| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| William D Shipman, Susan Chyou, Anusha Ramanathan, Peter M Izmirly, Sneh Sharma, Tania Pannellini, Dragos C Dasoveanu, Xiaoping Qing, Cynthia M Magro, Richard D Granstein, Michelle A Lowes, Eric G Pamer, Daniel H Kaplan, Jane E Salmon, Babak J Mehrara, James W Young, Robert M Clancy, Carl P Blobel, Theresa T L. A protective Langerhans cell-keratinocyte axis that is dysfunctional in photosensitivity. Science translational medicine. vol 10. issue 454. 2019-10-11. PMID:30111646. |
we identify a langerhans cell (lc)-keratinocyte axis that limits uvr-induced keratinocyte apoptosis and skin injury via keratinocyte epidermal growth factor receptor (egfr) stimulation. |
2019-10-11 |
2023-08-13 |
mouse |
| Yunyun Li, Wenrong Zhao, Ri Shi, Jun Jia, Xiaona Li, Jingxin Chen. Rs4759314 polymorphism located in HOTAIR is associated with the risk of congenital heart disease by alternating downstream signaling via reducing its expression. Journal of cellular biochemistry. vol 119. issue 10. 2019-10-04. PMID:29932240. |
hotair evidently increased egfr p-erk and p-p38 mapk expression levels, moreover hotair substantially promoted cell viability, and inhibited cell apoptosis. |
2019-10-04 |
2023-08-13 |
Not clear |
| Yuquan Bai, Wulin Shen, Li Zhang, Zetian Yang, Lecai Xiong, Hexiao Tang, Jinping Zha. Oestrogen receptor β5 and epidermal growth factor receptor synergistically promote lung cancer progression. Autoimmunity. vol 51. issue 4. 2019-10-04. PMID:30022688. |
these results indicated that the combination of erβ5 and egf induces cell proliferation and invasion, while the combination of erβ5 and gefitinib (egfr inhibitors, gef) induces cell apoptosis and promotes cell mitosis in a549 cell line. |
2019-10-04 |
2023-08-13 |
Not clear |
| Sadia Afrin, Francesca Giampieri, Tamara Y Forbes-Hernández, Massimiliano Gasparrini, Adolfo Amici, Danila Cianciosi, Josè L Quiles, Maurizio Battin. Manuka honey synergistically enhances the chemopreventive effect of 5-fluorouracil on human colon cancer cells by inducing oxidative stress and apoptosis, altering metabolic phenotypes and suppressing metastasis ability. Free radical biology & medicine. vol 126. 2019-09-19. PMID:30056083. |
compared to 5-fu alone, mh synergistically enhanced the chemotherapeutic effects of 5-fu, by reducing cell proliferation through the suppression of egfr, her2, p-akt and p-mtor expression, and promoting apoptosis by the modulation pro-apoptotic (p53, bax, cyto c, fasl caspase-3, -8, -9 and cleave-parp) and anti-apoptotic (bcl-2) markers. |
2019-09-19 |
2023-08-13 |
human |
| Anais Beaumont, Delphine Dayde, Anne-Sophie Hatat, Celine Barrial, Pascal Perron, Beatrice Eymin, Sylvie Gazzer. ARF promotes the degradation of the Epidermal Growth Factor Receptor by the lysosome. Experimental cell research. vol 370. issue 2. 2019-09-17. PMID:29959911. |
epidermal growth factor receptor (egfr) signaling regulates multiple cellular processes including proliferation, survival and apoptosis, and is attenuated by lysosomal receptor degradation. |
2019-09-17 |
2023-08-13 |
Not clear |
| Weijun Wei, Dalong Ni, Emily B Ehlerding, Quan-Yong Luo, Weibo Ca. PET Imaging of Receptor Tyrosine Kinases in Cancer. Molecular cancer therapeutics. vol 17. issue 8. 2019-09-17. PMID:30068751. |
overexpression and/or mutations of the receptor tyrosine kinase (rtk) subfamilies, such as epidermal growth factor receptors (egfr) and vascular endothelial growth factor receptors (vegfr), are closely associated with tumor cell growth, differentiation, proliferation, apoptosis, and cellular invasiveness. |
2019-09-17 |
2023-08-13 |
Not clear |
| Aanchal Shrestha, Ruo-Chen Che, Ai-Hua Zhan. Role of Aldosterone in Renal Fibrosis. Advances in experimental medicine and biology. vol 1165. 2019-09-13. PMID:31399972. |
