| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Georgia Arentz, Tim Chataway, Mark R Condina, Timothy J Price, Peter Hoffmann, Jennifer E Hardingha. Increased Phospho-Keratin 8 Isoforms in Colorectal Tumors Associated with EGFR Pathway Activation and Reduced Apoptosis. ISRN molecular biology. vol 2012. 2016-07-11. PMID:27398237. |
blocking of egfr signaling in caco2 cells showed a significant decrease (p < 0.0001) in k8 ps74 and ps432 levels by 59% and 66%, respectively, resulting in increased apoptosis. |
2016-07-11 |
2023-08-13 |
Not clear |
| Ewa Ryszczuk, Izabela Roszko-Kirpsza, Katarzyna Guzińska-Ustymowicz, Beata Janina Olejnik, Maciej Gustaw Kaczmarski, Elżbieta Maciorkowsk. EGFR and Bcl-2 in gastric mucosa of children infected with Helicobacter pylori. Postepy higieny i medycyny doswiadczalnej (Online). vol 70. 2016-06-24. PMID:27117101. |
the aim of the study was to evaluate the expression of egfr and bcl-2 proteins as inhibitory markers of apoptosis in surface epithelial cells and gland cells of antral gastric mucosa in children infected with helicobacter pylori according to the severity and activity of antral gastritis and to assess the correlation between the number of cells expressing egfr and the number of cells expressing bcl-2 in h. pylori infected children. |
2016-06-24 |
2023-08-13 |
Not clear |
| Onat Kadioglu, Jingming Cao, Mohamed E M Saeed, Henry Johannes Greten, Thomas Effert. Targeting epidermal growth factor receptors and downstream signaling pathways in cancer by phytochemicals. Targeted oncology. vol 10. issue 3. 2016-06-21. PMID:25410594. |
epidermal growth factor receptors (egfr, her2, her3) activate signal transduction pathways involved in cancer proliferation, apoptosis, differentiation, metastasis, and angiogenesis. |
2016-06-21 |
2023-08-13 |
Not clear |
| Manoharan Sangeetha, Perinkulam Ravi Deepa, Pukhraj Rishi, Vikas Khetan, Subramanian Krishnakuma. Global gene deregulations in FASN silenced retinoblastoma cancer cells: molecular and clinico-pathological correlations. Journal of cellular biochemistry. vol 116. issue 11. 2016-06-14. PMID:25958981. |
deregulation of various downstream cell signaling pathways such as egfr (n = 55 genes), tgf-beta (n = 45 genes), cell cycle (n = 41 genes), mapk (n = 39 genes), lipid metabolism (n = 23 genes), apoptosis (n = 21 genes), gpcr signaling (n = 21 genes), and oxidative phosporylation (n = 18 genes) were observed. |
2016-06-14 |
2023-08-13 |
Not clear |
| Tripti Singh, Nirzari A Gupta, Su Xu, Ram Prasad, Sadanandan E Velu, Santosh K Katiya. Honokiol inhibits the growth of head and neck squamous cell carcinoma by targeting epidermal growth factor receptor. Oncotarget. vol 6. issue 25. 2016-06-10. PMID:26020804. |
administration of honokiol by oral gavage (100 mg/kg body weight) significantly (p < 0.01-0.001) inhibited the growth of scc-1 and fadu xenografts in athymic nude mice, which was associated with: (i) inhibition of tumor cell proliferation, (ii) induction of apoptosis, (iii) reduced expressions of cyclins and cdks, and (iv) inhibition of egfr signaling pathway. |
2016-06-10 |
2023-08-13 |
mouse |
| Jiani Liu, Jiangxue Wu, Ling Zhou, Changchuan Pan, Yi Zhou, Wuying Du, Jie-Min Chen, Xiaofeng Zhu, Jingnan Shen, Shuai Chen, Ran-Yi Liu, Wenlin Huan. ZD6474, a new treatment strategy for human osteosarcoma, and its potential synergistic effect with celecoxib. Oncotarget. vol 6. issue 25. 2016-06-10. PMID:26050198. |
the data demonstrated that zd6474 inhibited the growth of osteosarcoma cells, and promoted g1-phase cell cycle arrest and apoptosis by inhibiting the activity of egfr tyrosine kinase, and consequently suppressing its downstream pi3k/akt and mapk/erk pathway. |
2016-06-10 |
2023-08-13 |
mouse |
| Takuro Mizukami, Yosuke Togashi, Shunsuke Sogabe, Eri Banno, Masato Terashima, Marco A De Velasco, Kazuko Sakai, Yoshihiko Fujita, Shuta Tomida, Takako Eguchi Nakajima, Narikazu Boku, Kazuto Nishi. EGFR and HER2 signals play a salvage role in MEK1-mutated gastric cancer after MEK inhibition. International journal of oncology. vol 47. issue 2. 2016-05-24. PMID:26081723. |
