| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fotis Nikolos, Christoforos Thomas, Gayani Rajapaksa, Igor Bado, Jan-Åke Gustafsso. ERβ regulates NSCLC phenotypes by controlling oncogenic RAS signaling. Molecular cancer research : MCR. vol 12. issue 6. 2015-04-15. PMID:24618619. |
downregulation of egfr and inactivation of ras and the downstream components erk1/2 were found to be involved in the erβ1-induced apoptosis. |
2015-04-15 |
2023-08-12 |
Not clear |
| Sung Keun Jung, Mee-Hyun Lee, Do Young Lim, Jong Eun Kim, Puja Singh, Sung-Young Lee, Chul-Ho Jeong, Tae-Gyu Lim, Hanyong Chen, Young-In Chi, Joydeb Kumar Kundu, Nam Hyouck Lee, Charles C Lee, Yong-Yeon Cho, Ann M Bode, Ki Won Lee, Zigang Don. Isoliquiritigenin induces apoptosis and inhibits xenograft tumor growth of human lung cancer cells by targeting both wild type and L858R/T790M mutant EGFR. The Journal of biological chemistry. vol 289. issue 52. 2015-04-14. PMID:25368326. |
isoliquiritigenin induces apoptosis and inhibits xenograft tumor growth of human lung cancer cells by targeting both wild type and l858r/t790m mutant egfr. |
2015-04-14 |
2023-08-13 |
human |
| Andrew S Brem, Rujun Gon. Therapeutic targeting of aldosterone: a novel approach to the treatment of glomerular disease. Clinical science (London, England : 1979). vol 128. issue 9. 2015-04-09. PMID:25671776. |
although mitochondrial dysfunction seems to mediate the aldosterone-induced mesangial apoptosis, the ros dependent epithelial growth factor receptor (egfr) transactivation is probably responsible for aldosterone-induced mesangial mitosis and proliferation. |
2015-04-09 |
2023-08-13 |
Not clear |
| Yingzhuan Zhan, Yinnan Chen, Rui Liu, Han Zhang, Yanmin Zhan. Potentiation of paclitaxel activity by curcumin in human breast cancer cell by modulating apoptosis and inhibiting EGFR signaling. Archives of pharmacal research. vol 37. issue 8. 2015-03-31. PMID:24318305. |
potentiation of paclitaxel activity by curcumin in human breast cancer cell by modulating apoptosis and inhibiting egfr signaling. |
2015-03-31 |
2023-08-12 |
mouse |
| Patricia Stiedl, Robert McMahon, Leander Blaas, Victoria Stanek, Jasmin Svinka, Beatrice Grabner, Gernot Zollner, Sonja M Kessler, Thierry Claudel, Mathias Müller, Wolfgang Mikulits, Martin Bilban, Harald Esterbauer, Robert Eferl, Johannes Haybaeck, Michael Trauner, Emilio Casanov. Growth hormone resistance exacerbates cholestasis-induced murine liver fibrosis. Hepatology (Baltimore, Md.). vol 61. issue 2. 2015-03-31. PMID:25179284. |
additionally, ghr(-/-);mdr2(-/-) mice had a pronounced down-regulation of hepatoprotective genes hnf6, egfr, and igf-1, and significantly increased levels of reactive oxygen species (ros) and apoptosis in hepatocytes, compared to control mice. |
2015-03-31 |
2023-08-13 |
mouse |
| Liang Ouyang, Yi Chen, Xiao-yan Wang, Rui-feng Lu, Shou-yue Zhang, Mao Tian, Tao Xie, Bo Liu, Gu H. Polygonatum odoratum lectin induces apoptosis and autophagy via targeting EGFR-mediated Ras-Raf-MEK-ERK pathway in human MCF-7 breast cancer cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 21. issue 12. 2015-03-30. PMID:25442274. |
additionally, we also found that pol induces mcf-7 cell apoptosis via egfr-mediated ras-raf-mek-erk pathway, suggesting that pol may be a potential egfr inhibitor. |
2015-03-30 |
2023-08-13 |
human |
