| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' G\\xc3\\xa9rard Milano, Nicolas Magn\\xc3\\xa. [Pharmacological consequences of the targeting of epidermal growth factor receptor]. Bulletin du cancer. vol 90 Spec No. 2004-02-17. PMID:14763140.' |
through clearly identified molecular mechanisms, egfr targeting leads to cell physiology modifications as cell proliferation, apoptosis and dna repair. |
2004-02-17 |
2023-08-12 |
Not clear |
| Manuela Campiglio, Alberta Locatelli, Clelia Olgiati, Nicola Normanno, Giulia Somenzi, Lucia Viganò, Marzia Fumagalli, Sylvie Ménard, Luca Giann. Inhibition of proliferation and induction of apoptosis in breast cancer cells by the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor ZD1839 ('Iressa') is independent of EGFR expression level. Journal of cellular physiology. vol 198. issue 2. 2004-02-06. PMID:14603528. |
inhibition of proliferation and induction of apoptosis in breast cancer cells by the epidermal growth factor receptor (egfr) tyrosine kinase inhibitor zd1839 ('iressa') is independent of egfr expression level. |
2004-02-06 |
2023-08-12 |
human |
| Viktor Grünwald, Manuel Hidalg. Development of the epidermal growth factor receptor inhibitor Tarceva (OSI-774). Advances in experimental medicine and biology. vol 532. 2004-02-03. PMID:12908562. |
in preclinical studies, tarceva inhibited the phosphorylation of the egfr in a dose and concentration dependent manner resulting in cell cycle arrest and induction of apoptosis. |
2004-02-03 |
2023-08-12 |
human |
| Baldassarre Stea, Ryan Falsey, Kerri Kislin, Jay Patel, Heather Glanzberg, Steven Carey, Aaron A Ambrad, Emmanuelle J Meuillet, Jesse D Martine. Time and dose-dependent radiosensitization of the glioblastoma multiforme U251 cells by the EGF receptor tyrosine kinase inhibitor ZD1839 ('Iressa'). Cancer letters. vol 202. issue 1. 2004-02-03. PMID:14643025. |
hyperactive epidermal growth factor receptor (egfr) signaling, which promotes unregulated cell growth and inhibits apoptosis, is believed to contribute to clinical radiation resistance of glioblastoma multiforme (gbm). |
2004-02-03 |
2023-08-12 |
Not clear |
| Fumiaki Koizumi, Fumihiko Kanzawa, Yutaka Ueda, Yasuhiro Koh, Shoji Tsukiyama, Fumiko Taguchi, Tomohide Tamura, Nagahiro Saijo, Kazuto Nishi. Synergistic interaction between the EGFR tyrosine kinase inhibitor gefitinib ("Iressa") and the DNA topoisomerase I inhibitor CPT-11 (irinotecan) in human colorectal cancer cells. International journal of cancer. vol 108. issue 3. 2004-01-23. PMID:14648715. |
this egfr activation was completely inhibited by 5 microm gefitinib and gefitinib-induced apoptosis was enhanced by combination with cpt-11, measured by parp activation although no parp activation was induced by 5 microm cpt-11 alone. |
2004-01-23 |
2023-08-12 |
mouse |
| Agustín Lage, Tania Crombet, Gisela Gonzále. Targeting epidermal growth factor receptor signaling: early results and future trends in oncology. Annals of medicine. vol 35. issue 5. 2003-12-23. PMID:12952019. |
epidermal growth factor receptor (egfr), a member of a family of membrane receptors with tyrosine kinase activity, is emerging as a target candidate for anti-cancer therapy, due to its overexpression in many carcinomas and its relationship with several hallmark properties of malignant behavior such as continuous cell proliferation, escape from apoptosis, cell migration and angiogenesis. |
2003-12-23 |
2023-08-12 |
Not clear |
| Agustín Lage, Tania Crombet, Gisela Gonzále. Targeting epidermal growth factor receptor signaling: early results and future trends in oncology. Annals of medicine. vol 35. issue 5. 2003-12-23. PMID:12952019. |