the combination of trametinib and lapatinib synergistically inhibited the cell growth of the ocum-1 cell line and strongly induced apoptosis by inhibiting the activated egfr and her2 signals. |
2016-05-24 |
2023-08-13 |
Not clear |
| Hee Suk Kim, Jang Mi Lim, Joo Young Kim, Yongjin Kim, Serkin Park, Jeongwon Soh. Panaxydol, a component of Panax ginseng, induces apoptosis in cancer cells through EGFR activation and ER stress and inhibits tumor growth in mouse models. International journal of cancer. vol 138. issue 6. 2016-05-13. PMID:26421996. |
panaxydol, a component of panax ginseng, induces apoptosis in cancer cells through egfr activation and er stress and inhibits tumor growth in mouse models. |
2016-05-13 |
2023-08-13 |
mouse |
| Hee Suk Kim, Jang Mi Lim, Joo Young Kim, Yongjin Kim, Serkin Park, Jeongwon Soh. Panaxydol, a component of Panax ginseng, induces apoptosis in cancer cells through EGFR activation and ER stress and inhibits tumor growth in mouse models. International journal of cancer. vol 138. issue 6. 2016-05-13. PMID:26421996. |
this study demonstrates that egfr activation and the resulting er stress mediate panaxydol-induced apoptosis, and that panaxydol suppresses in vivo tumor growth in syngeneic and xenogeneic mouse tumor models. |
2016-05-13 |
2023-08-13 |
mouse |
| Hee Suk Kim, Jang Mi Lim, Joo Young Kim, Yongjin Kim, Serkin Park, Jeongwon Soh. Panaxydol, a component of Panax ginseng, induces apoptosis in cancer cells through EGFR activation and ER stress and inhibits tumor growth in mouse models. International journal of cancer. vol 138. issue 6. 2016-05-13. PMID:26421996. |
in mcf-7 cells, egfr was activated immediately after exposure to panaxydol, and this activation was necessary for induction of apoptosis, suggesting that panaxydol might be a promising anticancer candidate, especially for egfr-addicted cancer. |
2016-05-13 |
2023-08-13 |
mouse |
| Hee Suk Kim, Jang Mi Lim, Joo Young Kim, Yongjin Kim, Serkin Park, Jeongwon Soh. Panaxydol, a component of Panax ginseng, induces apoptosis in cancer cells through EGFR activation and ER stress and inhibits tumor growth in mouse models. International journal of cancer. vol 138. issue 6. 2016-05-13. PMID:26421996. |
in summary, we identified roles of egfr, the camkii-tak1-p38/jnk pathway, and er stress in panaxydol-induced apoptosis and demonstrated the in vivo anticancer effect of panaxydol. |
2016-05-13 |
2023-08-13 |
mouse |
| Fu-quan Zhang, Wen-tao Yang, Shan-zhou Duan, Ying-chen Xia, Rong-ying Zhu, Yong-bing Che. JAK2 inhibitor TG101348 overcomes erlotinib-resistance in non-small cell lung carcinoma cells with mutated EGF receptor. Oncotarget. vol 6. issue 16. 2016-05-12. PMID:25869210. |
tg101348 significantly enhanced the cytotoxicity of erlotinib to erlotinib-resistant nsclc cells, stimulated erlotinib-induced apoptosis and downregulated the expressions of egfr, p-egfr, p-stat3, bcl-xl and survivin in erlotinib-resistant nsclc cells. |
2016-05-12 |
2023-08-13 |
mouse |
| Tatsunori Okamura, Gamil Antoun, Stephen T Keir, Henry Friedman, Darell D Bigner, Francis Ali-Osma. Phosphorylation of Glutathione S-Transferase P1 (GSTP1) by Epidermal Growth Factor Receptor (EGFR) Promotes Formation of the GSTP1-c-Jun N-terminal kinase (JNK) Complex and Suppresses JNK Downstream Signaling and Apoptosis in Brain Tumor Cells. The Journal of biological chemistry. vol 290. issue 52. 2016-05-10. PMID:26429914. |
phosphorylation of glutathione s-transferase p1 (gstp1) by epidermal growth factor receptor (egfr) promotes formation of the gstp1-c-jun n-terminal kinase (jnk) complex and suppresses jnk downstream signaling and apoptosis in brain tumor cells. |
2016-05-10 |
2023-08-13 |
human |
| Tatsunori Okamura, Gamil Antoun, Stephen T Keir, Henry Friedman, Darell D Bigner, Francis Ali-Osma. Phosphorylation of Glutathione S-Transferase P1 (GSTP1) by Epidermal Growth Factor Receptor (EGFR) Promotes Formation of the GSTP1-c-Jun N-terminal kinase (JNK) Complex and Suppresses JNK Downstream Signaling and Apoptosis in Brain Tumor Cells. The Journal of biological chemistry. vol 290. issue 52. 2016-05-10. PMID:26429914. |
