| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ashish Shah, Avinash Kumar Set. Current drug discovery technologies. vol 18. issue 1. 2021-07-15. PMID:31657688. |
epidermal growth factor receptor (egfr, erbb) belongs to family of receptor tyrosine kinase (rtks) that plays an important role in multiple cell signaling pathways, which includes cell growth, multiplication apoptosis, etc. |
2021-07-15 |
2023-08-13 |
Not clear |
| Minhai Dong, Qungen Xiao, Jinyang Hu, Fangling Cheng, Po Zhang, Weifeng Zong, Qiaoying Tang, Xiaopeng Li, Feng Mao, Yue He, Xingjiang Yu, Feng Wan, Ting Lei, Dongsheng Guo, Baofeng Wan. Targeting LRIG2 overcomes resistance to EGFR inhibitor in glioblastoma by modulating GAS6/AXL/SRC signaling. Cancer gene therapy. vol 27. issue 12. 2021-07-13. PMID:31988476. |
in this study, we report that lrig2 is induced by egfr inhibitor in gefitinib-treated gbm xenografts or cell lines and promotes resistance to egfr inhibition by driving cell cycle progression and inhibiting apoptosis in gbm cells. |
2021-07-13 |
2023-08-13 |
Not clear |
| Jia Luo, Alex Makhnin, Yosef Tobi, Linda Ahn, Sara A Hayes, Afsheen Iqbal, Kenneth Ng, Maria E Arcila, Gregory J Riely, Mark G Kris, Helena A Y. Erlotinib and Trametinib in Patients With JCO precision oncology. vol 5. 2021-07-13. PMID:34250388. |
erlotinib and trametinib in patients with inhibition of the mek/erk pathway is critical for bcl-2-like protein 11 (bim)-mediated epidermal growth factor receptor (egfr) tyrosine kinase inhibitor (tki)-induced apoptosis, and dysregulation of this pathway may be a mechanism of acquired resistance. |
2021-07-13 |
2023-08-13 |
Not clear |
| Yang Chen, Jie Wu, Hongfei Yan, Yang Cheng, Yizhe Wang, Yi Yang, Mingming Deng, Xiaofang Che, Kezuo Hou, Xiujuan Qu, Dan Zou, Yunpeng Liu, Ye Zhang, Xuejun H. Lymecycline reverses acquired EGFR-TKI resistance in non-small-cell lung cancer by targeting GRB2. Pharmacological research. vol 159. 2021-07-06. PMID:32561477. |
lymecycline inhibited the resistance of the cell cycle to egfr-tki and induced apoptosis in nsclc by inhibiting egfr phosphorylation and grb2-mediated akt/erk/stat3 signaling pathways. |
2021-07-06 |
2023-08-13 |
mouse |
| Sangah Lee, Jiyae Jung, Yu-Jin Lee, Seon-Kyu Kim, Jung-Ae Kim, Bo-Kyung Kim, Kyung Chan Park, Byoung-Mog Kwon, Dong Cho Ha. Targeting HSF1 as a Therapeutic Strategy for Multiple Mechanisms of EGFR Inhibitor Resistance in EGFR Mutant Non-Small-Cell Lung Cancer. Cancers. vol 13. issue 12. 2021-07-05. PMID:34203709. |
hsf1 inhibition by using hsf1 shrnas or kribb11 decreased the expression of hsf1 downstream proteins, such as hsp70 and hsp27, and also decreased the expression of hsp90/hsp70/bag3 client proteins, such as bcl2, mcl1, egfr, met, and axl, causing apoptosis of egfr-tki-resistant cancer cells. |
2021-07-05 |
2023-08-13 |
Not clear |
| Hwanhee Oh, Inah Hwang, Ja-Young Jang, Lingxiang Wu, Dongqing Cao, Jun Yao, Haoqiang Ying, Jian Yi Li, Yu Yao, Baoli Hu, Qianghu Wang, Hongwu Zheng, Jihye Pai. Therapy-Induced Transdifferentiation Promotes Glioma Growth Independent of EGFR Signaling. Cancer research. vol 81. issue 6. 2021-06-25. PMID:33509942. |
using an inducible oncogenic egfr-driven glioma mouse model system, our current study reveals that a small population of glioma cells can evade therapy-initiated apoptosis and potentiate relapse development by adopting a mesenchymal-like phenotypic state that no longer depends on oncogenic egfr signaling. |
2021-06-25 |
2023-08-13 |
mouse |
| Alexi Surette, Byong Hoon Yoo, Tallal Younis, Kara Matheson, Tarek Rameh, Jaime Snowdon, Gillian Bethune, Kirill V Rose. Tumor levels of the mediators of ErbB2-driven anoikis resistance correlate with breast cancer relapse in patients receiving trastuzumab-based therapies. Breast cancer research and treatment. vol 187. issue 3. 2021-06-23. PMID:33728523. |
we found previously that erbb2 blocks breast tumor cell anoikis, apoptosis induced by cell detachment from the extracellular matrix, by downregulating the pro-apoptotic protein irf6 and upregulating the anti-apoptotic protein epidermal growth factor receptor (egfr) in the cells and, thus, promotes their three-dimensional growth. |
