| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiulong Ma, Hongtao Ren, Yang Zhang, Baofeng Wang, Hongbing M. LncRNA RHPN1-AS1 inhibition induces autophagy and apoptosis in prostate cancer cells via the miR-7-5p/EGFR/PI3K/AKT/mTOR signaling pathway. Environmental toxicology. 2022-09-20. PMID:36125241. |
overexpression mir-7-5p or silencing egfr promoted lc3-i to lc3-ii conversion, enhanced autophagy activity, induced cleaved-caspase-3 expression and apoptosis in pca cells. |
2022-09-20 |
2023-08-14 |
Not clear |
| Xiulong Ma, Hongtao Ren, Yang Zhang, Baofeng Wang, Hongbing M. LncRNA RHPN1-AS1 inhibition induces autophagy and apoptosis in prostate cancer cells via the miR-7-5p/EGFR/PI3K/AKT/mTOR signaling pathway. Environmental toxicology. 2022-09-20. PMID:36125241. |
in summary, rhpn1-as1 acted as a cerna of mir-7-5p to upregulate egfr expression, silencing rhpn1-as1 suppressed pca tumor progression by inducing autophagy and apoptosis in pca cells through the mir-7-5p/egfr/pi3k/akt/mtor pathway. |
2022-09-20 |
2023-08-14 |
Not clear |
| Jamie-Lee Pitcher, Naomi Alexander, Panimaya Jeffreena Miranda, Terrance G John. ErbB4 in the brain: Focus on high grade glioma. Frontiers in oncology. vol 12. 2022-09-19. PMID:36119496. |
erbb4 is a unique member of the egfr family, implicated not only in pro-tumorigenic mechanisms, such as cell proliferation and migration, but also in anti-tumorigenic activities, including cell differentiation and apoptosis. |
2022-09-19 |
2023-08-14 |
Not clear |
| Kieun Bae, Jin Hee Kim, Ja Young Lee, Sun-Young Kong, Yun-Hee Kim, Sunshin Kim, Kyong-Ah Yoo. Oncogenic fusion of BCAR4 activates EGFR signaling and is sensitive to dual inhibition of EGFR/HER2. Frontiers in molecular biosciences. vol 9. 2022-09-09. PMID:36081848. |
tyrosine kinase inhibitors (tkis) of the egfr family significantly inhibit the migration of bcar4 fusion-overexpressing cells and induce apoptosis at high concentrations. |
2022-09-09 |
2023-08-14 |
mouse |
| Xue-Song Zhang, Yong-Juan Zhao, Yu Zhang, Tong Xu, Kai-Ling Cui, Bu-Ting Duan, Xiao-Ling Lv, Li Zhang, Zhi-Yong Xu, Rui Bai, Ming-Xue Zhen. Role of EtMIC4 EGF-like in regulating the apoptosis of Eimeria tenella host cells via the EGFR pathway. Poultry science. vol 101. issue 10. 2022-08-30. PMID:36041391. |
role of etmic4 egf-like in regulating the apoptosis of eimeria tenella host cells via the egfr pathway. |
2022-08-30 |
2023-08-14 |
Not clear |
| Xue-Song Zhang, Yong-Juan Zhao, Yu Zhang, Tong Xu, Kai-Ling Cui, Bu-Ting Duan, Xiao-Ling Lv, Li Zhang, Zhi-Yong Xu, Rui Bai, Ming-Xue Zhen. Role of EtMIC4 EGF-like in regulating the apoptosis of Eimeria tenella host cells via the EGFR pathway. Poultry science. vol 101. issue 10. 2022-08-30. PMID:36041391. |
this study aimed to explore the role and key point of etmic4 egf-like recombinant protein in regulating the apoptosis of eimeria tenella host cells via the epidermal growth factor receptor (egfr) pathway. |
2022-08-30 |
2023-08-14 |
Not clear |
| Xue-Song Zhang, Yong-Juan Zhao, Yu Zhang, Tong Xu, Kai-Ling Cui, Bu-Ting Duan, Xiao-Ling Lv, Li Zhang, Zhi-Yong Xu, Rui Bai, Ming-Xue Zhen. Role of EtMIC4 EGF-like in regulating the apoptosis of Eimeria tenella host cells via the EGFR pathway. Poultry science. vol 101. issue 10. 2022-08-30. PMID:36041391. |
infection and apoptosis rates as well as dynamic changes in the key genes and proteins of the egfr signaling pathway in the host cells were determined. |
