| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Abilasha Gayani Jayathilake, Elif Kadife, Nyanbol Kuol, Rodney Brain Luwor, Kulmira Nurgali, Xiao Qun S. Krill oil supplementation reduces the growth of CT-26 orthotopic tumours in Balb/c mice. BMC complementary medicine and therapies. vol 22. issue 1. 2022-02-05. PMID:35120511. |
this study aimed to investigate the in vivo efficacy of various doses of ko supplementation on the inhibition of crc tumour growth, molecular markers of proliferation, angiogenesis, apoptosis, the epidermal growth factor receptor (egfr) and its downstream molecular signalling. |
2022-02-05 |
2023-08-13 |
mouse |
| Yiqi Liu, Yuan Li, Liu Xu, Jiasen Shi, Xiujuan Yu, Xue Wang, Xizhi Li, Hong Jiang, Tingting Yang, Xiaoxing Yin, Lei Du, Qian L. Quercetin Attenuates Podocyte Apoptosis of Diabetic Nephropathy Through Targeting EGFR Signaling. Frontiers in pharmacology. vol 12. 2022-01-24. PMID:35069207. |
quercetin attenuates podocyte apoptosis of diabetic nephropathy through targeting egfr signaling. |
2022-01-24 |
2023-08-13 |
Not clear |
| Rin Liu, Satoru Shinriki, Manabu Maeshiro, Mayumi Hirayama, Hirofumi Jono, Ryoji Yoshida, Hideki Nakayama, Hirotaka Matsu. The Tumour Suppressor CYLD Is Required for Clathrin-Mediated Endocytosis of EGFR and Cetuximab-Induced Apoptosis in Head and Neck Squamous Cell Carcinoma. Cancers. vol 14. issue 1. 2022-01-11. PMID:35008337. |
the tumour suppressor cyld is required for clathrin-mediated endocytosis of egfr and cetuximab-induced apoptosis in head and neck squamous cell carcinoma. |
2022-01-11 |
2023-08-13 |
Not clear |
| Rin Liu, Satoru Shinriki, Manabu Maeshiro, Mayumi Hirayama, Hirofumi Jono, Ryoji Yoshida, Hideki Nakayama, Hirotaka Matsu. The Tumour Suppressor CYLD Is Required for Clathrin-Mediated Endocytosis of EGFR and Cetuximab-Induced Apoptosis in Head and Neck Squamous Cell Carcinoma. Cancers. vol 14. issue 1. 2022-01-11. PMID:35008337. |
loss of cyld restricted egfr to lipid rafts, which suppressed ctx-induced apoptosis without impeding ctx's inhibitory activity against downstream signalling pathways. |
2022-01-11 |
2023-08-13 |
Not clear |
| Hui Deng, Qian Lei, Weidong Shang, Ying Li, Liyun Bi, Na Yang, Zhiyi Yu, Weimin L. Potential applications of clickable probes in EGFR activity visualization and prediction of EGFR-TKI therapy response for NSCLC patients. European journal of medicinal chemistry. vol 230. 2022-01-10. PMID:35007861. |
the epithelial growth factor receptor (egfr) is abnormally overexpressed on the cell surface of cancer cells and is strongly associated with cancer cell proliferation, migration, differentiation, apoptosis, and angiogenesis. |
2022-01-10 |
2023-08-13 |
mouse |
| Yu-Jen Chiu, Jai-Sing Yang, Fuu-Jen Tsai, Hong-Yi Chiu, Yu-Ning Juan, Yu-Hsiang Lo, Jo-Hua Chian. Curcumin suppresses cell proliferation and triggers apoptosis in vemurafenib-resistant melanoma cells by downregulating the EGFR signaling pathway. Environmental toxicology. 2022-01-07. PMID:34994998. |
curcumin suppresses cell proliferation and triggers apoptosis in vemurafenib-resistant melanoma cells by downregulating the egfr signaling pathway. |
2022-01-07 |
2023-08-13 |
Not clear |
| Bo Mi Ku, Jae Yeong Heo, Jinchul Kim, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Keunchil Park, Myung-Ju Ah. ERK inhibitor ASN007 effectively overcomes acquired resistance to EGFR inhibitor in non-small cell lung cancer. Investigational new drugs. 2022-01-01. PMID:34973117. |
in addition, combination treatment with asn007 and egfr tkis significantly decreased the survival of resistant cells, enhanced induction of apoptosis, and effectively inhibited the growth of erlotinib-resistant xenografts, providing the preclinical rationale for testing combinations of asn007 and egfr tkis in egfr-mutated nsclc patients. |
2022-01-01 |
2023-08-13 |
Not clear |
