| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jin Lee, Eun Mi Hong, Jung Han Kim, Jung Hee Kim, Jang Han Jung, Se Woo Park, Dong Hee Koh, Hyun Joo Jan. Ursodeoxycholic acid shows antineoplastic effects in bile duct cancer cells via apoptosis induction; p53 activation; and EGFR-ERK, COX-2, and PI3K-AKT pathway inhibition. Molecular biology reports. vol 48. issue 9. 2021-09-14. PMID:34392440. |
aim of this study was to demonstrate whether udca actually inhibits proliferation and induces apoptosis in bile duct cancer cells; the effect of udca on the expression of cox-2, pi3k/akt, erk, and egfr; how udca affects cancer cell invasiveness and metastasis, since these effects are not established in bile duct cancer cells. |
2021-09-14 |
2023-08-13 |
human |
| Geng-Ruei Chang, Chan-Yen Kuo, Ming-Yang Tsai, Wei-Li Lin, Tzu-Chun Lin, Huei-Jyuan Liao, Chung-Hung Chen, Yu-Chen Wan. Anti-Cancer Effects of Zotarolimus Combined with 5-Fluorouracil Treatment in HCT-116 Colorectal Cancer-Bearing BALB/c Nude Mice. Molecules (Basel, Switzerland). vol 26. issue 15. 2021-09-10. PMID:34361836. |
compared with the control mice, mice treated with zotarolimus or zotarolimus combined with 5-fu showed retarded tumor growth; increased tumor apoptosis through the enhanced expression of cleaved caspase 3 and extracellular signal-regulated kinase (erk) phosphorylation; reduced inflammation-related factors such as il-1β, tnf-α, and cyclooxygenase-2 (cox-2) protein; and inhibited metastasis-related factors such as cd44, epidermal growth factor receptor (egfr), transforming growth factor β (tgf-β), and vascular endothelial growth factor (vegf). |
2021-09-10 |
2023-08-13 |
mouse |
| Marwa F Ahmed, Eman Y Santali, Eman M Mohi El-Deen, Ibrahim A Naguib, Radwan El-Hagga. Development of pyridazine derivatives as potential EGFR inhibitors and apoptosis inducers: Design, synthesis, anticancer evaluation, and molecular modeling studies. Bioorganic chemistry. vol 106. 2021-09-08. PMID:33243490. |
development of pyridazine derivatives as potential egfr inhibitors and apoptosis inducers: design, synthesis, anticancer evaluation, and molecular modeling studies. |
2021-09-08 |
2023-08-13 |
Not clear |
| Han Sol Kim, Ha-Na Oh, Ah-Won Kwak, Eunae Kim, Mee-Hyun Lee, Ji-Hye Seo, Seung-Sik Cho, Goo Yoon, Jung-Il Chae, Jung-Hyun Shi. Deoxypodophyllotoxin Inhibits Cell Growth and Induces Apoptosis by Blocking EGFR and MET in Gefitinib-Resistant Non-Small Cell Lung Cancer. Journal of microbiology and biotechnology. vol 31. issue 4. 2021-09-06. PMID:33746190. |
deoxypodophyllotoxin inhibits cell growth and induces apoptosis by blocking egfr and met in gefitinib-resistant non-small cell lung cancer. |
2021-09-06 |
2023-08-13 |
Not clear |
| Joaquín Yanes-Díaz, Raquel Palao-Suay, María Rosa Aguilar, Juan Ignacio Riestra-Ayora, Antonio Ferruelo-Alonso, Luis Rojo Del Olmo, Blanca Vázquez-Lasa, Ricardo Sanz-Fernández, Carolina Sánchez-Rodrígue. Antitumor Activity of Nanoparticles Loaded with PHT-427, a Novel AKT/PDK1 Inhibitor, for the Treatment of Head and Neck Squamous Cell Carcinoma. Pharmaceutics. vol 13. issue 8. 2021-08-31. PMID:34452203. |
apoptosis, epidermal growth factor receptor (egfr), and reactive oxygen species (ros) were also measured. |
2021-08-31 |
2023-08-13 |
Not clear |
| Wen Zhao, Danlei Yu, Zhen Chen, Weilong Yao, Jin Yang, Suresh S Ramalingam, Shi-Yong Su. Inhibition of MEK5/ERK5 signaling overcomes acquired resistance to the third generation EGFR inhibitor, osimertinib, via enhancing Bim-dependent apoptosis. Cancer letters. vol 519. 2021-08-30. PMID:34245854. |
inhibition of mek5/erk5 signaling overcomes acquired resistance to the third generation egfr inhibitor, osimertinib, via enhancing bim-dependent apoptosis. |
2021-08-30 |
2023-08-13 |
Not clear |
| Min-Chun Chuang, Jr-Hau Lung, Yi-Chuan Chen, Yu-Ching Lin, Ya-Chin Li, Ming-Szu Hun. The Association of Annexin A1 and Chemosensitivity to Osimertinib in Lung Cancer Cells. Cancers. vol 13. issue 16. 2021-08-30. PMID:34439260. |