2022-08-30 |
2023-08-14 |
Not clear |
| Xue-Song Zhang, Yong-Juan Zhao, Yu Zhang, Tong Xu, Kai-Ling Cui, Bu-Ting Duan, Xiao-Ling Lv, Li Zhang, Zhi-Yong Xu, Rui Bai, Ming-Xue Zhen. Role of EtMIC4 EGF-like in regulating the apoptosis of Eimeria tenella host cells via the EGFR pathway. Poultry science. vol 101. issue 10. 2022-08-30. PMID:36041391. |
in cells treated with etmic4 egf-like for 4 to 24 h, the apoptosis rate was significantly decreased (p < 0.01) and the relative mrna expression and protein phosphorylation levels of egfr, protein kinase b (akt), and extracellular regulated protein kinases (erk) were significantly increased (p < 0.01). |
2022-08-30 |
2023-08-14 |
Not clear |
| Xue-Song Zhang, Yong-Juan Zhao, Yu Zhang, Tong Xu, Kai-Ling Cui, Bu-Ting Duan, Xiao-Ling Lv, Li Zhang, Zhi-Yong Xu, Rui Bai, Ming-Xue Zhen. Role of EtMIC4 EGF-like in regulating the apoptosis of Eimeria tenella host cells via the EGFR pathway. Poultry science. vol 101. issue 10. 2022-08-30. PMID:36041391. |
these results indicated that e. tenella could activate the egfr pathway through etmic4 egf-like and regulate the expression of key genes in the akt and erk signaling pathways, thereby inhibiting cell apoptosis. |
2022-08-30 |
2023-08-14 |
Not clear |
| Xiu-Li Sun, Ze-Min Xiang, Yin-Rong Xie, Ning Zhang, Li-Xia Wang, Yi-Long Wu, Dong-Ying Zhang, Xuan-Jun Wang, Jun Sheng, Cheng-Ting Z. Dimeric-(-)-epigallocatechin-3-gallate inhibits the proliferation of lung cancer cells by inhibiting the EGFR signaling pathway. Chemico-biological interactions. 2022-08-15. PMID:35970427. |
collectively, our study results show that pbog may induce a decrease in intracellular phosphorylated egfr expression by binding to the egfr ectodomain protein, thereby inducing apoptosis and inhibiting cell cycle progression, thus providing a new strategy to treat lung cancer. |
2022-08-15 |
2023-08-14 |
Not clear |
| Saloni Ramani, Sayalee Samant, Sonal M Manoha. The story of EGFR: from signaling pathways to a potent anticancer target. Future medicinal chemistry. 2022-07-26. PMID:35880513. |
egfr inhibition using strategies such as tyrosine kinase inhibitors and monoclonal antibodies hinders cellular proliferation and promotes apoptosis in cancer cells |
2022-07-26 |
2023-08-14 |
human |
| Kunyu Shi, Guan Wang, Junping Pei, Jifa Zhang, Jiaxing Wang, Liang Ouyang, Yuxi Wang, Weimin L. Emerging strategies to overcome resistance to third-generation EGFR inhibitors. Journal of hematology & oncology. vol 15. issue 1. 2022-07-15. PMID:35840984. |
epidermal growth factor receptor (egfr), the receptor for members of the epidermal growth factor family, regulates cell proliferation and signal transduction; moreover, egfr is related to the inhibition of tumor cell proliferation, angiogenesis, invasion, metastasis, and apoptosis. |
2022-07-15 |
2023-08-14 |
Not clear |
| Tanuja T Yadav, Gulam Moin Shaikh, Maushmi S Kumar, Meena Chintamaneni, Mayur Y. A Review on Fused Pyrimidine Systems as EGFR Inhibitors and Their Structure-Activity Relationship. Frontiers in chemistry. vol 10. 2022-06-30. PMID:35769445. |
the egfr plays a vital role in the cellular proliferation process, differentiation, and apoptosis. |
2022-06-30 |
2023-08-14 |
Not clear |
