| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Martin Steins, Michael Thomas, Michael Geißle. Erlotinib. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer. vol 211. 2018-11-13. PMID:30069756. |
the epidermal growth factor receptor (egfr) has been implicated in a multiplicity of cancer-related signal transduction pathways like cellular proliferation, adhesion, migration, neoangiogenesis and apoptosis inhibition, all of which are important features of cancerogenesis and tumour progression. |
2018-11-13 |
2023-08-13 |
Not clear |
| Jin Zhou, Zhong Wu, Gabrielle Wong, Eirini Pectasides, Ankur Nagaraja, Matthew Stachler, Haikuo Zhang, Ting Chen, Haisheng Zhang, Jie Bin Liu, Xinsen Xu, Ewa Sicinska, Francisco Sanchez-Vega, Anil K Rustgi, J Alan Diehl, Kwok-Kin Wong, Adam J Bas. CDK4/6 or MAPK blockade enhances efficacy of EGFR inhibition in oesophageal squamous cell carcinoma. Nature communications. vol 8. 2018-11-09. PMID:28059068. |
we demonstrate that blockade of this rebound activation with mek (mitogen-activated protein kinase kinase) inhibition enhances egfr inhibitor-induced apoptosis and cell cycle arrest, and delays resistance to egfr monotherapy. |
2018-11-09 |
2023-08-13 |
Not clear |
| Yi Liu, Kai He, Ying Hu, Xiaojie Guo, Dongmei Wang, Weiwei Shi, Jingsong Li, Jianguo Son. YAP modulates TGF-β1-induced simultaneous apoptosis and EMT through upregulation of the EGF receptor. Scientific reports. vol 7. 2018-11-09. PMID:28425446. |
knockdown or inhibition of egfr abolished the suppressive effect of yap on apoptosis, whereas activation of egfr by egf significantly reduced apoptosis caused by the knockdown of yap. |
2018-11-09 |
2023-08-13 |
mouse |
| Yi Liu, Kai He, Ying Hu, Xiaojie Guo, Dongmei Wang, Weiwei Shi, Jingsong Li, Jianguo Son. YAP modulates TGF-β1-induced simultaneous apoptosis and EMT through upregulation of the EGF receptor. Scientific reports. vol 7. 2018-11-09. PMID:28425446. |
the results indicate that egfr and its activation are critical for yap-mediated suppression of tgf-β1-induced apoptosis. |
2018-11-09 |
2023-08-13 |
mouse |
| Fuzhi Ji, Huizi Sha, Fanyan Meng, Anqing Zhu, Naiqing Ding, Hang Zhang, Hui Xu, Hanqing Qian, Lixia Yu, Qizhan Liu, Baorui Li. Tumor‑penetrating peptide fused EGFR single‑domain antibody enhances radiation responses following EGFR inhibition in gastric cancer. Oncology reports. vol 40. issue 3. 2018-11-02. PMID:29956805. |
the radioenhancement of anti‑egfr‑irgd was associated with inhibited radiation‑induced upregulation of egfr, inhibited cell proliferation and promotion of cell apoptosis. |
2018-11-02 |
2023-08-13 |
Not clear |
| Venugopal Vinod Prabhu, Perumal Elangovan, Sivasithambaram Niranjali Devaraj, Kunnathur Murugesan Sakthive. Targeting apoptosis by 1,2-diazole through regulation of EGFR, Bcl-2 and CDK-2 mediated signaling pathway in human non-small cell lung carcinoma A549 cells. Gene. vol 679. 2018-10-22. PMID:30218747. |
targeting apoptosis by 1,2-diazole through regulation of egfr, bcl-2 and cdk-2 mediated signaling pathway in human non-small cell lung carcinoma a549 cells. |
2018-10-22 |
2023-08-13 |
human |
| Venugopal Vinod Prabhu, Perumal Elangovan, Sivasithambaram Niranjali Devaraj, Kunnathur Murugesan Sakthive. Targeting apoptosis by 1,2-diazole through regulation of EGFR, Bcl-2 and CDK-2 mediated signaling pathway in human non-small cell lung carcinoma A549 cells. Gene. vol 679. 2018-10-22. PMID:30218747. |
in the present study the anti-cancer mechanism of pyrazole, was examined by the expression level of proteins epidermal growth factor receptor (egfr), bcl-2-associated x protein (bax), b-cell lymphoma-2 (bcl-2) and cyclin-dependent kinase-2 (cdk-2) which are commonly associated with the cell signaling pathways that control cell survival and apoptosis, that could facilitate to develop a novel target and effective treatment approach for patients with nsclc. |
