| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tung-Yi Lin, Hsien-Yeh Hsu, Wei-Hsuan Sun, Tsung-Han Wu, Shu-Ming Tsa. Induction of Cbl-dependent epidermal growth factor receptor degradation in Ling Zhi-8 suppressed lung cancer. International journal of cancer. vol 140. issue 11. 2017-05-01. PMID:28198003. |
we provide the first evidence showing that rlz-8 inhibits growth and induces apoptosis of lung cancer cells by promoting egfr degradation. |
2017-05-01 |
2023-08-13 |
mouse |
| In-Su Kim, Sushruta Koppula, Shin-Young Park, Dong-Kug Cho. Analysis of Epidermal Growth Factor Receptor Related Gene Expression Changes in a Cellular and Animal Model of Parkinson's Disease. International journal of molecular sciences. vol 18. issue 2. 2017-04-28. PMID:28212331. |
the egfr pathway has been linked to diverse cellular events such as proliferation, differentiation, and apoptosis. |
2017-04-28 |
2023-08-13 |
human |
| Lin Mu, Tianjiao Wang, Yanwei Chen, Xinqiang Tang, Yuhui Yuan, Yongshun Zha. β-Elemene enhances the efficacy of gefitinib on glioblastoma multiforme cells through the inhibition of the EGFR signaling pathway. International journal of oncology. vol 49. issue 4. 2017-04-03. PMID:27498706. |
the combination medication of β-elemene and gefitinib not only inhibited the survival and proliferation of glioblastoma multiforme cells via inhibition of egfr signaling pathway but also induced more distinct apoptosis and autophagy in the glioblastoma multiforme cells than the gefitinib monotherapy. |
2017-04-03 |
2023-08-13 |
Not clear |
| Ning Zhong, Shunbin Shi, Hongzhen Wang, Guangzhou Wu, Yunliang Wang, Qiang Ma, Hongwei Wang, Yuanhua Liu, Jinzhi Wan. Silencing Aurora-A with siRNA inhibits cell proliferation in human lung adenocarcinoma cells. International journal of oncology. vol 49. issue 3. 2017-04-03. PMID:27571708. |
the potential mechanisms of aurka inhibition induced cell cycle arrest and apoptosis are associated with downregulated raf-1, ccnd2, ccnd3, cdk4, pak4, egfr and upregulated wee1 expression. |
2017-04-03 |
2023-08-13 |
human |
| Evangelos Tsiambas, Alicia Y Lefas, Stavros N Georgiannos, Vasileios Ragos, Panagiotis P Fotiades, Dimitra Grapsa, Athanasios Stamatelopoulos, Nikolaos Kavantzas, Efstratios Patsouris, Konstantinos Syrigo. EGFR gene deregulation mechanisms in lung adenocarcinoma: A molecular review. Pathology, research and practice. vol 212. issue 8. 2017-03-23. PMID:27461822. |
the epidermal growth factor receptor (egfr) signaling pathway plays a crucial role in regulating cell proliferation, differentiation and apoptosis in normal cells. |
2017-03-23 |
2023-08-13 |
Not clear |
| Melissa Skibba, Yuanyuan Qian, Yuyan Bao, Junjie Lan, Kesong Peng, Yunjie Zhao, Peng Zhong, Jie Hu, Xiaokun Li, Guang Lian. New EGFR inhibitor, 453, prevents renal fibrosis in angiotensin II-stimulated mice. European journal of pharmacology. vol 789. 2017-03-21. PMID:27497883. |
along with the inhibition of egfr and its downstream signaling pathways (akt and erk), 453 also prevented the activation of fibrotic (collagen, cfgf, tgf-β), inflammatory (cox2, il-6, il-1β, tnf-α), apoptosis and oxidative stress pathways. |
2017-03-21 |
2023-08-13 |
mouse |
| Zheng Yang, Kin Y Ta. Anti-cancer synergy of dichloroacetate and EGFR tyrosine kinase inhibitors in NSCLC cell lines. European journal of pharmacology. vol 789. 2017-03-21. PMID:27514773. |
this synergistic outcome appears to be a combination effect in promoting apoptosis, rather than co-suppression of either egfr or pdk signaling pathways. |
