| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Olga K Mirzoeva, Eric A Collisson, Peter M Schaefer, Byron Hann, Yun K Hom, Andrew H Ko, W Michael Kor. Subtype-specific MEK-PI3 kinase feedback as a therapeutic target in pancreatic adenocarcinoma. Molecular cancer therapeutics. vol 12. issue 10. 2014-05-19. PMID:23918833. |
inhibition of mek activated phosphoinositide 3-kinase in an egf receptor (egfr)-dependent fashion and combinations of mek and egfr inhibitors synergistically induced apoptosis. |
2014-05-19 |
2023-08-12 |
Not clear |
| Rui Li, Shuo You, Zhongliang Hu, Zhuo G Chen, Gabriel L Sica, Fadlo R Khuri, Walter J Curran, Dong M Shin, Xingming Den. Inhibition of STAT3 by niclosamide synergizes with erlotinib against head and neck cancer. PloS one. vol 8. issue 9. 2014-05-16. PMID:24019973. |
combined inhibition of egfr and stat3 by erlotinib and niclosamide more effectively induced apoptosis in tumor tissues without toxicity for normal tissues. |
2014-05-16 |
2023-08-12 |
Not clear |
| Ibrahim Alanazi, Esmaeil Ebrahimie, Peter Hoffmann, David L Adelso. Combined gene expression and proteomic analysis of EGF induced apoptosis in A431 cells suggests multiple pathways trigger apoptosis. Apoptosis : an international journal on programmed cell death. vol 18. issue 11. 2014-05-08. PMID:23892916. |
a431 cells, derived from epidermoid carcinoma, overexpress the epidermal growth factor receptor (egfr) and when treated with a high dose of egf will undergo apoptosis. |
2014-05-08 |
2023-08-12 |
Not clear |
| Wei Zheng, Qun Luo, Yu Lin, Yao Zhao, Xiuli Wang, Zhifeng Du, Xiang Hao, Yang Yu, Shuang Lü, Liyun Ji, Xianchan Li, Ling Yang, Fuyi Wan. Complexation with organometallic ruthenium pharmacophores enhances the ability of 4-anilinoquinazolines inducing apoptosis. Chemical communications (Cambridge, England). vol 49. issue 87. 2014-05-06. PMID:23856988. |
the complexation with organoruthenium fragments confers 4-anilinoquinazoline pharmacophores with higher potential for inducing cellular apoptosis while the highly inhibitory activity of 4-anilinoquinazolines against egfr and the reactivity of the ruthenium centre to 9-ethylguanine are well preserved. |
2014-05-06 |
2023-08-12 |
Not clear |
| A I Arsen'ev, A A Barchuk, E A Zhelbunova, D E Matsko, A S Barchuk, E V Levchenko, K É Gagua, K A Kostitsyn, S A Tarkov, A O Nefedo. [Morphological, immunohistochemical and spectral characteristics of dysplasia, preinvasive and invasive forms of lung cancer]. Vestnik khirurgii imeni I. I. Grekova. vol 172. issue 5. 2014-04-18. PMID:24640742. |
the tendency of angiogenesis (cd31 and cd34), proliferative activity (ki-67), level of apoptosis (p53), egfr expression were estimated. |
2014-04-18 |
2023-08-12 |
Not clear |
| Giulia Federici, Xi Gao, Janusz Slawek, Tomasz Arodz, Amanuel Shitaye, Julia D Wulfkuhle, Ruggero De Maria, Lance A Liotta, Emanuel F Petricoi. Systems analysis of the NCI-60 cancer cell lines by alignment of protein pathway activation modules with "-OMIC" data fields and therapeutic response signatures. Molecular cancer research : MCR. vol 11. issue 6. 2014-04-17. PMID:23635402. |
we aggregated the signaling data into biochemical modules of interconnected kinase substrates for 6 key cancer signaling pathways: akt, mtor, egf receptor (egfr), insulin-like growth factor-1 receptor (igf-1r), integrin, and apoptosis signaling. |
2014-04-17 |
2023-08-12 |
human |