| Niki Karachaliou, Ana Gimenez-Capitan, Ana Drozdowskyj, Santiago Viteri, Teresa Moran, Enric Carcereny, Bartomeu Massuti, Alain Vergnenegre, Filippo de Marinis, Miguel Angel Molina, Cristina Teixido, Rafael Rosel. ROR1 as a novel therapeutic target for EGFR-mutant non-small-cell lung cancer patients with the EGFR T790M mutation. Translational lung cancer research. vol 3. issue 3. 2015-03-25. PMID:25806291. |
activation of bypass signaling pathways, impairment of apoptosis and mutation of epidermal growth factor receptor (egfr) to a drug-resistant state are well known mechanisms of resistance to single-agent erlotinib therapy in non-small-cell lung cancer (nsclc) driven by egfr mutations. |
2015-03-25 |
2023-08-13 |
Not clear |
| Jie Cui, Yun-Feng Hu, Xie-Min Feng, Tao Tian, Ya-Huan Guo, Jun-Wei Ma, Ke-Jun Nan, Hong-Yi Zhan. EGFR inhibitors and autophagy in cancer treatment. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 12. 2015-03-10. PMID:25293518. |
on the other hand, a high level of autophagy after treatment of egfr inhibitors can also result in autophagic cell death lacking features of apoptosis, and the combination of egfr inhibitors with an autophagy inducer might be beneficial. |
2015-03-10 |
2023-08-13 |
Not clear |
| Weina Ma, Dongdong Zhang, Lei Zheng, Yingzhuan Zhan, Yanmin Zhan. Potential roles of Centipede Scolopendra extracts as a strategy against EGFR-dependent cancers. American journal of translational research. vol 7. issue 1. 2015-03-10. PMID:25755827. |
the mechanism of aecs to inhibit high-egfr expression cell proliferation is due to its ability to induce apoptosis and modulate the egfr pathway. |
2015-03-10 |
2023-08-13 |
Not clear |
| Nicholas Borcherding, David Kusner, Guang-Hui Liu, Weizhou Zhan. ROR1, an embryonic protein with an emerging role in cancer biology. Protein & cell. vol 5. issue 7. 2015-03-03. PMID:24752542. |
ror1 has been shown to inhibit apoptosis, potentiate egfr signaling, and induce epithelial-mesenchymal transition (emt). |
2015-03-03 |
2023-08-13 |
Not clear |
| Juthika Kundu, Bu Young Choi, Chul-Ho Jeong, Joydeb Kumar Kundu, Kyung-Soo Chu. Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Src‑mediated phosphorylation of EGF receptor tyrosine kinase. Oncology reports. vol 32. issue 2. 2015-02-12. PMID:24890449. |
collectively, our study revealed that tq induced apoptosis in hct116 cells by blocking stat3 signaling via inhibition of jak2- and src-mediated phosphorylation of egfr tyrosine kinase. |
2015-02-12 |
2023-08-13 |
human |
| Began Gopalan, Karthikeyan Narayanan, Zhiyuan Ke, Ting Lu, Yugen Zhang, Lang Zhu. Therapeutic effect of a multi-targeted imidazolium compound in hepatocellular carcinoma. Biomaterials. vol 35. issue 26. 2015-02-02. PMID:24912819. |
a sirna knockdown of egfr also proved that ibn-65 induced apoptosis mostly through inhibiting downstream egfr pathway signaling, much less at the receptor level. |
2015-02-02 |
2023-08-13 |
mouse |
| Lanfang Meng, Mengjun Shu, Yaqing Chen, Dexiao Yang, Qun He, Hui Zhao, Zhiyong Feng, Chris Liang, Ker Y. A novel lead compound CM-118: antitumor activity and new insight into the molecular mechanism and combination therapy strategy in c-Met- and ALK-dependent cancers. Cancer biology & therapy. vol 15. issue 6. 2015-01-22. PMID:24618813. |