2017-03-21 |
2023-08-13 |
Not clear |
| Weixin Li, Qilu Fang, Peng Zhong, Lingfeng Chen, Lintao Wang, Yali Zhang, Jun Wang, Xiaokun Li, Yi Wang, Jingying Wang, Guang Lian. EGFR Inhibition Blocks Palmitic Acid-induced inflammation in cardiomyocytes and Prevents Hyperlipidemia-induced Cardiac Injury in Mice. Scientific reports. vol 6. 2017-03-17. PMID:27087279. |
egfr inhibition attenuated pa-induced inflammatory response and apoptosis in h9c2 cells. |
2017-03-17 |
2023-08-13 |
mouse |
| Ratna Kumari, Surbhi Chouhan, Snahlata Singh, Rishi Raj Chhipa, Amrendra Kumar Ajay, Manoj Kumar Bha. Constitutively activated ERK sensitizes cancer cells to doxorubicin: Involvement of p53-EGFR-ERK pathway. Journal of biosciences. vol 42. issue 1. 2017-03-17. PMID:28229963. |
the role of egfr and erk in dna-damage-induced apoptosis is well known. |
2017-03-17 |
2023-08-13 |
human |
| Xiaodong Liu, Shuo Tian, Mei Liu, Lingyan Jian, Limei Zha. Wogonin inhibits the proliferation and invasion, and induces the apoptosis of HepG2 and Bel7402 HCC cells through NF‑κB/Bcl-2, EGFR and EGFR downstream ERK/AKT signaling. International journal of molecular medicine. vol 38. issue 4. 2017-03-06. PMID:27499272. |
wogonin inhibits the proliferation and invasion, and induces the apoptosis of hepg2 and bel7402 hcc cells through nf‑κb/bcl-2, egfr and egfr downstream erk/akt signaling. |
2017-03-06 |
2023-08-13 |
Not clear |
| Chengjun Feng, Xiaoke Liu, Xiaoyu Li, Fuchun Guo, Chuying Huang, Qing Qin, Yongsheng Wan. Zoledronic acid increases the antitumor effect of gefitinib treatment for non-small cell lung cancer with EGFR mutations. Oncology reports. vol 35. issue 6. 2017-03-03. PMID:27109760. |
the effects of za and gefitinib on nsclc tumor cells with egfr mutations (hcc827, hcc827 gr and h1975) in regards to proliferation, apoptosis, cell cycle and signaling pathways were detected. |
2017-03-03 |
2023-08-13 |
Not clear |
| Zhihao Wang, Fang Tang, Pengchao Hu, Ying Wang, Jun Gong, Shaoxing Sun, Conghua Xi. HDAC6 promotes cell proliferation and confers resistance to gefitinib in lung adenocarcinoma. Oncology reports. vol 36. issue 1. 2017-03-03. PMID:27221381. |
moreover, cay10603 synergized with gefitinib to induce apoptosis of the lung adenocarcinoma cell lines via the destabilization of egfr. |
2017-03-03 |
2023-08-13 |
Not clear |
| A S Yar Saglam, E Alp, Z Elmazoglu, S Menevs. Treatment with cucurbitacin B alone and in combination with gefitinib induces cell cycle inhibition and apoptosis via EGFR and JAK/STAT pathway in human colorectal cancer cell lines. Human & experimental toxicology. vol 35. issue 5. 2017-02-17. PMID:26183715. |
treatment with cucurbitacin b alone and in combination with gefitinib induces cell cycle inhibition and apoptosis via egfr and jak/stat pathway in human colorectal cancer cell lines. |
2017-02-17 |
2023-08-13 |
human |
| Jinbing Sun, Jianlong Jiang, Kuangyi Lu, Qiao Chen, Danhao Tao, Zhong Che. Therapeutic potential of ADAM17 modulation in gastric cancer through regulation of the EGFR and TNF-α signalling pathways. Molecular and cellular biochemistry. vol 426. issue 1-2. 2017-02-17. PMID:27878499. |
furthermore, the egfr signalling pathway, the cell membrane receptor-bound tnf-α level, and apoptosis were evaluated by western blotting and flow cytometry. |
2017-02-17 |
2023-08-13 |
human |
