| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takumi Chinen, Sayaka Kazami, Yoko Nagumo, Ichiro Hayakawa, Akiyuki Ikedo, Masatoshi Takagi, Akihito Yokosuka, Naoko Imamoto, Yoshihiro Mimaki, Hideo Kigoshi, Hiroyuki Osada, Takeo Usu. Glaziovianin A prevents endosome maturation via inhibiting microtubule dynamics. ACS chemical biology. vol 8. issue 5. 2014-01-29. PMID:23406355. |
consistent with the prolonged activation of egfr, glaziovianin a enhanced the egf-dependent apoptosis in a431 cells. |
2014-01-29 |
2023-08-12 |
Not clear |
| Guo-Hai Zhang, Le-Jing Cai, Yan-Fei Wang, Yuan-Hua Zhou, Yun-Feng An, Yan-Cheng Liu, Yan Peng, Zhen-Feng Chen, Hong Lian. Novel compound PS-101 exhibits selective inhibition in non-small-cell lung cancer cell by blocking the EGFR-driven antiapoptotic pathway. Biochemical pharmacology. vol 86. issue 12. 2014-01-28. PMID:24161785. |
the root cause for increase in bad and decrease in bcl-2 which altogether initiated caspase-dependent apoptosis were predominantly due to down-regulation the expression of egfr after ps-101 treatment. |
2014-01-28 |
2023-08-12 |
human |
| Ruchi Ghildiyal, Deobrat Dixit, Ellora Se. EGFR inhibitor BIBU induces apoptosis and defective autophagy in glioma cells. Molecular carcinogenesis. vol 52. issue 12. 2014-01-23. PMID:22753156. |
egfr inhibitor bibu induces apoptosis and defective autophagy in glioma cells. |
2014-01-23 |
2023-08-12 |
Not clear |
| Ruchi Ghildiyal, Deobrat Dixit, Ellora Se. EGFR inhibitor BIBU induces apoptosis and defective autophagy in glioma cells. Molecular carcinogenesis. vol 52. issue 12. 2014-01-23. PMID:22753156. |
apoptosis was accompanied by decreased egfr levels and its increased distribution towards caveolin rich lipid raft microdomains. |
2014-01-23 |
2023-08-12 |
Not clear |
| Eric S Taylor, Ann G Wylie, Brooke T Mossman, Steven K Lowe. Repetitive dissociation from crocidolite asbestos acts as persistent signal for epidermal growth factor receptor. Langmuir : the ACS journal of surfaces and colloids. vol 29. issue 21. 2014-01-14. PMID:23672436. |
the binding of asbestos to epidermal growth factor receptor (egfr), a transmembrane signal protein, has been proposed as a trigger for downstream signaling of kinases and expression of genes involved in cell proliferation and inhibition of apoptosis. |
2014-01-14 |
2023-08-12 |
Not clear |
| Hyun-Kyung Lee, Ga Bin Park, Yeong Seok Kim, Hyunkeun Song, V Courtney Broaddus, Dae Young Hu. Ligation of CM1 enhances apoptosis of lung cancer cells through different mechanisms in conformity with EGFR mutation. International journal of oncology. vol 42. issue 2. 2014-01-07. PMID:23232551. |
ligation of cm1 enhances apoptosis of lung cancer cells through different mechanisms in conformity with egfr mutation. |
2014-01-07 |
2023-08-12 |
Not clear |
| Hyun-Kyung Lee, Ga Bin Park, Yeong Seok Kim, Hyunkeun Song, V Courtney Broaddus, Dae Young Hu. Ligation of CM1 enhances apoptosis of lung cancer cells through different mechanisms in conformity with EGFR mutation. International journal of oncology. vol 42. issue 2. 2014-01-07. PMID:23232551. |
in the present study, we found that centrocyte/centroblast marker 1 (cm1), previously reported as a possible apoptosis inducer of b lymphoma cells, is expressed on both a549 with wild‑type egfr and hcc827 with mutant egfr lung cancer cells. |
2014-01-07 |
