| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Susumu Kobayashi, Hongbin Ji, Yuki Yuza, Matthew Meyerson, Kwok-Kin Wong, Daniel G Tenen, Balázs Halmo. An alternative inhibitor overcomes resistance caused by a mutation of the epidermal growth factor receptor. Cancer research. vol 65. issue 16. 2005-10-27. PMID:16103058. |
we show the ability of gefitinib to induce growth arrest and apoptosis in cells transfected with wild-type or l858r egfr, whereas the t790m mutation leads to high-level functional resistance against gefitinib and erlotinib. |
2005-10-27 |
2023-08-12 |
Not clear |
| Wenhui Cao, Lisa A Cavacini, Karl C Tillman, Marshall R Posne. CD40 function in squamous cell cancer of the head and neck. Oral oncology. vol 41. issue 5. 2005-09-29. PMID:15878750. |
cd40 induces secretion of specific proinflammatory and proangiogenic cytokines, inhibits spontaneous and fas-induced apoptosis and increases egfr phosphorylation. |
2005-09-29 |
2023-08-12 |
Not clear |
| Kenji Yokoi, Sun-Jin Kim, Premal Thaker, Sertac Yazici, Do-Hyun Nam, Junqin He, Takamitsu Sasaki, Paul J Chiao, Guido M Sclabas, James L Abbruzzese, Stanley R Hamilton, Isaiah J Fidle. Induction of apoptosis in tumor-associated endothelial cells and therapy of orthotopic human pancreatic carcinoma in nude mice. Neoplasia (New York, N.Y.). vol 7. issue 7. 2005-09-29. PMID:16026649. |
collectively, these data indicate that dual inhibition of phosphorylation of egfr and vegfr, in combination with gemcitabine, produces apoptosis of tumor-associated endothelial cells and significantly suppresses human pancreatic cancer in nude mice. |
2005-09-29 |
2023-08-12 |
mouse |
| Banu Sis, Sulen Sarioglu, Ali Celik, Mujdat Zeybel, Alper Soylu, Seymen Bor. Epidermal growth factor receptor expression in human renal allograft biopsies: an immunohistochemical study. Transplant immunology. vol 13. issue 3. 2005-09-28. PMID:15381206. |
epidermal growth factor receptor (egfr) expression has been implicated in the progression of many tumors related to cell proliferation, differentiation, invasion and inhibition of apoptosis, and egfr-targeted therapy options are under development. |
2005-09-28 |
2023-08-12 |
human |
| Hayao Nakanishi, Kenzo Yasui, Yuzuru Ikehara, Hiroyuki Yokoyama, Seiichi Munesue, Yasuhiro Kodera, Masae Tatemats. Establishment and characterization of three novel human gastric cancer cell lines with differentiated intestinal phenotype derived from liver metastasis. Clinical & experimental metastasis. vol 22. issue 2. 2005-09-26. PMID:16086234. |
this apoptosis is further enhanced by phosphatidylinositol 3-kinase (pi3k) inhibitor (ly294002), but not by mek1/2 inhibitor (u0126), indicating the strong dependency of their survival on pi3k/akt pathway rather than mapk pathway, the major downstream signaling pathways of egfr. |
2005-09-26 |
2023-08-12 |
mouse |
| Antonio Jimeno, Manuel Hidalg. Blockade of epidermal growth factor receptor (EGFR) activity. Critical reviews in oncology/hematology. vol 53. issue 3. 2005-09-22. PMID:15718144. |
the key role that egfr plays in the intracellular transduction of environmental variations and the maintenance of cellular homeostasis explains the dependence that many tumor types have on this pathway, and the pivotal role that it plays in the development of malignant features such as uncontrolled proliferation, augmented invasion, and the ability to escape apoptosis. |
2005-09-22 |
2023-08-12 |
Not clear |
| Roland Reinehr, Stephan Becker, Andrea Eberle, Susanne Grether-Beck, Dieter Häussinge. Involvement of NADPH oxidase isoforms and Src family kinases in CD95-dependent hepatocyte apoptosis. The Journal of biological chemistry. vol 280. issue 29. 2005-09-09. PMID:15917250. |
