| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Łukasz Biegała, Damian Kołat, Arkadiusz Gajek, Elżbieta Płuciennik, Agnieszka Marczak, Agnieszka Śliwińska, Michał Mikula, Aneta Rogalsk. Uncovering miRNA-mRNA Regulatory Networks Related to Olaparib Resistance and Resensitization of Cells. vol 13. issue 10. 2024-05-24. PMID:38786089. |
resensitized peo1-or cells were enriched in growth factor signaling via pdgf, egfr, fgfr1, vegfr2, and tgfβr, regulation of the cell cycle via the g2/m checkpoint, and caspase-mediated apoptosis. |
2024-05-24 |
2024-05-27 |
Not clear |
| Qi Li, Bo Li, Qian Wang, Chengen Wang, Miao Yu, Tianfu X. Marine-derived EGFR inhibitors: novel compounds targeting breast cancer growth and drug resistance. Frontiers in pharmacology. vol 15. 2024-05-17. PMID:38751788. |
these compounds not only induced early apoptosis through caspase-3 activation but also showed significant inhibitory effects on egfr mutations associated with drug resistance (t790m, l858r, and l858r/t790m), demonstrating high egfr kinase selectivity. |
2024-05-17 |
2024-05-27 |
Not clear |
| Qi Li, Bo Li, Qian Wang, Chengen Wang, Miao Yu, Tianfu X. Marine-derived EGFR inhibitors: novel compounds targeting breast cancer growth and drug resistance. Frontiers in pharmacology. vol 15. 2024-05-17. PMID:38751788. |
furthermore, binding competition assays using surface plasmon resonance technology revealed that tandyukisin and trichoharzin bound to distinct sites on egfr and that their combined use enhanced apoptosis in bc cells. |
2024-05-17 |
2024-05-27 |
Not clear |
| Rui Wang, Wenrui Cui, Lanxin Li, Xiangkai Wei, Chunhong Chu, Guoliang Zhang, Chenxue Liu, Huixia Xu, Chenyang Liu, Ke Wang, Yanming Li, Lei A. BDTX-189, a novel tyrosine kinase inhibitor, inhibits cell activity via ERK and AKT pathways in the EGFR C797S triple mutant cells. Chemico-biological interactions. vol 395. 2024-05-09. PMID:38710274. |
meanwhile, bdtx-189 reduces the protein phosphorylation levels of egfr, erk, and akt, promoting apoptosis. |
2024-05-09 |
2024-05-27 |
Not clear |
| Tomohito Doke, Shizheng Huang, Chengxiang Qiu, Xin Sheng, Matthew Seasock, Hongbo Liu, Ziyuan Ma, Matthew Palmer, Katalin Suszta. Genome-wide association studies identify the role of caspase-9 in kidney disease. Science advances. vol 7. issue 45. 2024-04-15. PMID:34739325. |
in summary, here, we prioritized casp9 as an egfr gwas target gene and demonstrated the causal role of casp9 in kidney disease development via improving mitophagy and lowering inflammation and apoptosis. |
2024-04-15 |
2024-04-17 |
mouse |
| Olusola Olalekan Elekofehinti, Ifeoluwa Rachael Adetoyi, Hannah Oluwaseun Popoola, Folasade Oluwatobiloba Ayodeji, Foluso Adeola Taiwo, Moses Orimoloye Akinjiyan, Omowunmi Funmilayo Koledoye, Opeyemi Iwaloye, Abayomi Emmanuel Adegboyeg. Discovery of potential epidermal growth factor receptor inhibitors from black pepper for the treatment of lung cancer: an In silico pharmacology. vol 12. issue 1. 2024-04-11. PMID:38601803. |
discovery of potential epidermal growth factor receptor inhibitors from black pepper for the treatment of lung cancer: an a tyrosine kinase receptor known as epidermal growth factor receptor (egfr) is one of the main tumour markers in many cancer types and also plays a crucial role in cell proliferation, differentiation, angiogenesis, and apoptosis, which is a result of the auto-phosphorylations (kinase activity enhancement) that trigger signals involved in different cellular processes. |
2024-04-11 |
2024-04-13 |
Not clear |
| Sha Lv, Qianrong Pan, Weijing Lu, Weisong Zhang, Naike Wang, Lijuan Huang, Lianjing Li, Jieyao Liu, Jiamei Ma, Zhan Li, Yong Huang, Qiudi Deng, Xueping Le. Tenovin 3 induces apoptosis and ferroptosis in EGFR 19del non small cell lung cancer cells. Scientific reports. vol 14. issue 1. 2024-04-01. PMID:38561419. |
