| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nikolaos A Chatzizacharias, Gregory P Kouraklis, Stamatios E Theochari. The role of focal adhesion kinase in early development. Histology and histopathology. vol 25. issue 8. 2010-09-22. PMID:20552554. |
scientific evidence have suggested that fak possessing a central position in the integrin signaling cascade, is responsible, at least in part, for the modulation of cellular proliferation, protection from apoptosis, adhesion, spreading and migration. |
2010-09-22 |
2023-08-12 |
human |
| Stergios J Moschos, Cindy A Sander, Wenjun Wang, Shelley L Reppert, Laura M Drogowski, Drazen M Jukic, Uma N M Rao, Charalambos Athanassiou, Manuela Buzoianu, Maja Mandic, Laura Richman, LuAnn McKinney, Joel Leininger, David A Tice, Luz Hammershaimb, John M Kirkwoo. Pharmacodynamic (phase 0) study using etaracizumab in advanced melanoma. Journal of immunotherapy (Hagerstown, Md. : 1997). vol 33. issue 3. 2010-08-10. PMID:20445352. |
patients treated at the highest dose may have had better clinical benefit secondary to suppression of the activated immediate downstream effector of alphavbeta3 signaling, fak, in melanoma cells, but this alone did not ultimately affect melanoma cell proliferation or apoptosis. |
2010-08-10 |
2023-08-12 |
Not clear |
| Alexander Schultze, Walter Fiedle. Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancer. Expert opinion on investigational drugs. vol 19. issue 6. 2010-08-06. PMID:20465362. |
fak plays an important role in regulation of proliferation, migration and apoptosis of neoplastic cells. |
2010-08-06 |
2023-08-12 |
Not clear |
| Xiaofeng Zhao, Xu Peng, Shaogang Sun, Ann Y J Park, Jun-Lin Gua. Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development. The Journal of cell biology. vol 189. issue 6. 2010-07-08. PMID:20530207. |
expression of kd fak reversed increased ec apoptosis observed with fak deletion in embryos and in vitro through suppression of up-regulated p21. |
2010-07-08 |
2023-08-12 |
mouse |
| Elizabeth A Beierle, Xiaojie Ma, Jerry Stewart, Carl Nyberg, Angelica Trujillo, William G Cance, Vita M Golubovskay. Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma. Cell cycle (Georgetown, Tex.). vol 9. issue 5. 2010-06-29. PMID:20160475. |
focal adhesion kinase (fak) is an intracellular kinase that regulates both cellular adhesion and apoptosis. |
2010-06-29 |
2023-08-12 |
mouse |
| Oumou Goundiam, Marie-Danielle Nagel, Muriel Vayssad. Growth and survival signalling in B16F10 melanoma cells in 3D culture. Cell biology international. vol 34. issue 4. 2010-06-24. PMID:20015052. |
for this, we analysed cell morphology, proliferation, apoptosis and the activation status of several proteins involved in cell proliferation and survival [rhoa, fak (focal adhesion kinase), akt, erk1/2 (extracellular-signal-regulated kinase 1/2)]. |
2010-06-24 |
2023-08-12 |
Not clear |
| Oumou Goundiam, Marie-Danielle Nagel, Muriel Vayssad. Growth and survival signalling in B16F10 melanoma cells in 3D culture. Cell biology international. vol 34. issue 4. 2010-06-24. PMID:20015052. |
fak and akt were transiently activated, and their inactivation was correlated with the induction of apoptosis. |
2010-06-24 |
2023-08-12 |
Not clear |
| Yuying Chen, Zhanxiang Wang, Pingan Chang, Liuxin Xiang, Feng Pan, Jianjun Li, Jinyan Jiang, Lan Zou, Li Yang, Zhiheng Bian, Houjie Lian. The effect of focal adhesion kinase gene silencing on 5-fluorouracil chemosensitivity involves an Akt/NF-kappaB signaling pathway in colorectal carcinomas. International journal of cancer. vol 127. issue 1. 2010-06-14. PMID:19904749. |