2023-08-12 |
Not clear |
| Arijit Bhowmik, Nilanjana Das, Uttam Pal, Madhumita Mandal, Seemana Bhattacharya, Moumita Sarkar, Parasuraman Jaisankar, Nakul C Maiti, Mrinal K Ghos. 2,2'-diphenyl-3,3'-diindolylmethane: a potent compound induces apoptosis in breast cancer cells by inhibiting EGFR pathway. PloS one. vol 8. issue 3. 2014-01-07. PMID:23555785. |
2,2'-diphenyl-3,3'-diindolylmethane: a potent compound induces apoptosis in breast cancer cells by inhibiting egfr pathway. |
2014-01-07 |
2023-08-12 |
rat |
| B Kalman, E Szep, F Garzuly, D E Pos. Epidermal growth factor receptor as a therapeutic target in glioblastoma. Neuromolecular medicine. vol 15. issue 2. 2014-01-03. PMID:23575987. |
engagement of the extracellular domain with a ligand activates the intracellular tyrosine kinase (tk) domain of egfr, leading to autophosphorylation and signal transduction that controls proliferation, gene transcription, and apoptosis. |
2014-01-03 |
2023-08-12 |
Not clear |
| Fang Yan, Liping Liu, Peter J Dempsey, Yu-Hwai Tsai, Elaine W Raines, Carole L Wilson, Hailong Cao, Zheng Cao, LinShu Liu, D Brent Pol. A Lactobacillus rhamnosus GG-derived soluble protein, p40, stimulates ligand release from intestinal epithelial cells to transactivate epidermal growth factor receptor. The Journal of biological chemistry. vol 288. issue 42. 2013-12-31. PMID:24043629. |
p40, a lactobacillus rhamnosus gg (lgg)-derived soluble protein, ameliorates intestinal injury and colitis, reduces apoptosis, and preserves barrier function by transactivation of the egf receptor (egfr) in intestinal epithelial cells. |
2013-12-31 |
2023-08-12 |
mouse |
| Fang Yan, Liping Liu, Peter J Dempsey, Yu-Hwai Tsai, Elaine W Raines, Carole L Wilson, Hailong Cao, Zheng Cao, LinShu Liu, D Brent Pol. A Lactobacillus rhamnosus GG-derived soluble protein, p40, stimulates ligand release from intestinal epithelial cells to transactivate epidermal growth factor receptor. The Journal of biological chemistry. vol 288. issue 42. 2013-12-31. PMID:24043629. |
knockdown of hb-egf expression by sirna suppresses p40 effects on transactivating egfr and akt, preventing apoptosis, and preserving tight junction function. |
2013-12-31 |
2023-08-12 |
mouse |
| Shao-hong Huang, Yun Li, Hui-guo Chen, Jian Rong, Sheng Y. Activation of proteinase-activated receptor 2 prevents apoptosis of lung cancer cells. Cancer investigation. vol 31. issue 9. 2013-12-19. PMID:24138209. |
the present study aims to investigate the activation of par2 in regulation of the expression of egfr and apoptosis of lc cells. |
2013-12-19 |
2023-08-12 |
Not clear |
| Shao-hong Huang, Yun Li, Hui-guo Chen, Jian Rong, Sheng Y. Activation of proteinase-activated receptor 2 prevents apoptosis of lung cancer cells. Cancer investigation. vol 31. issue 9. 2013-12-19. PMID:24138209. |
the results showed that exposure to tryptase increased egfr expression in a549 cells and suppressed the cell apoptosis. |
2013-12-19 |
2023-08-12 |
Not clear |
| Elizabeth M H Kim, Kelly Mueller, Elaina Gartner, Julie Boerne. Dasatinib is synergistic with cetuximab and cisplatin in triple-negative breast cancer cells. The Journal of surgical research. vol 185. issue 1. 2013-12-17. PMID:23899511. |
we hypothesize that dasatinib, an src family tyrosine kinase inhibitor, may help overcome egfr resistance to cetuximab, and in combination with cisplatin may enhance growth inhibition and apoptosis and reduce metastatic potential. |
