| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Behzad Baradaran, Jafar Majidi, Safar Farajnia, Jaleh Barar, Yadollah Omid. Targeted therapy of solid tumors by monoclonal antibody specific to epidermal growth factor receptor. Human antibodies. vol 23. issue 1-2. 2015-10-08. PMID:25812698. |
flow cytometry and immunofluorescence staining revalidated its specific reactivity with egfr and mtt assay revealed significant growth inhibition of a431 cells treated with mab bf4 mainly through induction of apoptosis. |
2015-10-08 |
2023-08-13 |
mouse |
| Yongqing Hou, Lei Wang, Dan Yi, Guoyao W. N-acetylcysteine and intestinal health: a focus on its mechanism of action. Frontiers in bioscience (Landmark edition). vol 20. 2015-09-28. PMID:25553484. |
the effects of nac are associated with some intestinal cell signaling pathways, such as egfr, tlr4, apoptosis and tight junction signaling. |
2015-09-28 |
2023-08-13 |
Not clear |
| James A McCubrey, Stephen L Abrams, Timothy L Fitzgerald, Lucio Cocco, Alberto M Martelli, Giuseppe Montalto, Melchiorre Cervello, Aurora Scalisi, Saverio Candido, Massimo Libra, Linda S Steelma. Roles of signaling pathways in drug resistance, cancer initiating cells and cancer progression and metastasis. Advances in biological regulation. vol 57. 2015-09-16. PMID:25453219. |
in this manuscript, we will discuss an inducible egfr model (v-erb-b:er) and its effects on cell growth, cell cycle progression, activation of signal transduction pathways, prevention of apoptosis in hematopoietic, breast and prostate cancer models. |
2015-09-16 |
2023-08-13 |
Not clear |
| Bryson W Katona, Yuanyuan Liu, Anqi Ma, Jian Jin, Xianxin Hu. EZH2 inhibition enhances the efficacy of an EGFR inhibitor in suppressing colon cancer cells. Cancer biology & therapy. vol 15. issue 12. 2015-09-16. PMID:25535899. |
co-inhibition of ezh2 and egfr with the small molecules unc1999 and gefitinib, led to a significant decrease in cell number and increased apoptosis compared to inhibition of either pathway alone, and similar results were noted after ezh2 shrna knockdown. |
2015-09-16 |
2023-08-13 |
Not clear |
| H Liu, J Lu, Y Hua, P Zhang, Z Liang, L Ruan, C Lian, H Shi, K Chen, Z T. Targeting heat-shock protein 90 with ganetespib for molecularly targeted therapy of gastric cancer. Cell death & disease. vol 6. 2015-09-15. PMID:25590805. |
egfr knockdown also induced cell-cycle arrest and apoptosis accompanied with a decrease of several egfr downstream proteins. |
2015-09-15 |
2023-08-13 |
Not clear |
| Ming-Xiang Ye, Yan Li, Hong Yin, Jian Zhan. Curcumin: updated molecular mechanisms and intervention targets in human lung cancer. International journal of molecular sciences. vol 13. issue 3. 2015-08-31. PMID:22489192. |
apart from transcription factors and apoptosis, emerging studies shed light on latent targets of curcumin against epidermal growth factor receptor (egfr), micrornas (mirna), autophagy and cancer stem cell. |
2015-08-31 |
2023-08-12 |
human |
| Ying-Ka Ingar Lau, Xing Du, Vinayak Rayannavar, Benjamin Hopkins, Jacquelyn Shaw, Eliana Bessler, Tiffany Thomas, Maira M Pires, Megan Keniry, Ramon E Parsons, Serge Cremers, Matthias Szabolcs, Matthew A Maure. Metformin and erlotinib synergize to inhibit basal breast cancer. Oncotarget. vol 5. issue 21. 2015-08-31. PMID:25361177. |
combined metformin and erlotinib led to partial regression of pten-null and egfr-amplified xenografted mda-mb-468 bbc tumors with evidence of significant apoptosis, reduction of egfr and akt signaling, and lack of altered plasma insulin levels. |
2015-08-31 |
2023-08-13 |
mouse |
| Shinji Takeuchi, Seiji Yan. Clinical significance of epidermal growth factor receptor tyrosine kinase inhibitors: sensitivity and resistance. Respiratory investigation. vol 52. issue 6. 2015-08-31. PMID:25453378. |
