| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rong Tian, You Li, Mei Ga. Shikonin causes cell-cycle arrest and induces apoptosis by regulating the EGFR-NF-κB signalling pathway in human epidermoid carcinoma A431 cells. Bioscience reports. vol 35. issue 2. 2016-01-25. PMID:25720435. |
then, the nf-κb inhibitors such as bay11-7082, sn50, helenalin and the egfr inhibitor ag1478 and its downstream inhibitor such as pi3k inhibitor ly294002 and stat3 inhibitor stattic dramatically blocked egf-reversed decreases in cell viability and increases in apoptosis induced by shikonin. |
2016-01-25 |
2023-08-13 |
human |
| Zhen-yi Xing, Lai-guang Sun, Wu-jun Gu. Elevated expression of Notch-1 and EGFR induced apoptosis in glioblastoma multiforme patients. Clinical neurology and neurosurgery. vol 131. 2016-01-12. PMID:25704190. |
elevated expression of notch-1 and egfr induced apoptosis in glioblastoma multiforme patients. |
2016-01-12 |
2023-08-13 |
human |
| Zijian Wei, Deshui Yu, Yunlong Bi, Yang Ca. A disintegrin and metalloprotease 17 promotes microglial cell survival via epidermal growth factor receptor signalling following spinal cord injury. Molecular medicine reports. vol 12. issue 1. 2016-01-08. PMID:25738567. |
western blot analysis demonstrated that inhibiting adam17 resulted in a reduction in the phosphorylation of the egfr signalling pathway components and thereby impaired functional recovery, inhibited cell viability and prompted microglial apoptosis following sci. |
2016-01-08 |
2023-08-13 |
mouse |
| Dandan Liang, Peng Zhong, Jie Hu, Feng Lin, Yuanyuan Qian, Zheng Xu, Jingying Wang, Chunlai Zeng, Xiaokun Li, Guang Lian. EGFR inhibition protects cardiac damage and remodeling through attenuating oxidative stress in STZ-induced diabetic mouse model. Journal of molecular and cellular cardiology. vol 82. 2016-01-06. PMID:25758431. |
it was observed that diabetes induced phospohorylation of egfr and akt, increased cardiac ros levels, and ultimately led to cardiac remodeling including cardiac hypertrophy, disorganization, apoptosis, and fibrosis, while all these molecular and pathological alterations were attenuated by the treatment with egfr inhibitors. |
2016-01-06 |
2023-08-13 |
mouse |
| Dandan Liang, Peng Zhong, Jie Hu, Feng Lin, Yuanyuan Qian, Zheng Xu, Jingying Wang, Chunlai Zeng, Xiaokun Li, Guang Lian. EGFR inhibition protects cardiac damage and remodeling through attenuating oxidative stress in STZ-induced diabetic mouse model. Journal of molecular and cellular cardiology. vol 82. 2016-01-06. PMID:25758431. |
in vitro, either pharmacological inhibition of egfr/akt or sh-rna silencing of egfr significantly inhibited high concentration glucose (hg)-induced ros generation and subsequently cell apoptosis in both cardiac h9c2 cells and primary rat cardiomyocytes, respectively. |
2016-01-06 |
2023-08-13 |
mouse |
| Nguyen Dinh Thang, Phan Tuan Nghia, Mayuko Y Kumasaka, Ichiro Yajima, Masashi Kat. Treatment of vemurafenib-resistant SKMEL-28 melanoma cells with paclitaxel. Asian Pacific journal of cancer prevention : APJCP. vol 16. issue 2. 2015-12-14. PMID:25684511. |
treatment of skmel-28r cells with 100 nm paclitaxel resulted in increased apoptosis and decreased cellular proliferation, invasion and colony formation via reduction of expression levels of egfr and pakts. |
2015-12-14 |
2023-08-13 |
Not clear |
| Ting-Ting Chao, Cheng-Yi Wang, Yen-Lin Chen, Chih-Cheng Lai, Fang-Yu Chang, Yi-Ting Tsai, Chung-Hao H Chao, Chung-Wai Shiau, Yuh-Chin T Huang, Chong-Jen Yu, Kuen-Feng Che. Afatinib induces apoptosis in NSCLC without EGFR mutation through Elk-1-mediated suppression of CIP2A. Oncotarget. vol 6. issue 4. 2015-12-04. PMID:25537503. |
