| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Manoranjan Santra, Michael Chopp, Sutapa Santra, Ankita Nallani, Shivam Vyas, Zheng Gang Zhang, Daniel C Morri. Thymosin beta 4 up-regulates miR-200a expression and induces differentiation and survival of rat brain progenitor cells. Journal of neurochemistry. vol 136. issue 1. 2016-04-25. PMID:26466330. |
thus, tβ4 up-regulated mbp synthesis, and inhibited ogd-induced apoptosis in a novel mir-200a dependent egfr signaling pathway. |
2016-04-25 |
2023-08-13 |
rat |
| Manoranjan Santra, Michael Chopp, Sutapa Santra, Ankita Nallani, Shivam Vyas, Zheng Gang Zhang, Daniel C Morri. Thymosin beta 4 up-regulates miR-200a expression and induces differentiation and survival of rat brain progenitor cells. Journal of neurochemistry. vol 136. issue 1. 2016-04-25. PMID:26466330. |
tβ4-induced micro-rna-200a (mir-200a) regulates egfr signaling pathways for mbp synthesis and apoptosis: up-regulation of mir-200a after tβ4 treatment, increases mbp synthesis after targeting grb2 and thereby inactivating c-jun from inhibition of mbp synthesis; and also inhibits ogd-mediated apoptosis after targeting egfr inhibitor (mig-6), pi3k inhibitors (fog2 and pten) and an inducer (p53) of pro-apoptotic genes, for akt activation and down-regulation of p53. |
2016-04-25 |
2023-08-13 |
rat |
| Fulin Xu, Feng Li, Weifeng Zhang, Pifeng Ji. Growth of glioblastoma is inhibited by miR-133-mediated EGFR suppression. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 12. 2016-04-21. PMID:26138587. |
together, these data suggest that reduced mir-133 levels in gbm tissues promotes cell growth and decreases cell apoptosis, possibly through targeting mrna of egfr to suppress its translation. |
2016-04-21 |
2023-08-13 |
Not clear |
| Yang Zhang, Wei Zheng, Qun Luo, Yao Zhao, Erlong Zhang, Suyan Liu, Fuyi Wan. Dual-targeting organometallic ruthenium(II) anticancer complexes bearing EGFR-inhibiting 4-anilinoquinazoline ligands. Dalton transactions (Cambridge, England : 2003). vol 44. issue 29. 2016-04-08. PMID:26106875. |
we have recently demonstrated that complexation with (η(6)-arene)ru(ii) fragments confers 4-anilinoquinazoline pharmacophores a higher potential for inducing cellular apoptosis while preserving the highly inhibitory activity of 4-anilinoquinazolines against egfr and the reactivity of the ruthenium centre to 9-ethylguanine (chem. |
2016-04-08 |
2023-08-13 |
Not clear |
| Arindam Mondal, Raktim Biswas, Yun-Hee Rhee, Jongkee Kim, Jin-Chul Ah. Sulforaphene promotes Bax/Bcl2, MAPK-dependent human gastric cancer AGS cells apoptosis and inhibits migration via EGFR, p-ERK1/2 down-regulation. General physiology and biophysics. vol 35. issue 1. 2016-04-08. PMID:26612919. |
sulforaphene promotes bax/bcl2, mapk-dependent human gastric cancer ags cells apoptosis and inhibits migration via egfr, p-erk1/2 down-regulation. |
2016-04-08 |
2023-08-13 |
human |
| Raktim Biswas, Arindam Mondal, Jin-Chul Ah. Deregulation of EGFR/PI3K and activation of PTEN by photodynamic therapy combined with carboplatin in human anaplastic thyroid cancer cells and xenograft tumors in nude mice. Journal of photochemistry and photobiology. B, Biology. vol 148. 2016-04-05. PMID:25910816. |
this suggests a combination of cbdca and pdt modulates egfr and pi3k as well as activates pten to inhibit tumor growth and induce apoptosis with an enhanced efficacy in anaplastic thyroid cancer. |
2016-04-05 |
2023-08-13 |
mouse |
| Ji-Yong Ma, Hai-Jun Yan, Wei G. Association between BIM deletion polymorphism and clinical outcome of EGFR-mutated NSCLC patient with EGFR-TKI therapy: A meta-analysis. Journal of cancer research and therapeutics. vol 11. issue 2. 2016-03-31. PMID:26148607. |
bim deletion polymorphism was deemed to be associated with downregulation of bim, resulting in a decreased apoptosis induced by epidermal growth factor receptor-tyrosine kinase inhibitors (egfr-tkis) in egfr mutation-positive non-small cell lung cancer (nsclc). |