combinations between vaccines and antibodies, or between vaccines to several molecular components of the system should be evaluated, as well as combinations between inhibitors of the egfr signaling pathway and inhibitors of other regulatory pathways related to cell proliferation, apoptosis and angiogenesis. |
2003-12-23 |
2023-08-12 |
Not clear |
| R S Herbst, F R Khuri, F V Fossella, B S Glisson, M S Kies, K M Pisters, J R Riddle, K A Terry, J S Le. ZD1839 (Iressa) in non-small-cell lung cancer. Clinical lung cancer. vol 3. issue 1. 2003-12-19. PMID:14656386. |
the epidermal growth factor receptor (egfr) signaling pathway plays an important role in a number of processes that are key to tumor progression, including cell proliferation, angiogenesis, metastatic spread, and inhibition of apoptosis. |
2003-12-19 |
2023-08-12 |
human |
| Nam Hoon Cho, Yong Bae Kim, Tchan Kyu Park, Gwi Eon Kim, Kyeongmee Park, Ki Jun Son. P63 and EGFR as prognostic predictors in stage IIB radiation-treated cervical squamous cell carcinoma. Gynecologic oncology. vol 91. issue 2. 2003-12-09. PMID:14599865. |
the purpose of this study was to determine the relation between p63, p53-related gene, epidermal growth factor receptor (egfr), and spontaneous apoptosis in relation to radiotherapy in patients with figo stage iib cervical carcinoma, who had undergone radiation and concurrent chemotherapy, retrospectively. |
2003-12-09 |
2023-08-12 |
Not clear |
| Tom A Zanardi, Soonpin Yei, Drew L Lichtenstein, Ann E Tollefson, William S M Wol. Distinct domains in the adenovirus E3 RIDalpha protein are required for degradation of Fas and the epidermal growth factor receptor. Journal of virology. vol 77. issue 21. 2003-12-02. PMID:14557654. |
additionally, the mutant proteins were tested for their ability to mediate internalization and degradation of egfr and fas and to protect cells from fas-mediated apoptosis. |
2003-12-02 |
2023-08-12 |
Not clear |
| Andrew W Knott, Russell J Juno, Marcus D Jarboe, Yufang Zhang, Sherri A Profitt, Janice C Thoerner, Christopher R Erwin, Brad W Warne. EGF receptor signaling affects bcl-2 family gene expression and apoptosis after massive small bowel resection. Journal of pediatric surgery. vol 38. issue 6. 2003-10-03. PMID:12778384. |
after massive small bowel resection (sbr), enterocyte apoptosis is elevated and inversely correlates with epidermal growth factor receptor (egfr) signaling. |
2003-10-03 |
2023-08-12 |
Not clear |
| Rita Nahta, Sally Trent, Chuanwei Yang, Emmett V Schmid. Epidermal growth factor receptor expression is a candidate target of the synergistic combination of trastuzumab and flavopiridol in breast cancer. Cancer research. vol 63. issue 13. 2003-08-25. PMID:12839951. |
taken together, our results suggest that synergy between flavopiridol and trastuzumab can result from enhanced apoptosis, and that combination effects on egfr expression are involved in the interaction. |
2003-08-25 |
2023-08-12 |
Not clear |
| Wayne A Fritz, Michelle S Cotroneo, Jun Wang, Isam-Eldin Eltoum, Coral A Lamartinier. Dietary diethylstilbestrol but not genistein adversely affects rat testicular development. The Journal of nutrition. vol 133. issue 7. 2003-08-25. PMID:12840195. |
immunohistochemical analysis of serial sections demonstrated that greater egfr expression correlated with increased cellular proliferation, rather than apoptosis, and reflected impaired testicular development in des-treated rats. |
2003-08-25 |
2023-08-12 |
rat |
