| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi Fang, Jia-Wei Jin, Xi-Liang Zh. Role of FAK in TNF-alpha/Cycloheximide-induced Apoptosis of SMMC-7721 Cells. Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica. vol 33. issue 1. 2019-11-20. PMID:12053189. |
therefore, fak regulated tnf-alpha/cycloheximide-induced apoptosis in a biphase manner. |
2019-11-20 |
2023-08-12 |
human |
| Xi-Liang Zh. Progress of Cell Adhesion Mediated Signal-Focal Adhesion Kinase. Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica. vol 31. issue 1. 2019-11-20. PMID:12142906. |
fak can suppress cell apoptosis and also is a substrate of caspase. |
2019-11-20 |
2023-08-12 |
Not clear |
| Luciene Cristina Gastalho Campos, João Carlos Ribeiro-Silva, Alessandra Santos Menegon, Valerio Garrone Barauna, Ayumi Aurea Miyakawa, Jose Eduardo Kriege. Cyclic stretch-induced Crp3 sensitizes vascular smooth muscle cells to apoptosis during vein arterialization remodeling. Clinical science (London, England : 1979). 2019-11-20. PMID:29437853. |
immunoblotting analysis indicated that ceramide stretch-induced apoptosis in smc is accompanied by a decrease in the phosphorylation status of both fak and akt, leading to an increase in bax expression and caspase-3 cleavage. |
2019-11-20 |
2023-08-13 |
human |
| Yuzhen Zhou, Changzhen Shu, Yan Huan. Fibronectin promotes cervical cancer tumorigenesis through activating FAK signaling pathway. Journal of cellular biochemistry. 2019-11-20. PMID:30977220. |
however, the mechanism by which fn1 promotes cervical cancer cell viability, migration, adhesion, and invasion, and inhibits cell apoptosis through focal adhesion kinase (fak) signaling pathway remains to be investigated. |
2019-11-20 |
2023-08-13 |
mouse |
| Yuzhen Zhou, Changzhen Shu, Yan Huan. Fibronectin promotes cervical cancer tumorigenesis through activating FAK signaling pathway. Journal of cellular biochemistry. 2019-11-20. PMID:30977220. |
these results suggest that fn1 regulates the viability, apoptosis, migration, invasion, and adhesion of cervical cancer cells through the fak signaling pathway and is a potential therapeutic target in the treatment of cervical cancer. |
2019-11-20 |
2023-08-13 |
mouse |
| Xinghuo Wu, Kun Wang, Wenbin Hua, Shuai Li, Xianzhe Liu, Yu Song, Yukun Zhang, Zengwu Shao, Suyun Li, Cao Yan. Fibronectin induced ITGβ1/FAK-dependent apoptotic pathways determines the fate of degenerative NP cells. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 37. issue 2. 2019-10-31. PMID:30370584. |
focal adhesion kinase (fak) is involved in the integrin (itg)-mediated control of cell adhesion and anoikis (apoptosis). |
2019-10-31 |
2023-08-13 |
Not clear |
| Wen-Kuan Huang, Pinar Akçakaya, Anastasia Gangaev, Linkiat Lee, Katarina Zeljic, Praveensingh Hajeri, Erik Berglund, Mehran Ghaderi, Jan Åhlén, Robert Bränström, Catharina Larsson, Weng-Onn Lu. miR-125a-5p regulation increases phosphorylation of FAK that contributes to imatinib resistance in gastrointestinal stromal tumors. Experimental cell research. vol 371. issue 1. 2019-09-18. PMID:30149002. |
fak phosphorylation was blocked using the fak inhibitor 14 (faki) and the effects on cell viability and apoptosis were evaluated using wst-1 assay and cleaved parp expression. |
2019-09-18 |
2023-08-13 |
Not clear |
| Min Su, Xiao-Jian Gong, Xin Zho. [Research progress in mechanism of traditional Chinese medicine active ingredients against cervical cancer]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 44. issue 4. 2019-08-14. PMID:30989879. |
