| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ulrich Baumgartner, Fabienne Berger, Ali Hashemi Gheinani, Sabrina Sofia Burgener, Katia Monastyrskaya, Erik Vassell. miR-19b enhances proliferation and apoptosis resistance via the EGFR signaling pathway by targeting PP2A and BIM in non-small cell lung cancer. Molecular cancer. vol 17. issue 1. 2019-01-22. PMID:29455644. |
mir-19b enhances proliferation and apoptosis resistance via the egfr signaling pathway by targeting pp2a and bim in non-small cell lung cancer. |
2019-01-22 |
2023-08-13 |
Not clear |
| Ulrich Baumgartner, Fabienne Berger, Ali Hashemi Gheinani, Sabrina Sofia Burgener, Katia Monastyrskaya, Erik Vassell. miR-19b enhances proliferation and apoptosis resistance via the EGFR signaling pathway by targeting PP2A and BIM in non-small cell lung cancer. Molecular cancer. vol 17. issue 1. 2019-01-22. PMID:29455644. |
epidermal growth factor receptor (egfr) mutations enable constitutive active downstream signaling of pi3k/akt, kras/erk and jak/stat pathways, and promote tumor progression by inducing uncontrolled proliferation, evasion of apoptosis and migration of non-small cell lung cancer (nsclc). |
2019-01-22 |
2023-08-13 |
Not clear |
| Jiunn-Liang Ko, Ching-Hsiung Lin, Heng-Chung Chen, Wei-Heng Hung, Peng-Ju Chien, Hui-Yi Chang, Bing-Yen Wan. Effects and mechanisms of betulinic acid on improving EGFR TKI-resistance of lung cancer cells. Environmental toxicology. vol 33. issue 11. 2019-01-22. PMID:30136359. |
based on flow cytometry, combination treatments of beta with an egfr tki enhanced sub-g1 accumulation, induced apoptosis and induced mitochondrial membrane potential loss. |
2019-01-22 |
2023-08-13 |
Not clear |
| Xiaohui Yan, Pengfei Li, Yihong Zhan, Miao Qi, Jin Liu, Zhifeng An, Weiwei Yang, Hui Xiao, Hongmei Wu, Yitao Qi, Huanjie Sha. Dihydroartemisinin suppresses STAT3 signaling and Mcl-1 and Survivin expression to potentiate ABT-263-induced apoptosis in Non-small Cell Lung Cancer cells harboring EGFR or RAS mutation. Biochemical pharmacology. vol 150. 2019-01-09. PMID:29360439. |
dihydroartemisinin suppresses stat3 signaling and mcl-1 and survivin expression to potentiate abt-263-induced apoptosis in non-small cell lung cancer cells harboring egfr or ras mutation. |
2019-01-09 |
2023-08-13 |
mouse |
| Xiaohui Yan, Pengfei Li, Yihong Zhan, Miao Qi, Jin Liu, Zhifeng An, Weiwei Yang, Hui Xiao, Hongmei Wu, Yitao Qi, Huanjie Sha. Dihydroartemisinin suppresses STAT3 signaling and Mcl-1 and Survivin expression to potentiate ABT-263-induced apoptosis in Non-small Cell Lung Cancer cells harboring EGFR or RAS mutation. Biochemical pharmacology. vol 150. 2019-01-09. PMID:29360439. |
together, dha effectively inhibits stat3 activity and modulates expression of mcl-1, survivin and bim, thereby synergizing with abt-263 to trigger apoptosis in nsclc cells harboring egfr or ras mutation. |
2019-01-09 |
2023-08-13 |
mouse |
| Zhaohui Dong, Lanying Zhang, Wei Xu, Gensheng Zhan. EGFR may participate in immune evasion through regulation of B7‑H5 expression in non‑small cell lung carcinoma. Molecular medicine reports. vol 18. issue 4. 2019-01-09. PMID:30106102. |
the expression levels of egfr, b7‑h5, survivin, apoptosis regulator bax, apoptosis regulator bcl‑2 (bcl‑2), tgf‑β, vascular endothelial growth factor (vegf), il‑10 and cyclooxygenase (cox)‑2 were assessed via quantitative pcr and western blotting. |
2019-01-09 |
2023-08-13 |
Not clear |
| Zhaohui Dong, Lanying Zhang, Wei Xu, Gensheng Zhan. EGFR may participate in immune evasion through regulation of B7‑H5 expression in non‑small cell lung carcinoma. Molecular medicine reports. vol 18. issue 4. 2019-01-09. PMID:30106102. |
