| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuchen Sun, Liangzhao Chu, Huijuan Wang, Han Peng, Jian Li. Inhibitory effect of gefitinib derivative LPY‑9 on human glioma. Molecular medicine reports. vol 24. issue 3. 2021-11-30. PMID:34212976. |
the present study aimed to investigate the effects of a gefitinib derivative, lpy‑9, on the proliferation, apoptosis and migration of human glioma cell line u251‑mg by cck8, transwell or flow cytometry, and the effect of lpy‑9 on the activity of caspase‑3 enzyme and related proteins in the vascular endothelial growth factor (vegf) and epidermal growth factor receptor (egfr) pathways by western blot and elisa. |
2021-11-30 |
2023-08-13 |
human |
| Razieh Mohammadian, Sussan Kabudanian Ardestani, Maliheh Safav. Evaluation of Anticancer and Epidermal Growth Factor Receptor Inhibition Activity by Benzochromeno Pyrimidin Derivatives in Three Human Cancer Cell Lines. Medicinal chemistry (Shariqah (United Arab Emirates)). 2021-11-25. PMID:34819010. |
based on our previous studies, we assumed that a hybrid of aminopyrimidine derivatives as egfr inhibitors and benzocheromen derivatives as cytotoxic agents can induce apoptosis in egfr positive cancer cells. |
2021-11-25 |
2023-08-13 |
human |
| Razieh Mohammadian, Sussan Kabudanian Ardestani, Maliheh Safav. Evaluation of Anticancer and Epidermal Growth Factor Receptor Inhibition Activity by Benzochromeno Pyrimidin Derivatives in Three Human Cancer Cell Lines. Medicinal chemistry (Shariqah (United Arab Emirates)). 2021-11-25. PMID:34819010. |
in the present study, the cytotoxic effect, ability of egfr inhibition and apoptosis induction of some syndfrthetic benzochromene pyrimidine derivatives were investigated on mda-mb231, skbr3 and pc3 cell lines. |
2021-11-25 |
2023-08-13 |
human |
| Qifan Yang, Xianxiu Qiu, Xiaozhe Zhang, Yingting Yu, Na Li, Xing Wei, Guoqin Feng, Yan Li, Yanxiang Zhao, Renxiao Wan. Optimization of Beclin 1-Targeting Stapled Peptides by Staple Scanning Leads to Enhanced Antiproliferative Potency in Cancer Cells. Journal of medicinal chemistry. vol 64. issue 18. 2021-11-23. PMID:34506131. |
optimized peptides showed potent antiproliferative efficacy in cancer cells that overexpressed egfr and her2 by inducing necrotic cell death but not apoptosis. |
2021-11-23 |
2023-08-13 |
Not clear |
| Elena M Tosca, Glenn Gauderat, Sylvain Fouliard, Mike Burbridge, Marylore Chenel, Paolo Magn. Modeling restoration of gefitinib efficacy by co-administration of MET inhibitors in an EGFR inhibitor-resistant NSCLC xenograft model: A tumor-in-host DEB-based approach. CPT: pharmacometrics & systems pharmacology. vol 10. issue 11. 2021-11-23. PMID:34708556. |
met receptor tyrosine kinase inhibitors (tkis) can restore sensitivity to gefitinib, a tki targeting epidermal growth factor receptor (egfr), and promote apoptosis in non-small cell lung cancer (nsclc) models resistant to gefitinib treatment in vitro and in vivo. |
2021-11-23 |
2023-08-13 |
mouse |
| Su-Pei Wang, Ya-Ping Hsu, Chien-Jen Chang, Yu-Chi Chan, Chien-Hung Chen, Rou-Hsin Wang, Kuang-Kai Liu, Pei-Ying Pan, Ya-Hui Wu, Chih-Man Yang, Chinpiao Chen, Jinn-Moon Yang, Mei-Chih Liang, Kwok-Kin Wong, Jui-I Cha. A novel EGFR inhibitor suppresses survivin expression and tumor growth in human gefitinib-resistant EGFR-wild type and -T790M non-small cell lung cancer. Biochemical pharmacology. vol 193. 2021-11-22. PMID:34597670. |
sp101 blocked egfr kinase activity and induced apoptosis in the a549 (egfr-wild type) and h1975 (egfr-t790m) lung cancer cells. |
2021-11-22 |
2023-08-13 |
mouse |
| Farag F Sherbiny, Ashraf H Bayoumi, Ahmed M El-Morsy, Mohamed Sobhy, Mohamed Hagra. Design, Synthesis, biological Evaluation, and molecular docking studies of novel Pyrazolo[3,4-d]Pyrimidine derivative scaffolds as potent EGFR inhibitors and cell apoptosis inducers. Bioorganic chemistry. vol 116. 2021-11-15. PMID:34507234. |