afatinib induces apoptosis in nsclc without egfr mutation through elk-1-mediated suppression of cip2a. |
2015-12-04 |
2023-08-13 |
mouse |
| Ting-Ting Chao, Cheng-Yi Wang, Yen-Lin Chen, Chih-Cheng Lai, Fang-Yu Chang, Yi-Ting Tsai, Chung-Hao H Chao, Chung-Wai Shiau, Yuh-Chin T Huang, Chong-Jen Yu, Kuen-Feng Che. Afatinib induces apoptosis in NSCLC without EGFR mutation through Elk-1-mediated suppression of CIP2A. Oncotarget. vol 6. issue 4. 2015-12-04. PMID:25537503. |
we found afatinib can also induce apoptosis in nsclc cells without egfr mutation through cip2a pathway. |
2015-12-04 |
2023-08-13 |
mouse |
| Ting-Ting Chao, Cheng-Yi Wang, Yen-Lin Chen, Chih-Cheng Lai, Fang-Yu Chang, Yi-Ting Tsai, Chung-Hao H Chao, Chung-Wai Shiau, Yuh-Chin T Huang, Chong-Jen Yu, Kuen-Feng Che. Afatinib induces apoptosis in NSCLC without EGFR mutation through Elk-1-mediated suppression of CIP2A. Oncotarget. vol 6. issue 4. 2015-12-04. PMID:25537503. |
in conclusion, afatinib induces apoptosis in nsclc without egfr mutations through elk-1/cip2a/pp2a/akt pathway. |
2015-12-04 |
2023-08-13 |
mouse |
| Izabella T Silva, Annelise Carvalho, Karen L Lang, Sabine E Dudek, Dörthe Masemann, Fernando J Durán, Miguel S B Caro, Ulf R Rapp, Viktor Wixler, Eloir P Schenkel, Cláudia M O Simões, Stephan Ludwi. In vitro and in vivo antitumor activity of a novel semisynthetic derivative of cucurbitacin B. PloS one. vol 10. issue 2. 2015-11-20. PMID:25674792. |
dace arrested the cell cycle of lung epithelial cells at the g2/m phase and induced cell apoptosis by interfering with egfr activation and its downstream signaling, including akt, erk, and stat3. |
2015-11-20 |
2023-08-13 |
mouse |
| Yichun Qian, Mantang Qiu, Qingquan Wu, Yanyan Tian, Yu Zhang, Ning Gu, Suyi Li, Lin Xu, Rong Yi. Enhanced cytotoxic activity of cetuximab in EGFR-positive lung cancer by conjugating with gold nanoparticles. Scientific reports. vol 4. 2015-11-17. PMID:25502402. |
c225-aunps significantly suppressed a549 cell proliferation and migration capacity and accelerated apoptosis compared with c225, and this effect was probably due to enhanced egfr endocytosis and the subsequent suppression of downstream signaling pathway. |
2015-11-17 |
2023-08-13 |
mouse |
| Yiwang Hu, Chi Pan, Jiyi Hu, Suzhan Zhan. The role of Reg IV in colorectal cancer, as a potential therapeutic target. Contemporary oncology (Poznan, Poland). vol 19. issue 4. 2015-11-11. PMID:26557771. |
reg iv activates the epidermal growth factor receptor (egfr) signaling pathway in colon cancer and increases expression of b-cell lymphoma-2 (bcl-2) and b-cell lymphoma-extra large (bcl-xl), which are associated with the inhibition of apoptosis, results in mitogenic signaling in colon cancer cells, increase cell proliferation, metastasis and decreased apoptosis. |
2015-11-11 |
2023-08-13 |
human |
| Wu Feng Huang, Ai Hua Liu, Hai Jin Zhao, Hang Ming Dong, Lai Yu Liu, Shao Xi Ca. BIM Gene Polymorphism Lowers the Efficacy of EGFR-TKIs in Advanced Nonsmall Cell Lung Cancer With Sensitive EGFR Mutations: A Systematic Review and Meta-Analysis. Medicine. vol 94. issue 33. 2015-11-10. PMID:26287412. |
the strong association between bcl-2-like 11 (bim) triggered apoptosis and the presence of epidermal growth factor receptor (egfr) mutations has been proven in nonsmall cell lung cancer (nsclc). |
2015-11-10 |
2023-08-13 |
Not clear |
| Hong Ma, Jianping Bi, Tao Liu, Yang Ke, Sheng Zhang, Tao Zhan. Icotinib hydrochloride enhances the effect of radiotherapy by affecting DNA repair in colorectal cancer cells. Oncology reports. vol 33. issue 3. 2015-11-03. PMID:25572529. |
