| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Simeng Wang, Dongliang Su, Han Chen, Jia-Cheng Lai, Chengfang Tang, Yu Li, Yidong Wang, Yuan Yang, Mingze Qin, Lina Jia, Wei Cui, Jingyu Yang, Lihui Wang, Chunfu W. PD-L2 drives resistance to EGFR-TKIs: dynamic changes of the tumor immune environment and targeted therapy. Cell death and differentiation. vol 31. issue 9. 2024-09-03. PMID:38816578. |
pd-l2 expression significantly affected egfr mutant cell apoptosis that depended on the proportion and function of cd8 |
2024-09-03 |
2024-09-05 |
mouse |
| Julianne du Plessis, Aurelie Deroubaix, Aadilah Omar, Clement Penn. A Bioinformatic Analysis Predicts That Cannabidiol Could Function as a Potential Inhibitor of the MAPK Pathway in Colorectal Cancer. Current issues in molecular biology. vol 46. issue 8. 2024-08-28. PMID:39194723. |
several signaling pathways, such as egfr and mapk, involved in cell proliferation, migration, and apoptosis, are often dysregulated in crc. |
2024-08-28 |
2024-08-30 |
Not clear |
| Prathibha Prasad, Mohamed Jaber, Tahani Awad Alahmadi, Hesham S Almoallim, Arun Kumar Ram. Solanine Inhibits Proliferation and Angiogenesis and Induces Apoptosis through Modulation of EGFR Signaling in KB-ChR-8-5 Multidrug-Resistant Oral Cancer Cells. Journal of clinical medicine. vol 13. issue 15. 2024-08-10. PMID:39124760. |
solanine inhibits proliferation and angiogenesis and induces apoptosis through modulation of egfr signaling in kb-chr-8-5 multidrug-resistant oral cancer cells. |
2024-08-10 |
2024-08-13 |
Not clear |
| Ketan R Hosamani, Hemalatha K, Rohit Pal, Gurubasavaraja Swamy Purawarga Matada, Kumaraswamy B, Aayishamma I, Nimmagadda Venkata Satya Sai D. Pyrazole, Pyrazoline, and Fused Pyrazole Derivatives: New Horizons in EGFR-Targeted Anticancer Agents. Chemistry & biodiversity. 2024-07-26. PMID:39056888. |
overexpression of egfr signaling promotes tumor growth by inhibiting apoptosis. |
2024-07-26 |
2024-07-28 |
Not clear |
| Soha Osama Hassanin, Amany Mohammed Mohmmed Hegab, Reham Hassan Mekky, Mohamed Adel Said, Mona G Khalil, Alaaeldin Ahmed Hamza, Amr Ami. Combining In Vitro, In Vivo, and Network Pharmacology Assays to Identify Targets and Molecular Mechanisms of Spirulina-Derived Biomolecules against Breast Cancer. Marine drugs. vol 22. issue 7. 2024-07-26. PMID:39057437. |
sp was finally reported to suppress mcf-7 cell growth and induce apoptosis by modulating the pi3k/akt/egfr and mapk signaling pathways suggesting egfr as a potential target of sp in breast cancer (bc) treatment. |
2024-07-26 |
2024-07-28 |
human |
| Mehlika Dilek Altıntop, İpek Ertorun, Gülşen Akalın Çiftçi, Ahmet Özdemi. Design, synthesis and biological evaluation of a new series of imidazothiazole-hydrazone hybrids as dual EGFR and Akt inhibitors for NSCLC therapy. European journal of medicinal chemistry. vol 276. 2024-07-24. PMID:39047611. |
in vitro mechanistic studies were performed to assess their effects on apoptosis, caspase-3, cell cycle, egfr and akt in a549 cells. |
2024-07-24 |
2024-07-28 |
human |
| Sha Lv, Qianrong Pan, Weijin Lu, Weisong Zhang, Naike Wang, Lijuan Huang, Lianjing Li, Jieyao Liu, Jiamei Ma, Zhan Li, Yong Huang, Qiudi Deng, Xueping Le. Author Correction: Tenovin 3 induces apoptosis and ferroptosis in EGFR 19del non small cell lung cancer cells. Scientific reports. vol 14. issue 1. 2024-07-24. PMID:39048657. |
author correction: tenovin 3 induces apoptosis and ferroptosis in egfr 19del non small cell lung cancer cells. |
2024-07-24 |
2024-07-28 |
Not clear |
| Haitao Long, Guanglong Zhang, Yue Zhou, Liqing Qin, Danxue Zhu, Jiayi Chen, Bo Liu, Huayuan Tan, Danping Chen, Zhurui Li, Chengpeng Li, Zhenchao Wan. A Novel Tryptanthrin Derivative D6 Induces Apoptosis and DNA Damage in Non-small-cell Lung Cancer Cells Through Regulating the EGFR Pathway. Anti-cancer agents in medicinal chemistry. 2024-07-22. PMID:39034729. |
a novel tryptanthrin derivative d6 induces apoptosis and dna damage in non-small-cell lung cancer cells through regulating the egfr pathway. |
2024-07-22 |
2024-07-24 |
Not clear |
