| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xianming Ge, Qiao Zhou, Yuhan Zhang, Wenjing Zhou, Yu Wu, Cheng Zhen, Mengxiao Zhang, Fangtian Fan, Gangsheng Chen, Junjun Zhao, Hao Li. [EGFR tyrosine kinase inhibitor HS-10296 induces autophagy and apoptosis in triplenegative breast cancer MDA-MB-231 cells]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 40. issue 7. 2020-09-10. PMID:32895156. |
[egfr tyrosine kinase inhibitor hs-10296 induces autophagy and apoptosis in triplenegative breast cancer mda-mb-231 cells]. |
2020-09-10 |
2023-08-13 |
Not clear |
| Gen Liu, Bao-Kang Jin, Cheng Ma, Zixuan Chen, Jun-Jie Zh. Potential-Resolved Electrochemiluminescence Nanoprobes for Visual Apoptosis Evaluation at Single-Cell Level. Analytical chemistry. vol 91. issue 9. 2020-09-04. PMID:30964659. |
the apoptosis of cells usually induces the decreasing expression of epidermal growth factor receptor (egfr) and promotes phosphatidylserine (ps) eversion on the cell membrane. |
2020-09-04 |
2023-08-13 |
Not clear |
| Ping Jin, Jingwen Jiang, Na Xie, Li Zhou, Zhao Huang, Lu Zhang, Siyuan Qin, Shuyue Fu, Liyuan Peng, Wei Gao, Bowen Li, Yunlong Lei, Edouard C Nice, Changlong Li, Jichun Shao, Ke Xi. MCT1 relieves osimertinib-induced CRC suppression by promoting autophagy through the LKB1/AMPK signaling. Cell death & disease. vol 10. issue 8. 2020-07-30. PMID:31409796. |
here, we found that osimertinib (osi) exhibits potent anti-crc effects by inducing apoptosis, independent of its selective inhibitory activity targeting the egfr t790m mutation. |
2020-07-30 |
2023-08-13 |
Not clear |
| Kimiya Memarzadeh, David J Savage, Andrew J Bea. Low UBE4B expression increases sensitivity of chemoresistant neuroblastoma cells to EGFR and STAT5 inhibition. Cancer biology & therapy. vol 20. issue 12. 2020-07-23. PMID:31475882. |
in chemoresistant neuroblastoma cells, depletion of ube4b yielded significantly reduced cell proliferation and migration, and enhanced apoptosis in response to egfr inhibitor, cetuximab. |
2020-07-23 |
2023-08-13 |
Not clear |
| Hyunsook Kang, Seong Jun Choi, Kye Hoon Park, Chi-Kyou Lee, Jong-Seok Moo. Impaired Glycolysis Promotes AlcoholExposure-Induced Apoptosis in HEI-OC1 Cells via Inhibition of EGFR Signaling. International journal of molecular sciences. vol 21. issue 2. 2020-06-03. PMID:31940844. |
impaired glycolysis promotes alcoholexposure-induced apoptosis in hei-oc1 cells via inhibition of egfr signaling. |
2020-06-03 |
2023-08-13 |
Not clear |
| Hyunsook Kang, Seong Jun Choi, Kye Hoon Park, Chi-Kyou Lee, Jong-Seok Moo. Impaired Glycolysis Promotes AlcoholExposure-Induced Apoptosis in HEI-OC1 Cells via Inhibition of EGFR Signaling. International journal of molecular sciences. vol 21. issue 2. 2020-06-03. PMID:31940844. |
here, we show that the inhibition of epidermal growth factor receptor (egfr)-induced glycolysis is a critical mechanism for alcohol exposure-induced apoptosis in hei-oc1 cells. |
2020-06-03 |
2023-08-13 |
Not clear |
| Hyunsook Kang, Seong Jun Choi, Kye Hoon Park, Chi-Kyou Lee, Jong-Seok Moo. Impaired Glycolysis Promotes AlcoholExposure-Induced Apoptosis in HEI-OC1 Cells via Inhibition of EGFR Signaling. International journal of molecular sciences. vol 21. issue 2. 2020-06-03. PMID:31940844. |
these results suggest that impaired glycolysis promotes alcohol exposure-induced apoptosis in hei-oc1 cells via the inhibition of egfr signaling. |
2020-06-03 |
2023-08-13 |
Not clear |
| Jun Shao, Xubin Pan, Xiaowen Yin, Guangming Fan, Chengye Tan, Yong Yao, Yu Xin, Chao Su. KCNQ1OT1 affects the progression of diabetic retinopathy by regulating miR-1470 and epidermal growth factor receptor. Journal of cellular physiology. vol 234. issue 10. 2020-06-01. PMID:30784065. |