in this paper,the inhibitory activity and mechanism of traditional chinese medicine against human cervical cancer cells were investigated from crude extract of traditional chinese medicine,polysaccharides,alkaloids,saponins,flavonoids,terpenoids,quinones,volatile oils,esters,phenols,arsenical,protein components as the starting point; anti-cervical cancer mechanism was investigated,such as inhibiting cell proliferation inducing apoptosis of cancer cells,inhibiting cell invasion,migration and focal adhesion kinase( fak) phosphorylation,inhibiting vascular endothelial growth factor( vegf)over-expression interfering with cell mitosis,inhibiting granzyme activity,regulating cellular signaling pathway,down-regulating hpv e6 gene expression,and regulating immune function. |
2019-08-14 |
2023-08-13 |
human |
| Yan Jia, Lihui Si, Ruixin Lin, Hongjuan Jin, Wenwen Jian, Qing Yu, Shuli Yan. Thiophenol-formaldehyde triazole causes apoptosis induction in ovary cancer cells and prevents tumor growth formation in mice model. European journal of medicinal chemistry. vol 172. 2019-06-17. PMID:30947122. |
in conclusion, the compound 5a inhibited ovary cancer cell viability and induced apoptosis through decrease in expression of vwf and metalloproteinase, suppression of fak activation and decrease in infiltration of macrophages. |
2019-06-17 |
2023-08-13 |
mouse |
| Brittelle E Kessler, Katie M Mishall, Meghan D Kellett, Erin G Clark, Umarani Pugazhenthi, Nikita Pozdeyev, Jihye Kim, Aik Choon Tan, Rebecca E Schwepp. Resistance to Src inhibition alters the BRAF-mutant tumor secretome to promote an invasive phenotype and therapeutic escape through a FAK>p130Cas>c-Jun signaling axis. Oncogene. vol 38. issue 14. 2019-04-29. PMID:30531837. |
we further demonstrate that upfront combined inhibition of fak and src synergistically inhibits growth and invasion, and induces apoptosis in a panel of braf- and ras-mutant thyroid cancer cell lines. |
2019-04-29 |
2023-08-13 |
Not clear |
| Jun-Jun Li, Wen-Zhi Tu, Xu-Ming Chen, Hou-Yu Ying, Ying Chen, Yu-Long Ge, Jing Wang, Yi Xu, Ting-Feng Chen, Xiao-Wei Zhang, Jin-Jun Ye, Yong Li. FAK alleviates radiation-induced rectal injury by decreasing apoptosis. Toxicology and applied pharmacology. vol 360. 2019-04-26. PMID:30292832. |
fak alleviates radiation-induced rectal injury by decreasing apoptosis. |
2019-04-26 |
2023-08-13 |
mouse |
| Jun-Jun Li, Wen-Zhi Tu, Xu-Ming Chen, Hou-Yu Ying, Ying Chen, Yu-Long Ge, Jing Wang, Yi Xu, Ting-Feng Chen, Xiao-Wei Zhang, Jin-Jun Ye, Yong Li. FAK alleviates radiation-induced rectal injury by decreasing apoptosis. Toxicology and applied pharmacology. vol 360. 2019-04-26. PMID:30292832. |
these results demonstrated that fak reduced radiation-induced rectal injury by decreasing apoptosis. |
2019-04-26 |
2023-08-13 |
mouse |
| Asmaa E Kassab, Rasha A Hassa. Novel benzotriazole N-acylarylhydrazone hybrids: Design, synthesis, anticancer activity, effects on cell cycle profile, caspase-3 mediated apoptosis and FAK inhibition. Bioorganic chemistry. vol 80. 2019-04-22. PMID:30014921. |
novel benzotriazole n-acylarylhydrazone hybrids: design, synthesis, anticancer activity, effects on cell cycle profile, caspase-3 mediated apoptosis and fak inhibition. |
2019-04-22 |
2023-08-13 |
human |
| Zhenhui Wang, Chenghua Li, Ronglian Xing, Yina Shao, Xuelin Zhao, Weiwei Zhang, Ming Gu. β-Integrin mediates LPS-induced coelomocyte apoptosis in sea cucumber Apostichopus japonicus via the integrin/FAK/caspase-3 signaling pathway. Developmental and comparative immunology. vol 91. 2019-04-08. PMID:30339873. |
