| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shigetoshi Nishihara, Toshimitsu Yamaoka, Fumihiro Ishikawa, Kensuke Higuchi, Yuki Hasebe, Ryo Manabe, Yasunari Kishino, Sojiro Kusumoto, Koichi Ando, Yusuke Kuroda, Tohru Ohmori, Hironori Sagara, Hitoshi Yoshida, Junji Tsurutan. Mechanisms of EGFR-TKI-Induced Apoptosis and Strategies Targeting Apoptosis in EGFR-Mutated Non-Small Cell Lung Cancer. Genes. vol 13. issue 12. 2022-12-23. PMID:36553449. |
apoptosis induction is an important mechanism underlying the therapeutic efficacy of epidermal growth factor receptor (egfr)-tyrosine kinase inhibitors (tkis) for egfr-mutated non-small cell lung cancer (nsclc). |
2022-12-23 |
2023-08-14 |
Not clear |
| Mackenzie L Hagan, Suchreet Mander, Carol Joseph, Michael McGrath, Amanda Barrett, Allison Lewis, William D Hill, Darren Browning, Meghan E McGee-Lawrence, Haifeng Cai, Kebin Liu, John T Barrett, David A Gewirtz, Muthusamy Thangaraju, Patricia V Schoenlei. Upregulation of the EGFR/MEK1/MAPK1/2 signaling axis as a mechanism of resistance to antiestrogen‑induced BimEL dependent apoptosis in ER International journal of oncology. vol 62. issue 2. 2022-12-16. PMID:36524361. |
upregulation of the egfr/mek1/mapk1/2 signaling axis as a mechanism of resistance to antiestrogen‑induced bimel dependent apoptosis in er the epidermal growth factor receptor (egfr) is commonly upregulated in multiple cancer types, including breast cancer. |
2022-12-16 |
2023-08-14 |
Not clear |
| Mackenzie L Hagan, Suchreet Mander, Carol Joseph, Michael McGrath, Amanda Barrett, Allison Lewis, William D Hill, Darren Browning, Meghan E McGee-Lawrence, Haifeng Cai, Kebin Liu, John T Barrett, David A Gewirtz, Muthusamy Thangaraju, Patricia V Schoenlei. Upregulation of the EGFR/MEK1/MAPK1/2 signaling axis as a mechanism of resistance to antiestrogen‑induced BimEL dependent apoptosis in ER International journal of oncology. vol 62. issue 2. 2022-12-16. PMID:36524361. |
the present study uniquely identified egfr upregulation as one of the mechanisms breast cancer cells utilize to evade the cytotoxic effects of antiestrogens mediated through bimel‑dependent apoptosis. |
2022-12-16 |
2023-08-14 |
Not clear |
| Sebastien Taurin, Rhonda J Rosengre. Raloxifene potentiates the effect of gefitinib in triple-negative breast cancer cell lines. Medical oncology (Northwood, London, England). vol 40. issue 1. 2022-12-09. PMID:36494506. |
the combination potentiates apoptosis and affects the expression and phosphorylation pattern of proteins involved in cell proliferation, such as nfκb, β-catenin, and egfr. |
2022-12-09 |
2023-08-14 |
Not clear |
| Emma Polonio-Alcalá, Rut Porta, Santiago Ruiz-Martínez, Carmen Vásquez-Dongo, Joana Relat, Joaquim Bosch-Barrera, Joaquim Ciurana, Teresa Pui. AZ12756122, a novel fatty acid synthase inhibitor, decreases resistance features in EGFR-TKI resistant EGFR-mutated NSCLC cell models. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 156. 2022-11-22. PMID:36411628. |
our findings revealed that az12756122 caused cytotoxic effects inducing apoptosis, downregulated fasn expression and activity, decreased the activation of egfr and akt/mtor pathway, and reduced cancer stem-like cells. |
2022-11-22 |
2023-08-14 |
Not clear |
| Laura J Jenkins, Ian Y Luk, Walter D Fairlie, Erinna F Lee, Michelle Palmieri, Kael L Schoffer, Tao Tan, Irvin Ng, Natalia Vukelic, Sharon Tran, Janson Wt Tse, Rebecca Nightingale, Zakia Alam, Fiona Chionh, George Iatropoulos, Matthias Ernst, Shoukat Afshar-Sterle, Jayesh Desai, Peter Gibbs, Oliver M Sieber, Amardeep S Dhillon, Niall C Tebbutt, John M Mariadaso. Genotype-tailored ERK/MAPK pathway and HDAC inhibition rewires the apoptotic rheostat to trigger colorectal cancer cell death. Molecular cancer therapeutics. 2022-11-07. PMID:36343387. |