2016-03-31 |
2023-08-13 |
Not clear |
| Sukriti Goyal, Salma Jamal, Asheesh Shanker, Abhinav Grove. Structural investigations of T854A mutation in EGFR and identification of novel inhibitors using structure activity relationships. BMC genomics. vol 16 Suppl 5. 2016-03-29. PMID:26041145. |
the epidermal growth factor receptor (egfr) is a member of the erbb family that is involved in a number of processes responsible for cancer development and progression such as angiogenesis, apoptosis, cell proliferation and metastatic spread. |
2016-03-29 |
2023-08-13 |
Not clear |
| Albert D Donnenberg, E Michael Meyer, J Peter Rubin, Vera S Donnenber. The cell-surface proteome of cultured adipose stromal cells. Cytometry. Part A : the journal of the International Society for Analytical Cytology. vol 87. issue 7. 2016-03-24. PMID:25929697. |
among other strongly expressed markers are several that are potentially immunomodulatory including three proteins that protect from complement mediated effects (cd46, cd55, and cd59), two that regulate apoptosis (cd77 and cd95) and several with ectoenzymatic (cd10, cd26, cd13, cd73, and cd143) or receptor tyrosine kinase (cd140b (pdgfr), cd340 (her-2), egfr) activity, suggesting mechanisms for the anti-inflammatory and tissue remodeling properties of asc. |
2016-03-24 |
2023-08-13 |
human |
| Sanguine Byun, Seung Ho Shin, Eunjung Lee, Jihoon Lee, Sung-Young Lee, Lee Farrand, Sung Keun Jung, Yong-Yeon Cho, Soo-Jong Um, Hong-Sig Sin, Youn-Ja Kwon, Chengjuan Zhang, Benjamin K Tsang, Ann M Bode, Hyong Joo Lee, Ki Won Lee, Zigang Don. The retinoic acid derivative, ABPN, inhibits pancreatic cancer through induction of Nrdp1. Carcinogenesis. vol 36. issue 12. 2016-03-24. PMID:26464195. |
low micromolar concentrations of abpn induced apoptosis in bxpc3 and hpac pancreatic cancer cell lines, concomitant with a reduction in phosphorylated egfr as well as decreased erbb3, met and bruce protein levels. |
2016-03-24 |
2023-08-13 |
mouse |
| Alejandra Tomas, Simon O Vaughan, Thomas Burgoyne, Alexander Sorkin, John A Hartley, Daniel Hochhauser, Clare E Futte. WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway. Nature communications. vol 6. 2016-03-23. PMID:26066081. |
egfr signalling from this mvb subpopulation delays apoptosis and might contribute to chemoresistance. |
2016-03-23 |
2023-08-13 |
Not clear |
| Fan Xie, Pengcheng Li, Jianhua Gong, Jiahong Zhang, Jingping M. The bisphosphonate zoledronic acid effectively targets lung cancer cells by inhibition of protein prenylation. Biochemical and biophysical research communications. vol 467. issue 4. 2016-03-15. PMID:26498526. |
this is achieved by the induction of apoptosis and inhibition of proliferation, through suppressing the activation of downstream ras and egfr signalling by zoledronic acid. |
2016-03-15 |
2023-08-13 |
mouse |
| Shuji Wakatsuki, Akiko Furuno, Makiko Ohshima, Toshiyuki Arak. Oxidative stress-dependent phosphorylation activates ZNRF1 to induce neuronal/axonal degeneration. The Journal of cell biology. vol 211. issue 4. 2016-03-09. PMID:26572622. |
we now demonstrate that oxidative stress serves as an activator of the ubiquitin ligase activity of znrf1 by inducing epidermal growth factor receptor (egfr)-mediated phosphorylation at the 103rd tyrosine residue and that the up-regulation of znrf1 activity by oxidative stress leads to neuronal apoptosis and wallerian degeneration. |
2016-03-09 |
2023-08-13 |
Not clear |
| Dmitry L Aminin, Ekaterina S Menchinskaya, Evgeny A Pisliagin, Alexandra S Silchenko, Sergey A Avilov, Vladimir I Kalini. Anticancer activity of sea cucumber triterpene glycosides. Marine drugs. vol 13. issue 3. 2016-03-03. PMID:25756523. |
the anticancer molecular mechanisms include the induction of tumor cell apoptosis through the activation of intracellular caspase cell death pathways, arrest of the cell cycle at s or g2/m phases, influence on nuclear factors, nf-κb, and up-down regulation of certain cellular receptors and enzymes participating in cancerogenesis, such as egfr (epidermal growth factor receptor), akt (protein kinase b), erk (extracellular signal-regulated kinases), fak (focal adhesion kinase), mmp-9 (matrix metalloproteinase-9) and others. |