we show that the cm-118-induced apoptosis in c-met-amplified h1993 nsclc cells involved a rapid suppression of c-met activity and c-met-to-egfr cross-talk, and was profoundly potentiated by egfr inhibitors as shown by the increased levels of apoptotic proteins cleaved-parp and bim as well as reduction of the survival protein mcl-1. |
2015-01-22 |
2023-08-12 |
mouse |
| Yanni Zhu, Khalid Sha. Multiple lesions in receptor tyrosine kinase pathway determine glioblastoma response to pan-ERBB inhibitor PF-00299804 and PI3K/mTOR dual inhibitor PF-05212384. Cancer biology & therapy. vol 15. issue 6. 2015-01-22. PMID:24658109. |
blocking pi3k/mtor dramatically inhibited cell proliferation in most gbm lines and enhanced dacomitinib induction of apoptosis in a gbm line that has both egfr amplification and egfr-independent pi3k activation. |
2015-01-22 |
2023-08-12 |
Not clear |
| Ling Xu, Xiujuan Qu, Heming Li, Ce Li, Jing Liu, Huachuan Zheng, Yunpeng Li. Src/caveolin-1-regulated EGFR activation antagonizes TRAIL-induced apoptosis in gastric cancer cells. Oncology reports. vol 32. issue 1. 2015-01-14. PMID:24840271. |
src/caveolin-1-regulated egfr activation antagonizes trail-induced apoptosis in gastric cancer cells. |
2015-01-14 |
2023-08-13 |
Not clear |
| Ling Xu, Xiujuan Qu, Heming Li, Ce Li, Jing Liu, Huachuan Zheng, Yunpeng Li. Src/caveolin-1-regulated EGFR activation antagonizes TRAIL-induced apoptosis in gastric cancer cells. Oncology reports. vol 32. issue 1. 2015-01-14. PMID:24840271. |
gastric cancer cells are insensitive to tumor necrosis factor-related apoptosis-inducing ligand (trail), and we recently showed that lipid raft-regulated epidermal growth factor receptor (egfr) activation antagonized trail-induced apoptosis. |
2015-01-14 |
2023-08-13 |
Not clear |
| Ling Xu, Xiujuan Qu, Heming Li, Ce Li, Jing Liu, Huachuan Zheng, Yunpeng Li. Src/caveolin-1-regulated EGFR activation antagonizes TRAIL-induced apoptosis in gastric cancer cells. Oncology reports. vol 32. issue 1. 2015-01-14. PMID:24840271. |
a src inhibitor prevented these interactions and the activation of caveolin-1 and egfr, and thus enhanced trail-induced apoptosis. |
2015-01-14 |
2023-08-13 |
Not clear |
| Ling Xu, Xiujuan Qu, Heming Li, Ce Li, Jing Liu, Huachuan Zheng, Yunpeng Li. Src/caveolin-1-regulated EGFR activation antagonizes TRAIL-induced apoptosis in gastric cancer cells. Oncology reports. vol 32. issue 1. 2015-01-14. PMID:24840271. |
these data suggest that src activates egfr through the interaction of both src-egfr and src-caveolin-1, and then antagonizes trail-induced apoptosis in gastric cancer cells. |
2015-01-14 |
2023-08-13 |
Not clear |
| Geping Qu, Changting Liu, Baojun Sun, Changxi Zhou, Zhijian Zhang, Peng Wan. Combination of BIBW2992 and ARQ 197 is effective against erlotinib-resistant human lung cancer cells with the EGFR T790M mutation. Oncology reports. vol 32. issue 1. 2015-01-14. PMID:24842595. |
the bibw2992/arq 197 combination significantly inhibited growth, induced cell cycle arrest and apoptosis, and altered the phosphorylation of egfr, met, akt and erk1/2 in the h1975 cells. |
2015-01-14 |
2023-08-13 |
human |
| Suning Huang, Rongquan He, Minhua Rong, Yiwu Dang, Gang Che. Synergistic effect of MiR-146a mimic and cetuximab on hepatocellular carcinoma cells. BioMed research international. vol 2014. 2015-01-14. PMID:24895573. |
moreover, mir-146a mimic could enhance the cell growth inhibition and apoptosis induction impact of various egfr targeting agents. |
2015-01-14 |
2023-08-13 |
Not clear |