| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vladimir N Ivanov, Tom K He. Combined treatment with EGFR inhibitors and arsenite upregulated apoptosis in human EGFR-positive melanomas: a role of suppression of the PI3K-AKT pathway. Oncogene. vol 24. issue 4. 2005-02-15. PMID:15580309. |
in contrast, induction of apoptosis in melanomas with negligible surface expression of egfr or with defective egfr signaling requires direct suppression of the pi3k-akt and mapk pathways by specific pharmacological inhibitors in the presence of arsenite. |
2005-02-15 |
2023-08-12 |
human |
| Marta L De Santis, Rasha Hammamieh, Rina Das, Marti Jet. Adipocyte-fatty acid binding protein induces apoptosis in DU145 prostate cancer cells. Journal of experimental therapeutics & oncology. vol 4. issue 2. 2005-02-10. PMID:15500004. |
the epidermal growth factor receptor (egfr)/phosphatidyl inositol 3-kinase (pi 3-kinase) signaling pathway was not altered in these cells, suggesting that a-fabp may cause apoptosis by inducing downregulation of essential autocrine growth factors and/or upregulation of pro-apoptotic ones. |
2005-02-10 |
2023-08-12 |
Not clear |
| Teresa G Tessner, Filipe Muhale, Terrence E Riehl, Shrikant Anant, William F Stenso. Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation. The Journal of clinical investigation. vol 114. issue 11. 2005-02-08. PMID:15578100. |
the in vitro studies indicate that dmpge2, most likely by signaling through the e prostaglandin receptor ep2, reduces radiation-induced apoptosis through transactivation of the egfr and enhanced activation of akt and that this results in reduced bax translocation to the mitochondria. |
2005-02-08 |
2023-08-12 |
mouse |
| Karen L Tedesco, A Craig Lockhart, Jordan D Berli. The epidermal growth factor receptor as a target for gastrointestinal cancer therapy. Current treatment options in oncology. vol 5. issue 5. 2005-01-24. PMID:15341677. |
when activated, egfr phosphorylates and activates other intracellular proteins that affect cell signaling pathways, cellular proliferation, control of apoptosis and angiogenesis. |
2005-01-24 |
2023-08-12 |
Not clear |
| Wenlin Deng, Helen Poppleton, Satoshi Yasuda, Natalia Makarova, Yoriko Shinozuka, De-An Wang, Leonard R Johnson, Tarun B Patel, Gabor Tigy. Optimal lysophosphatidic acid-induced DNA synthesis and cell migration but not survival require intact autophosphorylation sites of the epidermal growth factor receptor. The Journal of biological chemistry. vol 279. issue 46. 2005-01-21. PMID:15364923. |
lpa equally protected b82l cells, or transfectants expressing egfr, the kinase dead egfr(k721a), egfr(y5f) receptor mutant, which lacks five autophosphorylation sites, or egfr(y845f), which lacks the src phosphorylation site from tumor necrosis factor-alpha-induced apoptosis. |
2005-01-21 |
2023-08-12 |
Not clear |
| Bronislaw L Slomiany, Amalia Slomian. Src kinase-dependent epidermal growth factor receptor transactivation in PPARgamma ligand-induced suppression of Porphyromonas gingivalis interference with salivary mucin synthesis. IUBMB life. vol 56. issue 3. 2005-01-11. PMID:15185749. |
moreover, the inhibitory effect of ciglitazone on the lps-induced reduction in mucin synthesis and upregulation in apoptosis, caspase-3 activity, and no generation was blunted by a selective inhibitor of tyrosine kinase src, pp2, responsible for ligand-independent egfr transactivation. |
2005-01-11 |
2023-08-12 |
human |
