| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Puyu Shi, Shuo Zhang, Lei Zhu, Guoqing Qian, Hui Ren, Suresh S Ramalingam, Mingwei Chen, Shi-Yong Su. The Third-Generation EGFR Inhibitor, Osimertinib, Promotes c-FLIP Degradation, Enhancing Apoptosis Including TRAIL-Induced Apoptosis in NSCLC Cells with Activating EGFR Mutations. Translational oncology. vol 12. issue 5. 2020-10-01. PMID:30856555. |
the third-generation egfr inhibitor, osimertinib, promotes c-flip degradation, enhancing apoptosis including trail-induced apoptosis in nsclc cells with activating egfr mutations. |
2020-10-01 |
2023-08-13 |
Not clear |
| Puyu Shi, Shuo Zhang, Lei Zhu, Guoqing Qian, Hui Ren, Suresh S Ramalingam, Mingwei Chen, Shi-Yong Su. The Third-Generation EGFR Inhibitor, Osimertinib, Promotes c-FLIP Degradation, Enhancing Apoptosis Including TRAIL-Induced Apoptosis in NSCLC Cells with Activating EGFR Mutations. Translational oncology. vol 12. issue 5. 2020-10-01. PMID:30856555. |
the current study has demonstrated that osimertinib reduces c-flip levels via facilitating its degradation and enhances apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (trail) primarily in nsclc with activating egfr mutations. |
2020-10-01 |
2023-08-13 |
Not clear |
| Puyu Shi, Shuo Zhang, Lei Zhu, Guoqing Qian, Hui Ren, Suresh S Ramalingam, Mingwei Chen, Shi-Yong Su. The Third-Generation EGFR Inhibitor, Osimertinib, Promotes c-FLIP Degradation, Enhancing Apoptosis Including TRAIL-Induced Apoptosis in NSCLC Cells with Activating EGFR Mutations. Translational oncology. vol 12. issue 5. 2020-10-01. PMID:30856555. |
moreover, modulation of c-flip expression levels, to some degree, also alters the sensitivities of egfr mutant nsclc cells to undergo osimertinib-induced apoptosis, suggesting that c-flip suppression is an important event contributing to the antitumor activity of osimertinib against egfr mutant nsclc. |
2020-10-01 |
2023-08-13 |
Not clear |
| Simon Garinet, Audrey Didelot, Elena Garelli, Karine Pallier, Hélène Blons, Antoine Legra. How apoptosis and epithelial-to-mesenchymal transition are nested in EGFR inhibitors resistance in lung cancer. Journal of thoracic disease. vol 11. issue 1. 2020-10-01. PMID:30863568. |
how apoptosis and epithelial-to-mesenchymal transition are nested in egfr inhibitors resistance in lung cancer. |
2020-10-01 |
2023-08-13 |
Not clear |
| Nicole Amberg, Panagiota A Sotiropoulou, Gerwin Heller, Beate M Lichtenberger, Martin Holcmann, Bahar Camurdanoglu, Temenuschka Baykuscheva-Gentscheva, Cedric Blanpain, Maria Sibili. EGFR Controls Hair Shaft Differentiation in a p53-Independent Manner. iScience. vol 15. 2020-10-01. PMID:31082735. |
expression and alternative splicing analysis of rna sequencing data from interfollicular epidermis and outer root sheath indicate that egfr controls genes involved in epidermal differentiation and also in centrosome function, dna damage, cell cycle, and apoptosis. |
2020-10-01 |
2023-08-13 |
mouse |
| Srinivas Patnaik, Anupriy. Drugs Targeting Epigenetic Modifications and Plausible Therapeutic Strategies Against Colorectal Cancer. Frontiers in pharmacology. vol 10. 2020-10-01. PMID:31244652. |
tumor suppressor candidate 3 (tusc3) mrna expression is silenced by promoter methylation, which promotes epidermal growth factor receptor (egfr) signaling and rescues the crc cells from apoptosis and hence leading to poor survival rate. |
2020-10-01 |
2023-08-13 |
Not clear |
| Victor Jeannot, Benoit Busser, Laetitia Vanwonterghem, Sophie Michallet, Sana Ferroudj, Murat Cokol, Jean-Luc Coll, Mehmet Ozturk, Amandine Hurbi. Synergistic activity of vorinostat combined with gefitinib but not with sorafenib in mutant KRAS human non-small cell lung cancers and hepatocarcinoma. OncoTargets and therapy. vol 9. 2020-09-30. PMID:27877053. |