recently, bim (bcl2l11), which is a bh3-only proapoptotic member of the bcl-2 protein family, was shown to play a central role in inducing apoptosis in response to egfr-tki treatment in egfr mutant lung cancer cells. |
2015-08-31 |
2023-08-13 |
Not clear |
| Lei Zhao, Fumin Ca. [Effects of 17-DMAG on non-small cell lung cancer cell lines A549 and H1975
being resistant to EGFR-TKI]. Zhongguo fei ai za zhi = Chinese journal of lung cancer. vol 17. issue 11. 2015-08-28. PMID:25404267. |
in this study, we examined the effect of 17-dmag on nsclc cell lines a549 and h1975 which were primary and acquired resistant to egfr-tki respectively, the purpose was to explore its influence on cell proliferation, apoptosis and the expression of egfr in vitro as well as possible mechanism. |
2015-08-28 |
2023-08-13 |
Not clear |
| Charles E Rengifo, Rancés Blanco, Damián Blanco, Mercedes Cedeño, Milagros Frómeta, Enrique Rengifo Calzad. Immunohistochemical Characterization of Three Monoclonal Antibodies Raised against the Epidermal Growth Factor and Its Receptor in Non-Small-Cell Lung Cancer: Their Potential Use in the Selection of Patients for Immunotherapy. Journal of biomarkers. vol 2013. 2015-08-28. PMID:26317020. |
the ability of ior egf/r3 mab to bind the extracellular domain of egfr inhibiting cell proliferation and inducing apoptosis in nci-h125 cells was also demonstrated. |
2015-08-28 |
2023-08-13 |
human |
| Kwang Sup So, Cheol Hyeon Kim, Jin Kyung Rho, Sun Ye Kim, Yun Jung Choi, Joon Seon Song, Woo Sung Kim, Chang Min Choi, Young Jin Chun, Jae Cheol Le. Autophagosome-mediated EGFR down-regulation induced by the CK2 inhibitor enhances the efficacy of EGFR-TKI on EGFR-mutant lung cancer cells with resistance by T790M. PloS one. vol 9. issue 12. 2015-08-05. PMID:25486409. |
accordingly, apoptosis by a combination of cx-4945 and egfr-tki was suppressed by 3ma or atg7-targeted sirna pretreatment, thus suggesting that autophagosome-mediated egfr down-regulation would have an important role regarding apoptotic cell death by egfr-tki. |
2015-08-05 |
2023-08-13 |
Not clear |
| Min-Cong Wang, Xuan Liang, Zhi-Yan Liu, Jie Cui, Ying Liu, Li Jing, Li-Li Jiang, Jie-Qun Ma, Li-Li Han, Qian-Qian Guo, Cheng-Cheng Yang, Jing Wang, Tao Wu, Ke-Jun Nan, Yu Ya. In vitro synergistic antitumor efficacy of sequentially combined chemotherapy/icotinib in non‑small cell lung cancer cell lines. Oncology reports. vol 33. issue 1. 2015-07-28. PMID:25370413. |
hcc827, h1975, h1299 and a549 human nsclc cell lines with wild‑type and mutant egfr genes were used as in vitro models to define the differential effects of various schedules of cisplatin/paclitaxel with icotinib treatments on cell growth, proliferation, cell cycle distribution, apoptosis, and egfr signaling pathway. |
2015-07-28 |
2023-08-13 |
human |
| Haiyan Liu, Qiang Jian, Ke Xue, Cuiling Ma, Fang Xie, Rui Wang, Wenjun Liao, Yufeng Liu, Sumin Chi, Chengxin L. The MEK/ERK signalling cascade is required for sonic hedgehog signalling pathway-mediated enhancement of proliferation and inhibition of apoptosis in normal keratinocytes. Experimental dermatology. vol 23. issue 12. 2015-07-27. PMID:25256290. |
furthermore, we observed that epidermal growth factor receptor (egfr) signalling modulates the activity of shh signalling pathway; besides, shh and egfr signalling act additively to induce the erk activation and the increases in cyclin d1 and bcl2 thereby affecting proliferation and apoptosis in kcs in vitro. |
2015-07-27 |
2023-08-13 |
Not clear |
| Yukihiro Wada, Masayuki Iyoda, Kei Matsumoto, Yuki Shindo-Hirai, Yoshihiro Kuno, Yasutaka Yamamoto, Taihei Suzuki, Tomohiro Saito, Ken Iseri, Takanori Shibat. Epidermal growth factor receptor inhibition with erlotinib partially prevents cisplatin-induced nephrotoxicity in rats. PloS one. vol 9. issue 11. 2015-07-20. PMID:25390346. |
