| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Magdalena Donejko, Edyta Rysiak, Elżbieta Galicka, Robert Terlikowski, Edyta Katarzyna Głażewska, Andrzej Przylipia. Protective influence of hyaluronic acid on focal adhesion kinase activity in human skin fibroblasts exposed to ethanol. Drug design, development and therapy. vol 11. 2017-05-15. PMID:28293103. |
regarding the mechanism of ethanol action on human skin fibroblasts, we investigated cell viability and apoptosis, expression of focal adhesion kinase (fak), and the influence of ha on those processes. |
2017-05-15 |
2023-08-13 |
human |
| Jerfiz D Constanzo, Ke-Jing Tang, Smita Rindhe, Margherita Melegari, Hui Liu, Ximing Tang, Jaime Rodriguez-Canales, Ignacio Wistuba, Pier Paolo Scaglion. PIAS1-FAK Interaction Promotes the Survival and Progression of Non-Small Cell Lung Cancer. Neoplasia (New York, N.Y.). vol 18. issue 5. 2017-05-04. PMID:27237320. |
fak has previously been reported to undergo nuclear localization during cell migration, cell differentiation and apoptosis. |
2017-05-04 |
2023-08-13 |
Not clear |
| Qi Jiang, Qingwei Li, Jianmei Han, Meng Gou, Yuanyuan Zheng, Bowen Li, Rong Xiao, Jihong Wan. rLj-RGD3 induces apoptosis via the mitochondrial-dependent pathway and inhibits adhesion, migration and invasion of human HeyA8 cells via FAK pathway. International journal of biological macromolecules. vol 96. 2017-04-17. PMID:28038913. |
rlj-rgd3 induces apoptosis via the mitochondrial-dependent pathway and inhibits adhesion, migration and invasion of human heya8 cells via fak pathway. |
2017-04-17 |
2023-08-13 |
human |
| Tieluo Li, Xufeng Wei, Charles F Evans, Pablo G Sanchez, Shuying Li, Zhongjun J Wu, Bartley P Griffit. Left Ventricular Unloading After Acute Myocardial Infarction Reduces MMP/JNK Associated Apoptosis and Promotes FAK Cell-Survival Signaling. The Annals of thoracic surgery. vol 102. issue 6. 2017-04-11. PMID:27378553. |
left ventricular unloading after acute myocardial infarction reduces mmp/jnk associated apoptosis and promotes fak cell-survival signaling. |
2017-04-11 |
2023-08-13 |
Not clear |
| Rui Feng, Sheng Yan. Effects of combining erlotinib and RNA-interfered downregulation of focal adhesion kinase expression on gastric cancer. The Journal of international medical research. vol 44. issue 4. 2017-04-10. PMID:27278554. |
to investigate the synergistic effects of combining erlotinib and rna-interference downregulation of focal adhesion kinase (fak) expression on the proliferation, apoptosis, invasion and migration of the human gastric adenocarcinoma cell line ags. |
2017-04-10 |
2023-08-13 |
human |
| Dandan Ma, Xiaoxing Kou, Jing Jin, Taotao Xu, Mengjie Wu, Liquan Deng, Lusi Fu, Yi Liu, Gang Wu, Haiping L. Hydrostatic Compress Force Enhances the Viability and Decreases the Apoptosis of Condylar Chondrocytes through Integrin-FAK-ERK/PI3K Pathway. International journal of molecular sciences. vol 17. issue 11. 2017-04-03. PMID:27827993. |
primary condylar chondrocytes were exposed to hydrostatic compressive forces (hcfs) of different magnitudes (0, 50, 100, 150, 200, and 250 kpa) for 2 h. we measured the viability, morphology, and apoptosis of the chondrocytes with different treatments as well as the gene, protein expression, and phosphorylation of mechanosensitivity-related molecules, such as integrin α2, integrin α5, integrin β1, fak, erk, and pi3k. |
2017-04-03 |
2023-08-13 |
Not clear |
| Hsin-Ling Yin, Chun-Chieh Wu, Chih-Hung Lin, Chee-Yin Chai, Ming-Feng Hou, Shu-Jyuan Chang, Hung-Pei Tsai, Wen-Chun Hung, Mei-Ren Pan, Chi-Wen Lu. β1 Integrin as a Prognostic and Predictive Marker in Triple-Negative Breast Cancer. International journal of molecular sciences. vol 17. issue 9. 2017-03-23. PMID:27589736. |
overexpression of fak could restore cisplatin-induced apoptosis in β1 integrin-depleted cells. |
2017-03-23 |
2023-08-13 |
human |