the effects of the approved epidermal growth factor receptor (egfr)-tyrosine kinase inhibitor (gefitinib) or a multi-targeted kinase inhibitor (sorafenib) in combination with a histone deacetylase inhibitor (vorinostat) on cell proliferation, cell cycle distribution, apoptosis, and signaling pathway activation in human lung adenocarcinoma and hepatocarcinoma cells with wild-type |
2020-09-30 |
2023-08-13 |
human |
| Zhenxing Zhang, Xiaofeng Song, He Tian, Ye Miao, Xu Feng, Yang Li, Honglei Wan. MicroRNA-137 inhibits growth of glioblastoma through EGFR suppression. American journal of translational research. vol 9. issue 3. 2020-09-30. PMID:28386374. |
together, our data suggest that reduction in mir-137 levels in gbm tissues may increase cell growth and decrease cell apoptosis, possibly through suppression of egfr. |
2020-09-30 |
2023-08-13 |
Not clear |
| Daiyong Wang, Bing Wang, Ruohan Wang, Zaizhong Zhang, Youdong Lin, Guoliang Huang, Songbin Lin, Yifan Jiang, Wenyuan Wang, Lie Wang, Qiaojia Huan. High expression of EGFR predicts poor survival in patients with resected T3 stage gastric adenocarcinoma and promotes cancer cell survival. Oncology letters. vol 13. issue 5. 2020-09-30. PMID:28521408. |
annexin v apoptosis and mtt cell viability assays were performed to explore the effect of egfr on ags gastric adenocarcinoma cell survival. |
2020-09-30 |
2023-08-13 |
Not clear |
| Y-L Li, X-M Liu, C-Y Zhang, J-B Zhou, Y Shao, C Liang, H-M Wang, Z-Y Hua, S-D Lu, Z-L M. MicroRNA-34a/EGFR axis plays pivotal roles in lung tumorigenesis. Oncogenesis. vol 6. issue 8. 2020-09-30. PMID:28825720. |
we also confirmed that epidermal growth factor receptor (egfr) is a direct target of mir-34a, and our data reveal that sirna knockdown of egfr can inhibit cell proliferation, promote apoptosis and arrest cell-cycle progression. |
2020-09-30 |
2023-08-13 |
mouse |
| Y-L Li, X-M Liu, C-Y Zhang, J-B Zhou, Y Shao, C Liang, H-M Wang, Z-Y Hua, S-D Lu, Z-L M. MicroRNA-34a/EGFR axis plays pivotal roles in lung tumorigenesis. Oncogenesis. vol 6. issue 8. 2020-09-30. PMID:28825720. |
in addition, egfr can reverse the suppressive function of mir-34a overexpression on proliferation and cell apoptosis. |
2020-09-30 |
2023-08-13 |
mouse |
| Wanqun Chen, Yaya Yu, Naikun Yang, Jingli Zhu, Ke Li, Ruocun Li, Wenqiao Su, Lina Luo, Ling Hu, Gengxin Chen, Haixia Den. Effects of Yangzheng Sanjie Decoction-containing serum mediated by microRNA-7 on cell proliferation and apoptosis in gastric cancer. Oncology letters. vol 15. issue 3. 2020-09-30. PMID:29467883. |
this indicates that ycs inhibits proliferation and induces apoptosis of gc cells mediated by mir-7 targeting egfr, which may be one of the mechanisms whereby yzsjd exerts its effects on gc. |
2020-09-30 |
2023-08-13 |
Not clear |
| Siwen Liu, Haixia Cao, Dan Chen, Shaorong Yu, Huanhuan Sha, Jianzhong Wu, Rong Ma, Zhuo Wang, Changwen Jing, Junying Zhang, Jifeng Fen. LXR ligands induce apoptosis of EGFR-TKI-resistant human lung cancer cells Oncology letters. vol 15. issue 5. 2020-09-30. PMID:29731879. |
lxr ligands induce apoptosis of egfr-tki-resistant human lung cancer cells epidermal growth factor receptor tyrosine kinase inhibitors (egfr-tkis) are efficient in treating patients with non-small cell lung cancer (nsclc) harboring egfr activating mutations. |
2020-09-30 |
2023-08-13 |
human |
| Xi Dai, Run-Ze Li, Ze-Bo Jiang, Chun-Li Wei, Lian-Xiang Luo, Xiao-Jun Yao, Guo-Ping Li, Elaine L-H Leun. Honokiol Inhibits Proliferation, Invasion and Induces Apoptosis Through Targeting Lyn Kinase in Human Lung Adenocarcinoma Cells. Frontiers in pharmacology. vol 9. 2020-09-30. PMID:29892225. |