targeted mutagenesis and functional analysis demonstrated that the increased gstp1 binding to jnk results from phosphorylation of the gstp1 c-terminal tyr-198 by egfr and is associated with a >2.5-fold decrease in jnk downstream signaling and a significant suppression of both spontaneous and drug-induced apoptosis in the tumor cells. |
2016-05-10 |
2023-08-13 |
human |
| Kai Liu, Tao Jiang, Yabo Ouyang, Ying Shi, Yunjin Zang, Ning Li, Shichun Lu, Dexi Che. Nuclear EGFR impairs ASPP2-p53 complex-induced apoptosis by inducing SOS1 expression in hepatocellular carcinoma. Oncotarget. vol 6. issue 18. 2016-04-29. PMID:25980493. |
nuclear egfr impairs aspp2-p53 complex-induced apoptosis by inducing sos1 expression in hepatocellular carcinoma. |
2016-04-29 |
2023-08-13 |
Not clear |
| Kai Liu, Tao Jiang, Yabo Ouyang, Ying Shi, Yunjin Zang, Ning Li, Shichun Lu, Dexi Che. Nuclear EGFR impairs ASPP2-p53 complex-induced apoptosis by inducing SOS1 expression in hepatocellular carcinoma. Oncotarget. vol 6. issue 18. 2016-04-29. PMID:25980493. |
the in vivo assay demonstrated that egfr/sos1-promoted growth of nuclear p-akt+, bcl-2+ cells results in the resistance of hepatoma cells to aspp2-p53 complex-induced apoptosis and that blocking nuclear translocation of egfr dramatically improves and enhances the pro-apoptotic function of aspp2. |
2016-04-29 |
2023-08-13 |
Not clear |
| Kai Liu, Tao Jiang, Yabo Ouyang, Ying Shi, Yunjin Zang, Ning Li, Shichun Lu, Dexi Che. Nuclear EGFR impairs ASPP2-p53 complex-induced apoptosis by inducing SOS1 expression in hepatocellular carcinoma. Oncotarget. vol 6. issue 18. 2016-04-29. PMID:25980493. |
because evasion of apoptosis contributes to treatment resistance in hepatoma, our results also support further investigation of combined therapeutic blockade of egfr and sos1. |
2016-04-29 |
2023-08-13 |
Not clear |
| Saghir Akhtar, Bashayer Al-Zaid, Ahmed Z El-Hashim, Bindu Chandrasekhar, Sreeja Attur, Mariam H M Yousif, Ibrahim F Bente. Cationic Polyamidoamine Dendrimers as Modulators of EGFR Signaling In Vitro and In Vivo. PloS one. vol 10. issue 7. 2016-04-27. PMID:26167903. |
pf-mediated inhibition of egfr phosphorylation as well as sf or pf-mediated apoptosis in hek 293 cells could be significantly reversed by co-treatment with antioxidants such as tempol implying that both these effects involved an oxidative stress-dependent mechanism. |
2016-04-27 |
2023-08-13 |
human |
| Ibrahim F Benter, Fatima Sarkhou, Abeer T Al-Khaldi, Bindu Chandrasekhar, Sreeja Attur, Gursev S Dhaunsi, Mariam H M Yousif, Saghir Akhta. The dual targeting of EGFR and ErbB2 with the inhibitor Lapatinib corrects high glucose-induced apoptosis and vascular dysfunction by opposing multiple diabetes-induced signaling changes. Journal of drug targeting. vol 23. issue 6. 2016-04-25. PMID:26114862. |
the dual targeting of egfr and erbb2 with the inhibitor lapatinib corrects high glucose-induced apoptosis and vascular dysfunction by opposing multiple diabetes-induced signaling changes. |
2016-04-25 |
2023-08-13 |
rat |
| Manoranjan Santra, Michael Chopp, Sutapa Santra, Ankita Nallani, Shivam Vyas, Zheng Gang Zhang, Daniel C Morri. Thymosin beta 4 up-regulates miR-200a expression and induces differentiation and survival of rat brain progenitor cells. Journal of neurochemistry. vol 136. issue 1. 2016-04-25. PMID:26466330. |
the up-regulation of mir-200a down-regulated the expression of the following targets in vitro and in vivo models: (i) growth factor receptor-bound protein 2 (grb2), an adaptor protein involved in epidermal growth factor receptor (egfr)/grb2/ras/mek/erk1/c-jun signaling pathway, which negatively regulates the expression of myelin basic protein (mbp), a marker of mature oligodendrocyte; (ii) errfi-1/mig-6, an endogenous potent kinase inhibitor of egfr, which resulted in activation/phosphorylation of egfr; (iii) friend of gata 2, and phosphatase and tensin homolog deleted in chromosome 10 (pten), which are potent inhibitors of the phosphatidylinositol-3-kinase (pi3k)/akt signaling pathway, and resulted in marked activation of akt; and (iv) transcription factor, p53, which induces pro-apoptotic genes, and possibly reduced apoptosis of the progenitor cells subjected to oxygen glucose deprivation (ogd). |
2016-04-25 |
2023-08-13 |
rat |