| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laurel A Grisanti, Jennifer A Talarico, Rhonda L Carter, Justine E Yu, Ashley A Repas, Scott W Radcliffe, Hoang-Ai Tang, Catherine A Makarewich, Steven R Houser, Douglas G Tille. β-Adrenergic receptor-mediated transactivation of epidermal growth factor receptor decreases cardiomyocyte apoptosis through differential subcellular activation of ERK1/2 and Akt. Journal of molecular and cellular cardiology. vol 72. 2015-01-13. PMID:24566221. |
we hypothesized that acute βar-mediated egfr transactivation in the heart promotes differential subcellular activation of erk1/2 and akt, promoting cell survival through modulation of apoptosis. |
2015-01-13 |
2023-08-12 |
mouse |
| Min Luo, Li-Wu F. Redundant kinase activation and resistance of EGFR-tyrosine kinase inhibitors. American journal of cancer research. vol 4. issue 6. 2014-12-18. PMID:25520855. |
epidermal growth factor receptor (egfr) tyrosine kinase inhibitors (tkis) have shown dramatic effects against that tumors harboring egfr activating mutations in the egfr intracytoplasmic tyrosine kinase domain and resulted in cell apoptosis. |
2014-12-18 |
2023-08-13 |
Not clear |
| Young-Soo Hong, Won-Jun Jang, Kyung-Soo Chun, Chul-Ho Jeon. Hsp90 inhibition by WK88-1 potently suppresses the growth of gefitinib-resistant H1975 cells harboring the T790M mutation in EGFR. Oncology reports. vol 31. issue 6. 2014-12-17. PMID:24789511. |
our data revealed that inhibition of hsp90 by wk88-1 induced overall degradation of multiple oncogenic signaling molecules including egfr, erbb2 and erbb3, leading to subsequent growth arrest and apoptosis in the gefitinib-resistant h1975 cell line. |
2014-12-17 |
2023-08-13 |
Not clear |
| Elina Hakonen, Jarkko Ustinov, Décio L Eizirik, Hannu Sariola, Päivi J Miettinen, Timo Otonkosk. In vivo activation of the PI3K-Akt pathway in mouse beta cells by the EGFR mutation L858R protects against diabetes. Diabetologia. vol 57. issue 5. 2014-12-16. PMID:24493201. |
we tested whether beta cell proliferation can be triggered by egfr activation at any age and whether this can protect beta cells against apoptosis induced by diabetogenic insults in a mouse model. |
2014-12-16 |
2023-08-12 |
mouse |
| Shiwen Zhang, Yunlong Li, Xiaoguang He, Shouan Dong, Yunchao Huang, Xiaojiang Li, Yuxiao Li, Congguo Jin, Yingying Zhang, Yuanling Wan. Photothermolysis mediated by gold nanorods modified with EGFR monoclonal antibody induces Hep-2 cells apoptosis in vitro and in vivo. International journal of nanomedicine. vol 9. 2014-12-10. PMID:24790435. |
photothermolysis mediated by gold nanorods modified with egfr monoclonal antibody induces hep-2 cells apoptosis in vitro and in vivo. |
2014-12-10 |
2023-08-13 |
Not clear |
| Liyun Ji, Wei Zheng, Yu Lin, Xiuli Wang, Shuang Lü, Xiang Hao, Qun Luo, Xianchan Li, Ling Yang, Fuyi Wan. Novel ruthenium complexes ligated with 4-anilinoquinazoline derivatives: synthesis, characterisation and preliminary evaluation of biological activity. European journal of medicinal chemistry. vol 77. 2014-12-09. PMID:24631730. |
moreover, complex 2 was shown to be more active against the egf-stimulated proliferation of human breast cancer cell line mcf-7 than the better egfr inhibitor 4-(3'-chloro-4'-fluoroanilino)-6,7-dimethoxyquinazoline, being more potential to induce early-stage apoptosis than gefitinib. |
2014-12-09 |
2023-08-12 |
human |
| Lijuan Wang, Suxia Han, Guihua Jin, Xia Zhou, Meng Li, Xia Ying, Le Wang, Huili Wu, Qing Zh. Linc00963: a novel, long non-coding RNA involved in the transition of prostate cancer from androgen-dependence to androgen-independence. International journal of oncology. vol 44. issue 6. 2014-12-09. PMID:24691949. |
knockdown of linc00963 attenuated c4-2 cell proliferation, motility, invasion ability, the expression of egfr and phosphorylation levels of akt, and promoted cell apoptosis. |