| Xiang-Jun Tang, Kuan-Ming Huang, Hui Gui, Jun-Jie Wang, Jun-Ti Lu, Long-Jun Dai, Li Zhang, Gang Wan. Pluronic-based micelle encapsulation potentiates myricetin-induced cytotoxicity in human glioblastoma cells. International journal of nanomedicine. vol 11. 2017-02-13. PMID:27757032. |
the epidermal growth factor receptor (egfr)/pi3k/akt pathway located in the plasma membrane and cytosol and the ras-erk pathway located in mitochondria served as upstream and downstream targets, respectively, in myricetin-induced apoptosis. |
2017-02-13 |
2023-08-13 |
human |
| Shuang Li, Haiyang Zhang, Tao Ning, Xinyi Wang, Rui Liu, Haiou Yang, Yueting Han, Ting Deng, Likun Zhou, Le Zhang, Ming Bai, Xia Wang, Shaohua Ge, Guoguang Ying, Yi B. MiR-520b/e Regulates Proliferation and Migration by Simultaneously Targeting EGFR in Gastric Cancer. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 40. issue 6. 2017-02-08. PMID:27997901. |
other studies indicated that epidermal growth factor receptor (egfr) is highly expressed in many tumors, and involved in the development of tumors, such as cell proliferation, migration, angiogenesis and apoptosis. |
2017-02-08 |
2023-08-13 |
Not clear |
| Xilin Sun, Shaowei Li, Baozhong She. Identification of Disease States and Response to Therapy in Humans by Utilizing the Biomarker EGFR for Targeted Molecular Imaging. Current protein & peptide science. vol 17. issue 6. 2017-02-06. PMID:26721405. |
the epidermal growth factor receptor (egfr) plays important roles in cell proliferation, suppression of apoptosis, increased motility, and recruitment of neovasculature. |
2017-02-06 |
2023-08-13 |
human |
| Asuman Demiroglu-Zergeroglu, Gulsife Candemir, Ebru Turhanlar, Fatma Sagir, Nurettin Ayval. EGFR-dependent signalling reduced and p38 dependent apoptosis required by Gallic acid in Malignant Mesothelioma cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 84. 2017-02-01. PMID:27847212. |
the data provided here indicate that ga is able to inhibit egfr dependent proliferation and survival signals and induces p38 pathway dependent apoptosis in malignant mesothelioma cells. |
2017-02-01 |
2023-08-13 |
Not clear |
| Renato J Oliveira-Silva, Ana Carolina de Carvalho, Luciano de Souza Viana, André L Carvalho, Rui M Rei. Anti-EGFR Therapy: Strategies in Head and Neck Squamous Cell Carcinoma. Recent patents on anti-cancer drug discovery. vol 11. issue 2. 2017-01-09. PMID:26955963. |
epidermal growth factor receptor (egfr) is a tyrosine kinase receptor that activates downstream signaling pathways, including the ras-mek-erk and pi3k-akt pathways, leading to cell proliferation, resistance to apoptosis, angiogenesis and the ability to metastasize. |
2017-01-09 |
2023-08-13 |
Not clear |
| Monica Benvenuto, Laura Masuelli, Enrico De Smaele, Massimo Fantini, Rosanna Mattera, Danilo Cucchi, Elena Bonanno, Enrica Di Stefano, Giovanni Vanni Frajese, Augusto Orlandi, Isabella Screpanti, Alberto Gulino, Andrea Modesti, Roberto Be. In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors. Oncotarget. vol 7. issue 8. 2017-01-06. PMID:26843616. |
gdc-0449 and gant-61 exhibited the following effects: a) inhibited breast cancer cell survival; b) induced apoptosis; c) inhibited hh pathway activity by decreasing the mrna expression levels of gli1 and ptch and inhibiting the nuclear translocation of gli1; d) increased/decreased egfr and erbb2 protein expression, reduced p21-ras and erk1/erk2 mapk activities and inhibited akt activation; and e) decreased the nuclear translocation of nf-κb. |
2017-01-06 |
2023-08-13 |
mouse |