| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dahye Jang, Yu Mi Baek, Hanna Park, Yeo Eun Hwang, Dong-Eun Ki. Dual effects of a CpG-DNAzyme targeting mutant EGFR transcripts in lung cancer cells: TLR9 activation and EGFR downregulation. BMB reports. vol 51. issue 1. 2018-08-15. PMID:28893372. |
thus, dual effects of this dnazyme harboring the cpg site, such as tlr9 activation and egfr downregulation, leads to apoptosis of egfr-mutated nsclc cells. |
2018-08-15 |
2023-08-13 |
Not clear |
| Jing Wang, Hu-Shan Wang, Zhen-Bo S. MicroRNA-142 Inhibits Proliferation and Promotes Apoptosis in Airway Smooth Muscle Cells During Airway Remodeling in Asthmatic Rats via the Inhibition of TGF-β -Dependent EGFR Signaling Pathway. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 47. issue 4. 2018-08-15. PMID:29949788. |
microrna-142 inhibits proliferation and promotes apoptosis in airway smooth muscle cells during airway remodeling in asthmatic rats via the inhibition of tgf-β -dependent egfr signaling pathway. |
2018-08-15 |
2023-08-13 |
rat |
| Fusen Peng, Hailin Zhang, Youhong Du, Pingqing Ta. Cetuximab enhances cisplatin-induced endoplasmic reticulum stress-associated apoptosis in laryngeal squamous cell carcinoma cells by inhibiting expression of TXNDC5. Molecular medicine reports. vol 17. issue 3. 2018-08-14. PMID:29328423. |
it has been demonstrated that cisplatin and inhibition of egfr signaling may induce endoplasmic reticulum (er) stress‑associated apoptosis. |
2018-08-14 |
2023-08-13 |
human |
| Bruna Cristine de Almeida, Natalia Garcia, Giovana Maffazioli, Laura Gonzalez dos Anjos, Edmund Chada Baracat, Katia Candido Carvalh. Oncomirs Expression Profiling in Uterine Leiomyosarcoma Cells. International journal of molecular sciences. vol 19. issue 1. 2018-07-27. PMID:29295562. |
we identified four differentially expressed mirnas with the same profile when compared with patients' samples, which strongly interacted with relevant genes, including apoptosis regulator (bcl2), epidermal growth factor receptor (egfr), vascular endothelial growth factor a (vegfa), insulin like growth factor 1 receptor (igf1r),serine/threonine kinase (raf1), receptor tyrosine kinase (met), and bhlh transcription factor (mycn). |
2018-07-27 |
2023-08-13 |
Not clear |
| Tingting Sun, Lin Tang, Miaomiao Zhan. Long noncoding RNA Lnc‑EGFR promotes cell proliferation and inhibits cell apoptosis via regulating the expression of EGFR in human tongue cancer. Molecular medicine reports. vol 17. issue 1. 2018-07-12. PMID:29138845. |
long noncoding rna lnc‑egfr promotes cell proliferation and inhibits cell apoptosis via regulating the expression of egfr in human tongue cancer. |
2018-07-12 |
2023-08-13 |
human |
| Tingting Sun, Lin Tang, Miaomiao Zhan. Long noncoding RNA Lnc‑EGFR promotes cell proliferation and inhibits cell apoptosis via regulating the expression of EGFR in human tongue cancer. Molecular medicine reports. vol 17. issue 1. 2018-07-12. PMID:29138845. |
likewise, lnc‑egfr knockdown‑induced cell apoptosis was reversed by co‑treatment with recombinant egfr protein in um1 and cal‑27 cells. |
2018-07-12 |
2023-08-13 |
human |
| Yangfan Shangguan, Hongqiang Jiang, Zhengqi Pan, Hao Xiao, Yang Tan, Kai Tie, Jun Qin, Yu Deng, Liaobin Chen, Hui Wan. Glucocorticoid mediates prenatal caffeine exposure-induced endochondral ossification retardation and its molecular mechanism in female fetal rats. Cell death & disease. vol 8. issue 10. 2018-07-02. PMID:29072695. |
in vitro, a high-concentration corticosterone (1250 nm) upregulated mig-6 expression, inhibit egfr/c-jun n-terminal kinase (jnk) signaling pathway and terminal differentiation genes expression in chondrocytes and reduced cell apoptosis, and these above alterations could be partly reversed step-by-step after mig-6 and egfr knockdown. |
