| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francesco Canfarotta, Larissa Lezina, António Guerreiro, Joanna Czulak, Alexey Petukhov, Alexandra Daks, Katarzyna Smolinska-Kempisty, Alessandro Poma, Sergey Piletsky, Nickolai A Barle. Specific Drug Delivery to Cancer Cells with Double-Imprinted Nanoparticles against Epidermal Growth Factor Receptor. Nano letters. vol 18. issue 8. 2019-07-15. PMID:29969563. |
additionally, upon binding, doxorubicin-loaded anti-egfr nanomips elicited cytotoxicity and apoptosis only in those cells that over-expressed egfr. |
2019-07-15 |
2023-08-13 |
Not clear |
| Wanting Li, Qing Li, Liqun Wei, Xiaohang Pan, Daohang Huang, Jialiang Gan, Shuangyi Tan. Rosmarinic Acid Analogue-11 Induces Apoptosis of Human Gastric Cancer SGC-7901 Cells via the Epidermal Growth Factor Receptor (EGFR)/Akt/Nuclear Factor kappa B (NF-κB) Pathway. Medical science monitor basic research. vol 25. 2019-07-01. PMID:30799435. |
rosmarinic acid analogue-11 induces apoptosis of human gastric cancer sgc-7901 cells via the epidermal growth factor receptor (egfr)/akt/nuclear factor kappa b (nf-κb) pathway. |
2019-07-01 |
2023-08-13 |
human |
| Z Qi, B Zhang, J Zhang, Q Hu, F Xu, B Chen, C Zh. MicroRNA-30b inhibits non-small cell lung cancer cell growth by targeting the epidermal growth factor receptor. Neoplasma. vol 65. issue 2. 2019-06-26. PMID:29534579. |
then we investigated the ability of mir-30b to regulate egfr in several nsclc cell lines, and found that mir-30b inhibited proliferation, migration and invasion, induced apoptosis and enhanced sensitivity of the nsclc cells to egfr tyrosine kinase inhibitors (egfr-tkis) by targeting egfr and repressing egfr signaling pathways. |
2019-06-26 |
2023-08-13 |
Not clear |
| Chun-Hua Dai, Yang Shu, Ping Chen, Jian-Nong Wu, Li-Haun Zhu, Rong-Xia Yuan, Wei-Guo Long, Yu-Min Zhu, Jian L. YM155 sensitizes non-small cell lung cancer cells to EGFR-tyrosine kinase inhibitors through the mechanism of autophagy induction. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 12. 2019-06-24. PMID:30315932. |
in this study, we showed that ym155 markedly enhanced the sensitivity of erlotinib to egfr-tki resistant nsclc cell lines h1650 (egfr exon 19 deletion and pten loss) and a549 (egfr wild type and kras mutation) through inducing autophagy-dependent apoptosis and autophagic cell death. |
2019-06-24 |
2023-08-13 |
Not clear |
| Sachiko Nagasu, Tomoya Sudo, Tetsushi Kinugasa, Takatou Yomoda, Kenji Fujiyoshi, Takahiro Shigaki, Yoshito Akag. Y‑box‑binding protein 1 inhibits apoptosis and upregulates EGFR in colon cancer. Oncology reports. vol 41. issue 5. 2019-06-24. PMID:30864697. |
y‑box‑binding protein 1 inhibits apoptosis and upregulates egfr in colon cancer. |
2019-06-24 |
2023-08-13 |
Not clear |
| Sachiko Nagasu, Tomoya Sudo, Tetsushi Kinugasa, Takatou Yomoda, Kenji Fujiyoshi, Takahiro Shigaki, Yoshito Akag. Y‑box‑binding protein 1 inhibits apoptosis and upregulates EGFR in colon cancer. Oncology reports. vol 41. issue 5. 2019-06-24. PMID:30864697. |
these results indicated that yb‑1 plays an important role in cell proliferation, migration, apoptosis and egfr expression in colorectal cancer. |
2019-06-24 |
2023-08-13 |
Not clear |
| Sachiko Nagasu, Tomoya Sudo, Tetsushi Kinugasa, Takatou Yomoda, Kenji Fujiyoshi, Takahiro Shigaki, Yoshito Akag. Y‑box‑binding protein 1 inhibits apoptosis and upregulates EGFR in colon cancer. Oncology reports. vol 41. issue 5. 2019-06-24. PMID:30864697. |
furthermore, apoptosis and egfr expression may be affected by the mutational status of ras/raf and controlled through yb‑1. |
2019-06-24 |
2023-08-13 |
Not clear |
| Suchismita Daw, Aditya Law, Sujata La. Myelodysplastic Syndrome related alterations of MAPK signaling in the bone marrow of experimental mice including stem/progenitor compartment. Acta histochemica. vol 121. issue 3. 2019-06-11. PMID:30808519. |