| Zhe-Yuan Xu, Xu Li, Rui-Hong Yao, Li-Min Yang, Hao Peng, Wen-Jun Ren, Hong Lu, Ping Wan. Rhomboid domain containing 1 promotes the growth of non-small cell lung cancer through the activation of EGFR and regulation of the BIK-mediated apoptosis. Neoplasma. 2021-12-28. PMID:34962825. |
rhomboid domain containing 1 promotes the growth of non-small cell lung cancer through the activation of egfr and regulation of the bik-mediated apoptosis. |
2021-12-28 |
2023-08-13 |
Not clear |
| Alveiro Erira, Fernando Velandia, José Penagos, Camilo Zubieta, Gonzalo Arboled. Differential Regulation of the EGFR/PI3K/AKT/PTEN Pathway between Low- and High-Grade Gliomas. Brain sciences. vol 11. issue 12. 2021-12-24. PMID:34942957. |
the permanent activation of the egfr/pi3k/akt pathway by various genetic or post-translational alterations of egfr, pi3kca, and pten has been associated with increased proliferation and resistance to apoptosis. |
2021-12-24 |
2023-08-13 |
Not clear |
| Mara Pilmane, Dins Sumerags, Nityanand Jain, Shivani Jain, Gunta Sumerag. Singer's Nodules: Investigating the Etiopathogenetic Markers Progressing Their Pathogenesis and Clinical Manifestations. Biology. vol 10. issue 12. 2021-12-24. PMID:34943184. |
hence, we compared the immunohistochemical markers for proliferation (ki-67), apoptosis (tunel), growth (egfr), ischemia (vegf), inflammation (il-1α and 10), and immunoreactive innervation (pgp 9.5), in vocal nodule tissue samples obtained from 10 females (17-56 years) and vocal cord tissue from seven controls. |
2021-12-24 |
2023-08-13 |
Not clear |
| Kunyan He, Guang-Xing Wang, Li-Nan Zhao, Xiao-Fang Cui, Xian-Bin Su, Yi Shi, Tian-Pei Xie, Shang-Wei Hou, Ze-Guang Ha. Cinobufagin Is a Selective Anti-Cancer Agent against Tumors with EGFR Amplification and PTEN Deletion. Frontiers in pharmacology. vol 12. 2021-12-20. PMID:34925034. |
cinobufagin blocked egfr phosphorylation and its downstream signaling, which additionally induced apoptosis and cytotoxicity in egfr amplified cancer cells. |
2021-12-20 |
2023-08-13 |
Not clear |
| Zhen Chen, Karin A Vallega, Haiying Chen, Jia Zhou, Suresh S Ramalingam, Shi-Yong Su. The natural product berberine synergizes with osimertinib preferentially against MET-amplified osimertinib-resistant lung cancer via direct MET inhibition. Pharmacological research. vol 175. 2021-12-11. PMID:34826601. |
here, we report that berberine, when combined with osimertinib, synergistically and selectively decreased the survival of several met-amplified osimertinib-resistant egfr mutant nsclc cell lines with enhanced induction of apoptosis likely through bim elevation and mcl-1 reduction. |
2021-12-11 |
2023-08-13 |
mouse |
| Ji-Hyang Kim, Hack-Sun Choi, Dong-Sun Le. Primaquine Inhibits the Endosomal Trafficking and Nuclear Localization of EGFR and Induces the Apoptosis of Breast Cancer Cells by Nuclear EGFR/Stat3-Mediated c-Myc Downregulation. International journal of molecular sciences. vol 22. issue 23. 2021-12-10. PMID:34884765. |
primaquine inhibits the endosomal trafficking and nuclear localization of egfr and induces the apoptosis of breast cancer cells by nuclear egfr/stat3-mediated c-myc downregulation. |
2021-12-10 |
2023-08-13 |
Not clear |
| Ji Hye Kim, Jongwook Kim, Se Seul Im, Ji Hyeon Lee, Sein Hwang, Eun-Ju Chang, Dong-Myung Shin, Jin Kyung Rho, Jaekyoung So. BIX01294 inhibits EGFR signaling in EGFR-mutant lung adenocarcinoma cells through a BCKDHA-mediated reduction in the EGFR level. Experimental & molecular medicine. 2021-12-08. PMID:34876693. |
treatment with bix resulted in a significant reduction in the egfr level and inhibition of egfr signaling only in egfr-mutant nsclc cells, leading to apoptosis. |
2021-12-08 |
2023-08-13 |
Not clear |
| Ji Hye Kim, Jongwook Kim, Se Seul Im, Ji Hyeon Lee, Sein Hwang, Eun-Ju Chang, Dong-Myung Shin, Jin Kyung Rho, Jaekyoung So. BIX01294 inhibits EGFR signaling in EGFR-mutant lung adenocarcinoma cells through a BCKDHA-mediated reduction in the EGFR level. Experimental & molecular medicine. 2021-12-08. PMID:34876693. |
