| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuehong Zhao, Xiaoli Zhang, Xiaona Zhang, Guoqing Shen, Weiwei Li, Qun Wan. Integrinβ1/FAK/ERK signalling pathway is essential for Chinese mitten crab Eriocheir sinensis hemocyte survival. Fish & shellfish immunology. 2022-12-05. PMID:36470403. |
treatment with an integrinβ1 inhibitor rgd (a conserved tripeptide arg-gly-asp), decreased the levels of fak and erk expression and phosphorylation, followed by an intensification of apoptosis. |
2022-12-05 |
2023-08-14 |
Not clear |
| Hamed Alizadeh Pahlavan. Exercise-induced signaling pathways to counteracting cardiac apoptotic processes. Frontiers in cell and developmental biology. vol 10. 2022-08-29. PMID:36036015. |
however, research on exercise and factors such as pim-1, notch, and fak in cardiac apoptosis is scarce, so further research is needed. |
2022-08-29 |
2023-08-14 |
Not clear |
| Lu Ye, Ru Liu, Ping Lin, Wenjun Wan. Krüppel-like transcription factor 16 transcriptional up-regulation of cellular retinoic acid-binding proteins-2 promotes the invasion and migration and inhibits apoptosis of retinoblastoma cells by regulating integrin-β1/focal adhesion kinase /extracellular signal-regulated kinase pathway. Bioengineered. vol 13. issue 2. 2022-06-07. PMID:35671035. |
we conducted this study, aiming to explore the molecular mechanism of krüppel-like transcription factor 16 (klf16)/cellular retinoic acid-binding proteins-2 (crabp2) in regulating the invasion and migration and apoptosis of rb cells via integrin-β1/focal adhesion kinase (fak)/extracellular signal-regulated kinase (erk) pathway. |
2022-06-07 |
2023-08-14 |
Not clear |
| Cuihong Fan, Zhaojia Wu, David M L Cooper, Adam Magnus, Kim Harrison, B Frank Eames, Rajni Chibbar, Gary Groot, Junqiong Huang, Harald Genth, Jun Zhang, Xing Tan, Yulin Deng, Jim Xian. Activation of Focal Adhesion Kinase Restores Simulated Microgravity-Induced Inhibition of Osteoblast Differentiation via Wnt/Β-Catenin Pathway. International journal of molecular sciences. vol 23. issue 10. 2022-05-28. PMID:35628403. |
we previously demonstrated that smg altered the focal adhesion kinase (fak)-regulated mtorc1, ampk and erk1/2 pathways, leading to the inhibition of tumor cell proliferation/metastasis and promoting cell apoptosis. |
2022-05-28 |
2023-08-13 |
mouse |
| Fei Yang, Kangping Xu, Sha Zhang, Jinlin Zhang, Yaoren Qiu, Jin Luo, Guishan Tan, Zhenxing Zou, Wenxuan Wang, Fenghua Kan. Discovery of novel chloropyramine-cinnamic acid hybrids as potential FAK inhibitors for intervention of metastatic triple-negative breast cancer. Bioorganic & medicinal chemistry. vol 66. 2022-05-15. PMID:35569251. |
further mechanism studies indicated the ability of 7d in disrupting y925 autophosphorylation of fak, reducing formation of focal adhesions (fas) and stress fibers (sfs) as well as inducing apoptosis of tnbc cells. |
2022-05-15 |
2023-08-13 |
Not clear |
| Aranka Brockmueller, Parviz Shayan, Mehdi Shakibae. Evidence That β1-Integrin Is Required for the Anti-Viability and Anti-Proliferative Effect of Resveratrol in CRC Cells. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35563105. |
similarly, resveratrol-blocked tme-induced p65-nf-kb and its promoted gene markers linked to proliferation (cyclin d1), invasion (focal adhesion kinase, fak), or apoptosis (caspase-3), were largely abrogated by anti-β1-integrin or rgd peptide, suggesting that β1-integrin is a potential transmission pathway for resveratrol/integrin down-stream signaling in crc cells. |
2022-05-14 |
2023-08-13 |
Not clear |
| Yuan Du, Shenglan Li, Tong Zhou, Jing Zhao, Jiguang Li. SIPA1 boosts migration and proliferation, and blocks apoptosis of glioma by activating the phosphorylation of the FAK signaling pathway. Journal of medical biochemistry. vol 41. issue 1. 2022-04-18. PMID:35431649. |