| Ruchi Saxena, Iram Fatima, Vishal Chandra, Chellakkan S Blesson, Geetika Kharkwal, Mohammad K Hussain, Kanchan Hajela, Bal G Roy, Anila Dwived. Benzopyran derivative CDRI-85/287 induces G2-M arrest in estrogen receptor-positive breast cancer cells via modulation of estrogen receptors α- and β-mediated signaling, in parallel to EGFR signaling and suppresses the growth of tumor xenograft. Steroids. vol 78. issue 11. 2014-04-17. PMID:23891847. |
in parallel, compound also interfered with egfr activation, caused inhibition of pi-3-k/akt pathway and subsequent induction of apoptosis via intrinsic pathway. |
2014-04-17 |
2023-08-12 |
mouse |
| Yanjuan Liu, Junxi Liu, Duolong Di, Min Li, Yan Fe. Structural and mechanistic bases of the anticancer activity of natural aporphinoid alkaloids. Current topics in medicinal chemistry. vol 13. issue 17. 2014-04-15. PMID:23978138. |
induced cancer cells apoptosis, prevention of cell proliferation, dna topoisomerase inhibition, reducing the drug-resistant cellular side population (sp) or cancer stem cells (cscs) and inhibition of epidermal growth factor receptor (egfr) tyrosine kinase seem to play important roles in the molecular mechanisms of anticancer activity about aporphinoid alkaloids. |
2014-04-15 |
2023-08-12 |
Not clear |
| Elisa Gaucci, Fabio Altieri, Carlo Turano, Silvia Chichiarell. The protein ERp57 contributes to EGF receptor signaling and internalization in MDA-MB-468 breast cancer cells. Journal of cellular biochemistry. vol 114. issue 11. 2014-04-07. PMID:23696074. |
egfr is a tyrosine kinase receptor, which is able to activate numerous signaling cascades, leading to cell proliferation and inhibition of apoptosis. |
2014-04-07 |
2023-08-12 |
Not clear |
| Yun-Yun Xu, Si-Ning Li, Gao-Jian Yu, Qing-Hua Hu, Huan-Qiu L. Discovery of novel 4-anilinoquinazoline derivatives as potent inhibitors of epidermal growth factor receptor with antitumor activity. Bioorganic & medicinal chemistry. vol 21. issue 19. 2014-04-07. PMID:23962660. |
the egfr molecular docking model suggested that the new compound is nicely bound to the region of egfr, and cell morphology by hoechst stain experiment suggested that these compounds efficiently induced apoptosis of a549 cells. |
2014-04-07 |
2023-08-12 |
Not clear |
| Chang Seok Ki, Han Shih, Chien-Chi Li. Effect of 3D matrix compositions on the efficacy of EGFR inhibition in pancreatic ductal adenocarcinoma cells. Biomacromolecules. vol 14. issue 9. 2014-03-25. PMID:23889305. |
while the immobilization of an egfr peptide inhibitor, asn-tyr-gln-gln-asn or nyqqn, in soft hydrogels did not cause cell death, this peptide induced significant cell apoptosis when immobilized in stiff hydrogels. |
2014-03-25 |
2023-08-12 |
Not clear |
| Shozo Osera, Takayuki Yoshin. [Perspective of personalized (precise) cancer therapy based on predictive biomarkers]. Nihon rinsho. Japanese journal of clinical medicine. vol 72. issue 1. 2014-03-20. PMID:24597345. |
the epidermal growth factor receptor (egfr), a receptor tyrosine kinase, triggers a downstream signaling cascade through areas such as the ras-raf-mapk, pi3k-akt and jak-stat pathways, which are involved in cell proliferation, dedifferentiation and inhibition of apoptosis. |
2014-03-20 |
2023-08-12 |
Not clear |
| Xiao-You Li, Jian-Zhong Wu, Hai-Xia Cao, Rong Ma, Jian-Qiu Wu, Yue-Jiao Zhong, Ji-Feng Fen. Blockade of DNA methylation enhances the therapeutic effect of gefitinib in non-small cell lung cancer cells. Oncology reports. vol 29. issue 5. 2014-03-05. PMID:23440266. |