further study showed that the knockdown of anxa1 inhibited the phosphorylation of egfr and down-stream akt pathways and promoted apoptosis in lung cancer cells treated with osimertinib. |
2021-08-30 |
2023-08-13 |
mouse |
| Min Xiang, He-Guo Jiang, Yang Shu, Yu-Jiao Chen, Jun Jin, Yu-Min Zhu, Mei-Yu Li, Jian-Nong Wu, Jian L. Bisdemethoxycurcumin Enhances the Sensitivity of Non-small Cell Lung Cancer Cells to Icotinib via Dual Induction of Autophagy and Apoptosis. International journal of biological sciences. vol 16. issue 9. 2021-08-23. PMID:32226300. |
compared with bdmc or icotinib alone, the two drug combination induced more significant apoptosis and autophagy via suppressing egfr activity and interaction of sp1 and hdca1/hdca2, which was accompanied by accumulation of reactive oxygen species (ros), induction of dna damage, and inhibition of cell migration and invasion. |
2021-08-23 |
2023-08-13 |
Not clear |
| Nicolas Schlegel, Kevin Boerner, Jens Waschk. Targeting desmosomal adhesion and signalling for intestinal barrier stabilization in inflammatory bowel diseases-Lessons from experimental models and patients. Acta physiologica (Oxford, England). vol 231. issue 1. 2021-08-18. PMID:32419327. |
dsg2 is also involved in enterocyte proliferation, barrier differentiation and induction of apoptosis, in part by regulation of p38mapk and egfr signalling. |
2021-08-18 |
2023-08-13 |
mouse |
| Jiaoyun Dong, Chun Qing, Fei Song, Xiqiao Wang, Shuliang Lu, Ming Tia. Potential molecular mechanisms of negative pressure in promoting wound healing. International wound journal. vol 17. issue 5. 2021-08-18. PMID:32515909. |
cell ultrastructure; viability; apoptosis; and protein factors such as tumour necrosis factor-α (tnf-α), interferon-γ (ifn-γ), epidermal growth factor (egf), epidermal growth factor receptor (egfr), interleukin-17 (il-17), and cell division cycle 42 (cdc42) were determined by transmission electron microscopy (tem), cck8, flow cytometry (fcm), elisa, and simple western assays, respectively. |
2021-08-18 |
2023-08-13 |
Not clear |
| Chao Zhao, Chunxia Su, Xuefei Li, Caicun Zho. Association of CD8 T cell apoptosis and EGFR mutation in non-small lung cancer patients. Thoracic cancer. vol 11. issue 8. 2021-08-12. PMID:32500560. |
association of cd8 t cell apoptosis and egfr mutation in non-small lung cancer patients. |
2021-08-12 |
2023-08-13 |
Not clear |
| Dong Wei, Zhang Yu, Yue Cheng, Huang Jiawei, Gao Jian, Gao Hua, Dong Guila. Dysregulated miR-137 and its target EGFR contribute to the progression of pituitary adenomas. Molecular and cellular endocrinology. vol 520. 2021-08-12. PMID:33246030. |
dual-luciferase reporter gene assays showed that egfr was the target gene of mir-137, and mir-137 mimic could inhibit the cell proliferation of gh3 cells and induce apoptosis and g1-phase arrest of gh3 cells. |
2021-08-12 |
2023-08-13 |
Not clear |
| Andrew J McGovern, George E Barret. Network pharmacology identifies IL6 as an important hub and target of tibolone for drug repurposing in traumatic brain injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 140. 2021-08-10. PMID:34058440. |
following protein-protein functional analysis, the top connected proteins were related to kinase activity (mapk1/14/3, akt1 pik3r1), apoptosis (tp53, casp3), growth factors (egfr), estrogen signalling (esr1) and inflammation (il6, tnf), with il6 as an important signalling hub belonging to the top go categories. |
2021-08-10 |
2023-08-13 |
Not clear |
| b' \\xc3\\x81gnes E Kulm\\xc3\\xa1ny, \\xc3\\x89va Frank, D\\xc3\\xb3ra Kov\\xc3\\xa1cs, Kerstin Kirisits, Georg Krupitza, Patr\\xc3\\xadcia Neuperger, R\\xc3\\xb3bert Alf\\xc3\\xb6ldi, L\\xc3\\xa1szl\\xc3\\xb3 G Pusk\\xc3\\xa1s, G\\xc3\\xa1bor J Szebeni, Istv\\xc3\\xa1n Zupk\\xc3\\xb. Antiproliferative and antimetastatic characterization of an exo-heterocyclic androstane derivative against human breast cancer cell lines. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 140. 2021-08-09. PMID:34020244.' |
