| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Denoyelle, B Lambert, M Meryet-Figuière, N Vigneron, E Brotin, C Lecerf, E Abeilard, F Giffard, M-H Louis, P Gauduchon, P Juin, L Poulai. miR-491-5p-induced apoptosis in ovarian carcinoma depends on the direct inhibition of both BCL-XL and EGFR leading to BIM activation. Cell death & disease. vol 5. 2015-07-07. PMID:25299770. |
induction of apoptosis by mir-491-5p in this cell line is mimicked by a combination of egfr inhibition together with a bh3-mimetic molecule. |
2015-07-07 |
2023-08-13 |
Not clear |
| Eun Ji Joo, Jaemoo Chun, Young Wan Ha, Hye Jin Ko, Mei-Ying Xu, Yeong Shik Ki. Novel roles of ginsenoside Rg3 in apoptosis through downregulation of epidermal growth factor receptor. Chemico-biological interactions. vol 233. 2015-07-03. PMID:25824408. |
here, we provide the first description of the roles of rg3 in the reduction of cell surface egfr, the attenuation of egfr signal transduction, and the eventual activation of apoptosis in a549 human lung adenocarcinoma. |
2015-07-03 |
2023-08-13 |
human |
| Xianrong Zhang, Ji Zhu, Fei Liu, Yumei Li, Abhishek Chandra, L Scott Levin, Frank Beier, Motomi Enomoto-Iwamoto, Ling Qi. Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model. Bone research. vol 2. 2015-06-29. PMID:26120493. |
tunel staining demonstrated that egfr signaling protects chondrocytes from oa-induced apoptosis, which was further confirmed in primary chondrocyte culture. |
2015-06-29 |
2023-08-13 |
mouse |
| Nader N El-Chaar, Stephen R Piccolo, Kenneth M Boucher, Adam L Cohen, Jeffrey T Chang, Philip J Moos, Andrea H Bil. Genomic classification of the RAS network identifies a personalized treatment strategy for lung cancer. Molecular oncology. vol 8. issue 7. 2015-06-23. PMID:24908424. |
mechanistic studies demonstrated that co-inhibition of egfr and mek induced apoptosis and blocked both egfr-ras-raf-mek-erk and egfr-pi3k-akt-rps6 nodes simultaneously in ras-active, but not ras-inactive nsclc. |
2015-06-23 |
2023-08-13 |
Not clear |
| Sun Hee Ahn, Eun-Hui Jeong, Tae-Gul Lee, Seo Yun Kim, Hye-Ryoun Kim, Cheol Hyeon Ki. Gefitinib induces cytoplasmic translocation of the CDK inhibitor p27 and its binding to a cleaved intermediate of caspase 8 in non-small cell lung cancer cells. Cellular oncology (Dordrecht). vol 37. issue 5. 2015-06-22. PMID:25228008. |
it has been found that treatment with gefitinib induces cell cycle arrest and apoptosis in nsclc cells harboring activating egfr mutations. |
2015-06-22 |
2023-08-13 |
Not clear |
| S-H Lee, J-Y Lee, C L Jung, I H Bae, K H Suh, Y G Ahn, D-H Jin, T W Kim, Y-A Suh, S J Jan. A novel antagonist to the inhibitors of apoptosis (IAPs) potentiates cell death in EGFR-overexpressing non-small-cell lung cancer cells. Cell death & disease. vol 5. 2015-06-18. PMID:25321484. |
interestingly, cells overexpressing epidermal growth factor receptor (egfr) due to the mutations were more sensitive to hm90822b, undergoing cell cycle arrest and apoptosis when treated. |
2015-06-18 |
2023-08-13 |
Not clear |
| Melissa W Y Chua, Mike Z Lin, Janet L Martin, Robert C Baxte. Involvement of the insulin-like growth factor binding proteins in the cancer cell response to DNA damage. Journal of cell communication and signaling. vol 9. issue 2. 2015-06-08. PMID:25617051. |
the epidermal growth factor receptor (egfr) has been implicated in the nhej pathway, and egfr inhibition may inhibit repair, promoting apoptosis and thus improving sensitivity to chemotherapy or radiotherapy. |
2015-06-08 |
2023-08-13 |
human |
