| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yang Shen, Mulan Ren, Yuehua Shi, Yunxia Zhang, Yunlang Ca. Octreotide enhances the sensitivity of the SKOV3/DDP ovarian cancer cell line to cisplatin chemotherapy in vitro. Experimental and therapeutic medicine. vol 2. issue 6. 2021-10-21. PMID:22977639. |
it is suggested that oct inhibits ovarian cancer proliferation and promotes apoptosis, via the cell surface expression of ssrt2, and reverses cisplatin resistance through the inhibition of mrp2 and egfr expression. |
2021-10-21 |
2023-08-12 |
Not clear |
| Takashi Masui, Ichiro Ota, Masatoshi Kanno, Katsunari Yane, Hiroshi Hoso. Low-intensity ultrasound enhances the anticancer activity of cetuximab in human head and neck cancer cells. Experimental and therapeutic medicine. vol 5. issue 1. 2021-10-21. PMID:23251234. |
in this study, the combined effects of low-intensity ultrasound (liu) and cetuximab, an anti-epidermal growth factor receptor (egfr) antibody, on cell killing and induction of apoptosis in hsc-3 and hsc-4 head and neck cancer cells, and its mechanisms were investigated. |
2021-10-21 |
2023-08-12 |
human |
| Takashi Masui, Ichiro Ota, Masatoshi Kanno, Katsunari Yane, Hiroshi Hoso. Low-intensity ultrasound enhances the anticancer activity of cetuximab in human head and neck cancer cells. Experimental and therapeutic medicine. vol 5. issue 1. 2021-10-21. PMID:23251234. |
to elucidate the effect of cetuximab and us on egfr signaling and apoptosis in head and neck cancer cells after the treatments, the expression of egfr, phospho-egfr, and the activation of caspase-3 were evaluated with western blotting. |
2021-10-21 |
2023-08-12 |
human |
| Xiaozhi Liu, Lei Chen, Zhongmin Jiang, Junfei Wang, Zhiguo Su, Gang Li, Shizhu Yu, Zhenlin Li. Malignant behaviorial characteristics of CD133(+/-) glioblastoma cells from a Northern Chinese population. Experimental and therapeutic medicine. vol 5. issue 1. 2021-10-21. PMID:23251243. |
a comparison of tumor subtypes demonstrated that cd133(+) glioblastoma cells had a lower incidence of cell apoptosis in the tumor tissue and higher protein expression levels of oct4, sox2, pcna, egfr, ang2, mmp2 and mmp9 compared with cd133(-) cells. |
2021-10-21 |
2023-08-12 |
mouse |
| Yaping Xu, Liming Sheng, Weimin Ma. Role of epidermal growth factor receptor tyrosine kinase inhibitors in the treatment of esophageal carcinoma and the suggested mechanisms of action. Oncology letters. vol 5. issue 1. 2021-10-21. PMID:23255886. |
targeted inhibition of egfr activity suppresses signal transduction pathways which control tumor cell growth, proliferation and resistance to apoptosis. |
2021-10-21 |
2023-08-12 |
human |
| Jun Pu Wang, Wan Ming Hu, Kuan Song Wang, Jun Yu, Bai Hua Luo, Chang Wu, Zhi Hong Chen, Geng Qiu Luo, Yu Wu Liu, Qin Lai Liu, Yan Xiao, Hai Yan Zhou, Xiao Jing Yang, Hai Ying Jiang, Jing He Li, Ji Fang We. Expression of C-X-C chemokine receptor types 1/2 in patients with gastric carcinoma: Clinicopathological correlations and significance. Oncology letters. vol 5. issue 2. 2021-10-21. PMID:23420470. |
erk1/2 and akt phosphorylation and the expression of indicators of proliferation, growth and apoptosis (bcl-2 and bax, cyclin d1, egfr and ki-67), angiogenesis (vegf and cd34), invasion and metastasis (mmp-9, mmp-2, timp-2 and e-cadherin) were also detected by ihc. |
2021-10-21 |
2023-08-12 |
Not clear |
| Shiqi Ma, Lu Zhang, Yuan Ren, Wei Dai, Tingqing Chen, Liping Luo, Juan Zeng, Kun Mi, Jinyi Lang, Bangrong Ca. Epiregulin confers EGFR-TKI resistance via EGFR/ErbB2 heterodimer in non-small cell lung cancer. Oncogene. vol 40. issue 14. 2021-10-21. PMID:33750895. |
cells with egfr e746-a750del mutation were treated with recombinant egfr ligands, and analyzed for cell viability, proliferation, and apoptosis. |