2018-10-22 |
2023-08-13 |
human |
| Venugopal Vinod Prabhu, Perumal Elangovan, Sivasithambaram Niranjali Devaraj, Kunnathur Murugesan Sakthive. Targeting apoptosis by 1,2-diazole through regulation of EGFR, Bcl-2 and CDK-2 mediated signaling pathway in human non-small cell lung carcinoma A549 cells. Gene. vol 679. 2018-10-22. PMID:30218747. |
pyrazole significantly induced cell cycle arrest and initiated apoptosis through inhibition of downstream components of egfr tyrosine kinase pathway. |
2018-10-22 |
2023-08-13 |
human |
| Devesh M Sawant, Shivani Sharma, Ramdas S Pathare, Gaurav Joshi, Sourav Kalra, Sukanya Sukanya, Antim K Maurya, Ramesh K Metre, Vijai K Agnihotri, Shahnawaz Khan, Raj Kumar, R T Pardasan. Relay tricyclic Pd(ii)/Ag(i) catalysis: design of a four-component reaction driven by nitrene-transfer on isocyanide yields inhibitors of EGFR. Chemical communications (Cambridge, England). vol 54. issue 82. 2018-10-11. PMID:30137112. |
the relay catalysis enables four-component assembly of pyrazolo[1,5-c]quinazolines that selectively inhibit egfr, exhibit apoptosis through the ros-induced mitochondrial-mediated pathway, and arrest the cell cycle at the g1 phase. |
2018-10-11 |
2023-08-13 |
Not clear |
| Xianxiang Zhang, Guangwei Liu, Lei Ding, Tao Jiang, Shihong Shao, Yuan Gao, Yun L. HOXA3 promotes tumor growth of human colon cancer through activating EGFR/Ras/Raf/MEK/ERK signaling pathway. Journal of cellular biochemistry. vol 119. issue 3. 2018-10-09. PMID:29073728. |
hoxa3 knockdown could not induce the increase of cell apoptosis on the condition of egfr overexpression. |
2018-10-09 |
2023-08-13 |
mouse |
| Kazutoshi Isobe, Atsushi Kakimoto, Tetuo Mikami, Kyohei Kaburaki, Hiroshi Kobayashi, Takahiro Yoshizawa, Yuta Nakano, Takashi Makino, Hajime Otsuka, Go Sano, Keishi Sugino, Susumu Sakamoto, Yujiro Takai, Naobumi Tochigi, Akira Iyoda, Sakae Homm. PD-L1 mRNA expression in EGFR-mutant lung adenocarcinoma. Oncology reports. vol 40. issue 1. 2018-09-27. PMID:29767258. |
molecular mechanisms of programmed death-ligand 1 (pd-l1) mrna expression and roles of apoptosis and biomarkers are poorly understood in epidermal growth factor receptor (egfr)-mutant lung adenocarcinoma patients. |
2018-09-27 |
2023-08-13 |
human |
| Kazutoshi Isobe, Atsushi Kakimoto, Tetuo Mikami, Kyohei Kaburaki, Hiroshi Kobayashi, Takahiro Yoshizawa, Yuta Nakano, Takashi Makino, Hajime Otsuka, Go Sano, Keishi Sugino, Susumu Sakamoto, Yujiro Takai, Naobumi Tochigi, Akira Iyoda, Sakae Homm. PD-L1 mRNA expression in EGFR-mutant lung adenocarcinoma. Oncology reports. vol 40. issue 1. 2018-09-27. PMID:29767258. |
correlations of pd-l1 mrna expression with bim, p53 upregulated modular of apoptosis (puma), human epidermal growth factor receptor 2 (her2), mesenchymal-epithelial transition (met), egfr, and vascular endothelial growth factor a (vegfa) were determined. |
2018-09-27 |
2023-08-13 |
human |
| Zhaomeng Wu, Qingyi Zhu, Yu Zhang, Yingying Yin, Dan Kang, Runyi Cao, Qian Tian, Shan Lu, Ping Li. EGFR‑associated pathways involved in traditional Chinese medicine (TCM)‑1‑induced cell growth inhibition, autophagy and apoptosis in prostate cancer. Molecular medicine reports. vol 17. issue 6. 2018-09-26. PMID:29620175. |
inhibition of egfr further suppressed the downstream phosphatidylinositol 3‑kinase (pi3k)/rac‑α serine/threonine‑protein kinase (akt) and raf proto‑oncogene serine/threonine‑protein kinase/extracellular signal regulated kinase signaling pathways and resulted in a decrease in the phosphorylated‑forkhead box protein o1 (at ser256, thr24 and ser319) expression level, and induced cell growth inhibition and apoptosis by regulating the expression of apoptosis‑and cell cycle‑associated genes. |
2018-09-26 |
2023-08-13 |
mouse |
