| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J D Moyer, E G Barbacci, K K Iwata, L Arnold, B Boman, A Cunningham, C DiOrio, J Doty, M J Morin, M P Moyer, M Neveu, V A Pollack, L R Pustilnik, M M Reynolds, D Sloan, A Theleman, P Mille. Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer research. vol 57. issue 21. 1997-11-20. PMID:9354447. |
inhibition of the egfr also triggers apoptosis in these cells as determined by formation of dna fragments and other criteria. |
1997-11-20 |
2023-08-12 |
mouse |
| N Balaban, J Moni, M Shannon, L Dang, E Murphy, T Goldkor. The effect of ionizing radiation on signal transduction: antibodies to EGF receptor sensitize A431 cells to radiation. Biochimica et biophysica acta. vol 1314. issue 1-2. 1997-01-22. PMID:8972728. |
moreover, monoclonal antibodies to the egf receptor (egfr) sensitize cells to radiation by facilitating radiation-induced apoptosis. |
1997-01-22 |
2023-08-12 |
human |
| D A Haber, C Englert, S Maheswara. Functional properties of WT1. Medical and pediatric oncology. vol 27. issue 5. 1996-11-05. PMID:8827073. |
wt1-mediated apoptosis was associated with transcriptional repression of the epidermal growth factor receptor (egfr) and reduced synthesis of endogenous egfr protein synthesis. |
1996-11-05 |
2023-08-12 |
Not clear |
| D A Haber, C Englert, S Maheswara. Functional properties of WT1. Medical and pediatric oncology. vol 27. issue 5. 1996-11-05. PMID:8827073. |
we conclude that wild-type wt1 can induce apoptosis in embryonal cancer cells, presumably through the withdrawal of required growth factor survival signals, and that egfr is a physiological target gene for wt1. |
1996-11-05 |
2023-08-12 |
Not clear |
| K Umezaki, K Taga, T Nakajima, I Sawaragi, A Okamur. [Expression of Le(y) antigen in adenocarcinoma and its related lesions of the human uterine cervix]. Nihon Sanka Fujinka Gakkai zasshi. vol 47. issue 9. 1995-12-13. PMID:7594903. |
to conclude, the presence of the le(y) antigen might be correlated with differentiation, development and oncogenesis rather than with apoptosis in these lesions, egd might indicate a precancerous lesion, and localization of the egfr antigen indicates that tubal metaplasia, tubal type egd, early ad and ad may have a common origin. |
1995-12-13 |
2023-08-12 |
human |
| C Englert, X Hou, S Maheswaran, P Bennett, C Ngwu, G G Re, A J Garvin, M R Rosner, D A Habe. WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis. The EMBO journal. vol 14. issue 19. 1995-11-28. PMID:7588596. |
wt1-mediated apoptosis was associated with reduced synthesis of the epidermal growth factor receptor (egfr), but not of other postulated wt1-target genes, and it was abrogated by constitutive expression of egfr. |
1995-11-28 |
2023-08-12 |
Not clear |
| C Englert, X Hou, S Maheswaran, P Bennett, C Ngwu, G G Re, A J Garvin, M R Rosner, D A Habe. WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis. The EMBO journal. vol 14. issue 19. 1995-11-28. PMID:7588596. |
repression of egfr and induction of apoptosis by mechanism that may contribute to its critical role in normal kidney development and to the immortalization of tumor cells with inactivated wt1 alleles. |
1995-11-28 |
2023-08-12 |
Not clear |
| C J Brabyn, L P Klein. EGF causes hyperproliferation and apoptosis in T51B cells: involvement of high and low affinity EGFR binding sites. Cellular signalling. vol 7. issue 2. 1995-07-28. PMID:7794686. |
egf causes hyperproliferation and apoptosis in t51b cells: involvement of high and low affinity egfr binding sites. |
1995-07-28 |
2023-08-12 |
rat |