| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fumi Nakano, Hideki Kanamaru, Fumihiro Kawakita, Lei Liu, Yoshinari Nakatsuka, Hirofumi Nishikawa, Takeshi Okada, Hidenori Suzuk. Epidermal Growth Factor Receptor Mediates Neuronal Apoptosis After Subarachnoid Hemorrhage in Mice. Stroke. 2023-05-08. PMID:37154060. |
this study was aimed to investigate whether egfr (epidermal growth factor receptor)/nfκb (nuclear factor-kappa b) inducing kinase (nik)/nfκb (p65 and p50) pathway is involved in the neuronal apoptosis after sah in mice. |
2023-05-08 |
2023-08-14 |
mouse |
| Domnica Carpov, Rareş Buigă, Viorica Magdalena Nag. DNA damage response and potential biomarkers of radiosensitivity in head and neck cancers: clinical implications. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 64. issue 1. 2023-05-02. PMID:37128786. |
the purpose of this review was to elucidate the mechanisms involved in avoiding radiation-induced apoptosis of head and neck cancers mediated by modulating the repair of dna damage via p53, epidermal growth factor receptor (egfr) and p16. |
2023-05-02 |
2023-08-14 |
Not clear |
| Honoka Yamamoto, Takeshi Nakanishi, Kan-Ichiro Ihara, Taro Tachibana, Chikako Yokoyam. Generation of Rat Monoclonal Antibodies Against Human Epidermal Growth Factor Receptor 2. Monoclonal antibodies in immunodiagnosis and immunotherapy. 2023-04-19. PMID:37074339. |
it is a proto-oncogenic protein that, through signaling cascades, promotes cell proliferation and inhibits apoptosis in cancer cells through homo- and heterodimerization with other egfr family receptors. |
2023-04-19 |
2023-08-14 |
human |
| Sulfath Thottungal Parambil, Santhosh Kumar R Thankayyan, Gisha Rose Antony, Ajeesh Babu Littleflower, Paul Augustine, Thara Somanathan, Lakshmi Subhadradev. YAP transduction drives triple-negative breast cancer aggressiveness through modulating the EGFR‒AKT axis in patient-derived xenograft cells. Medical oncology (Northwood, London, England). vol 40. issue 5. 2023-04-04. PMID:37014473. |
here, we explored the putative role of the hippo transducer in enhancing cancer hostility and observed that yap transduction drives proliferation, migration, and survival of tnbc by preventing cellular apoptosis through mediating egfr activation. |
2023-04-04 |
2023-08-14 |
Not clear |
| Giulia Romano, Patricia Le, Giovanni Nigita, Michela Saviana, Lavender Micalo, Francesca Lovat, Daniel Del Valle Morales, Howard Li, Patrick Nana-Sinkam, Mario Acunz. A-to-I edited miR-411-5p targets MET and promotes TKI response in NSCLC-resistant cells. Oncogene. 2023-03-31. PMID:37002315. |
we found that the edited mir-411-5p reduces proliferation and induces apoptosis, promoting egfr tkis response in nsclc-resistant cells. |
2023-03-31 |
2023-08-14 |
Not clear |
| Natalia Lisiak, Patrycja Dzikowska, Urszula Wisniewska, Mariusz Kaczmarek, Barbara Bednarczyk-Cwynar, Lucjusz Zaprutko, Blazej Rubi. Biological Activity of Oleanolic Acid Derivatives HIMOXOL and Br-HIMOLID in Breast Cancer Cells Is Mediated by ER and EGFR. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982173. |
in our study, we revealed that proliferation, cell cycle, apoptosis, autophagy, and also the migratory potential of himoxol and br-himolid in breast cancer cells are mediated by er (mcf7) and egfr (mda-mb-231) receptors. |
2023-03-29 |
2023-08-14 |
Not clear |
| Kiichiro Taniguchi, Tatsushi Igak. Sas-Ptp10D shapes germ-line stem cell niche by facilitating JNK-mediated apoptosis. PLoS genetics. vol 19. issue 3. 2023-03-27. PMID:36972315. |