2014-12-09 |
2023-08-13 |
Not clear |
| Yu-Chin Lin, Meng-Hsuan Wu, Tzu-Tang Wei, Yun-Chieh Lin, Wen-Chih Huang, Liang-Yu Huang, Yi-Ting Lin, Ching-Chow Che. Metformin sensitizes anticancer effect of dasatinib in head and neck squamous cell carcinoma cells through AMPK-dependent ER stress. Oncotarget. vol 5. issue 1. 2014-12-04. PMID:24457597. |
we recently disclosed that egfr degradation is critical for dasatinib-induced apoptosis. |
2014-12-04 |
2023-08-12 |
human |
| Magdalena Nowakowska, Elżbieta Płuciennik, Wioletta I Wujcicka, Anna Sitkiewicz, Bernarda Kazanowska, Elżbieta Zielińska, Andrzej K Bednare. The correlation analysis of WWOX expression and cancer related genes in neuroblastoma- a real time RT-PCR study. Acta biochimica Polonica. vol 61. issue 1. 2014-11-25. PMID:24455756. |
we performed real-time rt-pcr to analyse levels of wwox expression in 22 neuroblastic tumour samples in correlation with genes involved in cell cycle regulation (ccne1, ccnd1), proliferation (mki67), apoptosis (bcl2, birc5, bax) and signal transduction (egfr, erbb4). |
2014-11-25 |
2023-08-12 |
Not clear |
| Jing Nan, Yuping Du, Xing Chen, Qifeng Bai, Yuxin Wang, Xinxin Zhang, Ning Zhu, Jing Zhang, Jianwen Hou, Qin Wang, Jinbo Yan. TPCA-1 is a direct dual inhibitor of STAT3 and NF-κB and regresses mutant EGFR-associated human non-small cell lung cancers. Molecular cancer therapeutics. vol 13. issue 3. 2014-11-12. PMID:24401319. |
inhibiting egfr, stat3, and nf-κb by combination of tkis with tpca-1 showed increased sensitivity and enhanced apoptosis induced by gefitinib. |
2014-11-12 |
2023-08-12 |
human |
| Dali Zhao, Bo Zhai, Changjun He, Gang Tan, Xian Jiang, Shangha Pan, Xuesong Dong, Zheng Wei, Lixin Ma, Haiquan Qiao, Hongchi Jiang, Xueying Su. Upregulation of HIF-2α induced by sorafenib contributes to the resistance by activating the TGF-α/EGFR pathway in hepatocellular carcinoma cells. Cellular signalling. vol 26. issue 5. 2014-11-04. PMID:24486412. |
blocking the tgf-α/egfr pathway by gefitinib, a specific egfr inhibitor, reduced the activation of stat (signal transducer and activator of transcription) 3, akt and erk (extracellular signal-regulated kinase), and synergized with sorafenib to inhibit proliferation and induce apoptosis of hypoxic hcc cells. |
2014-11-04 |
2023-08-12 |
Not clear |
| Yi-Chen Liang, Hong-Ge Wu, Hong-Jian Xue, Qing Liu, Liang-Liang Shi, Tao Liu, Gang W. Effects of PI3K inhibitor NVP-BKM120 on acquired resistance to gefitinib of human lung adenocarcinoma H1975 cells. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 33. issue 6. 2014-10-29. PMID:24337846. |
the effects of class i pi3k inhibitor nvp-bkm120 on cell proliferation, cell cycle distribution, cellular apoptosis, phosphorylation of several proteins of the pi3k/akt signaling pathway and the mrna expression levels of hif1-α, vegf and mmp9 in the acquired gefitinib resistant cell line h1975 were investigated, and whether nvp-bkm120 can overcome the acquired resistance caused by the egfr t790m mutation and the underlying mechanism were explored. |
2014-10-29 |
2023-08-12 |
human |
| Wei-Lin Shi, Jian Li, Quan-Lei Bao, Jian-Nong Wu, Li-Ping Ge, Li-Rong Zhu, Yi Wang, Wen-Fang Zh. Survivin mRNA expression in blood as a predictor of the response to EGFR-tyrosine kinase inhibitors and prognosis in patients with non-small cell lung cancer. Medical oncology (Northwood, London, England). vol 31. issue 4. 2014-10-22. PMID:24563335. |
recent study showed that survivin overexpression attenuated egfr-tki-induced apoptosis and inhibited the antitumor effect of egfr-tkis on egfr mutation nsclc cells. |
2014-10-22 |
2023-08-12 |
Not clear |
