| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Tabernero, T Macarulla, F J Ramos, J Baselg. Novel targeted therapies in the treatment of gastric and esophageal cancer. Annals of oncology : official journal of the European Society for Medical Oncology. vol 16. issue 11. 2006-02-09. PMID:15980157. |
these therapeutic strategies include egfr inhibitors, antiangiogenic agents, cell cycle inhibitors, apoptosis promoters and matrix metalloproteinases inhibitors. |
2006-02-09 |
2023-08-12 |
Not clear |
| S Skvortsov, I Skvortsova, B Sarg, J Loeffler-Ragg, H Lindner, P Lukas, J Tabernero, H Zwierzin. Irreversible pan-ErbB tyrosine kinase inhibitor CI-1033 induces caspase-independent apoptosis in colorectal cancer DiFi cell line. Apoptosis : an international journal on programmed cell death. vol 10. issue 5. 2006-01-30. PMID:16151650. |
we investigated the ability of ci-1033 to induce apoptosis and inhibition of proliferation in the colorectal cancer cell lines difi and caco-2, which both express high levels of egfr. |
2006-01-30 |
2023-08-12 |
Not clear |
| Floriana Morgillo, Ho-Young Le. Resistance to epidermal growth factor receptor-targeted therapy. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. vol 8. issue 5. 2006-01-30. PMID:16172017. |
since egfr antagonists interfere with the activation of several intracellular pathways that control cell proliferation, survival, apoptosis, angiogenesis, invasion and metastasis, acquired resistance can occur as a result of several different molecular mechanisms: autocrine/paracrine production of ligand, receptor mutation, constitutive activation of the downstream pathway and activation of alternative pathways. |
2006-01-30 |
2023-08-12 |
Not clear |
| Hiroko Asanuma, Toshihiko Torigoe, Kenjiro Kamiguchi, Yoshihiko Hirohashi, Tousei Ohmura, Koichi Hirata, Masaaki Sato, Noriyuki Sat. Survivin expression is regulated by coexpression of human epidermal growth factor receptor 2 and epidermal growth factor receptor via phosphatidylinositol 3-kinase/AKT signaling pathway in breast cancer cells. Cancer research. vol 65. issue 23. 2006-01-25. PMID:16322251. |
it was revealed that the survivin protein level was up-regulated by the coexpression of her2 and egfr, leading to the increased resistance against etoposide-induced apoptosis in breast cancer cells. |
2006-01-25 |
2023-08-12 |
human |
| Eric B Haura, Zhong Zheng, Lanxi Song, Alan Cantor, Gerold Beple. Activated epidermal growth factor receptor-Stat-3 signaling promotes tumor survival in vivo in non-small cell lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 11. issue 23. 2006-01-24. PMID:16322287. |
we evaluated stat3 activation in early stage non-small cell lung cancers (nsclc) and how this relates to upstream epidermal growth factor receptor (egfr) activation, tumor apoptosis, and prognosis. |
2006-01-24 |
2023-08-12 |
Not clear |
| X Altuna Mariezkurrena, J Algaba Guimerá, J Wang Rodríguez, R Weisman, W Ongkek. [Immunohistochemistry study of EGFR expression in head and neck squamous cell carcinoma]. Acta otorrinolaringologica espanola. vol 56. issue 4. 2006-01-19. PMID:15871288. |
egfr is an important transmembrane receptor member of the family of tyrosine kinases, that translates signals from both outside and inside the cell and plays a key role in numerous proceses that affect tumour development, growth, progresion, differentiation, inhibition of apoptosis and metastasis. |
2006-01-19 |
2023-08-12 |
Not clear |