here, we show that a transmembrane protein stranded at second (sas) and its receptor protein tyrosine phosphatase 10d (ptp10d), effectors of axon guidance and cell competition via epidermal growth factor receptor (egfr) inhibition, shape the dish-like niche structure by facilitating c-jun n-terminal kinase (jnk)-mediated apoptosis. |
2023-03-27 |
2023-08-14 |
drosophila_melanogaster |
| Kiichiro Taniguchi, Tatsushi Igak. Sas-Ptp10D shapes germ-line stem cell niche by facilitating JNK-mediated apoptosis. PLoS genetics. vol 19. issue 3. 2023-03-27. PMID:36972315. |
mechanistically, loss of sas-ptp10d elevates egfr signaling in the gonadal apical cells, thereby suppressing their naturally-occurring jnk-mediated apoptosis that is essential for the shaping of the dish-like niche structure by neighboring cap cells. |
2023-03-27 |
2023-08-14 |
drosophila_melanogaster |
| Guangyuan Hu, Na Luo, Qiuyun Guo, Dingkun Wang, Ping Peng, Dongbo Liu, Shunfang Liu, Linli Zhang, Guoxian Long, Wei Su. Ginsenoside Rg3 Sensitizes Nasopharyngeal Carcinoma Cells to Radiation by Suppressing Epithelial Mesenchymal Transition. Radiation research. 2023-03-22. PMID:36946792. |
this effect is mediated through restrained egfr nuclear translocation and increased cell apoptosis. |
2023-03-22 |
2023-08-14 |
Not clear |
| Binayak Kumar, Peeyush Prasad, Ragini Singh, Ram Krishna Sahu, Ashutosh Singh, Srikrishna Jayadev Magani, Suresh Heda. Role of identified proteins in the proteome profiles of CDK4/6 inhibitor-resistant breast cancer cell lines. Molecular omics. 2023-03-20. PMID:36938944. |
down-regulated proteins induce apoptosis signalling and nucleotide metabolisms and restrict egfr signalling; however, up-regulated proteins induce erk, wnt-β-catenin, vegfr-pi3k-akt, glucose transportation, and hypoxia signalling pathways and regulate hydrogen peroxide signalling pathways. |
2023-03-20 |
2023-08-14 |
Not clear |
| Yangyang Fan, Wei Li, Wenyan Nie, Han Yao, Yuanyuan Ren, Mengxuan Wang, Haoran Nie, Chenxi Gu, Jiadai Liu, Baijiao A. Novel Dual-Target Kinase Inhibitors of EGFR and ALK Were Designed, Synthesized, and Induced Cell Apoptosis in Non-Small Cell Lung Cancer. Molecules (Basel, Switzerland). vol 28. issue 5. 2023-03-11. PMID:36903251. |
novel dual-target kinase inhibitors of egfr and alk were designed, synthesized, and induced cell apoptosis in non-small cell lung cancer. |
2023-03-11 |
2023-08-14 |
Not clear |
| Kentaro Yoshida, Shigeo Hayash. Epidermal growth factor receptor signaling protects epithelia from morphogenetic instability and tissue damage in Drosophila. Development (Cambridge, England). vol 150. issue 5. 2023-03-10. PMID:36897356. |
here, we show that this process is apoptosis dependent, and clustered apoptosis, groove formation, and wounding sensitize egfr mutant epithelia to initiate massive tissue disintegration. |
2023-03-10 |
2023-08-14 |
drosophila_melanogaster |
| Chang-Yao Chu, Chien-Yu Lin, Chien-Chung Lin, Chien-Feng Li, Shang-Yin Wu, Jeng-Shiuan Tsai, Szu-Chun Yang, Chian-Wei Chen, Chia-Yin Lin, Chao-Chun Chang, Yi-Ting Yen, Yau-Lin Tseng, Po-Lan Su, Wu-Chou S. Effect of BIM expression on the prognostic value of PD-L1 in advanced non-small cell lung cancer patients treated with EGFR-TKIs. Scientific reports. vol 13. issue 1. 2023-03-09. PMID:36894581. |
our data suggest that among the pathways affecting tumor-intrinsic pd-l1 signaling, bim is potentially the underlying mechanism that affects the role of pd-l1 expression in predicting response to egfr tki and mediates cell apoptosis under treatment with gefitinib in egfr-mutant nsclc. |
2023-03-09 |
2023-08-14 |
Not clear |