sipa1 boosts migration and proliferation, and blocks apoptosis of glioma by activating the phosphorylation of the fak signaling pathway. |
2022-04-18 |
2023-08-13 |
Not clear |
| Yan Liao, Lei Liu, Jiayao Yang, Zhaohong Sh. ATX/LPA axis regulates FAK activation, cell proliferation, apoptosis, and motility in human pancreatic cancer cells. In vitro cellular & developmental biology. Animal. 2022-04-15. PMID:35426066. |
atx/lpa axis regulates fak activation, cell proliferation, apoptosis, and motility in human pancreatic cancer cells. |
2022-04-15 |
2023-08-13 |
human |
| Yan Liao, Lei Liu, Jiayao Yang, Zhaohong Sh. ATX/LPA axis regulates FAK activation, cell proliferation, apoptosis, and motility in human pancreatic cancer cells. In vitro cellular & developmental biology. Animal. 2022-04-15. PMID:35426066. |
this study aimed to determine the existence of the autocrine pathway of atx/lpa action in pancreatic cancer cells, and to elucidate its influence on focal adhesion kinase (fak) activation, cellular proliferation, apoptosis, and migration. |
2022-04-15 |
2023-08-13 |
human |
| Yan Liao, Lei Liu, Jiayao Yang, Zhaohong Sh. ATX/LPA axis regulates FAK activation, cell proliferation, apoptosis, and motility in human pancreatic cancer cells. In vitro cellular & developmental biology. Animal. 2022-04-15. PMID:35426066. |
this study verified the existence of autocrine regulation of lpa secretion via producing atx by pancreatic cancer cells in vitro and the important role of lpa/atx axis on fak activation, cell proliferation, apoptosis, and motility. |
2022-04-15 |
2023-08-13 |
human |
| Juan Carlos Juárez-Cruz, Michal Okoniewski, Mónica Ramírez, Carlos Ortuño-Pineda, Napoleón Navarro-Tito, Eduardo Castañeda-Sauced. Chronic Leptin Treatment Induces Epithelial-Mesenchymal Transition in MCF10A Mammary Epithelial Cells. Journal of mammary gland biology and neoplasia. 2022-02-23. PMID:35195812. |
furthermore, when cultured in non-adherent conditions leptin treated cells exhibited reduced cell aggregation, increased survival, and decreased apoptosis, which correlates with increased fak and akt phosphorylation. |
2022-02-23 |
2023-08-13 |
Not clear |
| Ilianna Zoi, Antonios N Gargalionis, Kostas A Papavassiliou, Narjes Nasiri-Ansari, Christina Piperi, Efthimia K Basdra, Athanasios G Papavassilio. Polycystin-1 and hydrostatic pressure are implicated in glioblastoma pathogenesis in vitro. Journal of cellular and molecular medicine. 2022-02-02. PMID:35106909. |
according to our data, pc1 and hp affect gbm cell proliferation, clonogenicity and migration; the diameter of gbm spheroids; the phosphorylation of mechanistic target of rapamycin (mtor), extracellular signal-regulated kinase (erk) and focal adhesion kinase (fak); the protein expression of transcription cofactors yes-associated protein (yap) and transcriptional coactivator with pdz-binding motif (taz); and the mrna expression of markers related to anti-apoptosis, apoptosis, angiogenesis, epithelial to mesenchymal transition (emt) and proliferation. |
2022-02-02 |
2023-08-13 |
Not clear |
| Rui Wang, Jingjing Xu, Jinbo Wu, Shunheng Gao, Zhiping Wan. Angiotensin-converting enzyme 2 alleviates pulmonary artery hypertension through inhibition of focal adhesion kinase expression. Experimental and therapeutic medicine. vol 22. issue 4. 2021-09-11. PMID:34504610. |
additionally, ace2 reduced fak expression around the pulmonary arterioles and promoted smooth muscle cell apoptosis. |
2021-09-11 |
2023-08-13 |
rat |
| Mingxing Fang, Tieling Xu, Shujuan Fan, Na Liu, Luping Li, Junxia Gao, Wenbin L. SOX11 and FAK participate in the stretch‑induced mechanical injury to alveolar type 2 epithelial cells. International journal of molecular medicine. vol 47. issue 1. 2021-07-15. PMID:33236128. |