as shown in this study, honokiol is an effective drug on inhibiting proliferation and inducing apoptosis depended on lyn and egfr signal pathway regulated by lyn, and its efficacy is stronger in pc-9 cells than a549 cells. |
2020-09-30 |
2023-08-13 |
human |
| Xinyang Lu, Lunhua Huang, Wei Zhang, Xiaofei Nin. Tepoxalin a dual 5-LOX-COX inhibitor and erlotinib an EGFR inhibitor halts progression of gastric cancer in tumor xenograft mice. American journal of translational research. vol 10. issue 11. 2020-09-30. PMID:30662635. |
after treatment protocol proliferating index was measured, expression of apoptosis related proteins, 5-lox, cox-2, egfr, vascular endothelial growth factor-c (vegf-c) and density of lymphatic vessel density was evaluated in tumor tissues. |
2020-09-30 |
2023-08-13 |
mouse |
| Xinyang Lu, Lunhua Huang, Wei Zhang, Xiaofei Nin. Tepoxalin a dual 5-LOX-COX inhibitor and erlotinib an EGFR inhibitor halts progression of gastric cancer in tumor xenograft mice. American journal of translational research. vol 10. issue 11. 2020-09-30. PMID:30662635. |
the results confirmed combination of tpx and erb produced a synergistic anticancer and antitumor activity, possibly by promoting apoptosis and antiproliferative effect on tumor cells via suppressing expression of cox-2, 5-lox, egfr and vegf-c. |
2020-09-30 |
2023-08-13 |
mouse |
| Praful R Nai. Delivering Combination Chemotherapies and Targeting Oncogenic Pathways via Polymeric Drug Delivery Systems. Polymers. vol 11. issue 4. 2020-09-30. PMID:30959799. |
these include inhibition of oncogenic pathways (including those involving her2, egfr, mapk, pi3k/akt, stat3, and hif-1α), augmentation of apoptosis by inhibiting anti-apoptosis proteins (bcl-2, bcl-xl, and survivin), and targeting dysregulated pathways such as wnt/β-catenin and hedgehog. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yi Pei, Yueyan Zhang, Ke Zheng, Guanning Shang, Yuming Wang, Wei Wang, Enduo Qiu, Xiaojing Zhan. Ursolic acid suppresses the biological function of osteosarcoma cells. Oncology letters. vol 18. issue 3. 2020-09-30. PMID:31404298. |
western blot analysis and reverse transcription-quantitative polymerase chain reaction were used to detect the effects of different concentrations of ursolic acid on egfr signaling pathway-related proteins, cell cycle, apoptosis and cell migration-related proteins. |
2020-09-30 |
2023-08-13 |
Not clear |
| Alaa Refaat, Sherif Abdelhamed, Ikuo Saiki, Hiroaki Sakura. Inhibition of p38 mitogen-activated protein kinase potentiates the apoptotic effect of berberine/tumor necrosis factor-related apoptosis-inducing ligand combination therapy. Oncology letters. vol 10. issue 3. 2020-09-29. PMID:26622773. |
in addition, it was revealed that the inhibition of p38 enhanced apoptosis in epidermal growth factor receptor (egfr)-overexpressing mda-mb-468 tnbc cells and egfr-mutant pc-9 non-small-cell lung carcinoma cells, which was associated with the downregulation of egfr serine phosphorylation. |
2020-09-29 |
2023-08-13 |
Not clear |
| Alaa Refaat, Sherif Abdelhamed, Ikuo Saiki, Hiroaki Sakura. Inhibition of p38 mitogen-activated protein kinase potentiates the apoptotic effect of berberine/tumor necrosis factor-related apoptosis-inducing ligand combination therapy. Oncology letters. vol 10. issue 3. 2020-09-29. PMID:26622773. |
in conclusion, the present study provided novel evidence for the role of p38 in suppressing bbr/trail-mediated apoptosis and its association with egfr, which may explain the mechanism of treatment resistance in certain types of cancer. |
2020-09-29 |
2023-08-13 |
Not clear |