integrin/focal adhesion kinase (fak) signaling pathway modulates the apoptosis in vertebrates. |
2019-04-08 |
2023-08-13 |
Not clear |
| Rajani Kanteti, Tamara Mirzapoiazova, Jacob J Riehm, Immanuel Dhanasingh, Bolot Mambetsariev, Jiale Wang, Prakash Kulkarni, Garima Kaushik, Parthasarathy Seshacharyulu, Moorthy P Ponnusamy, Hedy L Kindler, Mohd W Nasser, Surinder K Batra, Ravi Salgi. Focal adhesion kinase a potential therapeutic target for pancreatic cancer and malignant pleural mesothelioma. Cancer biology & therapy. vol 19. issue 4. 2019-04-03. PMID:29303405. |
furthermore, these compounds suppressed the phosphorylation of fak at its active site, y397, and functionally induced significant apoptosis and cell cycle arrest in both cell lines. |
2019-04-03 |
2023-08-13 |
mouse |
| Dinh-Chuong Pham, Yu-Chuan Chang, Shian-Ren Lin, Yuh-Ming Fuh, May-Jywan Tsai, Ching-Feng Wen. FAK and S6K1 Inhibitor, Neferine, Dually Induces Autophagy and Apoptosis in Human Neuroblastoma Cells. Molecules (Basel, Switzerland). vol 23. issue 12. 2019-01-30. PMID:30486505. |
fak and s6k1 inhibitor, neferine, dually induces autophagy and apoptosis in human neuroblastoma cells. |
2019-01-30 |
2023-08-13 |
human |
| Jie Xu, Weipei Zhu, Lijuan Chen, Lili Li. MicroRNA‑433 inhibits cell growth and induces apoptosis in human cervical cancer through PI3K/AKT signaling by targeting FAK. Oncology reports. vol 40. issue 6. 2018-12-11. PMID:30272334. |
microrna‑433 inhibits cell growth and induces apoptosis in human cervical cancer through pi3k/akt signaling by targeting fak. |
2018-12-11 |
2023-08-13 |
human |
| Jie Xu, Weipei Zhu, Lijuan Chen, Lili Li. MicroRNA‑433 inhibits cell growth and induces apoptosis in human cervical cancer through PI3K/AKT signaling by targeting FAK. Oncology reports. vol 40. issue 6. 2018-12-11. PMID:30272334. |
it was found that the downregulation of microrna‑433 promoted the growth and inhibited the apoptosis of cervical cancer cells through activating focal adhesion kinase (fak)/phosphoinositide 3‑kinase (pi3k)/akt signaling. |
2018-12-11 |
2023-08-13 |
human |
| Xiu-Ying Qin, Ya-Nan Wang, Xin-Ping Yang, Juan-Juan Liang, Ji-Lin Liu, Zhao-Hui Lu. Synthesis, characterization, and anticancer activity of two mixed ligand copper(ii) complexes by regulating the VEGF/VEGFR2 signaling pathway. Dalton transactions (Cambridge, England : 2003). vol 46. issue 47. 2018-08-13. PMID:29143014. |
these complexes can remarkably induce apoptosis, inhibit proliferation, suppress migration and metastasis, and inhibit angiogenesis to inhibit the growth of cervical cancer by down-regulating the expressions of the important proteins fak, akt and erk1/2 or their phosphorylated proteins p-fak, p-akt, and p-erk1/2 downstream of the vegf/vegfr2 signaling pathway. |
2018-08-13 |
2023-08-13 |
Not clear |
| Mehlika Dilek Altıntop, Belgin Sever, Gülşen Akalın Çiftçi, Gülhan Turan-Zitouni, Zafer Asım Kaplancıklı, Ahmet Özdemi. Design, synthesis, in vitro and in silico evaluation of a new series of oxadiazole-based anticancer agents as potential Akt and FAK inhibitors. European journal of medicinal chemistry. vol 155. 2018-08-07. PMID:29966916. |
compounds 2, 6 and 9 were found to be the most potent anticancer agents against a549 and c6 cell lines and therefore their effects on apoptosis, caspase-3 activation, akt, fak, mitochondrial membrane potential and ultrastructural morphological changes were evaluated. |
2018-08-07 |
2023-08-13 |
mouse |