| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lixia Ju, Caicun Zho. Association of integrin beta1 and c-MET in mediating EGFR TKI gefitinib resistance in non-small cell lung cancer. Cancer cell international. vol 13. issue 1. 2013-03-01. PMID:23402326. |
we found that the ligands of integrin beta1 and c-met could synergistically promote cell proliferation and their inhibitors could synergistically improve the sensitivity to gfitinib, increase apoptosis, and inhibit the downstream signal transduction: focal adhesion kinase (fak) and akt. |
2013-03-01 |
2023-08-12 |
Not clear |
| Xichao Wang, Qun Chen, Da Xin. Focal adhesion kinase activates NF-κB via the ERK1/2 and p38MAPK Pathways in amyloid-β25-35-induced apoptosis in PC12 cells. Journal of Alzheimer's disease : JAD. vol 32. issue 1. 2013-02-20. PMID:22776966. |
taken together, our results suggest that fak activates nf-κb via erk1/2 and p38mapk pathways in aβ(25-35)-induced apoptosis of differentiated pc12 cells. |
2013-02-20 |
2023-08-12 |
rat |
| Michael J Dabrowski, Joseph K Zolnerciks, Larissa M Balogh, Robert J Greene, Terrance J Kavanagh, William M Atkin. Stereoselective effects of 4-hydroxynonenal in cultured mouse hepatocytes. Chemical research in toxicology. vol 23. issue 10. 2013-02-19. PMID:20873854. |
caspase-3-dependent cleavage of the glutamate cysteine ligase (gcl) catalytic subunit and focal adhesion kinase (fak) were greater in cells treated with (s)-hne at 48 h. (s)-hne also caused a greater number of subg1 nuclei, a hallmark of apoptosis, at 30 h after treatment. |
2013-02-19 |
2023-08-12 |
mouse |
| Anna Alisi, Mario Arciello, Stefania Petrini, Beatrice Conti, Gabriele Missale, Clara Balsan. Focal adhesion kinase (FAK) mediates the induction of pro-oncogenic and fibrogenic phenotypes in hepatitis C virus (HCV)-infected cells. PloS one. vol 7. issue 8. 2013-02-12. PMID:22937161. |
moreover and interestingly, fak inhibition enhances apoptosis in hcv-conditioned lx-2 cells. |
2013-02-12 |
2023-08-12 |
Not clear |
| Muralidharan Anbalagan, Alaa Ali, Ryan K Jones, Carolyn G Marsden, Mei Sheng, Latonya Carrier, Yahao Bu, David Hangauer, Brian G Rowa. Peptidomimetic Src/pretubulin inhibitor KX-01 alone and in combination with paclitaxel suppresses growth, metastasis in human ER/PR/HER2-negative tumor xenografts. Molecular cancer therapeutics. vol 11. issue 9. 2013-02-07. PMID:22784709. |
kx-01 inhibited activity of src and downstream mediator fak in tumors that was coincident with reduced proliferation and angiogenesis and increased apoptosis. |
2013-02-07 |
2023-08-12 |
mouse |
| Yan Song, Douglas C McFarland, Sandra G Vellema. Syndecan-4 cytoplasmic domain regulation of turkey satellite cell focal adhesions and apoptosis. Molecular biology reports. vol 39. issue 8. 2012-11-13. PMID:22660841. |
these results suggested that the syndecan-4 cytoplasmic domain plays an important role in regulating fak activity and β1 integrin cell membrane localization but not cell apoptosis and vinculin or paxillin-containing focal adhesion formation. |
2012-11-13 |
2023-08-12 |
Not clear |
| Rachid Seqqat, Xinji Guo, Khadija Rafiq, Mikhail A Kolpakov, Jianfen Guo, Walter J Koch, Steven R Houser, Louis J Dell'italia, Abdelkarim Sabr. Beta1-adrenergic receptors promote focal adhesion signaling downregulation and myocyte apoptosis in acute volume overload. Journal of molecular and cellular cardiology. vol 53. issue 2. 2012-10-31. PMID:22609523. |
rats with eccentric cardiac hypertrophy induced after aorto-caval fistula (acf) develop reduced interstitial collagen content and decreased tyrosine phosphorylation of key fa signaling molecules fak, pyk(2) and paxillin along with an increase in cardiac myocyte apoptosis. |