bix exposure also led to a significant decrease in the egfr level, causing apoptosis in egfr-tki (tyrosine kinase inhibitor)-resistant cell lines, which are dependent on egfr signaling for survival. |
2021-12-08 |
2023-08-13 |
Not clear |
| Zhu Yue Lin, Qu Zhen Yun, Liu Wu, Tian Wen Zhang, Tang Ze Ya. Pharmacological basis and new insights of deguelin concerning its anticancer effects. Pharmacological research. vol 174. 2021-12-07. PMID:34644595. |
it possesses the inhibition of cancer cell proliferation by inducing apoptosis through regulating the phosphoinositide 3-kinase/protein kinase b (pi3k/akt) signaling pathway, the nf-κb signaling pathway, the wnt signaling pathway, the adenosine 5'-monophosphate (amp)-activated protein kinase (ampk) signaling pathway and epidermal growth factor receptor (egfr) signaling, activating the p38 mitogen-activated protein kinase (mapk) pathway, repression of bmi1, targeting cyclooxygenase-2 (cox-2), targeting galectin-1, promotion of glycogen synthase kinase-3β (gsk3β)/fbw7-mediated mcl-1 destabilization and targeting mitochondria via down-regulating hexokinases ii-mediated glycolysis, puma-mediation, which are some crucial molecules which modulate closely cancer cell growth and metastasis. |
2021-12-07 |
2023-08-13 |
Not clear |
| Yi Yan, Cheng-Han Wang, Shi-He Cui, Lin Zhai, Jing Sun, Xiao-Yu Liu, Xin Chen, Yi Sun, Hong-Gang Qian, Xiang Gao, Yi-Da Tang, Yuan-Jun Zhu, Yu-Jie Shi, Qiang Zhang, Jian-Cheng Wan. Enhanced cancer therapeutic efficiency of NO combined with siRNA by caspase-3 responsive polymers. Journal of controlled release : official journal of the Controlled Release Society. vol 339. 2021-12-07. PMID:34655677. |
by this way, cell apoptosis promotion and cell proliferation inhibition was achieved by sirna-based downregulation of egfr protein and the upregulated activity of caspase-3, followed by the enhanced cascade release of no from fdp/sirna nanoplexes. |
2021-12-07 |
2023-08-13 |
Not clear |
| Mohamed S Nafie, Safaa M Kishk, Sebaey Mahgoub, Atef M Ame. Quinoline-based thiazolidinone derivatives as potent cytotoxic and apoptosis-inducing agents through EGFR inhibition. Chemical biology & drug design. 2021-12-07. PMID:34873844. |
hence, ten quinoline-based thiazolidinone derivatives were evaluated for their anticancer activity through cytotoxic activity, egfr inhibition pathway, apoptosis investigation through flow cytometric analyses, rt-pcr gene expression, in vivo solid-ehrlich carcinoma model and finally in silico approach for highlighting the interaction pose. |
2021-12-07 |
2023-08-13 |
Not clear |
| X Ge, Y Zhang, F Huang, Y Wu, J Pang, X Li, F Fan, H Liu, S L. EGFR tyrosine kinase inhibitor Almonertinib induces apoptosis and autophagy mediated by reactive oxygen species in non-small cell lung cancer cells. Human & experimental toxicology. vol 40. issue 12_suppl. 2021-12-06. PMID:34219533. |
egfr tyrosine kinase inhibitor almonertinib induces apoptosis and autophagy mediated by reactive oxygen species in non-small cell lung cancer cells. |
2021-12-06 |
2023-08-13 |
Not clear |
| Paola Fernandes Pansini, Isabella Bittencourt do Valle, Thabata Coeli Dias Damasceno, Priscila Marinho de Abreu, Anna Clara Gregório Có, Rossana Verónica Mendoza López, Jeferson Lenzi, Ricardo Mai Rocha, Evandro Duccini Souza, Maria Paula Curado, Hisham Mehanna, Paul Nankivell, José Roberto Vasconcelos de Podestá, Sandra Ventorin von Zeidle. Differential Expression of Potential Biomarkers of Oral Squamous Cell Carcinoma Development. Head and neck pathology. vol 15. issue 4. 2021-12-01. PMID:33840043. |
to evaluate molecular epithelial changes, we investigated whether a profile of survivin, cyclin dependent kinase inhibitor 2a (cdkn2a), epidermal growth factor receptor (egfr), polo like kinase 1 (plk1), p63, p40 (Δnp63 isoform), cyclin d1 (ccnd1) and bcl2 apoptosis regulator (bcl2) proteins could predict malignant transformation. |
2021-12-01 |
2023-08-13 |
Not clear |