| R M Huber, D F Strataki. Molecular oncology--perspectives in lung cancer. Lung cancer (Amsterdam, Netherlands). vol 45 Suppl 2. 2004-12-22. PMID:15552801. |
), parameters concerning tumour cell proliferation and apoptosis (egfr, p53, k-ras, rb, bcl-2, etc.) |
2004-12-22 |
2023-08-12 |
Not clear |
| Roland Reinehr, Stephan Becker, Matthias Wettstein, Dieter Häussinge. Involvement of the Src family kinase yes in bile salt-induced apoptosis. Gastroenterology. vol 127. issue 5. 2004-12-03. PMID:15521021. |
hydrophobic bile acids induce cd95 (fas, apo-1)-dependent hepatocyte apoptosis, which involves epidermal growth factor receptor (egfr)-catalyzed cd95 tyrosine phosphorylation. |
2004-12-03 |
2023-08-12 |
Not clear |
| Orhan G Yigitbasi, Maher N Younes, Dao Doan, Samar A Jasser, Bradley A Schiff, Corazon D Bucana, Benjamin N Bekele, Isaiah J Fidler, Jeffrey N Myer. Tumor cell and endothelial cell therapy of oral cancer by dual tyrosine kinase receptor blockade. Cancer research. vol 64. issue 21. 2004-11-30. PMID:15520205. |
aee788 inhibited cell growth, induced apoptosis, and reduced the phosphorylation of egfr, vegfr-2, akt, and mitogen-activated protein kinase in both cell lines. |
2004-11-30 |
2023-08-12 |
mouse |
| Orhan G Yigitbasi, Maher N Younes, Dao Doan, Samar A Jasser, Bradley A Schiff, Corazon D Bucana, Benjamin N Bekele, Isaiah J Fidler, Jeffrey N Myer. Tumor cell and endothelial cell therapy of oral cancer by dual tyrosine kinase receptor blockade. Cancer research. vol 64. issue 21. 2004-11-30. PMID:15520205. |
inhibition of egfr and vegfr phosphorylation by aee788 effectively inhibits cellular proliferation of squamous cell carcinoma of the head and neck, induces apoptosis of tumor endothelial cells and tumor cells, and is well tolerated in mice. |
2004-11-30 |
2023-08-12 |
mouse |
| James A McCubrey, John G Shelton, Linda S Steelman, Richard A Franklin, Thazepadath Sreevalsan, Martin McMaho. Effects of a conditionally active v-ErbB and an EGF-R inhibitor on transformation of NIH-3T3 cells and abrogation of cytokine dependency of hematopoietic cells. Oncogene. vol 23. issue 47. 2004-11-29. PMID:15361836. |
however, mek and pi3k inhibitors only induced apoptosis at 1000-fold higher concentrations than the egfr inhibitor. |
2004-11-29 |
2023-08-12 |
human |
| Ramaswamy Govinda. Cetuximab in advanced non-small cell lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 10. issue 12 Pt 2. 2004-11-26. PMID:15217966. |
egfr activation results in phosphorylation of several downstream intracellular substrates involved in cell proliferation, angiogenesis, and inhibition of apoptosis. |
2004-11-26 |
2023-08-12 |
Not clear |
| Yutaka Masuda, Genryu Shima, Toshihiro Aiuchi, Masayo Horie, Kouichi Hori, Shigeo Nakajo, Sachiko Kajimoto, Toshiko Shibayama-Imazu, Kazuyasu Nakay. Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin. The Journal of biological chemistry. vol 279. issue 41. 2004-11-24. PMID:15292218. |
beta-hydroxyisovalerylshikonin (beta-hivs), a compound isolated from the traditional oriental medicinal herb lithospermum radix, is an atp non-competitive inhibitor of protein-tyrosine kinases, such as v-src and egfr, and it induces apoptosis in various lines of human tumor cells. |
2004-11-24 |
2023-08-12 |
human |
| Joachim P Steinbach, Christine Eisenmann, Andrea Klumpp, Michael Welle. Co-inhibition of epidermal growth factor receptor and type 1 insulin-like growth factor receptor synergistically sensitizes human malignant glioma cells to CD95L-induced apoptosis. Biochemical and biophysical research communications. vol 321. issue 3. 2004-11-03. PMID:15358139. |
