| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Konrad Steinestel, Marcel Trautmann, Esther-Pia Jansen, Uta Dirksen, Jan Rehkämper, Jan-Henrik Mikesch, Julia S Gerke, Martin F Orth, Giuseppina Sannino, Maria-Francisca Arteaga, Claudia Rossig, Eva Wardelmann, Thomas G P Grünewald, Wolfgang Hartman. Focal adhesion kinase confers pro-migratory and antiapoptotic properties and is a potential therapeutic target in Ewing sarcoma. Molecular oncology. vol 14. issue 2. 2021-02-02. PMID:31811703. |
conversely, treatment with the fak inhibitor 15 (1,2,4,5-benzenetetraamine tetrahydrochloride (y15) enhanced caspase-mediated apoptosis and ews cell migration, independent from the respective ewsr1-ets fusion type, mimicking an anoikis-like phenotype and paralleling the effects of fak sirna knockdown. |
2021-02-02 |
2023-08-13 |
Not clear |
| John C Dawson, Bryan Serrels, Adam Byron, Morwenna T Muir, Ashraff Makda, Amaya García-Muñoz, Alex von Kriegsheim, Daniel Lietha, Neil O Carragher, Margaret C Fram. A Synergistic Anticancer FAK and HDAC Inhibitor Combination Discovered by a Novel Chemical-Genetic High-Content Phenotypic Screen. Molecular cancer therapeutics. vol 19. issue 2. 2021-01-11. PMID:31784455. |
combined fak and hdac inhibitors arrest proliferation and induce apoptosis in a subset of cancer cell lines |
2021-01-11 |
2023-08-13 |
Not clear |
| Mingxing Fang, Na Liu, Xiaoguang Yao, Tieling Xu, Zhiyong Wan. Enhancement of FAK alleviates ventilator-induced alveolar epithelial cell injury. Scientific reports. vol 10. issue 1. 2020-11-17. PMID:31942012. |
the effects of fak on cell proliferation, migration and apoptosis were investigated. |
2020-11-17 |
2023-08-13 |
mouse |
| Mingxing Fang, Na Liu, Xiaoguang Yao, Tieling Xu, Zhiyong Wan. Enhancement of FAK alleviates ventilator-induced alveolar epithelial cell injury. Scientific reports. vol 10. issue 1. 2020-11-17. PMID:31942012. |
the protective effect of fak promoted aec proliferation and migration and prevented cells from undergoing apoptosis, which restored the integrity of the alveoli through akt pathway. |
2020-11-17 |
2023-08-13 |
mouse |
| Yanxian Chen, Xiaofeng Hu, Shu Yan. Clinical significance of focal adhesion kinase (FAK) in cervical cancer progression and metastasis. International journal of clinical and experimental pathology. vol 13. issue 10. 2020-11-12. PMID:33165433. |
this fak overexpression might be a potential target for anti-cancer drugs to attenuate rapid cell proliferation and invasion by inducing apoptosis. |
2020-11-12 |
2023-08-13 |
Not clear |
| Yuxi Zhang, Xinchen Su. Role of Focal Adhesion Kinase in Head and Neck Squamous Cell Carcinoma and Its Therapeutic Prospect. OncoTargets and therapy. vol 13. 2020-10-30. PMID:33116602. |
fak inhibition can induce cell cycle arrest and apoptosis, significantly decrease cell growth, invasion and migration in hnscc cell lines. |
2020-10-30 |
2023-08-13 |
Not clear |
| Zhenfeng Hao, Jing Qian, Jishi Yan. Shikonin induces apoptosis and inhibits migration of ovarian carcinoma cells by inhibiting the phosphorylation of Src and FAK. Oncology letters. vol 9. issue 2. 2020-10-01. PMID:25621031. |
shikonin induces apoptosis and inhibits migration of ovarian carcinoma cells by inhibiting the phosphorylation of src and fak. |
2020-10-01 |
2023-08-13 |
Not clear |
| Lin Sang, Dawei Lu, Jun Zhang, Shihua Du, Xingbo Zha. Mifepristone inhibits proliferation, migration and invasion of HUUA cells and promotes its apoptosis by regulation of FAK and PI3K/AKT signaling pathway. OncoTargets and therapy. vol 11. 2020-10-01. PMID:30233205. |
mifepristone inhibits proliferation, migration and invasion of huua cells and promotes its apoptosis by regulation of fak and pi3k/akt signaling pathway. |
2020-10-01 |
2023-08-13 |
Not clear |
| De-Bo Kong, Feng Chen, Ni Sim. Focal adhesion kinases crucially regulate TGFβ-induced migration and invasion of bladder cancer cells via Src kinase and E-cadherin. OncoTargets and therapy. vol 10. 2020-09-30. PMID:28367061. |
fak is found in cell-matrix attachment sites and implicated in cell migration, invasion, movement, gene expression, survival and apoptosis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Chuanyi Zhang, Xinzhou Deng, Li Qiu, Feng Peng, Shanshan Geng, Li Shen, Zhiguo Lu. Knockdown of C1GalT1 inhibits radioresistance of human esophageal cancer cells through modifying β1-integrin glycosylation. Journal of Cancer. vol 9. issue 15. 2020-09-30. PMID:30087707. |
furthermore, β1-integrin-blocking antibody and fak inhibitor enhanced radiation-induced apoptosis in esophageal cancer cells. |
2020-09-30 |
2023-08-13 |
human |
| Jingjing Hou, Yuyu Tan, Chen Su, Tao Wang, Zhixing Gao, Dan Song, Jiabao Zhao, Yueting Liao, Xiaotian Liu, Ying Jiang, Qian Feng, Zhong Wan, Yongsheng Y. Inhibition of protein FAK enhances 5-FU chemosensitivity to gastric carcinoma Computational and structural biotechnology journal. vol 18. 2020-09-30. PMID:31969973. |