of note, the combination treatment with 5-aza-cdr and gefitinib further enhanced the growth inhibitory effects and led to the induction of apoptosis, while a significant reduction in the expression of egfr protein and mrna was observed in the h1650 and h1299 cells. |
2014-03-05 |
2023-08-12 |
Not clear |
| Liwei Zhu, Xue Song, Jinhai Tang, Jianzhong Wu, Rong Ma, Haixia Cao, Minghua Ji, Changwen Jing, Zhuo Wan. Huntingtin-associated protein 1: a potential biomarker of breast cancer. Oncology reports. vol 29. issue 5. 2014-03-05. PMID:23440330. |
we also demonstrated that the expression of egfr and apoptosis-related genes might be involved in cell proliferation and apoptosis. |
2014-03-05 |
2023-08-12 |
Not clear |
| Wei-Yun Lai, Chi-Yuan Chen, Shuenn-Chen Yang, Jer-Yuarn Wu, Cheng-Ju Chang, Pan-Chyr Yang, Konan Pec. Overcoming EGFR T790M-based Tyrosine Kinase Inhibitor Resistance with an Allele-specific DNAzyme. Molecular therapy. Nucleic acids. vol 3. 2014-03-05. PMID:24594844. |
allele-specific silencing of egfr t790m expression and downstream signaling by dzt triggered apoptosis in non-small-cell lung cancer cells harboring this mutant. |
2014-03-05 |
2023-08-12 |
Not clear |
| Kyle J Bichsel, Navdeep Gogia, Timothy Malouff, Zachary Pena, Eric Forney, Brianna Hammiller, Patrice Watson, Laura A Hanse. Role for the epidermal growth factor receptor in chemotherapy-induced alopecia. PloS one. vol 8. issue 7. 2014-03-03. PMID:23894460. |
egfr mutant follicles responded with less proliferation, apoptosis, and fewer p53-positive cells after cyclophosphamide. |
2014-03-03 |
2023-08-12 |
mouse |
| Xiao-Dong Sun, Xing-E Liu, Dong-Sheng Huan. Curcumin induces apoptosis of triple-negative breast cancer cells by inhibition of EGFR expression. Molecular medicine reports. vol 6. issue 6. 2014-02-26. PMID:23023821. |
curcumin induces apoptosis of triple-negative breast cancer cells by inhibition of egfr expression. |
2014-02-26 |
2023-08-12 |
Not clear |
| Xiao-Dong Sun, Xing-E Liu, Dong-Sheng Huan. Curcumin induces apoptosis of triple-negative breast cancer cells by inhibition of EGFR expression. Molecular medicine reports. vol 6. issue 6. 2014-02-26. PMID:23023821. |
the mda-mb-231 tnbc cells were treated with curcumin, the growth inhibition ratio of the cells was measured by mtt assay, apoptosis was detected by flow cytometry and the expression levels of extracellular regulated protein kinase (erk1/2), perk1/2, egfr and pegfr were detected by western blotting. |
2014-02-26 |
2023-08-12 |
Not clear |
| Kushtrim Kryeziu, Ute Jungwirth, Mir Alireza Hoda, Franziska Ferk, Siegfried Knasmüller, Claudia Karnthaler-Benbakka, Christian R Kowol, Walter Berger, Petra Heffete. Synergistic anticancer activity of arsenic trioxide with erlotinib is based on inhibition of EGFR-mediated DNA double-strand break repair. Molecular cancer therapeutics. vol 12. issue 6. 2014-02-24. PMID:23548265. |
subsequent analyses revealed that this effect was based on the blockade of ato-induced egfr phosphorylation leading to more pronounced g2-m arrest as well as enhanced and more rapid induction of apoptosis. |
2014-02-24 |
2023-08-12 |
human |
| Jinfeng Wu, Fuguo Zuo, Juan Du, Pok Fai Wong, Haihong Qin, Jinhua X. Icariside II induces apoptosis via inhibition of the EGFR pathways in A431 human epidermoid carcinoma cells. Molecular medicine reports. vol 8. issue 2. 2014-02-13. PMID:23807305. |
icariside ii induces apoptosis via inhibition of the egfr pathways in a431 human epidermoid carcinoma cells. |
2014-02-13 |
2023-08-12 |
human |