aldosterone acts on renal vessels, renal cells (glomerular mesangial cells, podocytes, vascular smooth muscle cells, tubular epithelial cells, and interstitial fibroblasts), and infiltrating inflammatory cells, inducing reactive oxygen species (ros) production, upregulated epithelial growth factor receptor (egfr), and type 1 angiotensin (at1) receptor expressions, and activating nuclear factor kappa b (nf-κb), activator protein-1 (ap-1), and egfr to further promote cell proliferation, apoptosis, and proliferation. |
2019-09-13 |
2023-08-13 |
human |
| Subhadip Das, Kirti Kaul, Sanjay Mishra, Manish Charan, Ramesh K Ganj. Cannabinoid Signaling in Cancer. Advances in experimental medicine and biology. vol 1162. 2019-09-11. PMID:31332734. |
several of these pathways including akt, egfr, and mtor are known to contribute to tumor development and metastasis, and cannabinoids may reverse their effects, thereby by inducing apoptosis, autophagy and modulating the immune system. |
2019-09-11 |
2023-08-13 |
Not clear |
| Chaoyang Duan, Jin Han, Chongyu Zhang, Kunyi Wu, Yan Li. Inhibition of kidney cancer cell growth by Mulberroside-A is mediated via mitochondrial mediated apoptosis, inhibition of cell migration and invasion and targeting EGFR signalling pathway. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. vol 24. issue 1. 2019-09-03. PMID:30941984. |
inhibition of kidney cancer cell growth by mulberroside-a is mediated via mitochondrial mediated apoptosis, inhibition of cell migration and invasion and targeting egfr signalling pathway. |
2019-09-03 |
2023-08-13 |
Not clear |
| Lu Xue, Nita J Maihle, Xiaolin Yu, Shou-Ching Tang, Hong Yan Li. Synergistic Targeting HER2 and EGFR with Bivalent Aptamer-siRNA Chimera Efficiently Inhibits HER2-Positive Tumor Growth. Molecular pharmaceutics. vol 15. issue 11. 2019-08-26. PMID:30222359. |
in breast cancer xenograft models, heh is capable of triggering cell apoptosis, decreasing her2 and egfr expression, and suppressing tumor growth. |
2019-08-26 |
2023-08-13 |
Not clear |
| Ludmila Wintergerst, Martin Selmansberger, Cornelius Maihoefer, Lars Schüttrumpf, Axel Walch, Christina Wilke, Adriana Pitea, Christine Woischke, Philipp Baumeister, Thomas Kirchner, Claus Belka, Ute Ganswindt, Horst Zitzelsberger, Kristian Unger, Julia Hes. A prognostic mRNA expression signature of four 16q24.3 genes in radio(chemo)therapy-treated head and neck squamous cell carcinoma (HNSCC). Molecular oncology. vol 12. issue 12. 2019-08-23. PMID:30259648. |
subsequent pathway enrichment analysis of the network neighborhood (first and second) of the signature genes suggests involvement of hnscc-associated signaling pathways such as apoptosis, cell cycle, cell adhesion, egfr, jak-stat, and mtor. |
2019-08-23 |
2023-08-13 |
Not clear |
| Sanaz Naghizadeh, Ali Mohammadi, Behzad Baradaran, Behzad Mansoor. Overcoming multiple drug resistance in lung cancer using siRNA targeted therapy. Gene. vol 714. 2019-08-20. PMID:31301483. |
these genes may either be motivators of apoptosis inhibition, emt and dna repair system promoters or a member of intracellular signaling pathways, such as jak/stat, ras/raf/mek, pi3k/akt, nicd, b-catenin/tcf/lef and their stimulator receptors including igfr, egfr, fgfr, vegfr, cxcr4, met, integrins, notch1 and frizzled, so could be considered as appropriate targets. |
2019-08-20 |
2023-08-13 |
Not clear |
| Anastasia Tsagianni, Wendy M Mars, Bharat Bhushan, William C Bowen, Anne Orr, John Stoops, Shirish Paranjpe, George C Tseng, Silvia Liu, George K Michalopoulo. Combined Systemic Disruption of MET and Epidermal Growth Factor Receptor Signaling Causes Liver Failure in Normal Mice. The American journal of pathology. vol 188. issue 10. 2019-08-12. PMID:30031724. |