2021-10-21 |
2023-08-13 |
Not clear |
| Toheeb A Balogun, Nureni Ipinloju, Olayemi T Abdullateef, Segun I Moses, Damilola A Omoboyowa, Akinwumi C James, Oluwatosin A Saibu, Wumi F Akinyemi, Ebenezer A On. Computational Evaluation of Bioactive Compounds from Cancer informatics. vol 20. 2021-10-15. PMID:34646061. |
somatic mutations and overexpression of egfr have been reported to play a vital role in cancer cell development and progression, including cell proliferation, differentiation, angiogenesis, apoptosis, and metastatic spread. |
2021-10-15 |
2023-08-13 |
Not clear |
| M S Araujo, M D Guastali, F Paulini, A N Silva, M H Tsunemi, P K Fontes, A C S Castilho, F C Landim-Alvareng. Molecular and cellular effects of insulin-like growth factor-1 and LongR3-IGF-1 on in vitro maturation of bovine oocytes: comparative study. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 55. 2021-10-12. PMID:33038561. |
addition effects of insulin-like growth factor-1 (igf-1) and its synthetic analogue insulin-like growth factor-1 recombinant-3 (longr3-igf-1) after in vitro maturation (ivm) of cattle cumulus-oocyte complexes (cocs) were compared and evaluated on meiotic progression, apoptosis and profile genes of oocyte competence (gdf9, bmp15, bax, bcl2, oosp1, igfbp2, igbfp4 and igfbp5), and their respective cumulus cells (areg, egfr, fshr, cox2, bax, bcl2, igfbp2, igfbp4 and igfbp5). |
2021-10-12 |
2023-08-13 |
cattle |
| Kosuke Tanaka, Helena A Yu, Shaoyuan Yang, Song Han, S Duygu Selcuklu, Kwanghee Kim, Shriram Ramani, Yogesh Tengarai Ganesan, Allison Moyer, Sonali Sinha, Yuchen Xie, Kota Ishizawa, Hatice U Osmanbeyoglu, Yang Lyu, Nitin Roper, Udayan Guha, Charles M Rudin, Mark G Kris, James J Hsieh, Emily H Chen. Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis. Cancer cell. vol 39. issue 9. 2021-10-05. PMID:34388376. |
targeting aurora b kinase prevents and overcomes resistance to egfr inhibitors in lung cancer by enhancing bim- and puma-mediated apoptosis. |
2021-10-05 |
2023-08-13 |
Not clear |
| Tariq Javed, Sarwat Ali Raja, Kashif Ur Rehman, Samrah Khalid, Namrah Khalid, Sana Ria. In silico bimolecular characterization of anticancer phytochemicals from Fagonia indica. Pakistan journal of pharmaceutical sciences. vol 34. issue 3. 2021-10-04. PMID:34602410. |
a set of five proteins included for this research were epidermal growth factor protein (pdb id; 1m17), crystal structure of mutated egfr kinase (pdb id; 2eb3), crystal structure of bcl-xl (pdb id; 2yxj), apoptosis regulator protein mcl-1 bh3 (pdb id; 3mk8) and apoptosis proteins (pdb id; 5c3h). |
2021-10-04 |
2023-08-13 |
human |
| Yayun Lin, Yan Liu, Dongping Xu, Fanfan Guo, Wentao Zhang, Yidan Zhang, Guiqin Ba. HBxAg promotes HBV replication and EGFR activation in human placental trophoblasts. Experimental and therapeutic medicine. vol 22. issue 5. 2021-09-30. PMID:34584556. |
the association between hbx and egfr promoters was characterized using a luciferase reporter assay and egfr/pi3k/phosphorylated (p)-akt expression and apoptosis rate were also monitored. |
2021-09-30 |
2023-08-13 |
human |
| Yayun Lin, Yan Liu, Dongping Xu, Fanfan Guo, Wentao Zhang, Yidan Zhang, Guiqin Ba. HBxAg promotes HBV replication and EGFR activation in human placental trophoblasts. Experimental and therapeutic medicine. vol 22. issue 5. 2021-09-30. PMID:34584556. |
in egfr overexpressing cells, the expression of pi3k/p-akt was significantly increased, whereas the apoptosis rate was significantly decreased (p<0.05). |
2021-09-30 |
2023-08-13 |
human |
| Yayun Lin, Yan Liu, Dongping Xu, Fanfan Guo, Wentao Zhang, Yidan Zhang, Guiqin Ba. HBxAg promotes HBV replication and EGFR activation in human placental trophoblasts. Experimental and therapeutic medicine. vol 22. issue 5. 2021-09-30. PMID:34584556. |