tenovin 3 induces apoptosis and ferroptosis in egfr 19del non small cell lung cancer cells. |
2024-04-01 |
2024-04-04 |
Not clear |
| Zhenyi Hu, Po-Han Chen, Wenxue Li, Mackenzie Krone, Sijin Zheng, Jacques Saarbach, Ines Urquizo Velasco, John Hines, Yansheng Liu, Craig M Crew. EGFR targeting PhosTACs as a dual inhibitory approach reveals differential downstream signaling. Science advances. vol 10. issue 13. 2024-03-27. PMID:38536914. |
last, egfr phostacs, consistent with egfr dephosphorylation profiles, induced apoptosis and inhibited cancer cell viability during prolonged phostac treatment. |
2024-03-27 |
2024-03-30 |
Not clear |
| Rutuja Damare, Kritika Engle, Gautam Kuma. Targeting epidermal growth factor receptor and its downstream signaling pathways by natural products: A mechanistic insight. Phytotherapy research : PTR. 2024-03-04. PMID:38433568. |
further, the egfr gene mutations and protein overexpression activate downstream signaling pathways in cancerous cells, stimulating the growth, survival, resistance to apoptosis, and progression of tumors. |
2024-03-04 |
2024-03-06 |
Not clear |
| Rui-Jie Chen, Qian-Yu Bi, Jie-Min Shi, Jing Zhong, Jin-Tao Han, Xu-Ming J. [Mechanism of n-butanol fraction of Wenxia Formula combining with gefitinib in treating non-small cell lung cancer based on network pharmacology and in vitro experiment]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 2. 2024-02-25. PMID:38403323. |
the cell experiments demonstrated that nwxf combined with gef synergistically inhibited the proliferation, promoted the apoptosis, decreased p-egfr/egfr and p-jnk/jnk values, down-regulated the mrna levels of egfr and jnk, and up-regulated the mrna and protein levels of bax in a549 and pc-9 cells. |
2024-02-25 |
2024-02-28 |
human |
| Mingyang Qiu, Jianqing Zhang, Wenlong Wei, Yan Zhang, Mengmeng Li, Yuxin Bai, Hanze Wang, Qian Meng, De-An Gu. Integrated UPLC/Q-TOF-MS/MS Analysis and Network Pharmacology to Reveal the Neuroprotective Mechanisms and Potential Pharmacological Ingredients of Aurantii Fructus Immaturus and Aurantii Fructus. Pharmaceuticals (Basel, Switzerland). vol 17. issue 2. 2024-02-24. PMID:38399454. |
these activities are associated with the regulatory effects of related components on 146 important signaling pathways, derived from the kegg (kegg: kyoto encyclopedia of genes and genomes), such as neurodegeneration (hsa05022), the alzheimer's disease pathway (hsa05010), the nf-kappa b signaling pathway (hsa04064), the hypoxia-inducible factor (hif)-1 signaling pathway (hsa04066), apoptosis (hsa04210), the epidermal growth factor receptor (egfr) tyrosine kinase inhibitor resistance signaling pathway (hsa01521), and others, by targeting 108 proteins, including xanthine dehydrogenase (xdh), glutamate ionotropic receptor nmda type subunit 2b (grin2b), and glucose-6-phosphate dehydrogenase (g6pd), among others. |
2024-02-24 |
2024-02-26 |
human |
| Jing-Long Cao, Shu-Mei Li, Yan-Jun Tang, Wen-Shuang Hou, An-Qi Wang, Tian-Zhu Li, Cheng-Hao Ji. Network pharmacology analysis and experimental verification of the antitumor effect and molecular mechanism of isocryptomerin on HepG2 cells. Drug development research. vol 85. issue 2. 2024-02-24. PMID:38400652. |
overall, iso induced cell apoptosis and cell cycle arrest and inhibited cell migration by ros-mediated egfr, akt, and mapk signaling pathways in hepg2 cells. |
2024-02-24 |
2024-02-26 |
Not clear |
| Guoyang Sun, Jinjin Wang, Futao Liu, Cai Zhao, Shanshan Cui, Zhaoyang Wang, Zhen Liu, Qian Zhang, Cen Xiang, Yongmin Zhang, Herve Galons, Peng Yu, Yuou Ten. G-4 inhibits triple negative breast cancer by inducing cell apoptosis and promoting LCN2-dependent ferroptosis. Biochemical pharmacology. 2024-02-23. PMID:38395264. |
