| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Freeman, M Bien. EGF receptor/Rolled MAP kinase signalling protects cells against activated Armadillo in the Drosophila eye. EMBO reports. vol 2. issue 2. 2001-06-14. PMID:11258709. |
this latency is conferred by egf receptor (egfr)/map kinase signalling, which prevents activated armadillo from inducing apoptosis; when egfr signalling naturally ceases, the cells rapidly die. |
2001-06-14 |
2023-08-12 |
mouse |
| Y Gao, L Luo, F H. [Investigation of the apoptosis and proliferation in endometriotic cells]. Zhonghua fu chan ke za zhi. vol 34. issue 9. 2001-06-07. PMID:11360638. |
to clarify whether apoptosis is involved in endometriosis and the effects of estradiol, progesterone and mifepristone on the expression of epidermal growth factor receptor(egfr) in cultured human endometriotic cells. |
2001-06-07 |
2023-08-12 |
human |
| F Feuerhake, P Unterberger, E A Höfte. Cell turnover in apocrine metaplasia of the human mammary gland epithelium: apoptosis, proliferation, and immunohistochemical detection of Bcl-2, Bax, EGFR, and c-erbB2 gene products. Acta histochemica. vol 103. issue 1. 2001-05-21. PMID:11252628. |
cell turnover in apocrine metaplasia of the human mammary gland epithelium: apoptosis, proliferation, and immunohistochemical detection of bcl-2, bax, egfr, and c-erbb2 gene products. |
2001-05-21 |
2023-08-12 |
human |
| J W Davis, F T Lauer, A D Burdick, L G Hudson, S W Burchie. Prevention of apoptosis by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the MCF-10A cell line: correlation with increased transforming growth factor alpha production. Cancer research. vol 61. issue 8. 2001-05-10. PMID:11309286. |
we hypothesized that tcdd-mediated inhibition of apoptosis was due to its ability to stimulate the egf receptor (egfr) pathway. |
2001-05-10 |
2023-08-12 |
human |
| J W Davis, F T Lauer, A D Burdick, L G Hudson, S W Burchie. Prevention of apoptosis by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the MCF-10A cell line: correlation with increased transforming growth factor alpha production. Cancer research. vol 61. issue 8. 2001-05-10. PMID:11309286. |
indeed, in the present studies, the egfr inhibitor ag1478 was able to prevent tcdd-, egf-, and transforming growth factor alpha (tgf-alpha)-dependent cell recovery and inhibition of apoptosis. |
2001-05-10 |
2023-08-12 |
human |
| J W Davis, F T Lauer, A D Burdick, L G Hudson, S W Burchie. Prevention of apoptosis by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the MCF-10A cell line: correlation with increased transforming growth factor alpha production. Cancer research. vol 61. issue 8. 2001-05-10. PMID:11309286. |
the ability of tcdd to stimulate the egfr pathway and inhibit apoptosis may be due to the ability of tcdd to increase expression of tgf-alpha, a ligand for egfr. |
2001-05-10 |
2023-08-12 |
human |
| T Högnason, S Chatterjee, T Vartanian, R R Ratan, K M Ernewein, A A Habi. Epidermal growth factor receptor induced apoptosis: potentiation by inhibition of Ras signaling. FEBS letters. vol 491. issue 1-2. 2001-04-26. PMID:11226409. |
previous studies have shown that certain tumor cell lines which naturally express high levels of the epidermal growth factor receptor (egfr) undergo apoptosis when exposed to epidermal growth factor. |
2001-04-26 |
2023-08-12 |
Not clear |
| T Högnason, S Chatterjee, T Vartanian, R R Ratan, K M Ernewein, A A Habi. Epidermal growth factor receptor induced apoptosis: potentiation by inhibition of Ras signaling. FEBS letters. vol 491. issue 1-2. 2001-04-26. PMID:11226409. |
we show that experimentally increasing the level of egfr expression predictably leads to apoptosis in a variety of cell types which requires an active tyrosine kinase but not egfr autophosphorylation sites. |
2001-04-26 |
2023-08-12 |
Not clear |
| T Högnason, S Chatterjee, T Vartanian, R R Ratan, K M Ernewein, A A Habi. Epidermal growth factor receptor induced apoptosis: potentiation by inhibition of Ras signaling. FEBS letters. vol 491. issue 1-2. 2001-04-26. PMID:11226409. |
expression of a dominant negative ras mutant in egfr overexpressing cells results in a significant potentiation of egfr induced apoptosis suggesting that ras activation is a key survival signal generated by the egfr. |
2001-04-26 |
2023-08-12 |
Not clear |
| T Högnason, S Chatterjee, T Vartanian, R R Ratan, K M Ernewein, A A Habi. Epidermal growth factor receptor induced apoptosis: potentiation by inhibition of Ras signaling. FEBS letters. vol 491. issue 1-2. 2001-04-26. PMID:11226409. |
we propose that potentiation of egfr induced apoptosis by dominant negative ras results, at least in part, by a block of akt activation. |
2001-04-26 |
2023-08-12 |
Not clear |
| M Jost, T M Huggett, C Kari, L H Boise, U Rodec. Epidermal growth factor receptor-dependent control of keratinocyte survival and Bcl-xL expression through a MEK-dependent pathway. The Journal of biological chemistry. vol 276. issue 9. 2001-04-05. PMID:11098053. |