in conclusion, the present study demonstrated that hbx promotes hbv replication in trophoblasts via downregulation of smc5/6, activates the egfr promoter and inhibits trophoblast apoptosis via the pi3k/p-akt downstream signalling pathway, thereby increasing the risk of hbv intrauterine infection. |
2021-09-30 |
2023-08-13 |
human |
| Chengxiao Hu, Yangyang Zuo, Qian Ren, Xiaoli Sun, Shan Zhou, Jinlin Liao, Xue Hong, Jinhua Miao, Lili Zhou, Youhua Li. Matrix metalloproteinase-10 protects against acute kidney injury by augmenting epidermal growth factor receptor signaling. Cell death & disease. vol 12. issue 1. 2021-09-29. PMID:33436543. |
in vitro, mmp-10 potentiated egfr activation and protected kidney tubular cells against apoptosis induced by hypoxia/reoxygenation or cisplatin. |
2021-09-29 |
2023-08-13 |
Not clear |
| Sara Shojaei-Zarghani, Maryam Rafraf, Ahmad Yari-Khosroushah. Theanine and cancer: A systematic review of the literature. Phytotherapy research : PTR. vol 35. issue 9. 2021-09-29. PMID:33891786. |
theanine exerted its anticancer function by inhibiting egfr, vegfr, met, and akt/mtor, jak2/stat3, and erk/nfκb pathways, as well as activating the intrinsic apoptosis pathway and caspase-independent programmed cell death. |
2021-09-29 |
2023-08-13 |
Not clear |
| Liang Deng, Karin A Vallega, Shuo Zhang, Puyu Shi, Shi-Yong Su. MET inhibition downregulates DR4 expression in MET-amplified lung cancer cells with acquired resistance to EGFR inhibitors through suppressing AP-1-mediated transcription. Neoplasia (New York, N.Y.). vol 23. issue 8. 2021-09-23. PMID:34233230. |
osimertinib combined with met inhibition synergistically induces apoptosis in the met-amplified egfr mutant nsclc cells accompanied with augmented dr4 reduction both in vitro and in vivo. |
2021-09-23 |
2023-08-13 |
Not clear |
| Yu Liu, Lele Li, Ningxin Pan, Jiayi Gu, Zhaoxian Qiu, Guoping Cao, Yuping Dou, Lili Dong, Jie Shuai, Aimin San. TNF-α released from retinal Müller cells aggravates retinal pigment epithelium cell apoptosis by upregulating mitophagy during diabetic retinopathy. Biochemical and biophysical research communications. vol 561. 2021-09-16. PMID:34023779. |
herein, we investigated the role of the rpe cell epidermal growth factor receptor (egfr)/p38 mitogen-activated protein kinase (p38)/nuclear factor kappa b (nf-κb) pathway in müller cell-derived tnf-α-induced mitophagy-associated apoptosis during dr. our results showed that tnf-α released from müller cells activated the egfr/p38/nf-κb/p62 pathway to increase mitophagy and apoptosis in rpe cells under high glucose (hg) conditions. |
2021-09-16 |
2023-08-13 |
mouse |
| Fatemeh Safari, Termeh Shakery, Nadiya Sayadami. Evaluating the effect of secretome of human amniotic mesenchymal stromal cells on apoptosis induction and epithelial-mesenchymal transition inhibition in LNCaP prostate cancer cells based on 2D and 3D cell culture models. Cell biochemistry and function. vol 39. issue 6. 2021-09-16. PMID:34128234. |
significance of the study: the anti-tumour activity of hamscs on lncap prostate cancer cells using 2d and 3d cell culture models via induction of apoptosis, suppression of emt process and down-regulation of egfr was shown. |
2021-09-16 |
2023-08-13 |
human |
| Mi-So Jeong, Kang-Wook Lee, Yu-Jeong Choi, Yun-Gyeong Kim, Hyun-Ha Hwang, Seo-Yeon Lee, Se-Eun Jung, Sun-Ah Park, Jin-Hee Lee, Yong-Joon Joo, Sung-Gook Cho, Seong-Gyu K. Synergistic Antitumor Activity of SH003 and Docetaxel via EGFR Signaling Inhibition in Non-Small Cell Lung Cancer. International journal of molecular sciences. vol 22. issue 16. 2021-09-16. PMID:34445110. |
moreover, sh003 and dtx induced the apoptosis of h460 cells via the suppression of the egfr and signal transducer and activator of transcription 3 (stat3) signaling pathways. |
2021-09-16 |
2023-08-13 |
human |