activated egfr then triggered an ag1478-sensitive cd95-tyrosine phosphorylation, which was a signal for membrane targeting of the egfr/cd95 complex, subsequent recruitment of fas-associated death domain and caspase 8, and apoptosis induction. |
2005-09-09 |
2023-08-12 |
rat |
| Yunfei Zhou, Michael G Brattai. Synergy of epidermal growth factor receptor kinase inhibitor AG1478 and ErbB2 kinase inhibitor AG879 in human colon carcinoma cells is associated with induction of apoptosis. Cancer research. vol 65. issue 13. 2005-09-07. PMID:15994962. |
however, ag1478 failed to induce apoptosis in fet6alphas26x cells at concentrations sufficient for cell growth inhibition and complete suppression of egfr phosphorylation. |
2005-09-07 |
2023-08-12 |
human |
| Mihail S Iordanov, Aaron J Sundholm, Eric L Simpson, Jon M Hanifin, Olga P Ryabinina, Remy J Choi, Veselina B Korcheva, Pascal Schneider, Bruce E Magu. Cell death-induced activation of epidermal growth factor receptor in keratinocytes: implications for restricting epidermal damage in dermatitis. The Journal of investigative dermatology. vol 125. issue 1. 2005-09-01. PMID:15982313. |
in addition to apoptosis, treatment of keratinocyte cultures in vitro with fasl triggers a profound phoshorylation of the epidermal growth factor receptor (egfr) and of its downstream effectors erk and protein kinase b (pkb/akt). |
2005-09-01 |
2023-08-12 |
Not clear |
| Mihail S Iordanov, Aaron J Sundholm, Eric L Simpson, Jon M Hanifin, Olga P Ryabinina, Remy J Choi, Veselina B Korcheva, Pascal Schneider, Bruce E Magu. Cell death-induced activation of epidermal growth factor receptor in keratinocytes: implications for restricting epidermal damage in dermatitis. The Journal of investigative dermatology. vol 125. issue 1. 2005-09-01. PMID:15982313. |
using a variety of inhibitors and blocking antibodies, we demonstrated that: (i) apoptosis is required for the generation of the signal(s) leading to the activation of egfr, erk, and akt; (ii) the activation of egfr, erk, and akt by fasl is indeed mediated by its bona fide receptor fas; (iii) the activation of egfr is essential for the subsequent activation of erk and akt; and (iv) apoptotic keratinocytes secrete soluble egfr ligands (including amphiregulin) that are processed from membrane-bound proligand forms by metalloproteinase(s). |
2005-09-01 |
2023-08-12 |
Not clear |
| József Tímá. [Activity of the National Oncology R&D Consortium in 2004]. Magyar onkologia. vol 49. issue 1. 2005-08-31. PMID:15902326. |
we have found that ca-channel blockers and egfr tyrosine kinase inhibitors are effective in preclinical human melanoma models in breaking the apoptosis resistance of this tumor. |
2005-08-31 |
2023-08-12 |
human |
| Miguel M Murillo, Gaelle del Castillo, Aránzazu Sánchez, Margarita Fernández, Isabel Fabrega. Involvement of EGF receptor and c-Src in the survival signals induced by TGF-beta1 in hepatocytes. Oncogene. vol 24. issue 28. 2005-07-28. PMID:15856020. |
inhibition of egfr does not block the epithelial-mesenchymal transition (emt) induced by tgf-beta1 in hepatocytes, which indicates that activation of egfr plays an essential role in impairing apoptosis, but it is dispensable for the emt process. |
2005-07-28 |
2023-08-12 |
rat |
| Joanne Harding, Barbara Burtnes. Cetuximab: an epidermal growth factor receptor chemeric human-murine monoclonal antibody. Drugs of today (Barcelona, Spain : 1998). vol 41. issue 2. 2005-07-26. PMID:15821783. |
binding of the antibody to the egfr prevents stimulation of the receptor by endogenous ligands and results in inhibition of cell proliferation, enhanced apoptosis, and reduced angiogenesis, invasiveness and metastasis. |
2005-07-26 |
2023-08-12 |
mouse |
| Gyula Ostoros, Gábor Kovács, Klára Szondy, Balázs Döm. [New therapies for non-small cell lung cancer]. Orvosi hetilap. vol 146. issue 21. 2005-07-22. PMID:15991677. |