the use of shrna interference to target fak decreased proliferation and increased apoptosis of gc cells |
2020-09-30 |
2023-08-13 |
Not clear |
| Debo Kong, Feng Chen, N I Sim. Inhibition of focal adhesion kinase induces apoptosis in bladder cancer cells via Src and the phosphatidylinositol 3-kinase/Akt pathway. Experimental and therapeutic medicine. vol 10. issue 5. 2020-09-29. PMID:26640543. |
the aim of the present study was to investigate whether fak plays a role in the apoptosis of bladder cancer cells. |
2020-09-29 |
2023-08-13 |
Not clear |
| Frank Aboubakar Nana, Marie Vanderputten, Sebahat Oca. Role of Focal Adhesion Kinase in Small-Cell Lung Cancer and Its Potential as a Therapeutic Target. Cancers. vol 11. issue 11. 2020-09-28. PMID:31671774. |
the inhibition of fak in sclc cell lines demonstrated significative decrease in cell proliferation, invasion, and migration, and induced cell cycle arrest and apoptosis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Timothy Marlowe, Carlos Alvarado, Andrew Rivera, Felicia Lenzo, Rohini Nott, Dena Bondugji, Justin Montoya, Alana Hurley, Matt Kaplan, Andrew Capaldi, William Canc. Development of a High-Throughput Fluorescence Polarization Assay to Detect Inhibitors of the FAK-Paxillin Interaction. SLAS discovery : advancing life sciences R & D. vol 25. issue 1. 2020-09-22. PMID:31513463. |
focal adhesion kinase (fak) is a promising cancer drug target due to its massive overexpression in multiple solid tumors and its critical role in the integration of signals that control proliferation, invasion, apoptosis, and metastasis. |
2020-09-22 |
2023-08-13 |
Not clear |
| Xinghuo Wu, Suyun Li, Kun Wang, Wenbin Hua, Shuai Li, Yu Song, Yukun Zhang, Shuhua Yang, Cao Yan. TNF-α Regulates ITGβ1 and SYND4 Expression in Nucleus Pulposus Cells: Activation of FAK/PI3K Signaling. Inflammation. vol 42. issue 5. 2020-02-19. PMID:31111299. |
tnf-α induction could weaken fak activity and downstream levels of phospho-pi3k and akt, resulting in decreased adherence capacity and increased apoptosis. |
2020-02-19 |
2023-08-13 |
Not clear |
| Yongliang Ni, Xin Wang, Xiaoxuan Yin, Yan Li, Xigao Liu, Haixin Wang, Xiangjv Liu, Jun Zhang, Haiqing Gao, Benkang Shi, Shaohua Zha. Plectin protects podocytes from adriamycin-induced apoptosis and F-actin cytoskeletal disruption through the integrin α6β4/FAK/p38 MAPK pathway. Journal of cellular and molecular medicine. vol 22. issue 11. 2019-12-09. PMID:30187999. |
inhibitor studies demonstrated that fak y397 phosphorylation promoted p38 activation, resulting in podocyte apoptosis and f-actin cytoskeletal disruption. |
2019-12-09 |
2023-08-13 |
rat |
| Sirinapha Klungsaeng, Veerapol Kukongviriyapan, Auemduan Prawan, Sarinya Kongpetch, Laddawan Senggunpra. Cucurbitacin B induces mitochondrial-mediated apoptosis pathway in cholangiocarcinoma cells via suppressing focal adhesion kinase signaling. Naunyn-Schmiedeberg's archives of pharmacology. vol 392. issue 3. 2019-12-06. PMID:30470919. |
further molecular analyses revealed that cucurbitacin b inhibited focal adhesion kinase (fak), which is an important regulator of the apoptosis process, and its downstream pathway, pi3k/akt. |
2019-12-06 |
2023-08-13 |
Not clear |
| Sirinapha Klungsaeng, Veerapol Kukongviriyapan, Auemduan Prawan, Sarinya Kongpetch, Laddawan Senggunpra. Cucurbitacin B induces mitochondrial-mediated apoptosis pathway in cholangiocarcinoma cells via suppressing focal adhesion kinase signaling. Naunyn-Schmiedeberg's archives of pharmacology. vol 392. issue 3. 2019-12-06. PMID:30470919. |
knockdown of fak expression by small interfering rna appeared to induce cca cell apoptosis which was accompanied with elevated level of cytochrome c and cleaved caspase-9, and decreased level of bcl-2, phospho-pi3k, and phospho-akt. |
2019-12-06 |
2023-08-13 |
Not clear |
| Yi Fang, Jia-Wei Jin, Xi-Liang Zh. Role of FAK in TNF-alpha/Cycloheximide-induced Apoptosis of SMMC-7721 Cells. Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica. vol 33. issue 1. 2019-11-20. PMID:12053189. |
role of fak in tnf-alpha/cycloheximide-induced apoptosis of smmc-7721 cells. |
2019-11-20 |
2023-08-12 |
human |
| Yi Fang, Jia-Wei Jin, Xi-Liang Zh. Role of FAK in TNF-alpha/Cycloheximide-induced Apoptosis of SMMC-7721 Cells. Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica. vol 33. issue 1. 2019-11-20. PMID:12053189. |
when fak was 60% reduced as a result of the transfection of smmc-7721 cells with fak antisense construct, the percentage of tnf-alpha/cycloheximide-induced apoptosis was enhanced at lower dose of tnf-alpha but decreased at higher dose of tnf-alpha, compared with the control. |
2019-11-20 |
2023-08-12 |
human |