previous work has shown that the epidermal growth factor receptor (egfr) tyrosine kinase moiety provides protection to normal human keratinocytes against apoptosis. |
2001-04-05 |
2023-08-12 |
human |
| B R Lanoue, M D Gordon, R Battye, J R Jacob. Genetic analysis of vein function in the Drosophila embryonic nervous system. Genome. vol 43. issue 3. 2000-11-29. PMID:10902722. |
these data indicate that early midline egfr signaling, requiring vein and spitz, establishes mg precursor number, whereas later egfr signals, requiring spitz, suppress apoptosis in the mg. vein mutants show early irregularities during axon tract establishment, which resolve later to variable defasciculation and thinner intersegmental axon tracts. |
2000-11-29 |
2023-08-12 |
drosophila_melanogaster |
| M Sibilia, A Fleischmann, A Behrens, L Stingl, J Carroll, F M Watt, J Schlessinger, E F Wagne. The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development. Cell. vol 102. issue 2. 2000-09-14. PMID:10943841. |
the k5-sos-f papillomas and primary keratinocytesfrom wa2 mice display increased apoptosis, reduced akt phosphorylation and grafting experiments imply a cell-autonomous requirement for egfr in keratinocytes. |
2000-09-14 |
2023-08-12 |
mouse |
| S A Ettenberg, Y R Rubinstein, P Banerjee, M M Nau, M M Keane, S Lipkowit. cbl-b inhibits EGF-receptor-induced apoptosis by enhancing ubiquitination and degradation of activated receptors. Molecular cell biology research communications : MCBRC. vol 2. issue 2. 2000-08-29. PMID:10542134. |
the inhibitory effects of cbl-b overexpression on apoptosis and on egfr signaling are reversed by blocking proteosomal degradation of the egfr. |
2000-08-29 |
2023-08-12 |
caenorhabditis_elegans |
| S A Ettenberg, Y R Rubinstein, P Banerjee, M M Nau, M M Keane, S Lipkowit. cbl-b inhibits EGF-receptor-induced apoptosis by enhancing ubiquitination and degradation of activated receptors. Molecular cell biology research communications : MCBRC. vol 2. issue 2. 2000-08-29. PMID:10542134. |
these data demonstrate that the mechanism by which cbl-b inhibits egfr-induced apoptosis is by activation-dependent degradation of the egfr. |
2000-08-29 |
2023-08-12 |
caenorhabditis_elegans |
| D K Podolsk. Mechanisms of regulatory peptide action in the gastrointestinal tract: trefoil peptides. Journal of gastroenterology. vol 35 Suppl 12. 2000-06-28. PMID:10779222. |
in addition, trefoil peptides appear to block both p53 dependent and p53 independent apoptosis through pathways associated with activation of egfr and p13 kinase. |
2000-06-28 |
2023-08-12 |
Not clear |
| T Akimoto, N R Hunter, L Buchmiller, K Mason, K K Ang, L Mila. Inverse relationship between epidermal growth factor receptor expression and radiocurability of murine carcinomas. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 5. issue 10. 1999-11-24. PMID:10537357. |
the levels of egfr inversely correlated with radiation-induced apoptosis, suggesting that the lack of sensitivity to apoptosis induction was a major mechanism responsible for radioresistance of tumors with high egfr. |
1999-11-24 |
2023-08-12 |
mouse |
| C L Zanella, C R Timblin, A Cummins, M Jung, J Goldberg, R Raabe, T R Tritton, B T Mossma. Asbestos-induced phosphorylation of epidermal growth factor receptor is linked to c-fos and apoptosis. The American journal of physiology. vol 277. issue 4. 1999-11-22. PMID:10516208. |
we examined the mechanisms of interaction of crocidolite asbestos fibers with the epidermal growth factor (egf) receptor (egfr) and the role of the egfr-extracellular signal-regulated kinase (erk) signaling pathway in early-response protooncogene (c-fos/c-jun) expression and apoptosis induced by asbestos in rat pleural mesothelial (rpm) cells. |
1999-11-22 |
2023-08-12 |
rat |
| C L Zanella, C R Timblin, A Cummins, M Jung, J Goldberg, R Raabe, T R Tritton, B T Mossma. Asbestos-induced phosphorylation of epidermal growth factor receptor is linked to c-fos and apoptosis. The American journal of physiology. vol 277. issue 4. 1999-11-22. PMID:10516208. |
our findings suggest that asbestos-induced binding to egfr initiates signaling pathways responsible for increased expression of the protooncogene c-fos and the development of apoptosis. |
1999-11-22 |
2023-08-12 |
rat |
| C L Zanella, C R Timblin, A Cummins, M Jung, J Goldberg, R Raabe, T R Tritton, B T Mossma. Asbestos-induced phosphorylation of epidermal growth factor receptor is linked to c-fos and apoptosis. The American journal of physiology. vol 277. issue 4. 1999-11-22. PMID:10516208. |
the ability to block asbestos-induced elevations in c-fos mrna levels and apoptosis by small-molecule inhibitors of egfr phosphorylation may have therapeutic implications in asbestos-related diseases. |
1999-11-22 |
2023-08-12 |
rat |