| Fumikata Hara, Motoi Aoe, Hiroyoshi Doihara, Naruto Taira, Tadahiko Shien, Hirotoshi Takahashi, Seiji Yoshitomi, Kazunori Tsukuda, Shinichi Toyooka, Tetsuya Ohta, Nobuyoshi Shimiz. Antitumor effect of gefitinib ('Iressa') on esophageal squamous cell carcinoma cell lines in vitro and in vivo. Cancer letters. vol 226. issue 1. 2006-01-12. PMID:16004931. |
gefitinib inhibited egf-induced autophosphorylation of egfr and its downstream signaling pathways, ras/raf/mapk and pi3k/akt, and caused g(1) arrest of cell cycle and apoptosis confirmed with flow cytometry. |
2006-01-12 |
2023-08-12 |
mouse |
| Fumikata Hara, Motoi Aoe, Hiroyoshi Doihara, Naruto Taira, Tadahiko Shien, Hirotoshi Takahashi, Seiji Yoshitomi, Kazunori Tsukuda, Shinichi Toyooka, Tetsuya Ohta, Nobuyoshi Shimiz. Antitumor effect of gefitinib ('Iressa') on esophageal squamous cell carcinoma cell lines in vitro and in vivo. Cancer letters. vol 226. issue 1. 2006-01-12. PMID:16004931. |
immunohistochemical examination of the harvested tumor was performed to examine the status of phosphorylated egfr, pcna, factor viii and apoptosis. |
2006-01-12 |
2023-08-12 |
mouse |
| Fumikata Hara, Motoi Aoe, Hiroyoshi Doihara, Naruto Taira, Tadahiko Shien, Hirotoshi Takahashi, Seiji Yoshitomi, Kazunori Tsukuda, Shinichi Toyooka, Tetsuya Ohta, Nobuyoshi Shimiz. Antitumor effect of gefitinib ('Iressa') on esophageal squamous cell carcinoma cell lines in vitro and in vivo. Cancer letters. vol 226. issue 1. 2006-01-12. PMID:16004931. |
we found inhibition of egfr phosphorylation, cell cycle arrest (by pcna staining), decrease of microvessel density (factor viii) and induction of apoptosis by tunel staining. |
2006-01-12 |
2023-08-12 |
mouse |
| Massimo Di Maio, Cesare Gridelli, Nicola Normanno, Francesco Perrone, Fortunato Ciardiell. Trying to compose the puzzle with all the pieces: epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer. Journal of cellular physiology. vol 205. issue 3. 2006-01-11. PMID:15895392. |
however, clinical effectiveness might not be limited to patients carrying egfr mutations, in which the objective response is probably the detectable effect of apoptosis induction in cancer cells. |
2006-01-11 |
2023-08-12 |
Not clear |
| Okay Saydam, Daniel L Glauser, Irma Heid, Gulen Turkeri, Monika Hilbe, Andreas H Jacobs, Mathias Ackermann, Cornel Fraefe. Herpes simplex virus 1 amplicon vector-mediated siRNA targeting epidermal growth factor receptor inhibits growth of human glioma cells in vivo. Molecular therapy : the journal of the American Society of Gene Therapy. vol 12. issue 5. 2006-01-06. PMID:16112910. |
cell cycle analysis and annexin v staining revealed that sirna-mediated suppression of egfr induced apoptosis. |
2006-01-06 |
2023-08-12 |
mouse |
| Fumi Mikami, He Gu, Hirofumi Jono, Ali Andalibi, Hirofumi Kai, Jian-Dong L. Epidermal growth factor receptor acts as a negative regulator for bacterium nontypeable Haemophilus influenzae-induced Toll-like receptor 2 expression via an Src-dependent p38 mitogen-activated protein kinase signaling pathway. The Journal of biological chemistry. vol 280. issue 43. 2006-01-04. PMID:16115866. |
epidermal growth factor receptor (egfr) has been shown to play important roles in regulating diverse biological processes, including cell growth, differentiation, apoptosis, adhesion, and migration. |
2006-01-04 |
2023-08-12 |
human |
| Fiona Furlong, Darren Finlay, Finian Marti. PTPase inhibition restores ERK1/2 phosphorylation and protects mammary epithelial cells from apoptosis. Biochemical and biophysical research communications. vol 336. issue 4. 2005-12-12. PMID:16176809. |