| Fan Zeng, Rui-Jun Ju, Lei Liu, Hong-Jun Xie, Li-Min Mu, Yao Zhao, Yan Yan, Ying-Jie Hu, Jia-Shuan Wu, Wan-Liang L. Application of functional vincristine plus dasatinib liposomes to deletion of vasculogenic mimicry channels in triple-negative breast cancer. Oncotarget. vol 6. issue 34. 2017-03-02. PMID:26429872. |
the liposomes exhibited the superior performances in the following aspects: the enhancement of cellular uptake via targeted action; the induction of apoptosis via activation of caspase 8, 9, and 3, increased expression of bax, decreased expression of mcl-1, and generation of reactive oxygen species (ros); and the deletion of vm channels via inhibitions on the vm channel indicators, which consisted of vascular endothelial-cadherin (ve-cad), focal adhesion kinase (fak), phosphatidylinositide 3-kinase (pi3k), and matrix metallopeptidases (mmp-2, and mmp-9). |
2017-03-02 |
2023-08-13 |
mouse |
| Ilhan Elmaci, Meric A Altino. Thymoquinone: An edible redox-active quinone for the pharmacotherapy of neurodegenerative conditions and glial brain tumors. A short review. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 83. 2017-02-07. PMID:27459120. |
in fact, thymoquinone suppresses growth and invasion, and induces apoptosis of glial tumor cells via degrading tubulins and inhibiting 20s proteasome, telomerase, autophagy, fak and metalloproteinases. |
2017-02-07 |
2023-08-13 |
Not clear |
| Liang Lin, Fan Yan, Dandan Zhao, Meng Lv, Xiaodong Liang, Hui Dai, Xiaodan Qin, Yan Zhang, Jie Hao, Xiuyuan Sun, Yanhui Yin, Xiaojun Huang, Jun Zhang, Jin Lu, Qing G. Reelin promotes the adhesion and drug resistance of multiple myeloma cells via integrin β1 signaling and STAT3. Oncotarget. vol 7. issue 9. 2016-12-30. PMID:26848618. |
the resulting phosphorylation of focal adhesion kinase (fak) led to the activation of src/syk/stat3 and akt, crucial signaling molecules involved in enhancing cell adhesion and protecting cells from drug-induced cell apoptosis. |
2016-12-30 |
2023-08-13 |
Not clear |
| Xian Yu, Tingting Li, Yifan Xia, Jun Lei, Yan Wang, Lijuan Zhan. Herpes simplex virus type 1 VP22-mediated intercellular delivery of PTEN increases the antitumor activity of PTEN in esophageal squamous cell carcinoma cells in vitro and in vivo. Oncology reports. vol 35. issue 5. 2016-12-27. PMID:27004535. |
vp22 alone did not exert antiproliferative effects or induce cell cycle arrest, induction of apoptosis, blockage of the akt and focal adhesion kinase (fak) pathways, tumor growth inhibition, or antiangiogenic effects in eca109 cells. |
2016-12-27 |
2023-08-13 |
Not clear |
| Varadharajan Thiyagarajan, Shi-Xiang Lin, Chia-Hung Lee, Ching-Feng Wen. A focal adhesion kinase inhibitor 16-hydroxy-cleroda-3,13-dien-16,15-olide incorporated into enteric-coated nanoparticles for controlled anti-glioma drug delivery. Colloids and surfaces. B, Biointerfaces. vol 141. 2016-12-14. PMID:26851441. |
16-hydroxy-cleroda-3,13-dien-16,15-olide (hcd) which is extracted from a medicinal plant, polyalthia longifolia, was shown to exhibit anticancer activity through apoptosis and fak inhibition in our previous study. |
2016-12-14 |
2023-08-13 |
mouse |
| Yang Chen, Lei Wang, Hao Huang, Ruizhe Tan, Jupeng Zhao, Shenyu Yang, Rong Zeng, Hao Wu, Jiaqing Zhang, Bin Yu, Mei T. Mechano-regulatory cellular behaviors of NIH/3T3 in response to the storage modulus of liquid crystalline substrates. Journal of the mechanical behavior of biomedical materials. vol 57. 2016-12-13. PMID:26703364. |
our results demonstrated that nih/3t3 cells showed a hypersensitive response to the storage modulus of liquid crystalline substrates by the alteration in attachment, spreading, proliferation and viability, polarization, cell cycle and apoptosis, and activity of mechano-transduction-related signal molecules including fak, paxillin and erk. |
2016-12-13 |
2023-08-13 |
Not clear |
| Gang Su, Guangli Sun, Hai Liu, Liliang Shu, Jingchao Zhang, Longhui Guo, Chen Huang, Jing X. Niacin Suppresses Progression of Atherosclerosis by Inhibiting Vascular Inflammation and Apoptosis of Vascular Smooth Muscle Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 21. 2016-09-22. PMID:26712802. |