| Ye Ding, Hao Li, Saisai Cao, Yong Y. Effects of catechin on the malignant biological behavior of gastric cancer cells through the PI3K/Akt signaling pathway. Toxicology and applied pharmacology. 2024-07-15. PMID:39009138. |
the proliferation ability, cell cycle, apoptosis and migration of gastric cancer cells were detected, as well as the protein expression levels of pi3k, p-akt, and akt and the mrna expression levels of akt1, vegfa, egfr, hras, and hsp90aa1 in gastric cancer cells. |
2024-07-15 |
2024-07-18 |
Not clear |
| Zhijun Geng, Lugen Zuo, Jing Li, Lixia Yin, Jingjing Yang, Ting Duan, Lian Wang, Xiaofeng Zhang, Xue Song, Yueyue Wang, Jianguo H. Ginkgetin improved experimental colitis by inhibiting intestinal epithelial cell apoptosis through EGFR/PI3K/AKT signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 14. 2024-07-14. PMID:39003633. |
the underlying mechanism of gk's protective effect was explored by bioinformatics, rescue experiments and molecular docking, and it was found that gk might directly target and activate egfr, thereby interfering with pi3k/akt signaling to inhibit apoptosis of intestinal epithelial cells in vivo and in vitro. |
2024-07-14 |
2024-07-16 |
mouse |
| Zhijun Geng, Lugen Zuo, Jing Li, Lixia Yin, Jingjing Yang, Ting Duan, Lian Wang, Xiaofeng Zhang, Xue Song, Yueyue Wang, Jianguo H. Ginkgetin improved experimental colitis by inhibiting intestinal epithelial cell apoptosis through EGFR/PI3K/AKT signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 14. 2024-07-14. PMID:39003633. |
in conclusion, gk inhibited intestinal epithelial apoptosis in mice with experimental colitis, at least in part, by activating egfr and interfering with pi3k/akt activation, explaining the underlying mechanism for ameliorating colitis, which may provide new options for the treatment of ibd. |
2024-07-14 |
2024-07-16 |
mouse |
| Pei Wang, Yelu Zhou, Juan Wang, Yun Zhou, Xiaohui Zhang, Yanxing Liu, Ang Li, Yangsong He, Shuyi Chen, Airong Qian, Xin Wang, Yongzhan Nie, Daiming Fan, Tianyu Cao, Yuanyuan Lu, Xiaodi Zha. miR-107 reverses the multidrug resistance of gastric cancer by targeting the CGA/EGFR/GATA2 positive feedback circuit. The Journal of biological chemistry. 2024-07-03. PMID:38960034. |
hyperactivation of the egfr signaling pathway contributes to mdr by promoting cancer cell proliferation and inhibiting apoptosis. |
2024-07-03 |
2024-07-10 |
Not clear |
| Hiba N Alsaad, Baan M Al-Jasani, Ammar A Razzak Mahmood, Lubna H Tahtamouni, Khaled M Saleh, Mai F AlSakhen, Sana I Kanaan, Salem R Yasi. Novel 1,3,4-oxadiazole derivatives of naproxen targeting EGFR: Synthesis, molecular docking studies, and cytotoxic evaluation. Drug development research. vol 85. issue 5. 2024-07-03. PMID:38956926. |
the antiproliferative effects of the new compounds were evaluated by the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2h-tetrazolium bromide assay, cell cycle analysis, apoptosis detection by microscopy, quantitative reverse transcription-polymerase chain reaction, and immunoblotting, and egfr enzyme inhibition assay. |
2024-07-03 |
2024-07-06 |
Not clear |
| Thomas Morgan Li, Victoria Zyulina, Ethan S Seltzer, Marija Dacic, Yurii Chinenov, Andrea R Daamen, Keila R Veiga, Noa Schwartz, David J Oliver, Pamela Cabahug-Zuckerman, Jose Lora, Yong Liu, William D Shipman, William G Ambler, Sarah F Taber, Karen B Onel, Jonathan H Zippin, Mehdi Rashighi, James G Krueger, Niroshana Anandasabapathy, Inez Rogatsky, Ali Jabbari, Carl P Blobel, Peter E Lipsky, Theresa T L. The interferon-rich skin environment regulates Langerhans cell ADAM17 to promote photosensitivity in lupus. eLife. vol 13. 2024-06-11. PMID:38860651. |
we have previously shown that langerhans cells (lcs) limit keratinocyte apoptosis and photosensitivity via a disintegrin and metalloprotease 17 (adam17)-mediated release of epidermal growth factor receptor (egfr) ligands and that lc adam17 sheddase activity is reduced in lupus. |
2024-06-11 |
2024-06-14 |
mouse |