intact egfr signal transduction is required for ecm determined cell survival as the egfr pathway inhibitor, ag1478, induces apoptosis of these cultures. |
2005-12-12 |
2023-08-12 |
mouse |
| Chun-Sheng Kang, Pei-Yu Pu, Jie Li, Guang-Xiu Wan. [Inhibitory effect of antisense and dominant-negative AKT2 constructs on proliferation of glioma cell line TJ905]. Ai zheng = Aizheng = Chinese journal of cancer. vol 23. issue 11. 2005-12-09. PMID:15522171. |
serine/threonine kinase (akt) mediates a downstream signal transduction pathway of epidermal growth factor receptor (egfr), and plays an important role in survival and apoptosis of tumor cells. |
2005-12-09 |
2023-08-12 |
Not clear |
| Mrinal K Ghosh, Pankaj Sharma, Phyllis C Harbor, Shaik O Rahaman, S Jaharul Haqu. PI3K-AKT pathway negatively controls EGFR-dependent DNA-binding activity of Stat3 in glioblastoma multiforme cells. Oncogene. vol 24. issue 49. 2005-12-01. PMID:16007122. |
blockade of egfr activation inhibited the activation of both akt and stat3 in u87 and d54 gbm cells and induced spontaneous apoptosis, which were associated with reduction in the steady-state level of mcl-1. |
2005-12-01 |
2023-08-12 |
Not clear |
| Bruce E Johnson, Pasi A Jänn. Epidermal growth factor receptor mutations in patients with non-small cell lung cancer. Cancer research. vol 65. issue 17. 2005-11-15. PMID:16140912. |
nsclc lines with mutations of the egfr treated with concentrations of gefitinib and erlotinib that are achievable in the plasma undergo apoptosis rather than growth arrest. |
2005-11-15 |
2023-08-12 |
Not clear |
| Qing-Bai She, David B Solit, Qing Ye, Kathryn E O'Reilly, Jose Lobo, Neal Rose. The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells. Cancer cell. vol 8. issue 4. 2005-11-15. PMID:16226704. |
induction of pten sensitizes cells to egfr inhibition, and the combination causes synergistic apoptosis. |
2005-11-15 |
2023-08-12 |
Not clear |
| H E Jones, J M W Gee, K M Taylor, D Barrow, H D Williams, M Rubini, R I Nicholso. Development of strategies for the use of anti-growth factor treatments. Endocrine-related cancer. vol 12 Suppl 1. 2005-11-11. PMID:16113094. |
aberrant signalling through the epidermal growth factor receptor (egfr) is associated with increased cancer cell proliferation, reduced apoptosis, invasion and angiogenesis. |
2005-11-11 |
2023-08-12 |
Not clear |
| Istvan Hritz, Laszlo Herszenyi, Bela Molnar, Zsolt Tulassay, Laszlo Prona. Long-term omeprazole and esomeprazole treatment does not significantly increase gastric epithelial cell proliferation and epithelial growth factor receptor expression and has no effect on apoptosis and p53 expression. World journal of gastroenterology. vol 11. issue 30. 2005-11-02. PMID:16094717. |
to study the effect of proton pump inhibitor (ppi) treatment on patients with reflux esophagitis and its in vivo effect on apoptosis, p53- and epidermal growth factor receptor (egfr) expression. |
2005-11-02 |
2023-08-12 |
Not clear |
| Qiang Wang, Mark I Green. EGFR enhances Survivin expression through the phosphoinositide 3 (PI-3) kinase signaling pathway. Experimental and molecular pathology. vol 79. issue 2. 2005-11-01. PMID:15975575. |
here, we report that an activated form of egfr can elevate the levels of survivin, a member of the inhibitor of apoptosis protein (iap) family implicated in mitotic checkpoint control. |
2005-11-01 |
2023-08-12 |
Not clear |