importantly, we demonstrate that the paradigm of combined mapk/hdac inhibitor treatment to induce apoptosis can be tailored to specific mapk genotypes in crcs, by combining a hdac inhibitor with either an egfr, krasg12c or brafv600 inhibitor in kras/brafwt; krasg12c, brafv600e crc cell lines respectively. |
2022-11-07 |
2023-08-14 |
Not clear |
| Zhen Liu, Ye Xu, Lvqian Guo, Xinran Li, Junling Gao, Weiran Xie, Lianbo Zhao, Yuou Teng, Xuejiao Li, Peng Y. Development of 10-Hydroxycamptothecin-crizotinib conjugate based on the synergistic effect on lung cancer cells. Journal of enzyme inhibition and medicinal chemistry. vol 38. issue 1. 2022-10-28. PMID:36305251. |
the combination synergistically enhanced the cell apoptosis rate through releasing cyto-c by activation of bcl-2 family-mediated mitochondrial signalling, which was associate with inactivating of egfr related downstream signalling pathways including akt, erk, jnk, and p38 mapk. |
2022-10-28 |
2023-08-14 |
Not clear |
| Jin-Young Lee, Bok Yun Kang, Sang-Jin Jung, Ah-Won Kwak, Seung-On Lee, Jin Woo Park, Sang Hoon Joo, Goo Yoon, Mee-Hyun Lee, Jung-Hyun Shi. Picropodophyllotoxin Inhibits Cell Growth and Induces Apoptosis in Gefitinib-Resistant Non-Small Lung Cancer Cells by Dual-Targeting EGFR and MET. Biomolecules & therapeutics. 2022-10-25. PMID:36281696. |
picropodophyllotoxin inhibits cell growth and induces apoptosis in gefitinib-resistant non-small lung cancer cells by dual-targeting egfr and met. |
2022-10-25 |
2023-08-14 |
Not clear |
| Amna Mohamed Taha, Mohammad Mabrouk Aboulwafa, Hamdallah Zedan, Omneya Mohamed Helm. Ramucirumab combination with sorafenib enhances the inhibitory effect of sorafenib on HepG2 cancer cells. Scientific reports. vol 12. issue 1. 2022-10-25. PMID:36284117. |
cell proliferation; apoptosis and cell cycle distribution; gene expression of vegfr2, egfr, mmp-9 and caspase3; the protein levels of pvegfr2 and pstat3 and the protein expression of caspase3, egfr and vegfr2 were determined. |
2022-10-25 |
2023-08-14 |
Not clear |
| Menna El Gaafary, Samy A F Morad, Michael Schmiech, Tatiana Syrovets, Thomas Simme. Arglabin, an EGFR receptor tyrosine kinase inhibitor, suppresses proliferation and induces apoptosis in prostate cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 156. 2022-10-22. PMID:36272260. |
arglabin, an egfr receptor tyrosine kinase inhibitor, suppresses proliferation and induces apoptosis in prostate cancer cells. |
2022-10-22 |
2023-08-14 |
human |
| Wei Li, Han Yao, Chenxi Gu, Yuanyuan Ren, Jiadai Liu, Baijiao An, Wenhao Hu, Xingshu Li, Albert S C Cha. Discovery of a potent EGFR and ALK dual mutation inhibitor containing N-(3-((4-((2-(cyclopropylsulfinyl)phenyl)amino)pyrimidin-2-yl)amino) phenyl)acrylamide scaffold. Bioorganic chemistry. vol 129. 2022-10-11. PMID:36220003. |
the study of anti-tumor mechanism indicated that 8a could effectively block the phosphorylation of egfr and alk proteins, so as to effectively inhibiting the proliferation and inducing apoptosis of h1975 tumor cells, blocking the cell cycle and reducing the mitochondrial membrane potential inhibited the migration of h1975 cells. |
2022-10-11 |
2023-08-14 |
mouse |
| Tianshi Sun, Dengke Wu, Youwen Deng, Dongshan Zhan. EGFR mediated the renal cell apoptosis in rhabdomyolysis-induced model via upregulation of autophagy. Life sciences. 2022-10-09. PMID:36209831. |
egfr mediated the renal cell apoptosis in rhabdomyolysis-induced model via upregulation of autophagy. |
2022-10-09 |
2023-08-14 |
Not clear |
| Makoto Endo, Richard A Cerion. The brain-specific splice variant of the CDC42 GTPase works together with the kinase ACK to down-regulate the EGF receptor in promoting neurogenesis. The Journal of biological chemistry. 2022-10-07. PMID:36206843. |
by promoting egfr degradation, we found that cdc42b and ack stimulate autophagy, which protects emerging neurons from apoptosis and helps trigger neural progenitor cells to differentiate into neurons. |