2016-03-03 |
2023-08-13 |
human |
| Zongyuan Yang, Yi Liu, Xiao Wei, Xiaoshui Zhou, Cheng Gong, Taoran Zhang, Ping Jin, Sen Xu, Ding Ma, Qinglei Ga. Co-targeting EGFR and Autophagy Impairs Ovarian Cancer Cell Survival during Detachment from the ECM. Current cancer drug targets. vol 15. issue 3. 2016-02-17. PMID:25619386. |
activation of egfr signaling is involved in increased cell metastasis and decreased apoptosis of ovarian cancer. |
2016-02-17 |
2023-08-13 |
Not clear |
| Zongyuan Yang, Yi Liu, Xiao Wei, Xiaoshui Zhou, Cheng Gong, Taoran Zhang, Ping Jin, Sen Xu, Ding Ma, Qinglei Ga. Co-targeting EGFR and Autophagy Impairs Ovarian Cancer Cell Survival during Detachment from the ECM. Current cancer drug targets. vol 15. issue 3. 2016-02-17. PMID:25619386. |
blockage of autophagy with 3ma notably promoted spheroid death in suspension as well as ag1478-induced cell apoptosis, suggesting a protective autophagy contribution during tumor cells in suspension or under egfr inhibition. |
2016-02-17 |
2023-08-13 |
Not clear |
| Milota Kaluzova, Alexandros Bouras, Revaz Machaidze, Costas G Hadjipanayi. Targeted therapy of glioblastoma stem-like cells and tumor non-stem cells using cetuximab-conjugated iron-oxide nanoparticles. Oncotarget. vol 6. issue 11. 2016-02-11. PMID:25871395. |
treatment with cetuximab-ionps resulted in a significant antitumor effect that was greater than with cetuximab alone due to more efficient, cd133-independent cellular targeting and uptake, egfr signaling alterations, egfr internalization, and apoptosis induction in egfr-expressing gscs and neurospheres. |
2016-02-11 |
2023-08-13 |
human |
| Zejun Yan, Junhui Jiang, Fan Li, Weiming Yang, Guohai Xie, Cheng Zhou, Shujie Xia, Yue Chen. Adenovirus-mediated LRIG1 expression enhances the chemosensitivity of bladder cancer cells to cisplatin. Oncology reports. vol 33. issue 4. 2016-02-04. PMID:25695283. |
previous studies have confirmed that the epidermal growth factor receptor (egfr) and its signaling pathways are important in the chemoresistance of cancer cells against cddp‑induced cell apoptosis. |
2016-02-04 |
2023-08-13 |
Not clear |
| Zejun Yan, Junhui Jiang, Fan Li, Weiming Yang, Guohai Xie, Cheng Zhou, Shujie Xia, Yue Chen. Adenovirus-mediated LRIG1 expression enhances the chemosensitivity of bladder cancer cells to cisplatin. Oncology reports. vol 33. issue 4. 2016-02-04. PMID:25695283. |
based on these results, we concluded that the upregulation of lrig1 expression inhibited the egfr signaling pathway, activated the mitochondrial pathway of apoptosis and eventually increased the sensitivity of bladder cancer cells to cddp. |
2016-02-04 |
2023-08-13 |
Not clear |
| Suman Rao, Anne-Laure Larroque-Lombard, Lisa Peyrard, Cédric Thauvin, Zakaria Rachid, Christopher Williams, Bertrand J Jean-Claud. Target modulation by a kinase inhibitor engineered to induce a tandem blockade of the epidermal growth factor receptor (EGFR) and c-Src: the concept of type III combi-targeting. PloS one. vol 10. issue 2. 2016-02-01. PMID:25658745. |
here we showed that: (a) al776 blocked egfr and c-src as an intact structure using an in vitro kinase assay (ic50 egfr = 0.12 μm and ic50 c-src = 3 nm), (b) it could release k1 (al621, a nanomolar egfr inhibitor) and k2 (dasatinib, a clinically approved abl/c-src inhibitor) by hydrolytic cleavage both in vitro and in vivo, (c) it could robustly inhibit phosphorylation of egfr and c-src (0.25-1 μm) in cells, (d) it induced 2-4 fold stronger growth inhibition than gefitinib or dasatinib and apoptosis at concentrations as low as 1 μm, and, (e) blocked motility and invasion at sub-micromolar doses in the highly invasive 4t1 and mda-mb-231 cells. |
2016-02-01 |
2023-08-13 |
Not clear |