radiation combined with egfr blockade inhibited tumour proliferation, increased apoptosis, prolonged g2/m arrest and significantly enhanced dna injury in colorectal cancer. |
2015-11-03 |
2023-08-13 |
mouse |
| Justin M M Cates, Vincent A Memoli, Raul S Gonzale. Cell cycle and apoptosis regulatory proteins, proliferative markers, cell signaling molecules, CD209, and decorin immunoreactivity in low-grade myxofibrosarcoma and myxoma. Virchows Archiv : an international journal of pathology. vol 467. issue 2. 2015-11-03. PMID:25940995. |
ten cases each of intramuscular myxoma and low-grade myxofibrosarcoma were stained with antibodies directed against apoptosis regulatory proteins (bcl2, activated caspase-3, phospho-h2a.x, and cleaved parp), cell cycle regulatory proteins (rb1, cyclin-a, cdkn1b, and cdt1), proliferative markers (ki67, mcm2, phospho-histone h3, and geminin), cell signalling molecules (c-myc, egf, egfr, pla2g4a, and hsp90), a dendritic cell marker (cd209), and the extracellular matrix proteoglycan decorin. |
2015-11-03 |
2023-08-13 |
Not clear |
| Kandasamy Palanivel, Veerasamy Kanimozhi, Balamuthu Kadalmani, Mohammad Abdulkader Akbarsh. Verrucarin A induces apoptosis through ROS-mediated EGFR/MAPK/Akt signaling pathways in MDA-MB-231 breast cancer cells. Journal of cellular biochemistry. vol 115. issue 11. 2015-10-26. PMID:24963595. |
furthermore, va-induced apoptosis was accompanied by the activation of p38mapk and inhibition of phosphorylation of egfr as well as of akt and erk1/2. |
2015-10-26 |
2023-08-13 |
human |
| Kandasamy Palanivel, Veerasamy Kanimozhi, Balamuthu Kadalmani, Mohammad Abdulkader Akbarsh. Verrucarin A induces apoptosis through ROS-mediated EGFR/MAPK/Akt signaling pathways in MDA-MB-231 breast cancer cells. Journal of cellular biochemistry. vol 115. issue 11. 2015-10-26. PMID:24963595. |
however, pre-treatment with n-acetyl cysteine, an ros scavenger, and sb202190, a p38mapk inhibitor, significantly inhibited va-induced ros generation, egfr inhibition, p38mapk activation and apoptosis. |
2015-10-26 |
2023-08-13 |
human |
| Kandasamy Palanivel, Veerasamy Kanimozhi, Balamuthu Kadalmani, Mohammad Abdulkader Akbarsh. Verrucarin A induces apoptosis through ROS-mediated EGFR/MAPK/Akt signaling pathways in MDA-MB-231 breast cancer cells. Journal of cellular biochemistry. vol 115. issue 11. 2015-10-26. PMID:24963595. |
moreover, pharmacological inhibition of egfr and erk1/2 significantly accelerated the va-induced apoptosis in mda-mb-231 cells. |
2015-10-26 |
2023-08-13 |
human |
| Si-Feng Tao, Hai-Fei He, Qiang Che. Quercetin inhibits proliferation and invasion acts by up-regulating miR-146a in human breast cancer cells. Molecular and cellular biochemistry. vol 402. issue 1-2. 2015-10-26. PMID:25596948. |
all the results demonstrated that quercetin exhibited excellent effect on inhibiting cell proliferation in human breast cancer cells, which was performed by up-regulating mir-146a expression, then via inducing apoptosis through caspase-3 activation and mitochondrial-dependent pathways, and inhibiting invasion through down-regulating the expression of egfr. |
2015-10-26 |
2023-08-13 |
human |
| Zheng-Hua Huang, Hong-Fang Zheng, Wei-Lu Wang, Yong Wang, Long-Fei Zhong, Jiu-Long Wu, Qiao-Xing L. Berberine targets epidermal growth factor receptor signaling to suppress prostate cancer proliferation in vitro. Molecular medicine reports. vol 11. issue 3. 2015-10-16. PMID:25394789. |
in conclusion, the results indicate that berberine inhibits the proliferation of prostate cancer cells through apoptosis and/or cell cycle arrest by inactivation of the egfr signaling pathway. |
2015-10-16 |
2023-08-13 |
human |