| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Charli Dominguez, Kwong-Yok Tsang, Claudia Palen. Short-term EGFR blockade enhances immune-mediated cytotoxicity of EGFR mutant lung cancer cells: rationale for combination therapies. Cell death & disease. vol 7. issue 9. 2017-10-10. PMID:27685624. |
this effect positively correlated with the ability of short-term egfr blockade to modulate tumor phenotype towards a more epithelial one, as well as to increase susceptibility to caspase-mediated apoptosis. |
2017-10-10 |
2023-08-13 |
Not clear |
| D-W Wu, T-C Chen, H-S Huang, H Le. TC-N19, a novel dual inhibitor of EGFR and cMET, efficiently overcomes EGFR-TKI resistance in non-small-cell lung cancer cells. Cell death & disease. vol 7. issue 6. 2017-10-09. PMID:27362807. |
in summary, n19 may act as a novel dual inhibitor of egfr and cmet that induces apoptosis in tki-resistant egfr-mutated nsclc cells and suppresses xenograft tumor formation. |
2017-10-09 |
2023-08-13 |
mouse |
| Peng Song, Jing Yang, Xiaomei Li, Haili Huang, Xueguang Guo, Gang Zhou, Xian Xu, Yi Cai, Min Zhu, Peng Wang, Shu Zhao, Dong Zhan. Hepatocellular carcinoma treated with anti-epidermal growth factor receptor antibody nimotuzumab: A case report. Medicine. vol 96. issue 39. 2017-10-05. PMID:28953642. |
epidermal growth factor receptor (egfr) is closely related to tumor cell proliferation, apoptosis, invasion, and metastasis. |
2017-10-05 |
2023-08-13 |
Not clear |
| Florian Guisier, Pierre Bohn, Maxime Patout, Nicolas Piton, Insaf Farah, Pierre Vera, Luc Thiberville, Mathieu Salaü. In- and ex-vivo molecular imaging of apoptosis to assess sensitivity of non-small cell lung cancer to EGFR inhibitors using probe-based confocal laser endomicroscopy. PloS one. vol 12. issue 7. 2017-10-02. PMID:28671975. |
in- and ex-vivo molecular imaging of apoptosis to assess sensitivity of non-small cell lung cancer to egfr inhibitors using probe-based confocal laser endomicroscopy. |
2017-10-02 |
2023-08-13 |
Not clear |
| Tingting Fang, Jiayun Hou, Mingyan He, Lingyan Wang, Minghuan Zheng, Xiangdong Wang, Jinglin Xi. Actinidia chinensis Planch root extract (acRoots) inhibits hepatocellular carcinoma progression by inhibiting EP3 expression. Cell biology and toxicology. vol 32. issue 6. 2017-09-29. PMID:27475644. |
treatment with acroots and ep3 antagonist l-798106 led to decreases in vegf, egfr, mmp2, and mmp9 expression in hcc cells, along with significant effects on growth, migration, invasion, and apoptosis; the effects were reversed/blocked by the ep3 agonist sulprostone. |
2017-09-29 |
2023-08-13 |
Not clear |
| Chen Hu, Aoli Wang, Hong Wu, Ziping Qi, Xixiang Li, Xiao-E Yan, Cheng Chen, Kailin Yu, Fengming Zou, Wenchao Wang, Wei Wang, Jiaxin Wu, Juan Liu, Beilei Wang, Li Wang, Tao Ren, Shanchun Zhang, Cai-Hong Yun, Jing Liu, Qingsong Li. Discovery and characterization of a novel irreversible EGFR mutants selective and potent kinase inhibitor CHMFL-EGFR-26 with a distinct binding mode. Oncotarget. vol 8. issue 11. 2017-09-29. PMID:28407693. |
the compound showed highly potent anti-proliferative efficacy against egfr mutant but not wide-type nsclc cell lines through effective inhibition of the egfr mediated signaling pathway, induction of apoptosis and arresting of cell cycle progression. |
