| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tarfah Al-Warhi, Ahmed M El Kerdawy, Mohamed A Said, Amgad Albohy, Zainab M Elsayed, Nada Aljaeed, Eslam B Elkaeed, Wagdy M Eldehna, Hatem A Abdel-Aziz, Miral A Abdelmoa. Novel 2-(5-Aryl-4,5-Dihydropyrazol-1-yl)thiazol-4-One as EGFR Inhibitors: Synthesis, Biological Assessment and Molecular Docking Insights. Drug design, development and therapy. vol 16. 2022-05-24. PMID:35607598. |
epidermal growth factor receptor (egfr) regulates several cell functions which include cell growth, survival, multiplication, differentiation, and apoptosis. |
2022-05-24 |
2023-08-13 |
Not clear |
| Shigeki Nanjo, Wei Wu, Niki Karachaliou, Collin M Blakely, Junji Suzuki, Yu-Ting Chou, Siraj M Ali, D Lucas Kerr, Victor R Olivas, Jonathan Shue, Julia Rotow, Manasi K Mayekar, Franziska Haderk, Nilanjana Chatterjee, Anatoly Urisman, Jia Chi Yeo, Anders J Skanderup, Aaron C Tan, Wai Leong Tam, Oscar Arrieta, Kazuyoshi Hosomichi, Akihiro Nishiyama, Seiji Yano, Yuriy Kirichok, Daniel Sw Tan, Rafael Rosell, Ross A Okimoto, Trever G Bivon. Deficiency of the splicing factor RBM10 limits EGFR inhibitor response in EGFR mutant lung cancer. The Journal of clinical investigation. 2022-05-17. PMID:35579943. |
genetic inactivation of rbm10 diminished egfr inhibitor-mediated apoptosis by decreasing the ratio of bcl-xs-(pro-apoptotic)-to-bcl-xl(anti-apoptotic) bcl-x isoforms. |
2022-05-17 |
2023-08-13 |
Not clear |
| Suresh Chava, Suresh Bugide, Xuchen Zhang, Romi Gupta, Narendra Wajapeye. Betacellulin promotes tumor development and EGFR mutant lung cancer growth by stimulating the EGFR pathway and suppressing apoptosis. iScience. vol 25. issue 5. 2022-05-02. PMID:35494243. |
betacellulin promotes tumor development and egfr mutant lung cancer growth by stimulating the egfr pathway and suppressing apoptosis. |
2022-05-02 |
2023-08-13 |
Not clear |
| Jinxing Huang, Cheng Zhuang, Jie Chen, Xuanming Chen, Xiaojie Li, Ting Zhang, Bing Wang, Qiyi Feng, Xiuli Zheng, Meng Gong, Qiyong Gong, Kai Xiao, Kui Luo, Weimin L. Targeted drug/gene/photodynamic therapy via a stimuli-responsive dendritic polymer-based nano-cocktail for treatment of EGFR-TKI-resistant non-small cell lung cancer. Advanced materials (Deerfield Beach, Fla.). 2022-04-28. PMID:35481881. |
mechanism studies reveal that the cocktail therapy could block the egfr signaling pathway with gef, inhibit activation of the egfr bypass signaling pathway via yap-sirna and induce tumor cell apoptosis through photodynamic therapy (pdt). |
2022-04-28 |
2023-08-13 |
Not clear |
| Guiqin Xie, Liang Shan, Yuanyi Liu, Tzyy-Choou Wu, Xinbin G. Antitumor Efficacy of EGFR-Targeted Recombinant Immunotoxin in Human Head and Neck Squamous Cell Carcinoma. Biology. vol 11. issue 4. 2022-04-23. PMID:35453686. |
thus, the direct disruption of egfr signaling, transcription inhibition, dna damage, as well as apoptosis induced by hdt806 may contribute to its antitumor efficacy in hnscc. |
2022-04-23 |
2023-08-13 |
mouse |
| Wei Cheng, Dan Liu, Min Guo, Honglei Li, Qiang Wan. Sophoraflavanone G suppresses the progression of triple-negative breast cancer via the inactivation of EGFR-PI3K-AKT signaling. Drug development research. 2022-04-15. PMID:35426453. |
furthermore, the inhibitory effects of sg on cell proliferation and metastasis and the promotive effects of sg on cell apoptosis and oxidative stress were significantly attenuated due to the overexpression of egfr. |
2022-04-15 |
2023-08-13 |
mouse |
| Qibiao Wu, Yuanli Zhen, Lei Shi, Phuong Vu, Patricia Greninger, Ramzi Adil, Joshua Merritt, Regina Egan, Meng-Ju Wu, Xunqin Yin, Cristina R Ferrone, Vikram Deshpande, Islam Baiev, Christopher J Pinto, Daniel E McLoughlin, Charlotte S Walmsley, James R Stone, John D Gordan, Andrew X Zhu, Dejan Juric, Lipika Goyal, Cyril H Benes, Nabeel Bardees. EGFR Inhibition Potentiates FGFR Inhibitor Therapy and Overcomes Resistance in FGFR2 Fusion-Positive Cholangiocarcinoma. Cancer discovery. 2022-04-14. PMID:35420673. |