inhibition of egfr expression via gene silencing and egfr inhibition markedly decreased cell viability and increased the apoptosis of nci‑h1299 cells, by upregulating survivin and bcl‑2 expression. |
2019-01-09 |
2023-08-13 |
Not clear |
| Yang-Ling Li, Xiu Hu, Qing-Yu Li, Fei Wang, Bo Zhang, Ke Ding, Bi-Qin Tan, Neng-Ming Lin, Chong Zhan. Shikonin sensitizes wild‑type EGFR NSCLC cells to erlotinib and gefitinib therapy. Molecular medicine reports. vol 18. issue 4. 2019-01-09. PMID:30106133. |
furthermore, shikonin could potentiate mitochondrial‑mediated apoptosis induced by erlotinib/gefitinib in wild‑type egfr nsclc cells. |
2019-01-09 |
2023-08-13 |
Not clear |
| Yang-Ling Li, Xiu Hu, Qing-Yu Li, Fei Wang, Bo Zhang, Ke Ding, Bi-Qin Tan, Neng-Ming Lin, Chong Zhan. Shikonin sensitizes wild‑type EGFR NSCLC cells to erlotinib and gefitinib therapy. Molecular medicine reports. vol 18. issue 4. 2019-01-09. PMID:30106133. |
in addition, the present study demonstrated that shikonin could induce apoptosis by activating reactive oxygen species (ros)‑mediated endoplasmic reticulum (er) stress, and that erlotinib/gefitinib may also induce er stress in wild‑type egfr nsclc cells; however, shikonin plus erlotinib/gefitinib was more effective in activating er stress than either agent alone. |
2019-01-09 |
2023-08-13 |
Not clear |
| Francesco Agustoni, Kenichi Suda, Hui Yu, Shengxiang Ren, Christopher J Rivard, Kim Ellison, Charles Caldwell, Leslie Rozeboom, Kristine Brovsky, Fred R Hirsc. EGFR-directed monoclonal antibodies in combination with chemotherapy for treatment of non-small-cell lung cancer: an updated review of clinical trials and new perspectives in biomarkers analysis. Cancer treatment reviews. vol 72. 2019-01-07. PMID:30445271. |
activation of the epidermal growth factor receptor (egfr)-pathway promotes tumor growth and progression, including angiogenesis, invasion, metastasis and inhibition of apoptosis, providing a strong rationale for targeting this pathway. |
2019-01-07 |
2023-08-13 |
Not clear |
| Sang Eun Park, Dong Eun Kim, Mi Joung Kim, Jee Suk Lee, Jin Kyung Rho, Seong-Yun Jeong, Eun Kyung Choi, Choung-Soo Kim, Jung Jin Hwan. Vorinostat enhances gefitinib‑induced cell death through reactive oxygen species‑dependent cleavage of HSP90 and its clients in non‑small cell lung cancer with the EGFR mutation. Oncology reports. vol 41. issue 1. 2018-12-28. PMID:30365122. |
the treatment using a combination of vorinostat and gefitinib was more potent in promoting cell death by activating apoptosis than gefitinib alone in parental pc9 cells that harbor an egfr‑activating mutation (egfr exon 19 deletion) and gefitinib‑resistant pc9 cells (pc9gr) with an egfr t790m mutation. |
2018-12-28 |
2023-08-13 |
Not clear |
| Jinhua Dong, Yunfei Cao, Huaxiang Shen, Qiang Ma, Shuhui Mao, Suping Li, Jin Su. EGFR aptamer-conjugated liposome-polycation-DNA complex for targeted delivery of SATB1 small interfering RNA to choriocarcinoma cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 107. 2018-12-24. PMID:30142547. |
the results showed that egfr-lpds could specifically target choriocarcinoma cells, resulting in significant inhibition of satb1 expression, growth inhibitory effect and apoptosis in egfr over-expressing choriocarcinoma cells in vitro. |
2018-12-24 |
2023-08-13 |
mouse |
| Xianfeng Qu, Li Yang, Qingqing Shi, Xiaofei Wang, Dongguo Wang, Guiyang W. Lidocaine inhibits proliferation and induces apoptosis in colorectal cancer cells by upregulating mir-520a-3p and targeting EGFR. Pathology, research and practice. vol 214. issue 12. 2018-12-18. PMID:30262429. |
