| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Zhang, Hui Li, Jinzhao Wang, Zheng Dong, Shahzad Mian, Fu-Shin X Y. Role of EGFR transactivation in preventing apoptosis in Pseudomonas aeruginosa-infected human corneal epithelial cells. Investigative ophthalmology & visual science. vol 45. issue 8. 2004-08-31. PMID:15277479. |
role of egfr transactivation in preventing apoptosis in pseudomonas aeruginosa-infected human corneal epithelial cells. |
2004-08-31 |
2023-08-12 |
human |
| Jing Zhang, Hui Li, Jinzhao Wang, Zheng Dong, Shahzad Mian, Fu-Shin X Y. Role of EGFR transactivation in preventing apoptosis in Pseudomonas aeruginosa-infected human corneal epithelial cells. Investigative ophthalmology & visual science. vol 45. issue 8. 2004-08-31. PMID:15277479. |
to determine the role of epidermal growth factor (egf) receptor (egfr)-mediated signaling pathways in preventing infection-induced apoptosis in human corneal epithelial cells (hcecs). |
2004-08-31 |
2023-08-12 |
human |
| Marcus D Jarboe, Russell J Juno, Nicole P Bernal, Andrew W Knott, Yufang Zhang, Christopher R Erwin, Brad W Warne. Bax deficiency rescues resection-induced enterocyte apoptosis in mice with perturbed EGF receptor function. Surgery. vol 136. issue 2. 2004-08-24. PMID:15300170. |
epidermal growth factor receptor (egfr) inhibition attenuates adaptation and increases apoptosis. |
2004-08-24 |
2023-08-12 |
mouse |
| Marcus D Jarboe, Russell J Juno, Nicole P Bernal, Andrew W Knott, Yufang Zhang, Christopher R Erwin, Brad W Warne. Bax deficiency rescues resection-induced enterocyte apoptosis in mice with perturbed EGF receptor function. Surgery. vol 136. issue 2. 2004-08-24. PMID:15300170. |
this study tested the hypothesis that bax is required for the exaggerated postresection apoptosis induced by perturbed egfr signaling. |
2004-08-24 |
2023-08-12 |
mouse |
| I Skírnisdóttir, T Seidal, B Sorb. A new prognostic model comprising p53, EGFR, and tumor grade in early stage epithelial ovarian carcinoma and avoiding the problem of inaccurate surgical staging. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. vol 14. issue 2. 2004-07-29. PMID:15086725. |
in a series of 226 patients with epithelial ovarian carcinomas in figo stages ia-iic, a number of clinicopathological factors (age, figo stage, histopathologic type, and tumor grade) were studied in relation to the biological factors p53 and epidermal growth factor receptor (egfr), important regulators of the apoptosis and mitosis. |
2004-07-29 |
2023-08-12 |
Not clear |
| Amalia Azzariti, Jian-Ming Xu, Letizia Porcelli, Angelo Paradis. The schedule-dependent enhanced cytotoxic activity of 7-ethyl-10-hydroxy-camptothecin (SN-38) in combination with Gefitinib (Iressa, ZD1839). Biochemical pharmacology. vol 68. issue 1. 2004-07-19. PMID:15183125. |
we analyzed the different effects that three different combination schedules of sn-38 (the active cpt-11 metabolite) and gefitinib (gefitinib before; gefitinib simultaneously; gefitinib after sn-38) have on cell growth, cell cycle, apoptosis, and expression/phosphorylation of egfr, topo i and some steps of the signal transduction pathway. |
2004-07-19 |
2023-08-12 |
human |
| Roland Reinehr, Stephan Becker, Andrea Höngen, Dieter Haüssinge. The Src family kinase Yes triggers hyperosmotic activation of the epidermal growth factor receptor and CD95. The Journal of biological chemistry. vol 279. issue 23. 2004-07-08. PMID:15039424. |
hyperosmotic exposure of rat hepatocytes triggers epidermal growth factor receptor (egfr) activation, which results in an activation of the cd95 system and sensitizes the cells toward apoptosis (reinehr, r., schliess, f., and haüssinger, d. (2003) faseb j. |
2004-07-08 |
2023-08-12 |
rat |
| A P Sutter, M Zeitz, H Scherüb. Recent results in understanding molecular pathways in the medical treatment of esophageal and gastric cancer. Onkologie. vol 27. issue 1. 2004-07-07. PMID:15007244. |
therapeutic strategies discussed include agents targeting the epidermal growth factor receptor (egfr) family, the mitogen-activated protein kinase (mapk) pathway, regulators of apoptosis (nf-kappab, bcl-2, and the peripheral benzodiazepine receptor), cyclooxygenase-2, the vascular-endothelial growth factor receptor and matrix metalloproteinases. |
2004-07-07 |
2023-08-12 |
Not clear |
| Ana Cuadrado, Laura González, Yajaira Suárez, Teresa Martínez, Alberto Muño. JNK activation is critical for Aplidin-induced apoptosis. Oncogene. vol 23. issue 27. 2004-06-29. PMID:15122339. |
aplidin is an antitumor drug that induces apoptosis and activates egfr, src, jnk and p38mapk. |
2004-06-29 |
2023-08-12 |
mouse |
| Lung-Ta Lee, Ying-Tang Huang, Jiuan-Jiuan Hwang, Amy Y-L Lee, Ferng-Chun Ke, Chang-Jen Huang, Chithan Kandaswami, Ping-Ping H Lee, Ming-Ting Le. Transinactivation of the epidermal growth factor receptor tyrosine kinase and focal adhesion kinase phosphorylation by dietary flavonoids: effect on invasive potential of human carcinoma cells. Biochemical pharmacology. vol 67. issue 11. 2004-06-21. PMID:15135307. |