conclusions niacin inhibits vascular inflammation and apoptosis of vsmcs via inhibiting the nf-κb signaling and the fak signaling pathway, respectively, thus protecting apoe-/- mice against atherosclerosis. |
2016-09-22 |
2023-08-13 |
mouse |
| Alicia M Waters, Laura L Stafman, Evan F Garner, Smitha Mruthyunjayappa, Jerry E Stewart, Elizabeth Mroczek-Musulman, Elizabeth A Beierl. Targeting Focal Adhesion Kinase Suppresses the Malignant Phenotype in Rhabdomyosarcoma Cells. Translational oncology. vol 9. issue 4. 2016-08-29. PMID:27567948. |
fak inhibition resulted in decreased cellular survival, invasion, and migration and increased apoptosis. |
2016-08-29 |
2023-08-13 |
mouse |
| Ke Ren, Xiao Lu, Nan Yao, Yong Chen, Aizhen Yang, Hui Chen, Jian Zhang, Sujia Wu, Xin Shi, Chen Wang, Xiaoliang Su. Focal adhesion kinase overexpression and its impact on human osteosarcoma. Oncotarget. vol 6. issue 31. 2016-08-23. PMID:26393679. |
sirna-based knockdown of fak not only dramatically reduced the migration and invasion of mg63 and 143b cells, but also had a distinct effect on osteosarcoma cell proliferation and apoptosis. |
2016-08-23 |
2023-08-13 |
human |
| Jung Seok Hwang, So Young Eun, Sun Ah Ham, Taesik Yoo, Won Jin Lee, Kyung Shin Paek, Jeong Tae Do, Dae-Seog Lim, Han Geuk Se. PPARδ modulates oxLDL-induced apoptosis of vascular smooth muscle cells through a TGF-β/FAK signaling axis. The international journal of biochemistry & cell biology. vol 62. 2016-04-19. PMID:25732738. |
here, we demonstrate that pparδ modulates oxidized low-density lipoprotein (oxldl)-induced apoptosis of vsmcs through the transforming growth factor-β (tgf-β) and focal adhesion kinase (fak) signaling pathways. |
2016-04-19 |
2023-08-13 |
Not clear |
| Byungdo B Han, Suyang Li, Meng Tong, Andrew S Holpuch, Richard Spinney, Daren Wang, Michael B Border, Zhongfa Liu, Sachin Sarode, Ping Pei, Steven P Schwendeman, Susan R Maller. Fenretinide Perturbs Focal Adhesion Kinase in Premalignant and Malignant Human Oral Keratinocytes. Fenretinide's Chemopreventive Mechanisms Include ECM Interactions. Cancer prevention research (Philadelphia, Pa.). vol 8. issue 5. 2016-04-12. PMID:25712051. |
our data imply that fenretinide is uniquely capable of disrupting fak's and pyk2's prosurvival and mobility-enhancing effects and further extend fenretinide's chemopreventive contributions beyond induction of apoptosis and differentiation. |
2016-04-12 |
2023-08-13 |
human |
| Yueying Zhou, Leiyi Zhang, Hao Pan, Baisheng Wang, Fei Yan, Xiaodan Fang, Krishna Munnee, Zhangui Tan. Bmi1 essentially mediates podocalyxin-enhanced Cisplatin chemoresistance in oral tongue squamous cell carcinoma. PloS one. vol 10. issue 4. 2016-04-11. PMID:25915207. |
overexpression of podxl in both cell lines markedly elevated the expression level of bmi1 and the half maximal inhibitory concentration (ic50) of cisplain and reduced cisplatin-induced cell apoptosis, which was abolished by knockdown of bmi1 or a selective focal adhesion kinase (fak) inhibitor. |
2016-04-11 |
2023-08-13 |
human |
| Fu Jun Li, Ryan N Duggal, Octavio M Oliva, Suman Karki, Ranu Surolia, Zheng Wang, R Douglas Watson, Victor J Thannickal, Mickie Powell, Stephen Watts, Tejaswini Kulkarni, Hitesh Batra, Subhashini Bolisetty, Anupam Agarwal, Veena B Anton. Heme oxygenase-1 protects corexit 9500A-induced respiratory epithelial injury across species. PloS one. vol 10. issue 4. 2016-03-31. PMID:25835394. |
the expression of the intercellular junctional proteins, such as tight junction proteins occludin, zonula occludens (zo-1), zo-2 and adherens junctional proteins e-cadherin and focal adhesion kinase (fak), were remarkably inhibited by ce, suggesting that these proteins are involved in ce-induced increased permeability and subsequent apoptosis. |
2016-03-31 |
2023-08-13 |
mouse |