focal adhesion kinase (fak) plays an important role in apoptosis, survival and cell adhesion between cells and their extracellular matrix. |
2010-06-14 |
2023-08-12 |
human |
| Yuying Chen, Zhanxiang Wang, Pingan Chang, Liuxin Xiang, Feng Pan, Jianjun Li, Jinyan Jiang, Lan Zou, Li Yang, Zhiheng Bian, Houjie Lian. The effect of focal adhesion kinase gene silencing on 5-fluorouracil chemosensitivity involves an Akt/NF-kappaB signaling pathway in colorectal carcinomas. International journal of cancer. vol 127. issue 1. 2010-06-14. PMID:19904749. |
knockdown of fak reversed the formation and aggregation of mcss, significantly decreased the 50% inhibitory concentration of 5-fu, and markedly increased mcs culture cells apoptosis. |
2010-06-14 |
2023-08-12 |
human |
| Kae Tsutsumi, Takeshi Yamaura, Motowo Nakajima, Toshiyuki Honda, Tatsuhiko Kasaok. Silencing of focal adhesion kinase by tumor direct injection of small interfering RNA decreases in vivo tumor growth. Cancer biology & therapy. vol 8. issue 13. 2010-05-04. PMID:19458494. |
focal adhesion kinase (fak) is shown to be frequently correlated with malignancy of the tumor and poor prognosis of the diseases.because fak resides immediately downstream of the interaction of cell surface adhesion molecules and extracellular matricies, it is considered to be critical to regulate several cellular processes including growth, differentiation, adhesion, motility and apoptosis. |
2010-05-04 |
2023-08-12 |
Not clear |
| Elizabeth A Beierle, Xiaojie Ma, Angelica Trujillo, Elena V Kurenova, William G Cance, Vita M Golubovskay. Inhibition of focal adhesion kinase and src increases detachment and apoptosis in human neuroblastoma cell lines. Molecular carcinogenesis. vol 49. issue 3. 2010-03-25. PMID:19885861. |
the results of the current study suggest that both fak and src play a role in protecting neuroblastoma cells from apoptosis, and that dual inhibition of these kinases may be important when designing therapeutic interventions for this tumor. |
2010-03-25 |
2023-08-12 |
human |
| Jing-Song Chen, Xiao-Hui Huang, Qian Wang, Xi-Lin Chen, Xin-Hui Fu, Hao-Xiang Tan, Long-Juan Zhang, Wen Li, Jiong B. FAK is involved in invasion and metastasis of hepatocellular carcinoma. Clinical & experimental metastasis. vol 27. issue 2. 2010-03-25. PMID:20180147. |
furthermore, hcc cell adhesion, migration and invasion were substantially impaired by sirna-mediated knockdown of fak expression, whereas cell growth, apoptosis and cell cycle distribution were not affected. |
2010-03-25 |
2023-08-12 |
human |
| Bor-Sheng Ko, Tzu-Ching Chang, Chien-Hung Chen, Chia-Chia Liu, Cheng-Chin Kuo, Chiun Hsu, Ying-Chun Shen, Tang-Long Shen, Vita M Golubovskaya, Chung-Che Chang, Song-Kun Shyue, Jun-Yang Lio. Bortezomib suppresses focal adhesion kinase expression via interrupting nuclear factor-kappa B. Life sciences. vol 86. issue 5-6. 2010-02-22. PMID:20006625. |
to explore the role of bortezomib in reducing cancer cell migration and inducing apoptosis, we evaluated the effects of bortezomib on the expression of focal adhesion kinase (fak). |
2010-02-22 |
2023-08-12 |
Not clear |
| Donghang Zheng, Vita Golubovskaya, Elena Kurenova, Cheng Wood, Nicole A Massoll, David Ostrov, William G Cance, Steven N Hochwal. A novel strategy to inhibit FAK and IGF-1R decreases growth of pancreatic cancer xenografts. Molecular carcinogenesis. vol 49. issue 2. 2010-02-18. PMID:19885860. |