additionally, mrna of epidermal growth factor receptor (egfr) was proved as the target of mir-1470 and egfr targeting by mir-1470 initiated kcnq1ot1 deficiency-induced apoptosis and promoted proliferation. |
2020-06-01 |
2023-08-13 |
human |
| Ruth Herrmann, Joseph Skaf, Jeanette Roller, Christine Polednik, Ulrike Holzgrabe, Marianne Schmid. Anticancer effects of NSC‑631570 (Ukrain) in head and neck cancer cells: In vitro analysis of growth, invasion, angiogenesis and gene expression. Oncology reports. vol 43. issue 1. 2020-06-01. PMID:31789425. |
microarray analysis revealed the downregulation of genes encoding key regulators, including egfr, akt2, jak1, stat3 and ß‑catenin (ctnnb1), all of which are involved in cell proliferation, migration, angiogenesis, apoptosis as well as the radiation‑ and chemo‑resistance of hnscc. |
2020-06-01 |
2023-08-13 |
human |
| Ha-Na Oh, Mee-Hyun Lee, Eunae Kim, Ah-Won Kwak, Ji-Hye Seo, Goo Yoon, Seung-Sik Cho, Joon-Seok Choi, Sang-Myeong Lee, Kang-Seok Seo, Jung-Il Chae, Jung-Hyun Shi. Dual inhibition of EGFR and MET by Echinatin retards cell growth and induces apoptosis of lung cancer cells sensitive or resistant to gefitinib. Phytotherapy research : PTR. vol 34. issue 2. 2020-04-30. PMID:31698509. |
dual inhibition of egfr and met by echinatin retards cell growth and induces apoptosis of lung cancer cells sensitive or resistant to gefitinib. |
2020-04-30 |
2023-08-13 |
Not clear |
| D S Kutilin, T G Airapetova, P A Anistratov, S P Pyltsin, I A Leiman, N S Karnaukhov, O I Ki. Copy Number Variation in Tumor Cells and Extracellular DNA in Patients with Lung Adenocarcinoma. Bulletin of experimental biology and medicine. vol 167. issue 6. 2020-04-27. PMID:31655998. |
changed copy numbers were detected for genes responsible for apoptosis regulation (bax, p53, and casp3), proliferation (sox2), dna reparation (xrcc1), oxidative phosphorylation (hv2), egfr signaling pathway (grb2, sos1, mapk1, stat1, and braf), and for mir3678 gene in lung tumor cells and extracellular dna. |
2020-04-27 |
2023-08-13 |
Not clear |
| Lin Yang, Haoran Yuan, Ying Yu, Nan Yu, Lilu Ling, Jianying Niu, Yong G. Epidermal growth factor receptor mimotope alleviates renal fibrosis in murine unilateral ureteral obstruction model. Clinical immunology (Orlando, Fla.). vol 205. 2020-04-20. PMID:31152892. |
these evidence suggested that the egfr mimotope could alleviate renal fibrosis by both inhibiting egfr signaling and promoting macrophages apoptosis. |
2020-04-20 |
2023-08-13 |
Not clear |
| Lidia M Andrade, Estefânia M N Martins, Alice F Versiani, Daniela S Reis, Flavio G da Fonseca, Ivina P de Souza, Roberto M Paniago, Elene Pereira-Maia, Luiz O Ladeir. The physicochemical and biological characterization of a 24-month-stored nanocomplex based on gold nanoparticles conjugated with cetuximab demonstrated long-term stability, EGFR affinity and cancer cell death due to apoptosis. Materials science & engineering. C, Materials for biological applications. vol 107. 2020-04-15. PMID:31761220. |
the physicochemical and biological characterization of a 24-month-stored nanocomplex based on gold nanoparticles conjugated with cetuximab demonstrated long-term stability, egfr affinity and cancer cell death due to apoptosis. |
2020-04-15 |
2023-08-13 |
Not clear |
| Lidia M Andrade, Estefânia M N Martins, Alice F Versiani, Daniela S Reis, Flavio G da Fonseca, Ivina P de Souza, Roberto M Paniago, Elene Pereira-Maia, Luiz O Ladeir. The physicochemical and biological characterization of a 24-month-stored nanocomplex based on gold nanoparticles conjugated with cetuximab demonstrated long-term stability, EGFR affinity and cancer cell death due to apoptosis. Materials science & engineering. C, Materials for biological applications. vol 107. 2020-04-15. PMID:31761220. |