2021-06-23 |
2023-08-13 |
Not clear |
| F A Monsalve, A Rojas, I Gonzalez, R Perez, C Añasco, J Romero, P Araya, L S Santos, F Delgado-Lope. RID: Evaluation of the Possible Inhibiting Effect of the Proinflammatory Signaling Induced by TNF- Mediators of inflammation. vol 2020. 2021-06-21. PMID:32655311. |
rid downregulates the cell surface expression of epidermal growth factor receptor (egfr), tumor necrosis factor receptor (tnfr), and apoptosis antigen 1 (fas), causing a reduction of the effects of their respective ligands. |
2021-06-21 |
2023-08-13 |
human |
| Md Mohiuddin, Kazuo Kasahar. Pemetrexed Disodium Heptahydrate Induces Apoptosis and Cell-cycle Arrest in Non-small-cell Lung Cancer Carrying an EGFR Exon 19 Deletion. Anticancer research. vol 41. issue 6. 2021-06-21. PMID:34083287. |
pemetrexed disodium heptahydrate induces apoptosis and cell-cycle arrest in non-small-cell lung cancer carrying an egfr exon 19 deletion. |
2021-06-21 |
2023-08-13 |
Not clear |
| Gabriel Tao, Pavan Kumar Chityal. Epidermal growth factor receptor inhibitor-induced diarrhea: clinical incidence, toxicological mechanism, and management. Toxicology research. vol 10. issue 3. 2021-06-19. PMID:34141161. |
enterocytes apoptosis and increased inflammation accompany with many oral egfr inhibitors. |
2021-06-19 |
2023-08-13 |
human |
| Shenglin Wang, Hongxiang Wei, Zhen Huang, Xinwen Wang, Rongkai Shen, Zhaoyang Wu, Jianhua Li. Epidermal growth factor receptor promotes tumor progression and contributes to gemcitabine resistance in osteosarcoma. Acta biochimica et biophysica Sinica. vol 53. issue 3. 2021-06-10. PMID:33432347. |
a more profound proliferative inhibition and a higher rate of apoptosis were obtained in os cells via inducing cell cycle arrest at g1 phase upon gemcitabine treatment combined with egfr knockdown, as compared to gemcitabine alone. |
2021-06-10 |
2023-08-13 |
Not clear |
| Peiyuan Sun, Yana Qu, Yuna Wang, Jing Wang, Xuanjun Wang, Jun Shen. Wighteone exhibits an antitumor effect against EGFR L858R/T790M mutation non-small cell lung cancer. Journal of Cancer. vol 12. issue 13. 2021-06-08. PMID:34093797. |
the results showed that wighteone inhibited cell proliferation, suppressed egfr signaling pathway, caused cell cycle redistribution and induced cell apoptosis. |
2021-06-08 |
2023-08-13 |
human |
| b' Jean-Baptiste Guy, Sophie Espenel, Safa Louati, Arnaud Gauthier, Max-Adrien Garcia, Nicolas Vial, C\\xc3\\xa9line Mal\\xc3\\xa9sys, Dominique Ardail, Gersende Alphonse, Anne-Sophie Wozny, Claire Rodriguez-Lafrasse, Nicolas Magn\\xc3\\xa. Combining radiation to EGFR and Bcl-2 blockade: a new approach to target cancer stem cells in head and neck squamous cell carcinoma. Journal of cancer research and clinical oncology. vol 147. issue 7. 2021-06-07. PMID:33791846.' |
cscs have low egfr expression and, conversely, overexpress the anti-apoptotic bcl-2 protein, which is involved in resistance to apoptosis and the invasion/migration capacities of tumour cells. |
2021-06-07 |
2023-08-13 |
Not clear |
| Jean Bourhis, Alexander Stein, Jan Paul de Boer, Marc Van Den Eynde, Kathryn A Gold, Sebastian Stintzing, Jürgen C Becker, Michael Moran, Andreas Schroeder, Gregory Pennock, Satu Salmio, Regina Esser, Fortunato Ciardiell. Avelumab and cetuximab as a therapeutic combination: An overview of scientific rationale and current clinical trials in cancer. Cancer treatment reviews. vol 97. 2021-06-07. PMID:33989949. |
avelumab binds to pd-l1 expressed on tumor cells and immune regulatory cells, thus blocking its interaction with programmed death 1 and reventing t-cell suppression; cetuximab inhibits the egfr signaling pathway, inhibiting proliferation and inducing apoptosis. |
2021-06-07 |
2023-08-13 |
Not clear |
| Yan Zhou Tran, Rezan Minozada, Xiaofang Cao, Henrik J Johansson, Rui M Branca, Brinton Seashore-Ludlow, Lukas M Orr. Immediate Adaptation Analysis Implicates BCL6 as an EGFR-TKI Combination Therapy Target in NSCLC. Molecular & cellular proteomics : MCP. vol 19. issue 6. 2021-06-03. PMID:32234966. |