2018-07-02 |
2023-08-13 |
rat |
| Raimundo F De Araújo, Jonas B Pessoa, Luis J Cruz, Alan B Chan, Emílio De Castro Miguel, Rômulo S Cavalcante, Gerly Anne C Brito, Heloiza Fernada O Silva, Luiz H S Gasparotto, Paulo M M Guedes, Aurigena A Araúj. Apoptosis in human liver carcinoma caused by gold nanoparticles in combination with carvedilol is mediated via modulation of MAPK/Akt/mTOR pathway and EGFR/FAAD proteins. International journal of oncology. vol 52. issue 1. 2018-06-08. PMID:29115423. |
apoptosis was analyzed by fitc/propidium iodide staining flow cytometry; caspase-3, caspase-8, bcl-2 and mapk/erk activity by immunofluorescence microscopy; gene expression of proteins related to cell death as akt, mtor, egfr, mdr1, survivin, fadd and apaf, by the real-time pcr; and western blot analysis for mapk/erk, akt and mtor. |
2018-06-08 |
2023-08-13 |
human |
| Raimundo F De Araújo, Jonas B Pessoa, Luis J Cruz, Alan B Chan, Emílio De Castro Miguel, Rômulo S Cavalcante, Gerly Anne C Brito, Heloiza Fernada O Silva, Luiz H S Gasparotto, Paulo M M Guedes, Aurigena A Araúj. Apoptosis in human liver carcinoma caused by gold nanoparticles in combination with carvedilol is mediated via modulation of MAPK/Akt/mTOR pathway and EGFR/FAAD proteins. International journal of oncology. vol 52. issue 1. 2018-06-08. PMID:29115423. |
after exposure to a combination of gnps (6.25 µg/ml) and carvedilol (3 µm), death as promoted by apoptosis was detected using flow cytometry, for expression of pro-apoptotic proteins fadd, caspase-3, caspase-8 and sub-regulation of anti-apoptotic mapk/erk, akt, mtor, egfr and mdr1 resistance. |
2018-06-08 |
2023-08-13 |
human |
| Yongchang Lai, Liang Tao, Yifan Zhao, Xiaomin Zhang, Xingjuan Sun, Qin Wang, Chengfang X. Cx32 inhibits TNFα-induced extrinsic apoptosis with and without EGFR suppression. Oncology reports. vol 38. issue 5. 2018-06-04. PMID:28901517. |
cx32 inhibits tnfα-induced extrinsic apoptosis with and without egfr suppression. |
2018-06-04 |
2023-08-13 |
human |
| Yongchang Lai, Liang Tao, Yifan Zhao, Xiaomin Zhang, Xingjuan Sun, Qin Wang, Chengfang X. Cx32 inhibits TNFα-induced extrinsic apoptosis with and without EGFR suppression. Oncology reports. vol 38. issue 5. 2018-06-04. PMID:28901517. |
our previous study indicated that connexin32 (cx32) inhibited streptonigrin-induced intrinsic apoptosis via the epidermal growth factor receptor (egfr) pathway. |
2018-06-04 |
2023-08-13 |
human |
| Yongchang Lai, Liang Tao, Yifan Zhao, Xiaomin Zhang, Xingjuan Sun, Qin Wang, Chengfang X. Cx32 inhibits TNFα-induced extrinsic apoptosis with and without EGFR suppression. Oncology reports. vol 38. issue 5. 2018-06-04. PMID:28901517. |
however, whether cx32 can exert effects on the extrinsic apoptosis pathway through egfr signaling remains unclear. |
2018-06-04 |
2023-08-13 |
human |
| Joaquim Moreno-Càceres, Daniel Caballero-Díaz, Zeribe Chike Nwosu, Christoph Meyer, Judit López-Luque, Andrea Malfettone, Raquel Lastra, Teresa Serrano, Emilio Ramos, Steven Dooley, Isabel Fabrega. The level of caveolin-1 expression determines response to TGF-β as a tumour suppressor in hepatocellular carcinoma cells. Cell death & disease. vol 8. issue 10. 2018-06-04. PMID:29022911. |
apoptosis induced by tgf-β is mediated by upregulation of the nadph oxidase nox4, but counteracted by transactivation of the epidermal growth factor receptor (egfr) pathway. |
2018-06-04 |
2023-08-13 |
Not clear |
| Pinghu Zhang, Zuguo Zheng, Li Ling, Xiaohui Yang, Ni Zhang, Xue Wang, Maozhi Hu, Yu Xia, Yiwen Ma, Haoran Yang, Yunyi Wang, Hongqi Li. w09, a novel autophagy enhancer, induces autophagy-dependent cell apoptosis via activation of the EGFR-mediated RAS-RAF1-MAP2K-MAPK1/3 pathway. Autophagy. vol 13. issue 7. 2018-05-25. PMID:28513279. |