the phospho-protein status of rtk's(flt3, pdgfr, egfr) were markedly increased that activated mapk signaling proteins which finally executed their tasks by transcription of c-myc and rb leading to uncontrolled cellular proliferation, simultaneously the activated c-jun revealed stress related apoptosis. |
2019-06-11 |
2023-08-13 |
mouse |
| Jonathan P Robson, Bettina Wagner, Elisabeth Glitzner, Frank L Heppner, Thomas Steinkellner, Deeba Khan, Claudia Petritsch, Daniela D Pollak, Harald H Sitte, Maria Sibili. Impaired neural stem cell expansion and hypersensitivity to epileptic seizures in mice lacking the EGFR in the brain. The FEBS journal. vol 285. issue 17. 2019-06-10. PMID:30028091. |
mice lacking the epidermal growth factor receptor (egfr) develop an early postnatal degeneration of the frontal cortex and olfactory bulbs and show increased cortical astrocyte apoptosis. |
2019-06-10 |
2023-08-13 |
mouse |
| Priscila Chediek Dall'Acqua, Giovana Barros Nunes, Cíntia Rodrigues da Silva, Patrícia Kubo Fontes, Marcelo Fábio Gouveia Nogueira, Flávia Lombardi Lopes, Márcia Marinho, Gisele Zoccal Mingot. Differences in embryonic gene expression and quality indicate the benefit of epidermal growth factor receptor inhibitor during prematuration to improve competence in bovine oocytes. Reproduction in domestic animals = Zuchthygiene. vol 54. issue 4. 2019-05-29. PMID:30658018. |
here, we used an egfr inhibitor (ag1478) to inhibit spontaneous meiosis resumption in bovine oocytes (egfr- group) during 8 hr prematuration and assessed the competence of such oocytes for embryonic development, apoptosis and gene expression in comparison with control group which was not prematured. |
2019-05-29 |
2023-08-13 |
cattle |
| Hyun-Ji Park, Tae-Rin Min, Gyoo-Yong Chi, Yung-Hyun Choi, Shin-Hyung Par. Induction of apoptosis by morusin in human non-small cell lung cancer cells by suppression of EGFR/STAT3 activation. Biochemical and biophysical research communications. vol 505. issue 1. 2019-05-28. PMID:30243717. |
taken together, our results demonstrate that morusin induced apoptosis in human nsclc cells regardless of egfr mutation status through inhibition of egfr/stat3 activation. |
2019-05-28 |
2023-08-13 |
human |
| Yu Zhang, Liang Tao, Li-Xia Fan, Kun Huang, Hui-Min Luo, Hui Ge, Xiyan Wang, Qin Wan. Cx32 mediates cisplatin resistance in human ovarian cancer cells by affecting drug efflux transporter expression and activating the EGFR‑Akt pathway. Molecular medicine reports. vol 19. issue 3. 2019-05-23. PMID:30664215. |
when cx32 was overexpressed in a2780 cells, an opposite effect on the expression of efflux transporters (mrp‑2 and atp7a) and the activation of the egfr signalling pathway was observed, which resulted in insensitivity to cisplatin‑induced apoptosis. |
2019-05-23 |
2023-08-13 |
human |
| Leticia Vicosa Pires, Yuyin Yi, Jung-Chien Cheng, Lolita Schneider Pizzolato, Elvira Cordero, Peter C K Leung, Ilma Simoni Bru. Lapatinib Inhibits Amphiregulin-induced BeWo Choriocarcinoma Cell Proliferation by Reducing ERK1/2 and AKT Signaling Pathways. Anticancer research. vol 39. issue 5. 2019-05-23. PMID:31092430. |
lapatinib is a potent egfr and human epidermal growth factor receptor 2 (her2) inhibitor that inhibits cell proliferation and induces apoptosis in various human cancer cells. |
2019-05-23 |
2023-08-13 |
human |
| Swamy K Tripurani, Yan Wang, Ying-Xin Fan, Massod Rahimi, Lily Wong, Min-Hyung Lee, Matthew F Starost, Jeffrey S Rubin, Gibbes R Johnso. Suppression of Wnt/β-catenin signaling by EGF receptor is required for hair follicle development. Molecular biology of the cell. vol 29. issue 22. 2019-05-17. PMID:30188763. |