| Noémie Michel, Nathalie Heuzé-Vourc'h, Elise Lavergne, Christelle Parent, Marie-Lise Jourdan, Amandine Vallet, Sophie Iochmann, Orlando Musso, Pascale Reverdiau, Yves Court. Growth and survival of lung cancer cells: regulation by kallikrein-related peptidase 6 via activation of proteinase-activated receptor 2 and the epidermal growth factor receptor. Biological chemistry. vol 395. issue 9. 2015-06-02. PMID:24643912. |
we used an isogenic non-small cell lung cancer (nsclc) cell model system to demonstrate that klk6 promotes the proliferation of lung tumoral cells and restrains their apoptosis in vitro via ligand-dependent egfr transactivation. |
2015-06-02 |
2023-08-12 |
Not clear |
| Tae-Gul Lee, Eun-Hui Jeong, Seo Yun Kim, Hye-Ryoun Kim, Cheol Hyeon Ki. The combination of irreversible EGFR TKIs and SAHA induces apoptosis and autophagy-mediated cell death to overcome acquired resistance in EGFR T790M-mutated lung cancer. International journal of cancer. vol 136. issue 11. 2015-06-02. PMID:25382705. |
the combination of irreversible egfr tkis and saha induces apoptosis and autophagy-mediated cell death to overcome acquired resistance in egfr t790m-mutated lung cancer. |
2015-06-02 |
2023-08-13 |
Not clear |
| Timothy H Witney, R Fortt, Robin R Fortt, Eric O Aboagy. Preclinical assessment of carboplatin treatment efficacy in lung cancer by 18F-ICMT-11-positron emission tomography. PloS one. vol 9. issue 3. 2015-05-29. PMID:24618809. |
carboplatin-induced apoptosis in the ercc1 low/mutant egfr pc9 cells was characterised by time and dose-related increased caspase-3/7 activation, poly-adp-ribose polymerase cleavage and annexin v staining. |
2015-05-29 |
2023-08-12 |
Not clear |
| Alaa Refaat, Aminullah, Yue Zhou, Miho Kawanishi, Rika Tomaru, Sherif Abdelhamed, Myoung-Sook Shin, Keiichi Koizumi, Satoru Yokoyama, Ikuo Saiki, Hiroaki Sakura. Role of tyrosine kinase-independent phosphorylation of EGFR with activating mutation in cisplatin-treated lung cancer cells. Biochemical and biophysical research communications. vol 458. issue 4. 2015-05-26. PMID:25701783. |
we therefore introduce a potential combinatorial therapy composed of p38 inhibition and cisplatin to block the activation of egfr, therefore inducing cancer cell death and apoptosis. |
2015-05-26 |
2023-08-13 |
Not clear |
| Jiao Liu, Ying Liang, Ting Liu, Dengke Li, Xingsheng Yan. Anti-EGFR-Conjugated Hollow Gold Nanospheres Enhance Radiocytotoxic Targeting of Cervical Cancer at Megavoltage Radiation Energies. Nanoscale research letters. vol 10. 2015-05-21. PMID:25995714. |
the study aimed to confirm that anti-epidermal growth factor receptor (egfr) monoclonal antibody-conjugated hollow gold nanospheres (anti-egfr/hgns) can be selectively uptaken by cervical cancer cells and induce its apoptosis when combined with radiotherapy, as a result enhancing radiosensitivity of cervical cancer cells. |
2015-05-21 |
2023-08-13 |
Not clear |
| Abheepsa Mishra, Samiran S Gauri, Sourav K Mukhopadhyay, Soumya Chatterjee, Shibendu S Das, Santi M Mandal, Satyahari De. Identification and structural characterization of a new pro-apoptotic cyclic octapeptide cyclosaplin from somatic seedlings of Santalum album L. Peptides. vol 54. 2015-05-13. PMID:24503375. |
the co-localization studies revealed that the peptide sensitizes mda-mb-231 cells by possibly binding to egfr and induces apoptosis. |
2015-05-13 |
2023-08-12 |
human |
| Azusa Tanimoto, Tadaaki Yamada, Shigeki Nanjo, Shinji Takeuchi, Hiromichi Ebi, Kenji Kita, Kunio Matsumoto, Seiji Yan. Receptor ligand-triggered resistance to alectinib and its circumvention by Hsp90 inhibition in EML4-ALK lung cancer cells. Oncotarget. vol 5. issue 13. 2015-05-12. PMID:24952482. |
additionally, the heat shock protein 90 (hsp90) inhibitor suppressed protein expression of alk, met, egfr, and akt, and thereby induced apoptosis in eml4-alk nsclc cells, even in the presence of egfr ligands or hgf. |