mice with combined disruption of met and egfr signaling mice showed decreased liver/body weight ratios, increased apoptosis in nonparenchymal cells, impaired liver metabolic functions, and activation of distinct downstream signaling pathways related to inflammation, cell death, and survival. |
2019-08-12 |
2023-08-13 |
mouse |
| Yanwei Su, Heng Luo, Jixin Yan. Heparin-binding EGF-like growth factor attenuates lung inflammation and injury in a murine model of pulmonary emphysema. Growth factors (Chur, Switzerland). vol 36. issue 5-6. 2019-08-08. PMID:30600734. |
we conclude that hb-egf attenuates lung inflammation and injury, probably through the activation of egfr, followed by suppression of nf-Κb signalling, promotion of cell proliferation, and inhibition of apoptosis. |
2019-08-08 |
2023-08-13 |
Not clear |
| Yan Zhuang, Jing Zhao, Xi Xu, Laixi B. Downregulation of GLUT3 Promotes Apoptosis and Chemosensitivity of Acute Myeloid Leukemia Cells via EGFR Signaling. Archives of Iranian medicine. vol 21. issue 2. 2019-08-05. PMID:29664658. |
downregulation of glut3 promotes apoptosis and chemosensitivity of acute myeloid leukemia cells via egfr signaling. |
2019-08-05 |
2023-08-13 |
Not clear |
| Francesco Canfarotta, Larissa Lezina, António Guerreiro, Joanna Czulak, Alexey Petukhov, Alexandra Daks, Katarzyna Smolinska-Kempisty, Alessandro Poma, Sergey Piletsky, Nickolai A Barle. Specific Drug Delivery to Cancer Cells with Double-Imprinted Nanoparticles against Epidermal Growth Factor Receptor. Nano letters. vol 18. issue 8. 2019-07-15. PMID:29969563. |
additionally, upon binding, doxorubicin-loaded anti-egfr nanomips elicited cytotoxicity and apoptosis only in those cells that over-expressed egfr. |
2019-07-15 |
2023-08-13 |
Not clear |
| Wanting Li, Qing Li, Liqun Wei, Xiaohang Pan, Daohang Huang, Jialiang Gan, Shuangyi Tan. Rosmarinic Acid Analogue-11 Induces Apoptosis of Human Gastric Cancer SGC-7901 Cells via the Epidermal Growth Factor Receptor (EGFR)/Akt/Nuclear Factor kappa B (NF-κB) Pathway. Medical science monitor basic research. vol 25. 2019-07-01. PMID:30799435. |
rosmarinic acid analogue-11 induces apoptosis of human gastric cancer sgc-7901 cells via the epidermal growth factor receptor (egfr)/akt/nuclear factor kappa b (nf-κb) pathway. |
2019-07-01 |
2023-08-13 |
human |
| Z Qi, B Zhang, J Zhang, Q Hu, F Xu, B Chen, C Zh. MicroRNA-30b inhibits non-small cell lung cancer cell growth by targeting the epidermal growth factor receptor. Neoplasma. vol 65. issue 2. 2019-06-26. PMID:29534579. |
then we investigated the ability of mir-30b to regulate egfr in several nsclc cell lines, and found that mir-30b inhibited proliferation, migration and invasion, induced apoptosis and enhanced sensitivity of the nsclc cells to egfr tyrosine kinase inhibitors (egfr-tkis) by targeting egfr and repressing egfr signaling pathways. |
2019-06-26 |
2023-08-13 |
Not clear |
| Chun-Hua Dai, Yang Shu, Ping Chen, Jian-Nong Wu, Li-Haun Zhu, Rong-Xia Yuan, Wei-Guo Long, Yu-Min Zhu, Jian L. YM155 sensitizes non-small cell lung cancer cells to EGFR-tyrosine kinase inhibitors through the mechanism of autophagy induction. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 12. 2019-06-24. PMID:30315932. |
in this study, we showed that ym155 markedly enhanced the sensitivity of erlotinib to egfr-tki resistant nsclc cell lines h1650 (egfr exon 19 deletion and pten loss) and a549 (egfr wild type and kras mutation) through inducing autophagy-dependent apoptosis and autophagic cell death. |
2019-06-24 |
2023-08-13 |
Not clear |
| Sachiko Nagasu, Tomoya Sudo, Tetsushi Kinugasa, Takatou Yomoda, Kenji Fujiyoshi, Takahiro Shigaki, Yoshito Akag. Y‑box‑binding protein 1 inhibits apoptosis and upregulates EGFR in colon cancer. Oncology reports. vol 41. issue 5. 2019-06-24. PMID:30864697. |
y‑box‑binding protein 1 inhibits apoptosis and upregulates egfr in colon cancer. |
2019-06-24 |
2023-08-13 |
Not clear |