inhibition of wild-type egfr potentiated responses to fgfr inhibitors in both contexts, durably suppressing mek/erk and mtor signaling, increasing apoptosis, and causing marked tumor regressions in vivo. |
2022-04-14 |
2023-08-13 |
Not clear |
| Feng Ge, Yi Du, Yan H. Direct Observation of Endocytosis Dynamics of Anti-ErbB Modified Single Nanocargoes. ACS nano. 2022-03-29. PMID:35349254. |
the erbb receptor family, including the epidermal growth factor receptor (egfr) and erbb2/3/4, regulate cell proliferation, differentiation, apoptosis, motility, etc., and their abnormalities can cause cancer and other diseases. |
2022-03-29 |
2023-08-13 |
Not clear |
| Pedro Barrios-Bernal, Norma Hernandez-Pedro, Mario Orozco-Morales, Rubí Viedma-Rodríguez, José Lucio-Lozada, Federico Avila-Moreno, Andrés F Cardona, Rafael Rosell, Oscar Arriet. Metformin Enhances TKI-Afatinib Cytotoxic Effect, Causing Downregulation of Glycolysis, Epithelial-Mesenchymal Transition, and EGFR-Signaling Pathway Activation in Lung Cancer Cells. Pharmaceuticals (Basel, Switzerland). vol 15. issue 3. 2022-03-26. PMID:35337178. |
a549, h1975, and hcc827 cell lines were treated with afatinib, metformin, and their combination for 72 h. afterwards, several parameters were assessed including cytotoxicity, interactions, apoptosis, and egfr protein levels at the cell membrane and several glycolytic, oxidative phosphorylation (oxphos), and emt expression markers. |
2022-03-26 |
2023-08-13 |
Not clear |
| Yuanzhou Zhang, Shunshun Liang, Bowen Xiao, Jingying Hu, Yechun Pang, Yuling Liu, Juan Yang, Junpin Ao, Lin Wei, Xiaoying Lu. MiR-323a regulates ErbB3/EGFR and blocks gefitinib resistance acquisition in colorectal cancer. Cell death & disease. vol 13. issue 3. 2022-03-23. PMID:35319011. |
apoptosis is the mir-323a-3p inducing main biological process by functional enrichment analysis, and the egfr and erbb signaling are the mir-323a-3p inducing main pathway by kegg analysis. |
2022-03-23 |
2023-08-13 |
Not clear |
| Zhen-Jie Fu, Yan Chen, Yu-Qin Xu, Mei-Ai Lin, Hang Wen, Yi-Tao Chen, Pei-Lei Pa. Regulation of miR-30b in cancer development, apoptosis, and drug resistance. Open life sciences. vol 17. issue 1. 2022-03-16. PMID:35291564. |
moreover, mir-30b can inhibit the pi3k/akt signaling pathway through the regulation of egfr, akt, derlin-1, gna13, six1, and other target genes, thus inhibiting the emt process of tumor cells and promoting apoptosis. |
2022-03-16 |
2023-08-13 |
Not clear |
| Yun-Chieh Tu, Wei-Chen Yeh, Hsin-Hsien Yu, Yu-Cheng Lee, Bor-Chyuan S. Hedgehog Suppresses Paclitaxel Sensitivity by Regulating Akt-Mediated Phosphorylation of Bax in EGFR Wild-Type Non-Small Cell Lung Cancer Cells. Frontiers in pharmacology. vol 13. 2022-03-07. PMID:35250564. |
in the present study, we found that paclitaxel (ptx) treatment induces hedgehog signaling in egfr wt nsclc cells, and inhibition of hedgehog signaling with gdc-0449 (vismodegib) increases sensitivity to ptx-stimulated apoptosis. |
2022-03-07 |
2023-08-13 |
Not clear |
| Minwei He, Xing Wang, Wei Chen, Jianzhi Zhang, Ying Xiong, Lulu Cao, Liyi Zhang, Ning Zhao, Yue Yang, Lu Wan. PTPIP51 inhibits non-small-cell lung cancer by promoting PTEN-mediated EGFR degradation. Life sciences. 2022-03-03. PMID:35240162. |
the efficacy of the egfr inhibitor gefitinib improves in combination with ptpip51 to accelerate apoptosis and inhibit nsclc growth in vivo and in vitro. |
2022-03-03 |
2023-08-13 |
Not clear |
| Tong-Hong Wang, Yann-Lii Leu, Chin-Chuan Chen, Hsin-Jung Li, Shuenn-Chen Yang, Kuo-Yen Huang, Chi-Yuan Che. Psorachromene induces apoptosis and suppresses tumor growth in NSCLC cells harboring EGFR L858R/T790M/C797S. Phytotherapy research : PTR. 2022-03-01. PMID:35229911. |