| Maria Giovanna Scioli, Valerio Cervelli, Gaetano Arcuri, Pietro Gentile, Elena Doldo, Alessandra Bielli, Elena Bonanno, Augusto Orland. High insulin-induced down-regulation of Erk-1/IGF-1R/FGFR-1 signaling is required for oxidative stress-mediated apoptosis of adipose-derived stem cells. Journal of cellular physiology. vol 229. issue 12. 2014-10-20. PMID:24818995. |
specific inhibition of erk-1/2, igf-1r, and fgfr activity promoted asc apoptosis but did not increase insulin effects, whereas egfr and erbb2 inhibition potentiated insulin-induced apoptosis. |
2014-10-20 |
2023-08-13 |
human |
| Anna T Stratmann, David Fecher, Gaby Wangorsch, Claudia Göttlich, Thorsten Walles, Heike Walles, Thomas Dandekar, Gudrun Dandekar, Sarah L Nietze. Establishment of a human 3D lung cancer model based on a biological tissue matrix combined with a Boolean in silico model. Molecular oncology. vol 8. issue 2. 2014-10-15. PMID:24388494. |
egfr activation in hcc827 was inhibited by gefitinib, resulting in a significant reduction of proliferation (ki-67 proliferation index) and in the induction of apoptosis (tunel staining, m30-elisa). |
2014-10-15 |
2023-08-12 |
human |
| Saeid Abediankenari, Fereshteh Jeiva. Epidermal growth factor receptor gene polymorphisms and gastric cancer in Iran. Asian Pacific journal of cancer prevention : APJCP. vol 14. issue 5. 2014-10-14. PMID:23803102. |
epidermal growth factor receptor (egfr) is a transmembrane receptor which contributes to many processes involved in cell survival, proliferation and inhibits apoptosis, that may lead to cancer development. |
2014-10-14 |
2023-08-12 |
Not clear |
| Yin-dong Song, Ke-fei Zhang, Dong Liu, Yan-qi Guo, Da-yong Wang, Ming-yu Cui, Gang Li, Yuan-xin Sun, Jian-hui Shen, Xin-gang Li, Long Zhang, Feng-jun Sh. Inhibition of EGFR-induced glucose metabolism sensitizes chondrosarcoma cells to cisplatin. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 7. 2014-10-06. PMID:24748236. |
finally, we demonstrated that the combination of either egfr inhibitor or anaerobic glycolysis inhibitor with cisplatin showed synergistically inhibitory effects on cisplatin-resistant chondrosarcoma cells through the inducements of apoptosis and cell cycle arrest. |
2014-10-06 |
2023-08-13 |
human |
| Lihong Wang, Hailong Cao, Liping Liu, Bangmao Wang, W Allan Walker, Sari A Acra, Fang Ya. Activation of epidermal growth factor receptor mediates mucin production stimulated by p40, a Lactobacillus rhamnosus GG-derived protein. The Journal of biological chemistry. vol 289. issue 29. 2014-10-06. PMID:24895124. |
p40, a lactobacillus rhamnosus gg-derived soluble protein, has been shown to transactivate the egf receptor (egfr) in intestinal epithelial cells, which is required for inhibition of apoptosis and preservation of barrier function in the colon, thereby ameliorating intestinal injury and colitis. |
2014-10-06 |
2023-08-13 |
mouse |
| Rathi N Pillai, Suresh S Ramalinga. Heat shock protein 90 inhibitors in non-small-cell lung cancer. Current opinion in oncology. vol 26. issue 2. 2014-09-29. PMID:24463348. |
many cancers have increased expression of hsp90 to ensure their malignant phenotype of increased proliferation, decreased apoptosis, and metastatic potential by conservation of proteins like epidermal growth factor receptor (egfr), human epidermal growth factor receptor 2, anaplastic lymphoma kinase (alk), v-raf murine sarcoma viral oncogene homologue b1, akt, b-cell lymphoma 2, and cell cycle proteins. |
2014-09-29 |
2023-08-12 |
human |
| Masayuki Yasugi, Nagio Takigawa, Nobuaki Ochi, Kadoaki Ohashi, Daijiro Harada, Takashi Ninomiya, Toshi Murakami, Yoshihiro Honda, Eiki Ichihara, Mitsune Tanimoto, Katsuyuki Kiur. Everolimus prolonged survival in transgenic mice with EGFR-driven lung tumors. Experimental cell research. vol 326. issue 2. 2014-09-26. PMID:24768699. |
although apoptosis and autophagy were not induced in everolimus-treated egfr transgenic mice, angiogenesis was suppressed. |
2014-09-26 |
2023-08-13 |
mouse |