| Pengfei Jiao, Yingrui Wang, Gaofei Ren, Dan Chu, Yameng Li, Tianqing San. Integrating Network Pharmacology and Experimental Validation to Elucidate the Mechanism of Yiqi Yangyin Decoction in Suppressing Non-Small-Cell Lung Cancer. BioMed research international. vol 2023. 2023-03-06. PMID:36874921. |
furthermore, egfr activator significantly reversed yyd-mediated proliferation inhibition and apoptosis. |
2023-03-06 |
2023-08-14 |
mouse |
| Fengnan Sun, Junwei Liu, Yanzheng Wang, Hongmei Yang, Danfeng Song, Haiyan Fu, Xingxing Fen. BASP1 promotes high glucose-induced endothelial apoptosis in diabetes via activation of EGFR signaling. Journal of diabetes investigation. 2023-02-09. PMID:36756695. |
basp1 promotes high glucose-induced endothelial apoptosis in diabetes via activation of egfr signaling. |
2023-02-09 |
2023-08-14 |
Not clear |
| Yuki Katayama, Tadaaki Yamada, Keiko Tanimura, Shinsaku Tokuda, Kenji Morimoto, Soichi Hirai, Yohei Matsui, Ryota Nakamura, Masaki Ishida, Hayato Kawachi, Kazue Yoneda, Kazutaka Hosoya, Takahiro Tsuji, Hiroaki Ozasa, Akihiro Yoshimura, Masahiro Iwasaku, Young Hak Kim, Mano Horinaka, Toshiyuki Sakai, Takahiro Utsumi, Shinsuke Shiotsu, Takayuki Takeda, Ryohei Katayama, Koichi Takayam. Adaptive resistance to lorlatinib via EGFR signaling in ALK-rearranged lung cancer. NPJ precision oncology. vol 7. issue 1. 2023-01-26. PMID:36702855. |
egfr inhibition halted alk-rearranged lung cancer cell proliferation by enhancing alk inhibition-induced apoptosis via suppression of bcl-xl. |
2023-01-26 |
2023-08-14 |
Not clear |
| Yakup Kolcuoglu, Olcay Bekircan, Hilal Fazli, Emine Sahin, Aslı Ture, Atilla Akdemir, Senay Hamarat Sanlie. Design and synthesis of new heterocyclic compounds containing 5-[(1 Journal of biomolecular structure & dynamics. 2023-01-23. PMID:36688370. |
design and synthesis of new heterocyclic compounds containing 5-[(1 egfr is one of the important mediators of the signaling cascade that determines key roles in various biological processes such as growth, differentiation, metabolism and apoptosis in the cell in response to external and internal stimuli. |
2023-01-23 |
2023-08-14 |
Not clear |
| Qi Zhang, Yifeng Zheng, Jiajia Liu, Xiaoxiao Tang, Yuan Wang, Xianzheng Li, Huibin Li, Xiaoying Zhou, Shiru Tang, Yitao Tang, Xiaoyan Wang, Han He, Tingting L. CircIFNGR2 enhances proliferation and migration of CRC and induces cetuximab resistance by indirectly targeting KRAS via sponging to MiR-30b. Cell death & disease. vol 14. issue 1. 2023-01-13. PMID:36639711. |
cetuximab, the monoclonal antibody targeting the extracellular domain of egfr, has shown its great efficacy in the promotion of apoptosis and the inhibition of tumor cells-like characteristics in numerous cancers. |
2023-01-13 |
2023-08-14 |
Not clear |
| Jin Song, Xiaolong Xu, Shasha He, Ning Wang, Yunjing Bai, Zhaoxia Chen, Bo Li, Shengsheng Zhan. Myristicin Suppresses Gastric Cancer Growth via Targeting the EGFR/ERK Signaling Pathway. Current molecular pharmacology. 2023-01-04. PMID:36597605. |
in addition, egfr over-expression abolished the inhibitory function of myristicin on proliferation, apoptosis, and er stress. |
2023-01-04 |
2023-08-14 |
human |
| Jae Sik Kim, Joo Ho Lee, Sang-Rok Jeon, Yongsub Kim, Seung Hyuck Jeon, Hong-Gyun W. Identification of Genes Involved in EGF-induced Apoptosis Using CRISPR/Cas9 Knockout Screening: Implications for Novel Therapeutic Targets in EGFR-Overexpressing Cancers. Cancer research and treatment. 2023-01-03. PMID:36596724. |
exogenous epidermal growth factor (egf) causes apoptosis in egf receptor (egfr)-overexpressing cell lines. |
2023-01-03 |
2023-08-14 |
Not clear |