psorachromene induces apoptosis and suppresses tumor growth in nsclc cells harboring egfr l858r/t790m/c797s. |
2022-03-01 |
2023-08-13 |
Not clear |
| Walter Arthur Silva Valente, Déborah Barrocas, Luciana Armada, Fábio Ramôa Pire. Expression of epithelial growth factors and of apoptosis-regulating proteins, and presence of CD57+ cells in the development of inflammatory periapical lesions. Journal of applied oral science : revista FOB. vol 30. 2022-02-23. PMID:35195153. |
the mechanisms that stimulate the proliferation of epithelial cells in inflammatory periapical lesions are not completely understood and the literature suggests that changes in the balance between apoptosis and immunity regulation appear to influence this process.to evaluate the expression of the epidermal growth factor (egf), its receptor (egfr) and of the keratinocyte growth factor (kgf), the presence of cd57+ cells, the epithelial cell proliferation index, and the expression of the bcl-2 protein in inflammatory periapical lesions (ipl) at different stages of development. |
2022-02-23 |
2023-08-13 |
Not clear |
| Te Zhang, Liang Zhang, Jun-Fei Lu, Jun Wen, Yi-Lian Xiong, Ying Li. [Mechanism of polyphyllin Ⅰ targeting EGFR to affect proliferation and apoptosis of human breast cancer cells]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 3. 2022-02-18. PMID:35178955. |
[mechanism of polyphyllin Ⅰ targeting egfr to affect proliferation and apoptosis of human breast cancer cells]. |
2022-02-18 |
2023-08-13 |
human |
| Te Zhang, Liang Zhang, Jun-Fei Lu, Jun Wen, Yi-Lian Xiong, Ying Li. [Mechanism of polyphyllin Ⅰ targeting EGFR to affect proliferation and apoptosis of human breast cancer cells]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 3. 2022-02-18. PMID:35178955. |
in conclusion, ppⅠ inhibited the proliferation and induced apoptosis of breast cancer cells by targeting egfr to block its downstream signaling pathway. |
2022-02-18 |
2023-08-13 |
human |
| Yan Liang, Ruo-Lan Sun, Fu-Yan Liu, Tian-Tian Liu, Han-Qing Guan, De-Cai Tan. [Anti-colorectal cancer mechanism of Astragali Radix-Curcumae Rhizoma-Paridis Rhizoma based on network pharmacology and experimental verification]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 3. 2022-02-18. PMID:35178961. |
as revealed by network pharmacology, ar-cr-pr contained nine core components, such as quercetin, curcumin, and β-ecdysone, and the key targets included protein kinase b(akt1), mitogen-activated protein kinase 3(mapk3), mapk1, and epithelial growth factor receptor(egfr), which was indicated that the anti-crc effect of ar-cr-pr was presumedly achieved by regulating tumor cell proliferation, apoptosis, migration, and angiogenesis through pi3 k-akt, mapk and other signaling pathways. |
2022-02-18 |
2023-08-13 |
mouse |
| Marisa L Martin-Fernande. Fluorescence Imaging of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Resistance in Non-Small Cell Lung Cancer. Cancers. vol 14. issue 3. 2022-02-15. PMID:35158954. |
tkis block egfr activation, inducing apoptosis in cancer cells addicted to egfr signals. |
2022-02-15 |
2023-08-13 |
Not clear |
| Paola Ferrari, Cristian Scatena, Matteo Ghilli, Irene Bargagna, Giulia Lorenzini, Andrea Nicolin. Molecular Mechanisms, Biomarkers and Emerging Therapies for Chemotherapy Resistant TNBC. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163586. |
these include cancer stem cells (cscs) induction after neoadjuvant chemotherapy (nact), atp-binding cassette (abc) transporters, hypoxia and avoidance of apoptosis, single factors such as tyrosine kinase receptors (egfr, igfr1), a disintegrin and metalloproteinase 10 (adam10), and a few pathological molecular pathways. |
2022-02-15 |
2023-08-13 |
Not clear |