further inhibition of fak pathway using y15 significantly decreased cell survival, adhesion, and promoted apoptosis. |
2010-02-18 |
2023-08-12 |
human |
| Ssang-Taek Lim, Nichol L G Miller, Ju-Ock Nam, Xiao Lei Chen, Yangmi Lim, David D Schlaepfe. Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival. The Journal of biological chemistry. vol 285. issue 3. 2010-02-08. PMID:19880522. |
moreover, pyk2 ferm expression in human fibroblasts upon fak knockdown prevented cisplatin-mediated apoptosis. |
2010-02-08 |
2023-08-12 |
mouse |
| Hui-Fang Hao, Yoshio Naomoto, Xiao-Hong Bao, Nobuyuki Watanabe, Kazufumi Sakurama, Kazuhiro Noma, Yasuko Tomono, Takuya Fukazawa, Yasuhiro Shirakawa, Tomoki Yamatsuji, Junji Matsuoka, Munenori Takaok. Progress in researches about focal adhesion kinase in gastrointestinal tract. World journal of gastroenterology. vol 15. issue 47. 2010-02-05. PMID:20014455. |
fak also plays an important role in the restitution, cell survival and apoptosis and carcinogenesis of the gastrointestinal tract. |
2010-02-05 |
2023-08-12 |
Not clear |
| C Yan Cheng, Dolores D Mru. Regulation of blood-testis barrier dynamics by focal adhesion kinase (FAK): an unexpected turn of events. Cell cycle (Georgetown, Tex.). vol 8. issue 21. 2010-02-01. PMID:19823026. |
recent studies, however, have demonstrated that focal adhesion kinase (fak), a modulator of the integrin-based signaling that plays a crucial role in cell movement, apoptosis, cell survival and gene expression at the focal adhesion complex (fac, also known as focal contact, a cell-matrix anchoring junction type), is an integrated component of the btb, associated with the tj-integral membrane protein occludin and its adaptor zonula occludens-1 (zo-1). |
2010-02-01 |
2023-08-12 |
Not clear |
| Huina Zhang, Scott Holliste. Comparison of bone marrow stromal cell behaviors on poly(caprolactone) with or without surface modification: studies on cell adhesion, survival and proliferation. Journal of biomaterials science. Polymer edition. vol 20. issue 14. 2010-01-15. PMID:19874672. |
furthermore, bone marrow stromal cell (bmsc) behaviors including attachment, spreading, focal adhesion formation, focal adhesion kinase (fak) activation, apoptosis and proliferation when cultured on the modified pcl films were investigated. |
2010-01-15 |
2023-08-12 |
Not clear |
| Chandra S Boosani, Narasimharao Nalabothula, Veerendra Munugalavadla, Dominic Cosgrove, Venkateshwar G Keshamoun, Nader Sheibani, Akulapalli Sudhaka. FAK and p38-MAP kinase-dependent activation of apoptosis and caspase-3 in retinal endothelial cells by alpha1(IV)NC1. Investigative ophthalmology & visual science. vol 50. issue 10. 2009-10-02. PMID:19443723. |
fak and p38-map kinase-dependent activation of apoptosis and caspase-3 in retinal endothelial cells by alpha1(iv)nc1. |
2009-10-02 |
2023-08-12 |
mouse |
| Yu-Ying Chen, Zhan-Xiang Wang, Ping-An Chang, Jian-Jun Li, Feng Pan, Li Yang, Zhi-Heng Bian, Lan Zou, Jian-Ming He, Hou-Jie Lian. Knockdown of focal adhesion kinase reverses colon carcinoma multicellular resistance. Cancer science. vol 100. issue 9. 2009-09-10. PMID:19500106. |
however, silencing of fak combined with 5-fu treatment significantly decreased the 50% inhibitory concentration (ic(50)) of 5-fu and markedly increased the population of apoptosis cells, which was associated with the reduction of the levels of akt and nuclear factor-kappa b (nf-kappab). |
2009-09-10 |
2023-08-12 |
mouse |