| Harika Atmaca, Suleyman Ilhan, Çisil Çamli Pulat, Buse Aysen Dundar, Metin Zor. Evaluation of Novel Spiro-pyrrolopyridazine Derivatives as Anticancer Compounds: In Vitro Selective Cytotoxicity, Induction of Apoptosis, EGFR Inhibitory Activity, and Molecular Docking Analysis. ACS omega. vol 9. issue 22. 2024-06-10. PMID:38854531. |
evaluation of novel spiro-pyrrolopyridazine derivatives as anticancer compounds: in vitro selective cytotoxicity, induction of apoptosis, egfr inhibitory activity, and molecular docking analysis. |
2024-06-10 |
2024-06-14 |
Not clear |
| Anjana Sajeev, Bethsebie Sailo, Jyothsna Unnikrishnan, Ayesha Talukdar, Mohammed S Alqahtani, Mohamed Abbas, Athba Alqahtani, Gautam Sethi, Ajaikumar B Kunnumakar. Unlocking the Potential of Berberine: Advancing Cancer Therapy through Chemosensitization and Combination Treatments. Cancer letters. 2024-06-07. PMID:38849013. |
bbr's ability to modulate chemoresistance is attributed to its diverse mechanisms of action, including inducing dna breaks, inhibition of drug efflux pumps, modulation of apoptosis and necroptosis, downregulating multidrug resistance genes, enhancing immune response, suppressing angiogenesis and targeting multiple pathways within cancer cells, including protein kinase b/mammalian target of rapamycin (akt/mtor), epidermal growth factor receptor (egfr), mitogen-activated protein kinase (mapk), nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb), poly(adp-ribose) polymerase (parp1), janus kinase/signal transducers and activators of transcription (jak-stat), wnt/β-catenin etc. |
2024-06-07 |
2024-06-10 |
Not clear |
| Yanan Wang, Yongfeng Lao, Rongxin Li, Chengyu You, Liangliang Qing, Xi Xiao, Shuai Liu, Wenyun Wang, Yu Zhao, Zhilong Don. Network pharmacological analysis and experimental study of melatonin in chronic prostatitis/chronic pelvic pain syndrome. Naunyn-Schmiedeberg's archives of pharmacology. 2024-05-31. PMID:38822120. |
enrichment analysis indicates that mt affects cp/cpps through various biological processes, and pathway analysis emphasizes the significance of pi3k-akt, mapk, ras, foxo, hif-1, egfr, and apoptosis pathways. |
2024-05-31 |
2024-06-02 |
Not clear |
| Jing Sun, Wen-Juan Xu, Lin-Ying Zhong, Jian-Bo Chen, Ling Don. [UPLC-QE-Orbitrap-MS combined with network pharmacology to explore differential components and mechanisms of raw and scorched rhubarb for treatment of ulcerative colitis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 7. 2024-05-30. PMID:38812196. |
network pharmacology and molecular docking suggested that free anthraquinones, gallic acid, and 5-hmf may act on core targets such as b-cell lymphoma-2(bcl2), epidermal growth factor receptor(egfr), tumor necrosis factor(tnf), and caspase-3(casp3) and influence the signaling pathways such as phosphoinositide-3-kinase/protein kinase b(pi3k/akt), hypoxia inducible factor-1(hif-1), tnf, and mitogen-activated protein kinase(mapk), so as to regulate the inflammation response, oxidative stress, and cell apoptosis to relieve uc symptoms. |
2024-05-30 |
2024-06-17 |
mouse |
| Qinyao Wei, Juan Li, Xinyan Li, Jialin Xiang, Yao Zhang, Huadong Yin, Can Cu. CircRAB11A act as miR-24-5p sponge promotes proliferation and resists apoptosis of chicken granulosa cell via EGFR/ERK1/2 and RAB11A/ PI3K/AKT pathways. Poultry science. vol 103. issue 7. 2024-05-28. PMID:38806000. |
rab11a or egfr promoted proliferation and suppressed apoptosis in gcs through the phosphatidylinositol-kinase (pi3k)/akt or extracellular signal-regulated kinase (erk)1/2 pathway. |
2024-05-28 |
2024-06-03 |
chicken |
| Jingyu Mao, Qin Lu, Fei Gao, Hao Liu, Jinchuan Ta. Antagonistic Effect of Jiawei Shengjiang San on a Rat Model of Diabetic Nephropathy: Related to EGFR/MAPK3/1 Signaling Pathway. Journal of visualized experiments : JoVE. issue 207. 2024-05-27. PMID:38801274. |
kegg enrichment analysis denoted that jwsjs mitigates diabetic nephropathy by modulating lipids and atherosclerosis, the pi3k-akt signaling pathway, apoptosis, and the hif-1 signaling pathway, with mitogen-activated protein kinase 1 (mapk1), mapk3, epidermal growth factor receptor (egfr), and serine/threonine-protein kinase 1 (akt1) identified as collective targets of multiple pathways. |
2024-05-27 |
2024-05-31 |
rat |