2012-10-31 |
2023-08-12 |
rat |
| Rachid Seqqat, Xinji Guo, Khadija Rafiq, Mikhail A Kolpakov, Jianfen Guo, Walter J Koch, Steven R Houser, Louis J Dell'italia, Abdelkarim Sabr. Beta1-adrenergic receptors promote focal adhesion signaling downregulation and myocyte apoptosis in acute volume overload. Journal of molecular and cellular cardiology. vol 53. issue 2. 2012-10-31. PMID:22609523. |
adenoviral-mediated expression of a catalytically inactive pten mutant or wild-type fak restored fa signaling downregulation and attenuated myocyte apoptosis induced by β(1)-ars. |
2012-10-31 |
2023-08-12 |
rat |
| Masahiro Sakurai, Jun Ohtake, Takayuki Ishikawa, Kentaro Tanemura, Yumi Hoshino, Takahiro Arima, Eimei Sat. Distribution and Y397 phosphorylation of focal adhesion kinase on follicular development in the mouse ovary. Cell and tissue research. vol 347. issue 2. 2012-10-16. PMID:22322421. |
despite its important roles in apoptosis, the expression and function of fak in the ovaries remain unknown. |
2012-10-16 |
2023-08-12 |
mouse |
| Dorothee Fried, Beate B Böhm, Kristin Krause, Harald Burkhard. ADAM15 protein amplifies focal adhesion kinase phosphorylation under genotoxic stress conditions. The Journal of biological chemistry. vol 287. issue 25. 2012-08-24. PMID:22544741. |
moreover, the apoptosis induction elicited by specific inhibitors (pp2, fak 14 inhibitor) of fak/src signaling was significantly reduced by adam15 expression. |
2012-08-24 |
2023-08-12 |
Not clear |
| Yan Song, Douglas C McFarland, Sandra G Vellema. Role of syndecan-4 side chains in turkey satellite cell apoptosis and focal adhesion formation. Cell biology international. vol 36. issue 5. 2012-08-08. PMID:22272563. |
the results suggest that s4 and its side chains play important roles in regulating fak activity, and pkcα and β1-integrin cell membrane localization, but not cell apoptosis and vinculin-containing focal adhesion formation. |
2012-08-08 |
2023-08-12 |
Not clear |
| Jeffrey C Horowitz, Iyabode O Ajayi, Priya Kulasekaran, David S Rogers, Joshua B White, Sarah K Townsend, Eric S White, Richard S Nho, Peter D R Higgins, Steven K Huang, Thomas H Sisso. Survivin expression induced by endothelin-1 promotes myofibroblast resistance to apoptosis. The international journal of biochemistry & cell biology. vol 44. issue 1. 2012-07-12. PMID:22041029. |
focal adhesion kinase (fak) also promotes myofibroblast resistance to apoptosis through pi3k/akt-dependent and -independent mechanisms, although the role of fak in et-1 mediated resistance to apoptosis has not been explored. |
2012-07-12 |
2023-08-12 |
Not clear |
| Jeffrey C Horowitz, Iyabode O Ajayi, Priya Kulasekaran, David S Rogers, Joshua B White, Sarah K Townsend, Eric S White, Richard S Nho, Peter D R Higgins, Steven K Huang, Thomas H Sisso. Survivin expression induced by endothelin-1 promotes myofibroblast resistance to apoptosis. The international journal of biochemistry & cell biology. vol 44. issue 1. 2012-07-12. PMID:22041029. |
the goal of this study was to investigate whether fak contributes to et-1 mediated myofibroblast resistance to apoptosis and to examine potential mechanisms downstream of fak and pi3k/akt by which et-1 regulates myofibroblast survival. |
2012-07-12 |
2023-08-12 |
Not clear |
| Jeffrey C Horowitz, Iyabode O Ajayi, Priya Kulasekaran, David S Rogers, Joshua B White, Sarah K Townsend, Eric S White, Richard S Nho, Peter D R Higgins, Steven K Huang, Thomas H Sisso. Survivin expression induced by endothelin-1 promotes myofibroblast resistance to apoptosis. The international journal of biochemistry & cell biology. vol 44. issue 1. 2012-07-12. PMID:22041029. |