genetic ablation of egfr in mice resulted in increased mitotic activity in matrix cells, apoptosis in hair follicles, and impaired differentiation of epithelial lineages that form hair. |
2019-05-17 |
2023-08-13 |
mouse |
| Khyati N Shah, Roma Bhatt, Julia Rotow, Julia Rohrberg, Victor Olivas, Victoria E Wang, Golzar Hemmati, Maria M Martins, Ashley Maynard, Jonathan Kuhn, Jacqueline Galeas, Hayley J Donnella, Swati Kaushik, Angel Ku, Sophie Dumont, Gregor Krings, Henry J Haringsma, Liliane Robillard, Andrew D Simmons, Thomas C Harding, Frank McCormick, Andrei Goga, Collin M Blakely, Trever G Bivona, Sourav Bandyopadhya. Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer. Nature medicine. vol 25. issue 1. 2019-05-10. PMID:30478424. |
nongenetic resistance through the activation of aurka by its coactivator tpx2 emerges in response to chronic egfr inhibition where it mitigates drug-induced apoptosis. |
2019-05-10 |
2023-08-13 |
Not clear |
| Aleksandra Omari, Paulina Nastały, Sara Stoupiec, Aneta Bałabas, Michalina Dąbrowska, Beata Bielińska, Sebastian Huss, Klaus Pantel, Axel Semjonow, Elke Eltze, Burkhard Brandt, Natalia Bednarz-Knol. Somatic aberrations of BRCA1 gene are associated with ALDH1, EGFR, and tumor progression in prostate cancer. International journal of cancer. vol 144. issue 3. 2019-04-22. PMID:30265376. |
it was compared to clinico-pathological parameters, patients' outcome as well as selected proteins (ki-67, apoptosis marker, cytokeratins, vimentin, e- and n-cadherin, aldh1 and egfr) examined immunohistochemically. |
2019-04-22 |
2023-08-13 |
Not clear |
| Manisha Majhi, Meer Asif Ali, Akanksha Limaye, Kritika Sinha, Praveena Bairagi, Megha Chouksey, Ruchi Shukla, Nisha Kanwar, Tajamul Hussain, Anuraj Nayarisseri, Sanjeev Kumar Sing. An In Silico Investigation of Potential EGFR Inhibitors for the Clinical Treatment of Colorectal Cancer. Current topics in medicinal chemistry. vol 18. issue 27. 2019-04-08. PMID:30499396. |
epidermal growth factor receptor (egfr), a transmembrane protein, participates in plc gamma-1, ras-raf-mek-mapks, phosphatidylinositol-3 kinase, akt pathways and plays a key role in normal functioning of cell division, cell differentiation, apoptosis and migration. |
2019-04-08 |
2023-08-13 |
Not clear |
| Liying Wang, Hongfeng Zhang, Jiaxin Zheng, Xiaoli Wei, Jingwen Du, Haibo Lu, Qiuying Sun, Weiyu Zhou, Rui Zhang, Yu Ha. Dual silencing of EGFR and HER2 enhances the sensitivity of gastric cancer cells to gefitinib. Molecular carcinogenesis. vol 57. issue 8. 2019-03-26. PMID:29637613. |
in contrast, resistance to her2-sirna-induced growth inhibition and apoptosis was linked to compensatory activation of egfr. |
2019-03-26 |
2023-08-13 |
Not clear |
| Hui-Ping Ma, Wei-Xiang Kong, Xiu-Ying Li, Wei Li, Yan Zhang, Yan W. miRNA-223 is an anticancer gene in human non-small cell lung cancer through the PI3K/AKT pathway by targeting EGFR. Oncology reports. vol 41. issue 3. 2019-03-06. PMID:30747217. |
thus, a new pathway has been identified in the present study, and application of mirna-223 may induce the apoptosis of nsclc through the pi3k/akt pathway by egfr. |
2019-03-06 |
2023-08-13 |
human |
| Rong Yan, Kang Li, Da-Wei Yuan, Hao-Nan Wang, Yong Zhang, Cheng-Xue Dang, Kun Zh. Downregulation of microRNA-4295 enhances cisplatin-induced gastric cancer cell apoptosis through the EGFR/PI3K/Akt signaling pathway by targeting LRIG1. International journal of oncology. vol 53. issue 6. 2019-03-04. PMID:30320337. |
the aim of the present study was to investigate the mechanism of microrna-4295 (mir-4295), which regulates cisplatin (ddp)-induced apoptosis in gc cells through the leucine-rich repeats and immunoglobulin-like domains 1 (lrig1)-mediated epidermal growth factor receptor (egfr)/phosphoinositide 3-kinase (pi3k)/protein kinase b (akt) signaling pathway. |
2019-03-04 |
2023-08-13 |
human |