design, synthesis, biological evaluation, and molecular docking studies of novel pyrazolo[3,4-d]pyrimidine derivative scaffolds as potent egfr inhibitors and cell apoptosis inducers. |
2021-11-15 |
2023-08-13 |
Not clear |
| Bharti Sharma, Vikram Jeet Singh, Pooja A Chawl. Epidermal growth factor receptor inhibitors as potential anticancer agents: An update of recent progress. Bioorganic chemistry. vol 116. 2021-11-15. PMID:34628226. |
epidermal growth factor receptor (egfr) is a vital intermediate in cell signaling pathway including cell proliferation, angiogenesis, apoptosis, and metastatic spread and also having four divergent members with similar structural features, such as egfr (her1/erbb1), erbb2 (her2/neu), erbb3 (her3), and erbb4 (her4). |
2021-11-15 |
2023-08-13 |
Not clear |
| Christina Nadolny, Xinmu Zhang, Qiwen Chen, Syed F Hashmi, Winifer Ali, Christopher Hemme, Nagib Ahsan, Yuan Chen, Ruitang Den. Dysregulation and activities of ubiquitin specific peptidase 2b in the pathogenesis of hepatocellular carcinoma. American journal of cancer research. vol 11. issue 10. 2021-11-13. PMID:34765291. |
unbiased proteomic analysis of usp2-knockout (ko) and parental hepg2 cells resulted in identification of usp2-regulated downstream target proteins involved in cell proliferation, apoptosis, and tumorigenesis, including serine/threonine kinase 4 (stk4), epidermal growth factor receptor (egfr), dipeptidyl peptidase 4 (dpp4) and fatty acid binding protein 1 (fabp1). |
2021-11-13 |
2023-08-13 |
mouse |
| Ahmed M Farghaly, Omaima M AboulWafa, Hoda H Baghdadi, Heba A Abd El Razik, Samir M Y Sedra, Marium M Shama. New thieno[3,2-d]pyrimidine-based derivatives: Design, synthesis and biological evaluation as antiproliferative agents, EGFR and ARO inhibitors inducing apoptosis in breast cancer cells. Bioorganic chemistry. vol 115. 2021-11-09. PMID:34365057. |
new thieno[3,2-d]pyrimidine-based derivatives: design, synthesis and biological evaluation as antiproliferative agents, egfr and aro inhibitors inducing apoptosis in breast cancer cells. |
2021-11-09 |
2023-08-13 |
Not clear |
| Kuo-Yen Huang, Tong-Hong Wang, Chin-Chuan Chen, Yann-Lii Leu, Hsin-Jung Li, Cai-Ling Jhong, Chi-Yuan Che. Growth Suppression in Lung Cancer Cells Harboring EGFR-C797S Mutation by Quercetin. Biomolecules. vol 11. issue 9. 2021-11-08. PMID:34572484. |
we demonstrated that quercetin exhibited potent cytotoxic effects on nsclc cells harboring the egfr c797s mutation by inhibiting axl and inducing apoptosis. |
2021-11-08 |
2023-08-13 |
Not clear |
| Sumin Geng, Shaohua Tu, Weilun Fu, Jianbo Wang, Zhenwei Ba. LncRNA PITPNA-AS1 stimulates cell proliferation and suppresses cell apoptosis in glioblastoma via targeting miR-223-3p/EGFR axis and activating PI3K/AKT signaling pathway. Cell cycle (Georgetown, Tex.). vol 20. issue 19. 2021-11-05. PMID:34470587. |
eventually, rescue assays validated pitpna-as1 sponged mir-223-3p to promote egfr expression, thus activating pi3k/akt signaling pathway to accelerate proliferation and inhibit apoptosis of gbm cells. |
2021-11-05 |
2023-08-13 |
Not clear |
| Nam-Sook Park, Yu-Kyung Park, Anil Kumar Yadav, Young-Min Shin, David Bishop-Bailey, Jong-Soon Choi, Jong Wook Park, Byeong-Churl Jan. Anti-growth and pro-apoptotic effects of dasatinib on human oral cancer cells through multi-targeted mechanisms. Journal of cellular and molecular medicine. vol 25. issue 17. 2021-11-04. PMID:34318593. |
strikingly, dasatinib at 10 µm strongly suppressed the growth and induced apoptosis of yd-38 cells and inhibited the phosphorylation of src, egfr, stat-3, stat-5, pkb and erk-1/2. |
2021-11-04 |
2023-08-13 |
human |