the present work, we demonstrate that qu and lu at concentration of 20 microm transinactivated egfr tyrosine kinase activity with marked reduction in phosphotyrosyl level of 170, 125, 65, 60 and 42 kda cellular proteins, and induced apoptosis in miapaca-2 cells. |
2004-06-21 |
2023-08-12 |
human |
| J Bellmunt, M Hussain, C P Dinne. Novel approaches with targeted therapies in bladder cancer. Therapy of bladder cancer by blockade of the epidermal growth factor receptor family. Critical reviews in oncology/hematology. vol 46 Suppl. 2004-06-10. PMID:12850530. |
additional studies indicate that therapy with egfr inhibitors enhances the activity of conventional cytoreductive chemotherapeutic agents, in part by inhibiting tumor cell proliferation, angiogenesis, and inducing apoptosis. |
2004-06-10 |
2023-08-12 |
mouse |
| Sinisa Urban, Gemma Brown, Matthew Freema. EGF receptor signalling protects smooth-cuticle cells from apoptosis during Drosophila ventral epidermis development. Development (Cambridge, England). vol 131. issue 8. 2004-06-03. PMID:15084467. |
reducing egfr signalling results in apoptosis of smooth-cuticle cells between stages 12 and 14, bringing adjacent denticle regions together to result in denticle belt fusions by stage 15. |
2004-06-03 |
2023-08-12 |
drosophila_melanogaster |
| Sinisa Urban, Gemma Brown, Matthew Freema. EGF receptor signalling protects smooth-cuticle cells from apoptosis during Drosophila ventral epidermis development. Development (Cambridge, England). vol 131. issue 8. 2004-06-03. PMID:15084467. |
pointed mutants display the lowest frequency of fusions, suggesting that egfr signalling may inhibit apoptosis primarily at the post-translational level. |
2004-06-03 |
2023-08-12 |
drosophila_melanogaster |
| Lulu Farhana, Marcia I Dawson, Ying Huang, Yuxiang Zhang, Arun K Rishi, Kaladhar B Reddy, Robert S Freeman, Joseph A Fontan. Apoptosis signaling by the novel compound 3-Cl-AHPC involves increased EGFR proteolysis and accompanying decreased phosphatidylinositol 3-kinase and AKT kinase activities. Oncogene. vol 23. issue 10. 2004-05-13. PMID:14981538. |
apoptosis signaling by the novel compound 3-cl-ahpc involves increased egfr proteolysis and accompanying decreased phosphatidylinositol 3-kinase and akt kinase activities. |
2004-05-13 |
2023-08-12 |
Not clear |
| Lulu Farhana, Marcia I Dawson, Ying Huang, Yuxiang Zhang, Arun K Rishi, Kaladhar B Reddy, Robert S Freeman, Joseph A Fontan. Apoptosis signaling by the novel compound 3-Cl-AHPC involves increased EGFR proteolysis and accompanying decreased phosphatidylinositol 3-kinase and AKT kinase activities. Oncogene. vol 23. issue 10. 2004-05-13. PMID:14981538. |
overexpression of egfr results in increased akt activity and inhibition of 3-cl-ahpc-mediated decrease in akt activation, akt activity and 3-cl-ahpc-mediated apoptosis. |
2004-05-13 |
2023-08-12 |
Not clear |
| Oleg Tikhomirov, Graham Carpente. Ligand-induced, p38-dependent apoptosis in cells expressing high levels of epidermal growth factor receptor and ErbB-2. The Journal of biological chemistry. vol 279. issue 13. 2004-05-07. PMID:14711810. |
data herein show that ligand stimulation of cells that express both the egfr and the erbb-2 may result either in cell proliferation or apoptosis depending on the expression levels of egfr and erbb-2. |
2004-05-07 |
2023-08-12 |
Not clear |
| Oleg Tikhomirov, Graham Carpente. Ligand-induced, p38-dependent apoptosis in cells expressing high levels of epidermal growth factor receptor and ErbB-2. The Journal of biological chemistry. vol 279. issue 13. 2004-05-07. PMID:14711810. |
in contrast, fibroblastic cells or mammary tumor cells, which co-express high levels of egfr and erbb-2 invariably undergo apoptosis in response to egf. |
2004-05-07 |
2023-08-12 |
Not clear |
| Oleg Tikhomirov, Graham Carpente. Ligand-induced, p38-dependent apoptosis in cells expressing high levels of epidermal growth factor receptor and ErbB-2. The Journal of biological chemistry. vol 279. issue 13. 2004-05-07. PMID:14711810. |
ligand-dependent apoptosis in cells co-expressing high levels of egfr and erbb-2 could be a natural mechanism that protects tissues from unrestricted proliferation in response to the sustained activation of receptor-tyrosine kinases. |
2004-05-07 |
2023-08-12 |
Not clear |
| Joachim P Steinbach, Andrea Klumpp, Hartwig Wolburg, Michael Welle. Inhibition of epidermal growth factor receptor signaling protects human malignant glioma cells from hypoxia-induced cell death. Cancer research. vol 64. issue 5. 2004-03-31. PMID:14996711. |
epidermal growth factor receptor (egfr) signaling has become an important target for drug development because egfr signaling enhances tumor cell proliferation, migration, and invasion and inhibits apoptosis. |
2004-03-31 |
2023-08-12 |
human |
| Angela R Kamer, Peter G Sacks, Adrian Vladutiu, Charles Liebo. EGF mediates multiple signals: dependence on the conditions. International journal of molecular medicine. vol 13. issue 1. 2004-03-16. PMID:14654986. |
significant inverse correlation was shown between egfr expression level and apoptosis. |
2004-03-16 |
2023-08-12 |
Not clear |