2013-12-17 |
2023-08-12 |
Not clear |
| Natarajan Sathishkumar, Veerappan Karpagam, Subramaniyam Sathiyamoorthy, Min Jin Woo, Yeon-Ju Kim, Deok-Chun Yan. Computer-aided identification of EGFR tyrosine kinase inhibitors using ginsenosides from Panax ginseng. Computers in biology and medicine. vol 43. issue 6. 2013-12-09. PMID:23668355. |
the egfr family tyrosine kinase receptor is a cell surface receptor that regulates diverse biological processes including cell proliferation, differentiation, survival, and apoptosis. |
2013-12-09 |
2023-08-12 |
human |
| Vugar Yagublu, Zhala Ahmadova, Yegana Hajiyeva, Mathias Hafner, Michael Kees. Combination of the EGFR tyrosine kinase inhibitor AG1478 and 5-FU: no synergistic effect on EGFR phosphorylation, cell proliferation and apoptosis induction. Anticancer research. vol 33. issue 9. 2013-11-27. PMID:24023306. |
combination of the egfr tyrosine kinase inhibitor ag1478 and 5-fu: no synergistic effect on egfr phosphorylation, cell proliferation and apoptosis induction. |
2013-11-27 |
2023-08-12 |
human |
| Ying-Bo Li, Zhong-Qing Wang, Xu Yan, Mei-Wan Chen, Jiao-Lin Bao, Guo-Sheng Wu, Ze-Mei Ge, De-Min Zhou, Yi-Tao Wang, Run-Tao L. IC-4, a new irreversible EGFR inhibitor, exhibits prominent anti-tumor and anti-angiogenesis activities. Cancer letters. vol 340. issue 1. 2013-11-26. PMID:23856030. |
ic-4 potentially suppressed proliferation, induced apoptosis and a g2/m cell cycle arrest in breast cancer cells, correlating with inhibition of egf-induced egfr activation, but independent of dna damage. |
2013-11-26 |
2023-08-12 |
human |
| Shipra Gupta, Gauri Misra, Mohan Chandra Pant, Prahlad Kishore Set. Targeting the epidermal growth factor receptor: exploring the potential of novel inhibitor N-(3-ethynylphenyl)-6, 7-bis (2-methoxyethoxy) quinolin- 4-amine using docking and molecular dynamics simulation. Protein and peptide letters. vol 19. issue 9. 2013-11-18. PMID:22486613. |
egfr regulates the hnscc by inducing signalling events responsible for regulating key tumorigenic processes such as proliferation, inhibition of apoptosis, cell adhesion/ motility, growth and survival. |
2013-11-18 |
2023-08-12 |
Not clear |
| Elena Galvani, Elisa Giovannetti, Francesca Saccani, Andrea Cavazzoni, Leticia G Leon, Henk Dekker, Roberta Alfieri, Caterina Carmi, Marco Mor, Andrea Ardizzoni, Pier Giorgio Petronini, Godefridus J Peter. Molecular mechanisms underlying the antitumor activity of 3-aminopropanamide irreversible inhibitors of the epidermal growth factor receptor in non-small cell lung cancer. Neoplasia (New York, N.Y.). vol 15. issue 1. 2013-11-13. PMID:23359111. |
the inhibition of the autophosphorylation of egfr occurred at nanomolar concentrations and both upr1282 and upr1268 caused a significant induction of apoptosis. |
2013-11-13 |
2023-08-12 |
Not clear |
| Jitka Mlcochova, Petra Faltejskova, Radim Nemecek, Marek Svoboda, Ondrej Slab. MicroRNAs targeting EGFR signalling pathway in colorectal cancer. Journal of cancer research and clinical oncology. vol 139. issue 10. 2013-11-12. PMID:23817698. |
one of them is epidermal growth factor receptor (egfr) signalling pathway that regulates cell proliferation, differentiation, migration, angiogenesis and apoptosis. |
2013-11-12 |
2023-08-12 |
Not clear |