the main investigated agents are epidermal growth factor receptor (egfr) family inhibitors, angiogenesis inhibitors and antivascular drugs, signal transduction inhibitors, apoptosis inducers, eicosanoid pathway inhibitors and immunotherapeutic drugs. |
2005-07-22 |
2023-08-12 |
Not clear |
| I Hritz, L Herszenyi, B Molnár, Z Tulassay, L Próna. Proton pump inhibitor co-therapy normalizes the increased cell turnover of the gastric mucosa both in NSAID and selective COX-2 users. International journal of immunopathology and pharmacology. vol 18. issue 1. 2005-07-14. PMID:15698513. |
to evaluate the effect of ppi co-therapy on gastric mucosa we investigated epithelial cell proliferation, apoptosis, epithelial growth factor receptor (egfr) and p53 expression in patients on chronic non-selective nsaid or cyclooxygenase-2 selective inhibitor (cox-2) treatment. |
2005-07-14 |
2023-08-12 |
Not clear |
| I Hritz, L Herszenyi, B Molnár, Z Tulassay, L Próna. Proton pump inhibitor co-therapy normalizes the increased cell turnover of the gastric mucosa both in NSAID and selective COX-2 users. International journal of immunopathology and pharmacology. vol 18. issue 1. 2005-07-14. PMID:15698513. |
cell proliferation, apoptosis, egfr and p53 expression were measured by immunohistochemistry. |
2005-07-14 |
2023-08-12 |
Not clear |
| Daniel Vallbohmer, Heinz-Josef Len. Epidermal growth factor receptor as a target for chemotherapy. Clinical colorectal cancer. vol 5 Suppl 1. 2005-07-14. PMID:15871762. |
the egfr is known to be involved in carcinogenetic processes such as cell proliferation, apoptosis, angiogenesis, cell motility, and metastasis. |
2005-07-14 |
2023-08-12 |
Not clear |
| Alfredo Cesario, Alessia Catassi, Luigi Festi, Andrea Imperatori, Andrea Pericelli, Domenico Galetta, Stefano Margaritora, Venanzio Porziella, Vittorio Cardaci, Pierluigi Granone, Lorenzo Dominioni, Patrizia Russ. Farnesyltransferase inhibitors and human malignant pleural mesothelioma: a first-step comparative translational study. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 11. issue 5. 2005-06-20. PMID:15756029. |
we checked on mpm cells (10 human cell lines, 11 primary cultures obtained by human biopsies, and 7 short-term normal mesothelial cell cultures) concerning the following: (a) the relative overexpression of egfr (western blotting, flow cytometry, immunohistochemistry), (b) the relative expression of egfr ligands (egf, amphiregulin, tgf-alpha, elisa), (c) the relative increase of the activated form of ras (ras-bound gtp) after egf stimulation (ras activation assay), (d) the efficacy of five different ftis (hdj2 prenylation, cell cytotoxicity, and apoptosis using apoptag and gel ladder). |
2005-06-20 |
2023-08-12 |
human |
| Ferenc Sipos, Béla Molnár, Tamás Zágoni, Lajos Berczi, Zsolt Tulassa. Growth in epithelial cell proliferation and apoptosis correlates specifically to the inflammation activity of inflammatory bowel diseases: ulcerative colitis shows specific p53- and EGFR expression alterations. Diseases of the colon and rectum. vol 48. issue 4. 2005-06-03. PMID:15747078. |
growth in epithelial cell proliferation and apoptosis correlates specifically to the inflammation activity of inflammatory bowel diseases: ulcerative colitis shows specific p53- and egfr expression alterations. |
2005-06-03 |
2023-08-12 |
Not clear |
| Antonio Jimeno, Belen Rubio-Viqueira, Maria L Amador, Darin Oppenheimer, Nadia Bouraoud, Peter Kulesza, Valeria Sebastiani, Anirban Maitra, Manuel Hidalg. Epidermal growth factor receptor dynamics influences response to epidermal growth factor receptor targeted agents. Cancer research. vol 65. issue 8. 2005-06-03. PMID:15833824. |
combined treatment with cetuximab blunted the erlotinib-induced egfr up-regulation and resulted in inhibition of cell proliferation and apoptosis in the hucct1 cells. |
2005-06-03 |
2023-08-12 |
mouse |