| Tanuja T Yadav, Gulam Moin Shaikh, Maushmi S Kumar, Meena Chintamaneni, Mayur Y. A Review on Fused Pyrimidine Systems as EGFR Inhibitors and Their Structure-Activity Relationship. Frontiers in chemistry. vol 10. 2022-06-30. PMID:35769445. |
in the case of cancer, egfr undergoes uncontrolled auto-phosphorylation that results in increased cellular proliferation and decreased apoptosis, causing cancer promotion. |
2022-06-30 |
2023-08-14 |
Not clear |
| b' Clelia Madeddu, Clelia Donisi, Nicole Liscia, Eleonora Lai, Mario Scartozzi, Antonio Macci\\xc3\\xb. EGFR-Mutated Non-Small Cell Lung Cancer and Resistance to Immunotherapy: Role of the Tumor Microenvironment. International journal of molecular sciences. vol 23. issue 12. 2022-06-24. PMID:35742933.' |
egfr activation increases pd-l1 expression in tumor cells, inducing t cell apoptosis and immune escape. |
2022-06-24 |
2023-08-14 |
Not clear |
| Shi-Wen Zhang, Hao Wang, You-Yu Qiu, Ren-Chao Huang, Zi-Chen Dong, Lu Zhang, Liu-Fang Zhao, Hong-Yang Xu, Wei-Di Su. Photothermolysis Mediated by Gold Nanorods Conjugated with Epidermal Growth Factor Receptor (EGFR) Monoclonal Antibody Induces Apoptosis via the Mitochondrial Apoptosis Pathway in Laryngeal Squamous Cell Cancer. Journal of biomedical nanotechnology. vol 18. issue 3. 2022-06-18. PMID:35715914. |
photothermolysis mediated by gold nanorods conjugated with epidermal growth factor receptor (egfr) monoclonal antibody induces apoptosis via the mitochondrial apoptosis pathway in laryngeal squamous cell cancer. |
2022-06-18 |
2023-08-14 |
Not clear |
| Chaoyu Zhang, Wenjie Sheng, Marwah Al-Rawe, T M Mohiuddin, Marcus Niebert, Felix Zeppernick, Ivo Meihold-Heerlein, Ahmad Fawzi Hussai. EpCAM- and EGFR-Specific Antibody Drug Conjugates for Triple-Negative Breast Cancer Treatment. International journal of molecular sciences. vol 23. issue 11. 2022-06-10. PMID:35682800. |
both adcs showed specific cytotoxicity to egfr or epcam positive cell lines via inducing apoptosis at a nanomolar concentration. |
2022-06-10 |
2023-08-14 |
Not clear |
| Jingjing Yang, Xiaofeng Li, Yao Tong, Yufei Yang, Li Zhao, Qian Zhou, Jiawen Xu, Lun Dong, Yanyan Jian. Targeting co-delivery of doxorubicin and gefitinib by biotinylated Au NCs for overcoming multidrug resistance in imaging-guided anticancer therapy. Colloids and surfaces. B, Biointerfaces. vol 217. 2022-06-09. PMID:35679735. |
gef can block signaling in target cancer cells with mutated and overactive egfr, thereby inhibiting tumor growth and metastasis and promoting tumor cell apoptosis. |
2022-06-09 |
2023-08-14 |
human |
| Xinran Xie, Leying Chen, Xin Liu, Zhaoyu Wu, Dazhao Lv, Yurui Ma, Jie Luo, Shiyi Zhan. PROPHYLACTIC EFFECT OF NITRIC OXIDE DONORS ON RAT MODELS OF EGFR INHIBITORS-INDUCED CUTANEOUS TOXICITIES. The Journal of investigative dermatology. 2022-05-26. PMID:35618045. |
here, we show that inhibition of egfr initiated keratinocyte hacat cell cycle arrest and apoptosis, which fueled a robust secondary inflammatory response. |
2022-05-26 |
2023-08-13 |
rat |
| Li Huang, Xuedi Zhang, Junyu Fan, Xiaolei Liu, Shuhua Luo, Dianqing Cao, Youtan Liu, Zhengyuan Xia, Hanhui Zhong, Cuiping Chen, Liangqing Zhang, Zhifeng Liu, Jing Tan. EGFR promotes the apoptosis of CD4 Journal of advanced research. 2022-05-26. PMID:35618635. |
egfr promotes the apoptosis of cd4 sepsis-induced apoptosis leads to lymphopenia including the decrease of cd4 |
2022-05-26 |
2023-08-13 |
Not clear |