taken together, these data indicate that erlotinib has renoprotective properties that are likely mediated through decreases in the apoptosis and proliferation of tubular cells, effects that reflect inhibition of downstream signaling pathways of egfr. |
2015-07-20 |
2023-08-13 |
human |
| Jing Wang, Hong Wei, Baoxia Zhao, Mei Li, Weipeng Lv, Ling Lv, Bo Song, Shen L. The reverse effect of X-ray irradiation on acquired gefitinib resistance in non-small cell lung cancer cell line NCI-H1975 in vitro. Journal of molecular histology. vol 45. issue 6. 2015-07-15. PMID:25008024. |
in the three cell lines, subsequently cell growth curves and cell population doubling time were calculated by cell proliferation assay, the changes of cell viability were evaluated by trypan blue dye exclusion method and mtt assay, the cell cycle distribution and apoptosis were investigated by flow cytometry, the expressions of e-cadherin and vimentin used to indicate epithelial-mesenchymal transition (emt) were determined by western blot analysis, the protein expressions in egfr/kras/braf transduction pathway were detected by immunocytochemistry, and the mutations of egfr, kras and braf were detected by high resolution melting analysis and direct sequencing. |
2015-07-15 |
2023-08-13 |
human |
| Y Zhen, L Guanghui, Z Xief. Knockdown of EGFR inhibits growth and invasion of gastric cancer cells. Cancer gene therapy. vol 21. issue 11. 2015-07-15. PMID:25394504. |
knockdown of egfr reduced cell proliferation and invasion of gc with decreased expression of akt, pcna and mmp-9 and induced cell apoptosis and cycle arrest. |
2015-07-15 |
2023-08-13 |
human |
| Cheng-Yi Wang, Ting-Ting Chao, Fang-Yu Chang, Yen-Lin Chen, Yi-Ting Tsai, Hen-I Lin, Yuh-Chin T Huang, Chung-Wai Shiau, Chong-Jen Yu, Kuen-Feng Che. CIP2A mediates erlotinib-induced apoptosis in non-small cell lung cancer cells without EGFR mutation. Lung cancer (Amsterdam, Netherlands). vol 85. issue 2. 2015-07-09. PMID:24954871. |
cip2a mediates erlotinib-induced apoptosis in non-small cell lung cancer cells without egfr mutation. |
2015-07-09 |
2023-08-13 |
Not clear |
| Alessandro Castorina, Salvatore Giunt. Mucin 1 (MUC1) signalling contributes to increase the resistance to cell death in human bronchial epithelial cells exposed to nickel acetate. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 27. issue 6. 2015-07-07. PMID:25053108. |
we have previously reported that nickel acetate (ni(2+)), a well-known human carcinogenic agents, differentially affected apoptosis in two different airway epithelial cell lines derived from the human respiratory tract (a549 and beas-2b, respectively), suggesting a potential involvement of epidermal growth factor receptor (egfr)/neu receptors in mediating this effect. |
2015-07-07 |
2023-08-13 |
human |
| Alessandro Castorina, Salvatore Giunt. Mucin 1 (MUC1) signalling contributes to increase the resistance to cell death in human bronchial epithelial cells exposed to nickel acetate. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 27. issue 6. 2015-07-07. PMID:25053108. |
conversely, beas-2b cells exposed to equivalent concentrations of ni(2+) showed increased expression of muc1 levels and this correlated with increased phosphorylation of both egfr and of the extracellular-regulated kinase 1/2 (erk1/2) and increase resistance to apoptosis, as indicated by cell viability assessments and dna damage. |
2015-07-07 |
2023-08-13 |
human |
| C Denoyelle, B Lambert, M Meryet-Figuière, N Vigneron, E Brotin, C Lecerf, E Abeilard, F Giffard, M-H Louis, P Gauduchon, P Juin, L Poulai. miR-491-5p-induced apoptosis in ovarian carcinoma depends on the direct inhibition of both BCL-XL and EGFR leading to BIM activation. Cell death & disease. vol 5. 2015-07-07. PMID:25299770. |
mir-491-5p-induced apoptosis in ovarian carcinoma depends on the direct inhibition of both bcl-xl and egfr leading to bim activation. |
2015-07-07 |
2023-08-13 |
Not clear |