lidocaine inhibits proliferation and induces apoptosis in colorectal cancer cells by upregulating mir-520a-3p and targeting egfr. |
2018-12-18 |
2023-08-13 |
Not clear |
| Xianfeng Qu, Li Yang, Qingqing Shi, Xiaofei Wang, Dongguo Wang, Guiyang W. Lidocaine inhibits proliferation and induces apoptosis in colorectal cancer cells by upregulating mir-520a-3p and targeting EGFR. Pathology, research and practice. vol 214. issue 12. 2018-12-18. PMID:30262429. |
micrornas (mirnas) have been consistently demonstrated to be involved in crc, and mir-520a-3p could suppress crc migration, promote apoptosis by targeting epidermal growth factor receptor (egfr). |
2018-12-18 |
2023-08-13 |
Not clear |
| Xianfeng Qu, Li Yang, Qingqing Shi, Xiaofei Wang, Dongguo Wang, Guiyang W. Lidocaine inhibits proliferation and induces apoptosis in colorectal cancer cells by upregulating mir-520a-3p and targeting EGFR. Pathology, research and practice. vol 214. issue 12. 2018-12-18. PMID:30262429. |
the results suggested that lidocaine could suppress the expression of egfr by upregulating mir-520a-3p, and it could induce apoptosis and inhibit proliferation in crc cells. |
2018-12-18 |
2023-08-13 |
Not clear |
| Chengxiang Qiu, Robert L Hanson, Gudeta Fufaa, Sayuko Kobes, Caroline Gluck, Jing Huang, Yong Chen, Dominic Raj, Robert G Nelson, William C Knowler, Katalin Suszta. Cytosine methylation predicts renal function decline in American Indians. Kidney international. vol 93. issue 6. 2018-12-17. PMID:29709239. |
probes at which methylation significantly associated with egfr decline were localized to gene regulatory regions and enriched for genes with metabolic functions and apoptosis. |
2018-12-17 |
2023-08-13 |
human |
| Fan Zhang, Xin Ma, Hongzhao Li, Yu Zhang, Xintao Li, Luyao Chen, Gang Guo, Yu Gao, Liangyou Gu, Yongpeng Xie, Junyao Duan, Xu Zhan. FOXK2 suppresses the malignant phenotype and induces apoptosis through inhibition of EGFR in clear-cell renal cell carcinoma. International journal of cancer. vol 142. issue 12. 2018-12-11. PMID:29368368. |
foxk2 suppresses the malignant phenotype and induces apoptosis through inhibition of egfr in clear-cell renal cell carcinoma. |
2018-12-11 |
2023-08-13 |
Not clear |
| Fan Zhang, Xin Ma, Hongzhao Li, Yu Zhang, Xintao Li, Luyao Chen, Gang Guo, Yu Gao, Liangyou Gu, Yongpeng Xie, Junyao Duan, Xu Zhan. FOXK2 suppresses the malignant phenotype and induces apoptosis through inhibition of EGFR in clear-cell renal cell carcinoma. International journal of cancer. vol 142. issue 12. 2018-12-11. PMID:29368368. |
overexpression of egfr is able to rescue the inhibited proliferation capacity and the enhanced apoptosis capacity due to the overexpression of foxk2 in 769-p cells. |
2018-12-11 |
2023-08-13 |
Not clear |
| I-Lun Hsin, Jen-Chieh Hsu, Wen-Jun Wu, Hsueh-Ju Lu, Ming-Fang Wu, Jiunn-Liang K. GMI, a fungal immunomodulatory protein from Ganoderma microsporum, induce apoptosis via β-catenin suppression in lung cancer cells. Environmental toxicology. vol 33. issue 9. 2018-12-11. PMID:29974605. |
gmi induced apoptosis in lung cancer cells bearing wild-type and mutated egfr. |
2018-12-11 |
2023-08-13 |
Not clear |
| Yi Mu, Deyu Su. Lapatinib, a Dual Inhibitor of Epidermal Growth Factor Receptor (EGFR) and HER-2, Enhances Radiosensitivity in Mouse Bladder Tumor Line-2 (MBT-2) Cells In Vitro and In Vivo. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-12-11. PMID:30125265. |
conclusions lapatinib treatment enhanced the radiation sensitivity in an in vitro and in vivo murine bladder cancer model by decreasing radiation-mediated egfr and her-2 activation, and by causing dna damage leading to cell apoptosis. |
2018-12-11 |
2023-08-13 |
mouse |