke Imoto, Muneyoshi Okada, Hideyuki Yamawak. Canstatin inhibits hypoxia-induced apoptosis through activation of integrin/focal adhesion kinase/Akt signaling pathway in H9c2 cardiomyoblasts. PloS one. vol 12. issue 2. 2017-08-21. PMID:28235037. |
in summary, we for the first time clarified that canstatin inhibits hypoxia-induced apoptosis via fak and akt pathways through activating integrins in h9c2 cardiomyoblasts. |
2017-08-21 |
2023-08-13 |
Not clear |
| Amanda K Wheaton, Manisha Agarwal, Shijing Jia, Kevin K Ki. Lung epithelial cell focal adhesion kinase signaling inhibits lung injury and fibrosis. American journal of physiology. Lung cellular and molecular physiology. vol 312. issue 5. 2017-07-31. PMID:28283477. |
within primary aecs, activated fak directly associates with caspase-8 and inhibits activation of the caspase cascade resulting in less apoptosis in response to tgf-β. |
2017-07-31 |
2023-08-13 |
mouse |
| Amanda K Wheaton, Manisha Agarwal, Shijing Jia, Kevin K Ki. Lung epithelial cell focal adhesion kinase signaling inhibits lung injury and fibrosis. American journal of physiology. Lung cellular and molecular physiology. vol 312. issue 5. 2017-07-31. PMID:28283477. |
our studies support a model in which dynamic changes to the extracellular matrix after injury promote fibroblast activation and inhibition of epithelial cell apoptosis in response to tgf-β through fak activation potentially complicating attempts to nonspecifically target this pathway for antifibrotic therapy. |
2017-07-31 |
2023-08-13 |
mouse |
| Qiang Ding, Indhu Subramanian, Tracy R Luckhardt, Pulin Che, Meghna Waghray, Xue-Ke Zhao, Nathaniel Bone, Ashish R Kurundkar, Louise Hecker, Meng Hu, Yong Zhou, Jeffrey C Horowitz, Ragini Vittal, Victor J Thannicka. Focal adhesion kinase signaling determines the fate of lung epithelial cells in response to TGF-β. American journal of physiology. Lung cellular and molecular physiology. vol 312. issue 6. 2017-07-31. PMID:28360109. |
while blockade of smad signaling inhibited emp, it had a minimal effect on apoptosis; in contrast, inhibition of fak signaling markedly shifted to an apoptotic fate. |
2017-07-31 |
2023-08-13 |
rat |
| Qiang Ding, Indhu Subramanian, Tracy R Luckhardt, Pulin Che, Meghna Waghray, Xue-Ke Zhao, Nathaniel Bone, Ashish R Kurundkar, Louise Hecker, Meng Hu, Yong Zhou, Jeffrey C Horowitz, Ragini Vittal, Victor J Thannicka. Focal adhesion kinase signaling determines the fate of lung epithelial cells in response to TGF-β. American journal of physiology. Lung cellular and molecular physiology. vol 312. issue 6. 2017-07-31. PMID:28360109. |
the data support that fak activation determines whether aecs undergo emp vs. apoptosis in response to tgf-β1 stimulation. |
2017-07-31 |
2023-08-13 |
rat |
| Qiang Ding, Indhu Subramanian, Tracy R Luckhardt, Pulin Che, Meghna Waghray, Xue-Ke Zhao, Nathaniel Bone, Ashish R Kurundkar, Louise Hecker, Meng Hu, Yong Zhou, Jeffrey C Horowitz, Ragini Vittal, Victor J Thannicka. Focal adhesion kinase signaling determines the fate of lung epithelial cells in response to TGF-β. American journal of physiology. Lung cellular and molecular physiology. vol 312. issue 6. 2017-07-31. PMID:28360109. |
tgf-β1-induced emp is fak- dependent, whereas tgf-β1-induced apoptosis is favored when fak signaling is inhibited. |
2017-07-31 |
2023-08-13 |
rat |
| Antonio Serapio-Palacios, Fernando Navarro-Garci. EspC, an Autotransporter Protein Secreted by Enteropathogenic Escherichia coli, Causes Apoptosis and Necrosis through Caspase and Calpain Activation, Including Direct Procaspase-3 Cleavage. mBio. vol 7. issue 3. 2017-06-15. PMID:27329750. |
espc produced by epec cleaves fodrin, paxillin, and focal adhesion kinase (fak), which are also cleaved by caspases and calpains during apoptosis. |
2017-06-15 |
2023-08-13 |
Not clear |
| D Bai, S Cong, L P Zh. Attenuation of Focal Adhesion Kinase Reduces Lipopolysaccharide-Induced Inflammation Injury through Inactivation of the Wnt and NF-κB Pathways in A549 Cells. Biochemistry. Biokhimiia. vol 82. issue 4. 2017-05-31. PMID:28371601. |
flow cytometry, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (mtt) assay, quantitative reverse transcription polymerase chain reaction, and western blot analysis were used to explore the correlation of fak expression with cell apoptosis, viability, and the inflammatory cytokine activity in a549 cells. |
2017-05-31 |
2023-08-13 |
Not clear |
| D Bai, S Cong, L P Zh. Attenuation of Focal Adhesion Kinase Reduces Lipopolysaccharide-Induced Inflammation Injury through Inactivation of the Wnt and NF-κB Pathways in A549 Cells. Biochemistry. Biokhimiia. vol 82. issue 4. 2017-05-31. PMID:28371601. |
the results showed that knockdown of fak enhanced cell viability, suppressed apoptosis, and decreased inflammatory cytokine activity. |
2017-05-31 |
2023-08-13 |
Not clear |
| Tetsuya Yoshimoto, Tsuyoshi Fujita, Mikihito Kajiya, Kazuhisa Ouhara, Shinji Matsuda, Hitoshi Komatsuzawa, Hideki Shiba, Hidemi Kurihar. Aggregatibacter actinomycetemcomitans outer membrane protein 29 (Omp29) induces TGF-β-regulated apoptosis signal in human gingival epithelial cells via fibronectin/integrinβ1/FAK cascade. Cellular microbiology. vol 18. issue 12. 2017-05-18. PMID:27121139. |
accordingly, we hypothesized that omp29-induced actin rearrangements via fak activity would enhance the activation of tgf-β, leading to gingival epithelial cell apoptosis in vitro. |
2017-05-18 |
2023-08-13 |
human |