inhibition of epidermal growth factor receptor (egfr) signaling sensitizes human malignant glioma cells to death ligand-induced apoptosis. |
2004-11-03 |
2023-08-12 |
human |
| Joachim P Steinbach, Christine Eisenmann, Andrea Klumpp, Michael Welle. Co-inhibition of epidermal growth factor receptor and type 1 insulin-like growth factor receptor synergistically sensitizes human malignant glioma cells to CD95L-induced apoptosis. Biochemical and biophysical research communications. vol 321. issue 3. 2004-11-03. PMID:15358139. |
we here report that antagonism of the igf-1r with the small-molecule inhibitor ag1024 in combination with inhibitors of the egfr synergistically sensitizes human malignant glioma cells to cd95l-induced apoptosis. |
2004-11-03 |
2023-08-12 |
human |
| Ken-ichi Sato, Tomomi Nagao, Tetsushi Iwasaki, Yusuke Nishihira, Yasuo Fukam. Src-dependent phosphorylation of the EGF receptor Tyr-845 mediates Stat-p21waf1 pathway in A431 cells. Genes to cells : devoted to molecular & cellular mechanisms. vol 8. issue 12. 2004-09-28. PMID:14750954. |
cell surface receptor for the epidermal growth factor (egfr) and cytoplasmic tyrosine kinase c-src co-operate in several cellular functions such as proliferation and apoptosis. |
2004-09-28 |
2023-08-12 |
Not clear |
| Tsugumichi Saito, Shuichi Okada, Kihachi Ohshima, Eijiro Yamada, Minoru Sato, Yutaka Uehara, Hiroyuki Shimizu, Jeffrey E Pessin, Masatomo Mor. Differential activation of epidermal growth factor (EGF) receptor downstream signaling pathways by betacellulin and EGF. Endocrinology. vol 145. issue 9. 2004-09-28. PMID:15192046. |
interestingly btc had a greater inhibitory effect on apoptosis, compared with egf, and expression of y1068f egfr abolished this enhanced inhibitory effect. |
2004-09-28 |
2023-08-12 |
human |
| D C Lev, L S Kim, V Melnikova, M Ruiz, H N Ananthaswamy, J E Pric. Dual blockade of EGFR and ERK1/2 phosphorylation potentiates growth inhibition of breast cancer cells. British journal of cancer. vol 91. issue 4. 2004-09-14. PMID:15280923. |
the egfr tyrosine kinase inhibitor pki166 inhibited growth and induced apoptosis in some cells with high levels of growth factor receptors (mda-mb-468, sum149, skbr3), but was less effective in cells that also had high basal erk1/2 activity (mda-mb-231). |
2004-09-14 |
2023-08-12 |
Not clear |
| Raffaella Sordella, Daphne W Bell, Daniel A Haber, Jeffrey Settlema. Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science (New York, N.Y.). vol 305. issue 5687. 2004-09-10. PMID:15284455. |
nsclc cells expressing mutant egfrs underwent extensive apoptosis after small interfering rna-mediated knockdown of the mutant egfr or treatment with pharmacological inhibitors of akt and stat signaling and were relatively resistant to apoptosis induced by conventional chemotherapeutic drugs. |
2004-09-10 |
2023-08-12 |
Not clear |
| Huamin Wang, Hua Wang, Wei Zhang, Helen J Huang, Warren S L Liao, Gregory N Fulle. Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas. Laboratory investigation; a journal of technical methods and pathology. vol 84. issue 8. 2004-09-02. PMID:15184909. |
as downstream targets of the pten and egfr signaling pathways, akt, nfkappab, and signal transducer and activator of transcription-3 (stat3) have been shown to play important roles in the control of cell proliferation, apoptosis, and oncogenesis. |
2004-09-02 |
2023-08-12 |
human |