hence, our findings not only suggested that activation of the egfr-ras-raf1-map2k-mapk1/3 signaling pathway may play a critical role in w09-induced autophagy and apoptosis, but also imply that induction of autophagic cancer cell death through activation of the egfr pathway may be a potential therapeutic strategy for egfr-disregulated gastric tumors. |
2018-05-25 |
2023-08-13 |
Not clear |
| Chien-Chang Huang, Cheng-Che Lee, Hsiao-Han Lin, Jang-Yang Chan. Cathepsin S attenuates endosomal EGFR signalling: A mechanical rationale for the combination of cathepsin S and EGFR tyrosine kinase inhibitors. Scientific reports. vol 6. 2018-05-22. PMID:27387133. |
notably, cellular apoptosis was markedly enhanced by combining treatment with the egfr inhibitor iressa and ctss inhibitor 6r. |
2018-05-22 |
2023-08-13 |
Not clear |
| Xing Lu, Yi-Ming Wu, Jing-Mei Yang, Feng-E Ma, Liang-Ping Li, Sheng Chen, Ye Zhang, Qing-Ling Ni, Ying-Ming Pan, Xue Hong, Yan Pen. Preparation of Rhodium(III) complexes with 2(1H)-quinolinone derivatives and evaluation of their in vitro and in vivo antitumor activity. European journal of medicinal chemistry. vol 151. 2018-05-14. PMID:29614419. |
further investigation revealed that complex 9 caused cell cycle arrest at the g2/m phase and induced apoptosis, and inhibited the proliferation of hep g2 cells by impeding the phosphorylation of epidermal growth factor receptor (egfr) and its downstream enzymes. |
2018-05-14 |
2023-08-13 |
mouse |
| Ruirui Zhao, Tao Li, Guirong Zheng, Kai Jiang, Lulu Fan, Jingwei Sha. Simultaneous inhibition of growth and metastasis of hepatocellular carcinoma by co-delivery of ursolic acid and sorafenib using lactobionic acid modified and pH-sensitive chitosan-conjugated mesoporous silica nanocomplex. Biomaterials. vol 143. 2018-05-01. PMID:28755539. |
moreover, the complex nanoparticles significantly increased the cellular apoptosis and down-regulated the expression of egfr and vegfr2 proteins related with cell proliferation and tumor angiogenesis. |
2018-05-01 |
2023-08-13 |
mouse |
| Hong Yan Liu, Xiaolin Yu, Haitao Liu, Daqing Wu, Jin-Xiong Sh. Co-targeting EGFR and survivin with a bivalent aptamer-dual siRNA chimera effectively suppresses prostate cancer. Scientific reports. vol 6. 2018-04-23. PMID:27456457. |
the chimera is able to inhibit egfr and survivin simultaneously and induce apoptosis effectively in vitro and in vivo. |
2018-04-23 |
2023-08-13 |
Not clear |
| Chaoliang Wang, Jianxiang Zhang, Qi Li, Tianbiao Zhang, Zishi Deng, Jing Lian, Donghui Jia, Rui Li, Tao Zheng, Xiaoju Ding, Fan Yang, Chao Ma, Rui Wang, Weixing Zhang, Jian Guo We. Low concentration of BPA induces mice spermatocytes apoptosis via GPR30. Oncotarget. vol 8. issue 30. 2018-04-23. PMID:28446726. |
the results of mtt assay, comet assay and flow cytometry indicated that the activation of gpr30 induced by bpa inhibited the cell growth and induced cell apoptosis and ici, gpr30 sirna, egfr inhibitor (ag), and mapk (pd) inhibitor could partially reverse this effect. |
2018-04-23 |
2023-08-13 |
mouse |
| Francesca Megiorni, Moreno Colaiacovo, Samantha Cialfi, Heather P McDowell, Alessandro Guffanti, Simona Camero, Armando Felsani, Paul D Losty, Barry Pizer, Rajeev Shukla, Carlo Cappelli, Eva Ferrara, Antonio Pizzuti, Anna Moles, Carlo Dominic. A sketch of known and novel MYCN-associated miRNA networks in neuroblastoma. Oncology reports. vol 38. issue 1. 2018-04-06. PMID:28586032. |
functional annotation analysis of the target genes of these differentially expressed mirnas demonstrated that many mrnas were involved in cancer-related pathways, such as dna-repair and apoptosis as well as fgfr and egfr signalling. |
2018-04-06 |
2023-08-13 |
Not clear |