single cell mass cytometry revealed that chemosensitive subpopulations of mda-mb-231 cells engaged to apoptosis were less positive for egfr, cd274, and cd326, while the percentage of cells positive for glut1, mct4, pan-keratin, cd66(a,c,e), galectin-3 and tmem45a increased in response to 17apad treatment. |
2021-08-09 |
2023-08-13 |
human |
| Wu Chen, Danlei Yu, Shi-Yong Sun, Feng L. Nanoparticles for co-delivery of osimertinib and selumetinib to overcome osimertinib-acquired resistance in non-small cell lung cancer. Acta biomaterialia. vol 129. 2021-08-02. PMID:34048974. |
osi and sel combination np can overcome osi resistance by simultaneously inhibiting both egfr and mitogen-activated protein kinase (mek), thus effectively inducing apoptosis in osi-resistant nsclc cells and inhibiting osi-resistant tumors in vivo. |
2021-08-02 |
2023-08-13 |
Not clear |
| Wu Chen, Danlei Yu, Shi-Yong Sun, Feng L. Nanoparticles for co-delivery of osimertinib and selumetinib to overcome osimertinib-acquired resistance in non-small cell lung cancer. Acta biomaterialia. vol 129. 2021-08-02. PMID:34048974. |
the combination np can simultaneously inhibit egfr and mitogen-activated protein kinase (mek), thus effectively inducing apoptosis in osi-resistant nsclc cells. |
2021-08-02 |
2023-08-13 |
Not clear |
| Zheng-Hong Zhong, Ze-Lin Yi, Yi-Dan Zhao, Jue Wang, Ze-Bo Jiang, Cong Xu, Ya-Jia Xie, Qi-Da He, Zi-Yan Tong, Xiao-Jun Yao, Elaine Lai-Han Leung, Paolo Saul Coghi, Xing-Xing Fan, Min Che. Pyronaridine induces apoptosis in non-small cell lung cancer cells by upregulating death receptor 5 expression and inhibiting epidermal growth factor receptor. Chemical biology & drug design. 2021-08-01. PMID:34288496. |
in summary, pyronaridine can selectively kill nsclc by regulating trail-mediated apoptosis and downregulating the protein level of egfr. |
2021-08-01 |
2023-08-13 |
Not clear |
| Malgorzata Jozkowiak, Marta Dyszkiewicz-Konwinska, Piotr Ramlau, Wieslawa Kranc, Julia Spaczynska, Marcin Wierzchowski, Mariusz Kaczmarek, Jadwiga Jodynis-Liebert, Hanna Piotrowska-Kempist. Individual and Combined Treatments with Methylated Resveratrol Analogue DMU-214 and Gefitinib Inhibit Tongue Cancer Cells Growth via Apoptosis Induction and EGFR Inhibition. International journal of molecular sciences. vol 22. issue 12. 2021-07-26. PMID:34201116. |
individual and combined treatments with methylated resveratrol analogue dmu-214 and gefitinib inhibit tongue cancer cells growth via apoptosis induction and egfr inhibition. |
2021-07-26 |
2023-08-13 |
human |
| Malgorzata Jozkowiak, Marta Dyszkiewicz-Konwinska, Piotr Ramlau, Wieslawa Kranc, Julia Spaczynska, Marcin Wierzchowski, Mariusz Kaczmarek, Jadwiga Jodynis-Liebert, Hanna Piotrowska-Kempist. Individual and Combined Treatments with Methylated Resveratrol Analogue DMU-214 and Gefitinib Inhibit Tongue Cancer Cells Growth via Apoptosis Induction and EGFR Inhibition. International journal of molecular sciences. vol 22. issue 12. 2021-07-26. PMID:34201116. |
we showed for the first time the anti-cancer effects of dmu-214, gefitinib, and their combination in tongue cancer cells triggered via cell cycle arrest, apoptosis induction, and inhibition of the egfr signaling pathway. |
2021-07-26 |
2023-08-13 |
human |
| Bin Xu, Jie Mei, Wei Ji, Zhengyuan Huo, Zheng Bian, Jiantong Jiao, Xiaoqing Li, Jun Sun, Junfei Sha. MicroRNAs involved in the EGFR pathway in glioblastoma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 134. 2021-07-19. PMID:33341046. |
notably, mirnas regulate various carcinogenic pathways, one of which is the epidermal growth factor receptor (egfr) signaling pathway, which controls cell proliferation, invasion, migration, angiogenesis and apoptosis. |
2021-07-19 |
2023-08-13 |
Not clear |