| Wayne A Fritz, Michelle S Cotroneo, Jun Wang, Isam-Eldin Eltoum, Coral A Lamartinier. Dietary diethylstilbestrol but not genistein adversely affects rat testicular development. The Journal of nutrition. vol 133. issue 7. 2003-08-25. PMID:12840195. |
genistein in the diet did not significantly alter testicular weights, morphology, ar, egfr and erk expression or apoptosis. |
2003-08-25 |
2023-08-12 |
rat |
| Danica Ramljak, Christine M Coticchia, Tagvor G Nishanian, Motoyasu Saji, Matthew D Ringel, Suzanne D Conzen, Robert B Dickso. Epidermal growth factor inhibition of c-Myc-mediated apoptosis through Akt and Erk involves Bcl-xL upregulation in mammary epithelial cells. Experimental cell research. vol 287. issue 2. 2003-08-15. PMID:12837294. |
blockade of egfr kinase activity and the pi3-k/akt and mek/erk pathways with pharmacological inhibitors resulted in a significant induction of cellular apoptosis, paralleled by a downregulation of both akt and erk1/2 proteins. |
2003-08-15 |
2023-08-12 |
mouse |
| Danica Ramljak, Christine M Coticchia, Tagvor G Nishanian, Motoyasu Saji, Matthew D Ringel, Suzanne D Conzen, Robert B Dickso. Epidermal growth factor inhibition of c-Myc-mediated apoptosis through Akt and Erk involves Bcl-xL upregulation in mammary epithelial cells. Experimental cell research. vol 287. issue 2. 2003-08-15. PMID:12837294. |
consistent with a survival-promoting role of akt, we observed that constitutively activated akt (myr-akt) inhibited apoptosis of pro-apoptotic, c-myc-overexpressing cells following the inhibition of egfr tyrosine kinase activity. |
2003-08-15 |
2023-08-12 |
mouse |
| Huang Shao, Haiyun Y Cheng, Richard G Cook, David J Tweard. Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor. Cancer research. vol 63. issue 14. 2003-08-13. PMID:12873986. |
in squamous cell carcinoma of the head and neck, stat3 activation is mediated by up-regulation of the autocrine ligand-receptor pair, tumor growth factor alpha and epidermal growth factor receptor (egfr), resulting in cell growth and resistance to apoptosis. |
2003-08-13 |
2023-08-12 |
human |
| Janet E Dancey, Boris Freidli. Targeting epidermal growth factor receptor--are we missing the mark? Lancet (London, England). vol 362. issue 9377. 2003-07-23. PMID:12853203. |
aberrant signalling through the epidermal growth factor receptor (egfr) is associated with neoplastic cell proliferation, migration, stromal invasion, resistance to apoptosis, and angiogenesis. |
2003-07-23 |
2023-08-12 |
human |
| Yuya Yoshimoto, Takaaki Jyojima, Tsuyoshi Arita, Minoru Ueda, Masaya Imoto, Shuichi Matsumura, Kazunobu Toshim. Vacuolar-type H(+)-ATPase inhibitory activity of synthetic analogues of the concanamycins: is the hydrogen bond network involving the lactone carbonyl, the hemiacetal hydroxy group, and the C-19 hydroxy group essential for the biological activity of the concanamycins? Bioorganic & medicinal chemistry letters. vol 12. issue 24. 2003-07-16. PMID:12443768. |
synthetic analogue of the concanamycins, which lacks the hydrogen bond network existing in the concanamycin structure, retains vacuolar-type h(+)-atpase (v-atpase) inhibitory activity and induces apoptosis to cancer cells that overexpressing epidermal growth factor receptors (egfr). |
2003-07-16 |
2023-08-12 |
Not clear |
| Viktor Grünwald, Manuel Hidalg. Development of the epidermal growth factor receptor inhibitor OSI-774. Seminars in oncology. vol 30. issue 3 Suppl 6. 2003-07-10. PMID:12802792. |
in preclinical studies, osi-774 inhibited the phosphorylation of the egfr in a dose-dependent and concentration-dependent manner resulting in cell cycle arrest and induction of apoptosis. |
2003-07-10 |
2023-08-12 |
human |