proteomics profiling revealed that bcl6 inhibited transcription of multiple target genes including p53, resulting in reduced apoptosis which implicates bcl6 upregulation as a new egfr inhibitor treatment escape mechanism. |
2021-06-03 |
2023-08-13 |
Not clear |
| Christian David Hernández-Silva, Julio César Villegas-Pineda, Ana Laura Pereira-Suáre. Expression and Role of the G Protein-Coupled Estrogen Receptor (GPR30/GPER) in the Development and Immune Response in Female Reproductive Cancers. Frontiers in endocrinology. vol 11. 2021-06-03. PMID:32973677. |
besides, the g protein-coupled estrogen receptor (gper, formerly known as gpr30) was recently described as a seven-transmembrane receptor that mediates non-genomic estrogenic signaling, including calcium mobilization, camp synthesis, cleavage of matrix metalloproteinases, transactivation of epidermal growth factor receptor (egfr), and the subsequent activation of pi3k and mapk signaling pathways, which are the reasons why it is related to cellular processes, such as cell-cycle progression, cellular proliferation, differentiation, apoptosis, migration, and invasion. |
2021-06-03 |
2023-08-13 |
Not clear |
| Ching-Feng Wu, Ching-Yang Wu, Robin Y-Y Chiou, Wei-Cheng Yang, Chuen-Fu Lin, Chao-Min Wang, Po-Hsun Hou, Tzu-Chun Lin, Chan-Yen Kuo, Geng-Ruei Chan. The Anti-Cancer Effects of a Zotarolimus and 5-Fluorouracil Combination Treatment on A549 Cell-Derived Tumors in BALB/c Nude Mice. International journal of molecular sciences. vol 22. issue 9. 2021-06-03. PMID:33925400. |
compared the results with those for control mice, we found that mice treated with zotarolimus or zotarolimus combined with 5-fu retarded tumor growth; increased tumor apoptosis through the enhanced expression of cleaved caspase 3 and extracellular signal-regulated kinase (erk) phosphorylation; decreased inflammation cytokines levels (e.g., il-1β, tnf-α, and il-6); reduced inflammation-related factors such as cyclooxygenase-2 (cox-2) protein and nuclear factor-κb (nf-κb) mrna; enhanced anti-inflammation-related factors including il-10 and inhibitor of nf-κb kinase α (iκbα) mrna; and inhibited metastasis-related factors such as transforming growth factor β (tgf-β), cd44, epidermal growth factor receptor (egfr), and vascular endothelial growth factor (vegf). |
2021-06-03 |
2023-08-13 |
mouse |
| Jian Wang, Xiean Ling, Min Zhou, Guanggui Ding, Bin Peng, Jun Wa. Thermal treatment decreases resistance to osimertinib in non-small cell lung cancer through the EGFR/PI3K/AKT pathway. Neoplasma. vol 68. issue 3. 2021-06-02. PMID:33724860. |
cell viability, apoptosis, sensitivity to osi, threonine-methionine amino acid substitution at position 790 (t790m) mutation levels, and protein expression of epidermal growth factor receptor (egfr), phosphatidylinositol 3-kinase (pi3k), protein kinase b (akt), hypoxia-inducible factor-1 alpha (hif-1a) were detected using different methods. |
2021-06-02 |
2023-08-13 |
mouse |
| Cinzia Antognelli, Isabella Palumbo, Simonetta Piattoni, Monica Calzuola, Beatrice Del Papa, Vincenzo N Talesa, Cynthia Ariste. Exploring the radiosensitizing potential of AZD8931: a pilot study on the human LoVo colorectal cancer cell line. International journal of radiation biology. vol 96. issue 11. 2021-05-24. PMID:32910714. |
to explore the radiosensitizing effect of azd8931, a novel equipotent and reversible inhibitor of signaling by egfr (her1), her2 and her3 receptors, focusing on cell cycle progression, apoptosis and clonogenic capacity in the human lovo colorectal cancer (crc) cell line, also in comparison with the egfr-blocking monoclonal antibody cetuximab or the egfr tyrosine kinase selective small molecular inhibitor gefitinib. |
2021-05-24 |
2023-08-13 |
human |
| Nipin Sp, Dong Young Kang, Jin-Moo Lee, Se Won Bae, Kyoung-Jin Jan. Potential Antitumor Effects of 6-Gingerol in p53-Dependent Mitochondrial Apoptosis and Inhibition of Tumor Sphere Formation in Breast Cancer Cells. International journal of molecular sciences. vol 22. issue 9. 2021-05-24. PMID:33925065. |
epidermal growth factor receptor (egfr) promotes tumor growth by stimulating signaling of downstream targets that in turn activates tumor protein 53 (p53) to promote apoptosis. |
2021-05-24 |
2023-08-13 |
Not clear |