| L Wu, F Xu, B M Reinhar. Nanoconjugation prolongs endosomal signaling of the epidermal growth factor receptor and enhances apoptosis. Nanoscale. vol 8. issue 28. 2018-09-21. PMID:27378391. |
we demonstrate that nanoconjugation prolongs the dwell time of phosphorylated receptors in the early endosomes and that the retention of activated egfr in the early endosomes is accompanied by an egf mediated apoptosis at effective concentrations that do not induce apoptosis in the case of free egf. |
2018-09-21 |
2023-08-13 |
human |
| Xiaofan Chen, Guangxian Mao, Hua Chen, Suyue Liu, Sichao Wang, Xiaoqiang Li, Yiwang Ye, Hao Wu, Jixian Li. TW37 enhances the pro-apoptosis and anti-migration ability of gefitinib in Non-Small Cell Lung Cancer. Cellular and molecular biology (Noisy-le-Grand, France). vol 64. issue 4. 2018-09-11. PMID:29631678. |
moreover, tw37 can promote apoptosis ability by inhibiting the phosphorylation level of egfr protein in h1975 cells. |
2018-09-11 |
2023-08-13 |
Not clear |
| Bin Li, Cui-Min Ding, Yan-Xiao Li, Jing-Cui Peng, Nan Geng, Wen-Wen Qi. Over-regulation of microRNA-133b inhibits cell proliferation of cisplatin-induced non-small cell lung cancer cells through PI3K/Akt and JAK2/STAT3 signaling pathway by targeting EGFR. Oncology reports. vol 39. issue 3. 2018-08-30. PMID:29344640. |
over-regulation of microrna-133b inhibited cell proliferation and ldh activity, induced apoptosis and caspase-3 activity, suppressed the protein expression of egfr, pi3k, p-akt, p-jak2 and p-stat3, decreased cyclin d1 and increased bax protein expression in cisplatin‑induced a549 cells. |
2018-08-30 |
2023-08-13 |
Not clear |
| Bin Li, Cui-Min Ding, Yan-Xiao Li, Jing-Cui Peng, Nan Geng, Wen-Wen Qi. Over-regulation of microRNA-133b inhibits cell proliferation of cisplatin-induced non-small cell lung cancer cells through PI3K/Akt and JAK2/STAT3 signaling pathway by targeting EGFR. Oncology reports. vol 39. issue 3. 2018-08-30. PMID:29344640. |
egfr inhibitor (lapatinib) suppressed egfr protein expression, inhibited cell proliferation and ldh activity, and induced apoptosis and caspase-3 activity in cisplatin-induced a549 cells by over-regulation of microrna-133b. |
2018-08-30 |
2023-08-13 |
Not clear |
| Zheng Shi, Jie Chen, Xiaolan Guo, Lijia Cheng, Xiaoheng Guo, Tian Y. Journal of cancer research and therapeutics. vol 14. issue 1. 2018-08-30. PMID:29516953. |
the receptor tyrosine kinase of the epidermal growth factor receptor (egfr, erbb) family played an important role in multisignaling pathways, which controlled numerous biological activities including proliferation, differentiation, apoptosis, etc. |
2018-08-30 |
2023-08-13 |
human |
| Yu Saito, Shota Moriya, Hiromi Kazama, Kazuhiro Hirasawa, Kana Miyahara, Hiroko Kokuba, Hirotsugu Hino, Hiroyuki Kikuchi, Naoharu Takano, Masaki Hiramoto, Kiyoaki Tsukahara, Keisuke Miyazaw. Amino acid starvation culture condition sensitizes EGFR-expressing cancer cell lines to gefitinib-mediated cytotoxicity by inducing atypical necroptosis. International journal of oncology. vol 52. issue 4. 2018-08-23. PMID:29484439. |
since epidermal growth factor receptor (egfr)-tyrosine kinase inhibitors, including gefitinib (gef) have been reported to induce the apoptosis of several cancer cell lines, in the present study, we examined whether the cytotoxic effects of gef are further enhanced under amino acid starvation (aas) culture conditions. |
2018-08-23 |
2023-08-13 |
Not clear |
| Yuji Sakum. Epithelial-to-mesenchymal transition and its role in EGFR-mutant lung adenocarcinoma and idiopathic pulmonary fibrosis. Pathology international. vol 67. issue 8. 2018-08-15. PMID:28678431. |
lung adenocarcinoma cells with activating epidermal growth factor receptor (egfr) mutations are highly dependent upon egfr signaling for survival and undergo apoptosis when egfr signaling is inhibited by tyrosine kinase inhibitor (tki) treatment. |
2018-08-15 |
2023-08-13 |
Not clear |