the anti-apoptotic actions of fak are, in turn, dependent on activation of pi3k/akt and the subsequent increased expression of survivin, a member of the inhibitor of apoptosis protein (iap) family. |
2012-07-12 |
2023-08-12 |
Not clear |
| Jiunn-Min Shieh, Tzu-Tang Wei, Yen-An Tang, Sin-Ming Huang, Wei-Ling Wen, Mei-Yu Chen, Hung-Chi Cheng, Santosh B Salunke, Ching-Shih Chen, Pinpin Lin, Chien-Tien Chen, Yi-Ching Wan. Mitochondrial apoptosis and FAK signaling disruption by a novel histone deacetylase inhibitor, HTPB, in antitumor and antimetastatic mouse models. PloS one. vol 7. issue 1. 2012-07-09. PMID:22279574. |
mitochondrial apoptosis and fak signaling disruption by a novel histone deacetylase inhibitor, htpb, in antitumor and antimetastatic mouse models. |
2012-07-09 |
2023-08-12 |
mouse |
| Pratibha Gaur, Priya Ranjan, Shipra Sharma, Jenish R Patel, J Bradford Bowzard, Shah K Rahman, Rashmi Kumari, Shivaprakash Gangappa, Jacqueline M Katz, Nancy J Cox, Renu B Lal, Suryaprakash Sambhara, Sunil K La. Influenza A virus neuraminidase protein enhances cell survival through interaction with carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) protein. The Journal of biological chemistry. vol 287. issue 18. 2012-07-02. PMID:22396546. |
na/c6 interaction leads to increased tyrosyl phosphorylation of src, fak, akt, gsk3β, and bcl-2, which affects cell survival, proliferation, migration, differentiation, and apoptosis. |
2012-07-02 |
2023-08-12 |
human |
| Pratibha Gaur, Priya Ranjan, Shipra Sharma, Jenish R Patel, J Bradford Bowzard, Shah K Rahman, Rashmi Kumari, Shivaprakash Gangappa, Jacqueline M Katz, Nancy J Cox, Renu B Lal, Suryaprakash Sambhara, Sunil K La. Influenza A virus neuraminidase protein enhances cell survival through interaction with carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) protein. The Journal of biological chemistry. vol 287. issue 18. 2012-07-02. PMID:22396546. |
sirna-mediated suppression of c6 resulted in a down-regulation of activated src, fak, and akt, increased apoptosis, and reduced expression of viral proteins and viral titers in influenza virus-infected human lung adenocarcinoma epithelial and normal human bronchial epithelial cells. |
2012-07-02 |
2023-08-12 |
human |
| Shiro Mizuno, Masanori Yasuo, Harm J Bogaard, Donatas Kraskauskas, Aysar Alhussaini, Jose Gomez-Arroyo, Daniela Farkas, Laszlo Farkas, Norbert F Voelke. Copper deficiency induced emphysema is associated with focal adhesion kinase inactivation. PloS one. vol 7. issue 1. 2012-06-04. PMID:22276220. |
cell detachment from the extracellular matrix can induce apoptosis (anoikis) via inactivation of focal adhesion kinase (fak). |
2012-06-04 |
2023-08-12 |
Not clear |
| Hyunsoo Shin, Yeo Song Lee, Yong Chan Le. Sodium butyrate-induced DAPK-mediated apoptosis in human gastric cancer cells. Oncology reports. vol 27. issue 4. 2012-05-30. PMID:22160140. |
these data suggest that dapk expression prompts apoptosis by reducing the fak protein level in sodium butyrate-induced apoptosis of human gastric cancer cells. |
2012-05-30 |
2023-08-12 |
human |
| Sunyoung Ahn, Hyun Jeong Kim, Sung-Gil Chi, Heonyong Par. XIAP reverses various functional activities of FRNK in endothelial cells. Biochemical and biophysical research communications. vol 419. issue 2. 2012-05-07. PMID:22366087. |
we recently found that fak is recruited into focal adhesion (fa) sites through interactions with xiap (x-chromosome linked inhibitor of apoptosis protein) and activated by src kinase in response to shear stress. |
2012-05-07 |
2023-08-12 |
Not clear |