2015-05-12 |
2023-08-13 |
Not clear |
| Annika Sommerfeld, Roland Reinehr, Dieter Häussinge. Free fatty acids shift insulin-induced hepatocyte proliferation towards CD95-dependent apoptosis. The Journal of biological chemistry. vol 290. issue 7. 2015-05-08. PMID:25548285. |
saturated long chain ffas induced apoptosis and jnk activation in primary rat hepatocytes, but did not activate the cd95 (fas, apo-1) system, whereas insulin triggered egfr activation and hepatocyte proliferation. |
2015-05-08 |
2023-08-13 |
mouse |
| Annika Sommerfeld, Roland Reinehr, Dieter Häussinge. Free fatty acids shift insulin-induced hepatocyte proliferation towards CD95-dependent apoptosis. The Journal of biological chemistry. vol 290. issue 7. 2015-05-08. PMID:25548285. |
coadministration of insulin and ffas, however, abolished hepatocyte proliferation and triggered cd95-dependent apoptosis due to a jnk-dependent association of the activated egfr with cd95, subsequent cd95 tyrosine phosphorylation and formation of the death-inducing signaling complex (disc). |
2015-05-08 |
2023-08-13 |
mouse |
| Annika Sommerfeld, Roland Reinehr, Dieter Häussinge. Free fatty acids shift insulin-induced hepatocyte proliferation towards CD95-dependent apoptosis. The Journal of biological chemistry. vol 290. issue 7. 2015-05-08. PMID:25548285. |
it is concluded that ffas can shift insulin-induced hepatocyte proliferation toward hepatocyte apoptosis by triggering a jnk signal, which allows activated egfr to associate with cd95 and to trigger cd95-dependent apoptosis. |
2015-05-08 |
2023-08-13 |
mouse |
| Lin-Tao Jia, Rui Zhang, Lan Shen, An-Gang Yan. Regulators of carcinogenesis: emerging roles beyond their primary functions. Cancer letters. vol 357. issue 1. 2015-04-21. PMID:25448403. |
for example, the epidermal growth factor receptor (egfr) regulates dna synthesis, microrna maturation and drug resistance by interacting with previously undescribed partners; cyclins and cyclin-dependent kinases (cdks) crosstalk with multiple canonical pathways by phosphorylating novel substrates or by functioning as transcriptional factors; apoptosis executioners play extensive roles in necroptosis, autophagy, and in the self-renewal of stem cells; and various metabolic enzymes and their mutants control carcinogenesis independently of their enzymatic activity. |
2015-04-21 |
2023-08-13 |
Not clear |
| Donghern Kim, Jin Dai, Leonard Yenwong Fai, Hua Yao, Young-Ok Son, Lei Wang, Poyil Pratheeshkumar, Kazuya Kondo, Xianglin Shi, Zhuo Zhan. Constitutive activation of epidermal growth factor receptor promotes tumorigenesis of Cr(VI)-transformed cells through decreased reactive oxygen species and apoptosis resistance development. The Journal of biological chemistry. vol 290. issue 4. 2015-04-21. PMID:25477514. |
inhibition of egfr or areg increased bax expression and reduced bcl-2 expression, resulting in reduced apoptosis resistance. |
2015-04-21 |
2023-08-13 |
mouse |
| Donghern Kim, Jin Dai, Leonard Yenwong Fai, Hua Yao, Young-Ok Son, Lei Wang, Poyil Pratheeshkumar, Kazuya Kondo, Xianglin Shi, Zhuo Zhan. Constitutive activation of epidermal growth factor receptor promotes tumorigenesis of Cr(VI)-transformed cells through decreased reactive oxygen species and apoptosis resistance development. The Journal of biological chemistry. vol 290. issue 4. 2015-04-21. PMID:25477514. |
in summary, the present study suggests that ligand-dependent constitutive activation of egfr causes reduced ros generation and increased antioxidant expression, leading to development of apoptosis resistance, contributing to cr(vi)-induced tumorigenesis. |
2015-04-21 |
2023-08-13 |
mouse |