2017-09-29 |
2023-08-13 |
mouse |
| Jing Yang, Zhengchao Tu, Xin Xu, Jinfeng Luo, Xing Yan, Chongzhao Ran, Xinliang Mao, Ke Ding, Chunhua Qia. Novel conjugates of endoperoxide and 4-anilinoquinazoline as potential anticancer agents. Bioorganic & medicinal chemistry letters. vol 27. issue 6. 2017-09-26. PMID:28236592. |
further experiments revealed the conjugate's reactive oxygen species (ros) generating ability, apoptosis inducing activity and involvement in egfr downstream signaling pathways. |
2017-09-26 |
2023-08-13 |
Not clear |
| Nicole M Jackson, Brian P Ceres. EGFR-mediated apoptosis via STAT3. Experimental cell research. vol 356. issue 1. 2017-09-26. PMID:28433699. |
paradoxically, cell lines that hyperexpress the egfr have been documented to undergo receptor-mediated apoptosis. |
2017-09-26 |
2023-08-13 |
Not clear |
| Nicole M Jackson, Brian P Ceres. EGFR-mediated apoptosis via STAT3. Experimental cell research. vol 356. issue 1. 2017-09-26. PMID:28433699. |
in an attempt to identify this mechanism, we assessed downstream effectors of egfr in mda-mb-468 cells during conditions of egf-induced apoptosis. |
2017-09-26 |
2023-08-13 |
Not clear |
| Ping Wang, Xiaomin Liu, Yang Shao, Huimin Wang, Chen Liang, Baohui Han, Zhongliang M. MicroRNA-107-5p suppresses non-small cell lung cancer by directly targeting oncogene epidermal growth factor receptor. Oncotarget. vol 8. issue 34. 2017-09-25. PMID:28915650. |
moreover, our results indicated that mir-107-5p could suppress cell proliferation, inhibit metastasis, impede cell cycle, and promote apoptosis via directly targeting egfr. |
2017-09-25 |
2023-08-13 |
human |
| Lin Chen, Zhe Zhu, Wei Gao, Qixin Jiang, Jiangming Yu, Chuangang F. Systemic analysis of different colorectal cancer cell lines and TCGA datasets identified IGF-1R/EGFR-PPAR-CASPASE axis as important indicator for radiotherapy sensitivity. Gene. vol 627. 2017-09-20. PMID:28687332. |
the irradiation induced apoptosis rates of wild type and egfr agonist (egf) or igf-1r inhibitor (nvp-adw742) treated ht29 and sw480 cells were quantified by flow cytometry. |
2017-09-20 |
2023-08-13 |
Not clear |
| Lin Chen, Zhe Zhu, Wei Gao, Qixin Jiang, Jiangming Yu, Chuangang F. Systemic analysis of different colorectal cancer cell lines and TCGA datasets identified IGF-1R/EGFR-PPAR-CASPASE axis as important indicator for radiotherapy sensitivity. Gene. vol 627. 2017-09-20. PMID:28687332. |
as a result, the apoptosis rate of egf and nvp-adw742 treated ht29 cells was significantly higher than that of those wild type ones, which indicated that high egfr and low igf-1r expression level in crc was associated with the high sensitivity to radiotherapy. |
2017-09-20 |
2023-08-13 |
Not clear |
| Kanakaraju Manupati, Neha R Dhoke, Tanusree Debnath, Ragini Yeeravalli, Kalpana Guguloth, Shahrzad Saeidpour, Utpal Chandra De, Sudhan Debnath, Amitava Da. Inhibiting epidermal growth factor receptor signalling potentiates mesenchymal-epithelial transition of breast cancer stem cells and their responsiveness to anticancer drugs. The FEBS journal. vol 284. issue 12. 2017-09-11. PMID:28398698. |
chrysin analog chm-09 and known egfr inhibitors demonstrated a comparable anti-proliferative, anti-migratory activity along with the induction of apoptosis and cell cycle arrest in mda-mb-231. |