| Zhiying Wang, Xiaohui Liang, Aizhen Xiong, Lili Ding, Wei Li, Li Yang, Xiaojun Wu, Hailian Shi, Yue Zhou, Zhengtao Wan. Helichrysetin and TNF‑α synergistically promote apoptosis by inhibiting overactivation of the NF‑κB and EGFR signaling pathways in HeLa and T98G cells. International journal of molecular medicine. vol 47. issue 4. 2021-11-03. PMID:33576459. |
helichrysetin and tnf‑α synergistically promote apoptosis by inhibiting overactivation of the nf‑κb and egfr signaling pathways in hela and t98g cells. |
2021-11-03 |
2023-08-13 |
mouse |
| Zhiying Wang, Xiaohui Liang, Aizhen Xiong, Lili Ding, Wei Li, Li Yang, Xiaojun Wu, Hailian Shi, Yue Zhou, Zhengtao Wan. Helichrysetin and TNF‑α synergistically promote apoptosis by inhibiting overactivation of the NF‑κB and EGFR signaling pathways in HeLa and T98G cells. International journal of molecular medicine. vol 47. issue 4. 2021-11-03. PMID:33576459. |
tumor necrosis factor‑α (tnf‑α) has different effects on apoptosis depending on activation or inactivation of the nuclear factor‑κb (nf‑κb) and epidermal growth factor receptor (egfr) signaling pathways. |
2021-11-03 |
2023-08-13 |
mouse |
| Zhiying Wang, Xiaohui Liang, Aizhen Xiong, Lili Ding, Wei Li, Li Yang, Xiaojun Wu, Hailian Shi, Yue Zhou, Zhengtao Wan. Helichrysetin and TNF‑α synergistically promote apoptosis by inhibiting overactivation of the NF‑κB and EGFR signaling pathways in HeLa and T98G cells. International journal of molecular medicine. vol 47. issue 4. 2021-11-03. PMID:33576459. |
the present study aimed to identify the effect of helichrysetin on activation of the nf‑κb and egfr signaling pathways induced by tnf‑α, and the synergistic effect of helichrysetin and tnf‑α on apoptosis of hela and t98g cells. |
2021-11-03 |
2023-08-13 |
mouse |
| Huayi Zhang, Yaqin Zheng, Yongmei Zhan. Knockdown of TRIM66 in MDA-MB-468 triple negative breast cancer cell line suppresses proliferation and promotes apoptosis through EGFR signaling. Polish journal of pathology : official journal of the Polish Society of Pathologists. vol 72. issue 2. 2021-10-29. PMID:34706523. |
knockdown of trim66 in mda-mb-468 triple negative breast cancer cell line suppresses proliferation and promotes apoptosis through egfr signaling. |
2021-10-29 |
2023-08-13 |
human |
| Huayi Zhang, Yaqin Zheng, Yongmei Zhan. Knockdown of TRIM66 in MDA-MB-468 triple negative breast cancer cell line suppresses proliferation and promotes apoptosis through EGFR signaling. Polish journal of pathology : official journal of the Polish Society of Pathologists. vol 72. issue 2. 2021-10-29. PMID:34706523. |
knockdown of trim66 suppresses proliferation, invasion and migration of mda-mb-468 cell line and promotes apoptosis in these cells through egfr signaling. |
2021-10-29 |
2023-08-13 |
human |
| Teng Wang, Chun-Yi Lyu, Yue-Hua Jiang, Xue-Yan Dong, Yan Wang, Zong-Hong Li, Jin-Xin Wang, Rui-Rong X. A drug-biomarker interaction model to predict the key targets of Scutellaria barbata D. Don in adverse-risk acute myeloid leukaemia. Molecular diversity. vol 25. issue 4. 2021-10-28. PMID:32676746. |
the results suggest that luteolin and quercetin are the main active components of sbd against adverse-risk aml, and affected drug resistance, apoptosis, immune regulation and angiogenesis through the core targets akt1, mapk1, il6, egfr, src, vegfa and tp53. |
2021-10-28 |
2023-08-13 |
Not clear |
| Shanwu Wu, Sheng Yang, Hongyan Q. circ_CHFR regulates ox-LDL-mediated cell proliferation, apoptosis, and EndoMT by miR-15a-5p/EGFR axis in human brain microvessel endothelial cells. Open life sciences. vol 16. issue 1. 2021-10-23. PMID:34676300. |
thus, we concluded that circ_chfr silencing hindered ox-ldl-mediated cell proliferation, apoptosis, and endomt by downregulating egfr expression through sponging mir-15a-5p in hbmecs. |
2021-10-23 |
2023-08-13 |
human |