the nanocomplex with 24 months of manufacturing promoted efficient egfr binding and induced tumour cell death due to apoptosis. |
2020-04-15 |
2023-08-13 |
Not clear |
| Wei-Siang Liao, Yu Ho, Yu-Wei Lin, Emmanuel Naveen Raj, Kuang-Kai Liu, Chinpiao Chen, Xiao-Zhen Zhou, Kun-Ping Lu, Jui-I Cha. Targeting EGFR of triple-negative breast cancer enhances the therapeutic efficacy of paclitaxel- and cetuximab-conjugated nanodiamond nanocomposite. Acta biomaterialia. vol 86. 2020-04-08. PMID:30660004. |
nd-ptx-cet could specifically bind to egfr and enhanced the anticancer effects including drug uptake levels, mitotic catastrophe, and apoptosis in the egfr-expressed mda-mb-231 cells but not in the egfr-negative mcf-7 cells. |
2020-04-08 |
2023-08-13 |
mouse |
| Wei-Siang Liao, Yu Ho, Yu-Wei Lin, Emmanuel Naveen Raj, Kuang-Kai Liu, Chinpiao Chen, Xiao-Zhen Zhou, Kun-Ping Lu, Jui-I Cha. Targeting EGFR of triple-negative breast cancer enhances the therapeutic efficacy of paclitaxel- and cetuximab-conjugated nanodiamond nanocomposite. Acta biomaterialia. vol 86. 2020-04-08. PMID:30660004. |
taken together, these results demonstrated that nd-ptx-cet nanocomposite enhanced mitotic catastrophe and apoptosis by targeting egfr of tnbc cells, which can provide a feasible strategy for tnbc therapy. |
2020-04-08 |
2023-08-13 |
mouse |
| Wei-Ting Kuo, Jian-Yuan Huang, Min-Hua Chen, Ching-Yun Chen, Yan-Jye Shyong, Ko-Chung Yen, Yu-Jun Sun, Cherng-Jyh Ke, Yung-Hsin Cheng, Feng-Huei Li. Development of gelatin nanoparticles conjugated with phytohemagglutinin erythroagglutinating loaded with gemcitabine for inducing apoptosis in non-small cell lung cancer cells. Journal of materials chemistry. B. vol 4. issue 14. 2020-04-08. PMID:32263194. |
in conclusion, gnp-(pha-e)-gem could induce growth inhibition and cytotoxicity, which was mediated through inhibition of egfr phosphorylation and the switching on of p53 that causes cell apoptosis of nsclc cells a-549 and h292. |
2020-04-08 |
2023-08-13 |
Not clear |
| Sara Lundsten, Diana Spiegelberg, Bo Stenerlöw, Marika Nesto. The HSP90 inhibitor onalespib potentiates 177Lu‑DOTATATE therapy in neuroendocrine tumor cells. International journal of oncology. vol 55. issue 6. 2020-04-02. PMID:31638190. |
the radiosensitizing mechanisms of onalespib involved the downregulation of egfr expression and the induction of apoptosis. |
2020-04-02 |
2023-08-13 |
Not clear |
| Cristiana Maria Grapa, Teodora Mocan, Diana Gonciar, Claudiu Zdrehus, Ofelia Mosteanu, Teodora Pop, Lucian Moca. Epidermal Growth Factor Receptor and Its Role in Pancreatic Cancer Treatment Mediated by Nanoparticles. International journal of nanomedicine. vol 14. 2020-03-31. PMID:31849462. |
nanoparticles have been used in trying to improve the efficacy of antitumor treatment; thus, using egfr's ligand, egf, for nanoconjugation, showed promising results in increasing the cellular uptake mechanisms and apoptosis of the targeted cells. |
2020-03-31 |
2023-08-13 |
Not clear |
| Yanhong Qu, Yougai Zhang, Kaijuan Wang, Chunhua Song, Peng Wang, Hua Ye, Jianying Zhang, Liping Da. Single Nucleotide Polymorphisms in MicroRNA-Binding Site of Epidermal Growth Factor Receptor Signaling Pathway and Susceptibility to Esophageal Squamous Cell Carcinoma. Digestive diseases (Basel, Switzerland). vol 38. issue 1. 2020-03-11. PMID:31269493. |
epidermal growth factor receptor (egfr) signaling pathway plays a fundamental role in regulating cell proliferation, differentiation, apoptosis, migration, and so on, which are associated with tumor development, including the esophageal squamous cell carcinoma (escc). |
2020-03-11 |
2023-08-13 |
Not clear |