2022-10-07 |
2023-08-14 |
Not clear |
| Erika Powe, Daniel Parschauer, Jessica Istifan, Stacy Lin, Huanyun Duan, Rebecca Gryka, Denise Jean-Louis, Amit K Tiwari, Samson Amo. Luteolin enhances erlotinib's cell proliferation inhibitory and apoptotic effects in glioblastoma cell lines. Frontiers in pharmacology. vol 13. 2022-10-06. PMID:36199696. |
increased expression of egfr leads to increased proliferation, decreased apoptosis, and increased resistance to chemotherapeutic agents. |
2022-10-06 |
2023-08-14 |
Not clear |
| Erika Powe, Daniel Parschauer, Jessica Istifan, Stacy Lin, Huanyun Duan, Rebecca Gryka, Denise Jean-Louis, Amit K Tiwari, Samson Amo. Luteolin enhances erlotinib's cell proliferation inhibitory and apoptotic effects in glioblastoma cell lines. Frontiers in pharmacology. vol 13. 2022-10-06. PMID:36199696. |
we investigated the combined effects of erlotinib and luteolin on proliferation and apoptosis on glioblastoma cell lines overexpressing egfr or glioma cells expressing truncated egfr (Δegfr). |
2022-10-06 |
2023-08-14 |
Not clear |
| Tao Gui, Yulong Wei, Lijun Luo, Jun Li, Leilei Zhong, Lutian Yao, Frank Beier, Charles L Nelson, Andrew Tsourkas, X Sherry Liu, Motomi Enomoto-Iwamoto, Feifan Yu, Zhiliang Cheng, Ling Qi. Activating EGFR signaling attenuates osteoarthritis development following loading injury in mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2022-09-30. PMID:36178273. |
mechanistically, over-activation of egfr signaling protected chondrocytes from loading-induced apoptosis and loss of proliferative ability and lubricant synthesis. |
2022-09-30 |
2023-08-14 |
mouse |
| Simeng Hou, Haotian Wu, Si Chen, Xubo Li, Zhenxing Zhang, Yiwen Cheng, Yuanyuan Chen, Meirong He, Qi An, Churiga Man, Li Du, Qiaoling Chen, Fengyang Wan. Bovine skin fibroblasts mediated immune responses to defend against bovine Acinetobacter baumannii infection. Microbial pathogenesis. 2022-09-30. PMID:36179976. |
in addition, casp3 and jun were the core functional genes of apoptosis, while il-6, erbb2, egfr, chuk and mapk8 were the core functional genes of immunity by protein-protein interaction (ppi) analysis. |
2022-09-30 |
2023-08-14 |
cattle |
| Shahrbanou Ashrafian, Mahshid Zarrineh, Pia Jensen, Arkadiusz Nawrocki, Hassan Rezadoost, Alireza Madjid Ansari, Leila Farahmand, Alireza Ghassempour, Martin R Larse. Quantitative Phosphoproteomics and Acetylomics of Safranal Anticancer Effects in Triple-Negative Breast Cancer Cells. Journal of proteome research. 2022-09-29. PMID:36173113. |
safranal influences the phosphorylation level on proteins involved in dna replication and repair, translation, and egfr activation/accumulation, which can lead the cells into apoptosis. |
2022-09-29 |
2023-08-14 |
Not clear |
| Shi-Yong Su. Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors. Frontiers of medicine. 2022-09-24. PMID:36152124. |
targeting apoptosis to manage acquired resistance to third generation egfr inhibitors. |
2022-09-24 |
2023-08-14 |
Not clear |
| Xiulong Ma, Hongtao Ren, Yang Zhang, Baofeng Wang, Hongbing M. LncRNA RHPN1-AS1 inhibition induces autophagy and apoptosis in prostate cancer cells via the miR-7-5p/EGFR/PI3K/AKT/mTOR signaling pathway. Environmental toxicology. 2022-09-20. PMID:36125241. |
subsequently, we transfected pca cells with rhpn1-as1 overexpression vector (rhpn1-as1), knockdown plasmids (sh-rhpn1-as1) and/or mir-7-5p mimics or inhibitor and/or overexpression vector (egfr) or small interfering rna of egfr (si-egfr) or its control, and found that overexpression of rhpn1-as1 inhibited mir-7-5p expression and promoted egfr expression, silencing rhpn1-as1 inhibited proliferation and invasion, and induced g2/m arrest, apoptosis and autophagy in pca cells. |
2022-09-20 |
2023-08-14 |
Not clear |