the overexpression of sox11 significantly alleviates at2 cell injury through the upregulation of fak and akt, and the inhibition of apoptosis. |
2021-07-15 |
2023-08-13 |
Not clear |
| Nehal Gupta, Sanjay K Srivastav. Atovaquone Suppresses the Growth of Metastatic Triple-Negative Breast Tumors in Lungs and Brain by Inhibiting Integrin/FAK Signaling Axis. Pharmaceuticals (Basel, Switzerland). vol 14. issue 6. 2021-07-14. PMID:34071408. |
we showed that atovaquone induced apoptosis and reduced the survival of several aggressive metastatic tnbc cell lines including metastatic patient-derived cells by reducing the expression of integrin α6, integrin β4, fak, src, and vimentin. |
2021-07-14 |
2023-08-13 |
mouse |
| Subramanyam Dasari, Taruni Pandhiri, Tommaso Grassi, Daniel W Visscher, Francesco Multinu, Komal Agarwal, Andrea Mariani, Viji Shridhar, Anirban K Mitr. Signals from the Metastatic Niche Regulate Early and Advanced Ovarian Cancer Metastasis through miR-4454 Downregulation. Molecular cancer research : MCR. vol 18. issue 8. 2021-07-02. PMID:32350057. |
its mechanism of action was through the upregulation of its targets, secreted protein acidic and cysteine rich (sparc) and bcl2 associated athanogene 5 (bag5), which activated focal adhesion kinase (fak) signaling, promoted mutant p53 gain of function by its stabilization, and inhibited apoptosis. |
2021-07-02 |
2023-08-13 |
Not clear |
| Subramanyam Dasari, Taruni Pandhiri, Tommaso Grassi, Daniel W Visscher, Francesco Multinu, Komal Agarwal, Andrea Mariani, Viji Shridhar, Anirban K Mitr. Signals from the Metastatic Niche Regulate Early and Advanced Ovarian Cancer Metastasis through miR-4454 Downregulation. Molecular cancer research : MCR. vol 18. issue 8. 2021-07-02. PMID:32350057. |
implications: this study identifies a mirna, mir-4454, which is downregulated by signals from the microenvironment and promotes early and advanced ovarian cancer metastasis through its effects on fak activation, mutant p53 stabilization, and apoptosis inhibition. |
2021-07-02 |
2023-08-13 |
Not clear |
| Houjun Xia, Shasha Li, Xiong Li, Weichao Wang, Yingjie Bian, Shuang Wei, Sara Grove, Weimin Wang, Linda Vatan, J Rebecca Liu, Karen McLean, Ramandeep Rattan, Adnan Munkarah, Jun-Lin Guan, Ilona Kryczek, Weiping Zo. Autophagic adaptation to oxidative stress alters peritoneal residential macrophage survival and ovarian cancer metastasis. JCI insight. vol 5. issue 18. 2021-05-31. PMID:32780724. |
furthermore, genetic deficiency of autophagy element fak family-interacting protein of 200 kda resulted in tim-4+ tam loss via ros-mediated apoptosis and elevated t cell immunity and id8 tumor inhibition in vivo. |
2021-05-31 |
2023-08-13 |
mouse |
| Lei Li, Yuancai Xiang, Yi Zeng, Bin Xiao, Wenjing Yu, Chunyan Duan, Xianming Xia, Ting Zhang, Yongqiu Zeng, Youping Liu, Rongyang Da. GSK‑3β inhibition promotes doxorubicin‑induced apoptosis in human cholangiocarcinoma cells via FAK/AKT inhibition. Molecular medicine reports. vol 22. issue 5. 2021-04-30. PMID:33000181. |
blocking gsk‑3β enhanced the sensitivity of human cca cells to doxorubicin (dox)‑induced apoptosis, which was accompanied by decreased akt and focal adhesion kinase (fak) activity. |
2021-04-30 |
2023-08-13 |
human |
| Lei Li, Yuancai Xiang, Yi Zeng, Bin Xiao, Wenjing Yu, Chunyan Duan, Xianming Xia, Ting Zhang, Yongqiu Zeng, Youping Liu, Rongyang Da. GSK‑3β inhibition promotes doxorubicin‑induced apoptosis in human cholangiocarcinoma cells via FAK/AKT inhibition. Molecular medicine reports. vol 22. issue 5. 2021-04-30. PMID:33000181. |
moreover, inhibiting gsk‑3β using 6‑bromoindirubin‑3'‑oxime, chir99021 or small interfering rna decreased phosphorylation of fak and akt, and promoted apoptosis of dox‑induced human cca cells. |
2021-04-30 |
2023-08-13 |
human |