2017-09-11 |
2023-08-13 |
Not clear |
| D Dayde, M Guerard, P Perron, A-S Hatat, C Barrial, B Eymin, S Gazzer. Nuclear trafficking of EGFR by Vps34 represses Arf expression to promote lung tumor cell survival. Oncogene. vol 35. issue 30. 2017-09-01. PMID:26686095. |
finally, in lung tumor cells that carry mutant egfr-l858r, we demonstrated that inhibition of vps34 using small interfering rna restrains nuclear egfr location and restores arf expression leading to apoptosis. |
2017-09-01 |
2023-08-13 |
human |
| Timothy Su, M Kay Washington, Reid M Ness, Douglas K Rex, Walter E Smalley, Thomas M Ulbright, Qiuyin Cai, Wei Zheng, Martha J Shrubsol. Comparison of biomarker expression between proximal and distal colorectal adenomas: The Tennessee-Indiana Adenoma Recurrence Study. Molecular carcinogenesis. vol 56. issue 2. 2017-09-01. PMID:27479195. |
eight biomarkers in the most advanced adenomas were evaluated by immunohistochemistry (ki-67, cox-2, tgfβrii, egfr, β-catenin, cyclin d1, c-myc) or tunel (apoptosis). |
2017-09-01 |
2023-08-13 |
human |
| Fusanori Yotsumoto, Satoshi Fukagawa, Kohei Miyata, Sung Ouk Nam, Takahiro Katsuda, Daisuke Miyahara, Takashi Odawara, Sadao Manabe, Toyokazu Ishikawa, Shin'ichiro Yasunaga, Shingo Miyamot. HB-EGF Is a Promising Therapeutic Target for Lung Cancer with Secondary Mutation of Anticancer research. vol 37. issue 7. 2017-08-29. PMID:28668882. |
crm197 induced significant cell apoptosis and marked suppression of tumorigenicity in lung cancer cells with single or double mutation of egfr. |
2017-08-29 |
2023-08-13 |
Not clear |
| Arnim Weber, Melanie Heinlein, Jörn Dengjel, Claudia Alber, Prafull Kumar Singh, Georg Häcke. The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis. EMBO reports. vol 17. issue 5. 2017-08-15. PMID:27013495. |
finally, deletion of usp27x reduces apoptosis in nsclc cells treated with an egfr inhibitor. |
2017-08-15 |
2023-08-13 |
Not clear |
| Boas Nam, Jin Kyung Rho, Dong-Myung Shin, Jaekyoung So. Gallic acid induces apoptosis in EGFR-mutant non-small cell lung cancers by accelerating EGFR turnover. Bioorganic & medicinal chemistry letters. vol 26. issue 19. 2017-08-15. PMID:27597244. |
gallic acid induces apoptosis in egfr-mutant non-small cell lung cancers by accelerating egfr turnover. |
2017-08-15 |
2023-08-13 |
Not clear |
| Boas Nam, Jin Kyung Rho, Dong-Myung Shin, Jaekyoung So. Gallic acid induces apoptosis in EGFR-mutant non-small cell lung cancers by accelerating EGFR turnover. Bioorganic & medicinal chemistry letters. vol 26. issue 19. 2017-08-15. PMID:27597244. |
moreover, treatment with gallic acid induced egfr turnover leading to apoptosis in egfr-tki (tyrosine kinase inhibitor)-resistant cell lines, which are dependent on egfr signaling for survival. |
2017-08-15 |
2023-08-13 |
Not clear |
| Boas Nam, Jin Kyung Rho, Dong-Myung Shin, Jaekyoung So. Gallic acid induces apoptosis in EGFR-mutant non-small cell lung cancers by accelerating EGFR turnover. Bioorganic & medicinal chemistry letters. vol 26. issue 19. 2017-08-15. PMID:27597244. |
thus, these studies suggest that gallic acid can induce apoptosis in egfr-dependent lung cancers that are dependent on egfr for growth and survival via acceleration of egfr turnover. |
2017-08-15 |
2023-08-13 |
Not clear |