flow cytometry and immunoblotting showed that g-4 not only arrested the s phase of the cell cycle, but also induced apoptosis in tnbc cells via the mitochondrial pathway through inhibiting epidermal growth factor receptor (egfr), akt and mapk pathways. |
2024-02-23 |
2024-02-26 |
Not clear |
| Ahmed A Gaber, Ayman Abo Elmaaty, Marwa Sharaky, Aliaa A Mosa, Abdullah Yahya Abdullah Alzahrani, Saad Shaaban, Wagdy M Eldehna, Ahmed A Al-Karmalaw. Multi-target rational design and synthesis of novel diphenyl-tethered pyrazolopyrimidines targeting EGFR and topoisomerase II with potential DNA intercalation and apoptosis induction. Bioorganic chemistry. vol 145. 2024-02-22. PMID:38387399. |
multi-target rational design and synthesis of novel diphenyl-tethered pyrazolopyrimidines targeting egfr and topoisomerase ii with potential dna intercalation and apoptosis induction. |
2024-02-22 |
2024-02-25 |
Not clear |
| Yang Zhang, Ye Chen, Li-Li Lu, Xiu-Li Xie, Ren Huan, Li-Fang Wu, Li-Na Tan, Tao Xu, Yong Ji. The Role and Therapeutic Potential of Non-coding RNAs in Resistance to EGFR-TKIs targeted therapy for Non-small Cell Lung Cancer. Current medicinal chemistry. 2024-02-20. PMID:38375847. |
ncrnas are involved in nsclc resistance to egfr-tkis by mediating cellular drug efflux, epithelial-mesenchymal transition, apoptosis, autophagy, and egfr mutation. |
2024-02-20 |
2024-02-22 |
Not clear |
| Biao Wang, Junfeng He, Yan Cui, Sijiu Yu, Huizhu Zhang, Pengqiang Wei, Qian Zhan. The HIF-1α/EGF/EGFR Signaling Pathway Facilitates the Proliferation of Yak Alveolar Type II Epithelial Cells in Hypoxic Conditions. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38338723. |
furthermore, activation of egfr expression under normoxic conditions further promoted at2 cell proliferation while simultaneously suppressing apoptosis. |
2024-02-10 |
2024-02-12 |
Not clear |
| Fatemeh Keshavarz, Mohsen Soltanshahi, Fatemeh Khosravani, Farzaneh Bakhshiyan, Amir Ghanbari, Sajad Hassanzadeh, Mozhgan Amirpour, Ghasem Ghalamfars. Thymol-loaded liposomes effectively induced apoptosis and decreased EGFR expression in colorectal cancer cells. Naunyn-Schmiedeberg's archives of pharmacology. 2024-01-19. PMID:38240780. |
thymol-loaded liposomes effectively induced apoptosis and decreased egfr expression in colorectal cancer cells. |
2024-01-19 |
2024-01-21 |
Not clear |
| Fatemeh Ardalan Moghadam Al, Mohammad Mahdi Forghanifard, Vajiheh Zarrinpou. PYGO2 increases proliferation and migration capacities through critical signaling pathways in esophageal squamous cell carcinoma. Journal of biochemical and molecular toxicology. vol 38. issue 1. 2024-01-17. PMID:38229324. |
the development of esophageal squamous cell carcinoma (escc) involves various genetic abnormalities that affect key cell signaling pathways, including wnt, hh, apoptosis, mapk, egfr, akt, notch, and emt. |
2024-01-17 |
2024-01-19 |
Not clear |
| Fatemeh Ardalan Moghadam Al, Mohammad Mahdi Forghanifard, Vajiheh Zarrinpou. PYGO2 increases proliferation and migration capacities through critical signaling pathways in esophageal squamous cell carcinoma. Journal of biochemical and molecular toxicology. vol 38. issue 1. 2024-01-17. PMID:38229324. |
furthermore, pygo2 gene expression induction analysis showed the correlation of several involved genes in wnt, hh, apoptosis, mapk, egfr, akt, and emt pathways with various lncrnas. |
2024-01-17 |
2024-01-19 |
Not clear |
| Fatma G Abdulrahman, Hamada S Abulkhair, Hoda S El Saeed, Nehad M El-Dydamony, Ebtehal M Hussein. Design, synthesis, and mechanistic insight of novel imidazolones as potential EGFR inhibitors and apoptosis inducers. Bioorganic chemistry. vol 144. 2024-01-14. PMID:38219482. |
design, synthesis, and mechanistic insight of novel imidazolones as potential egfr inhibitors and apoptosis inducers. |
2024-01-14 |
2024-01-17 |
Not clear |