| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Agnieszka Bojko, Kinga Reichert, Anna Adamczyk, Joanna Ligęza, Janusz Ligęza, Andrzej Klei. The effect of tyrphostins AG494 and AG1478 on the autocrine growth regulation of A549 and DU145 cells. Folia histochemica et cytobiologica. vol 50. issue 2. 2013-03-26. PMID:22763976. |
both egfr's inhibitors induced apoptosis of the investigated lung and prostate cancer cell lines, but the proapoptotic effect of the investigated tyrphostins was greater in a549 than in du145 cells. |
2013-03-26 |
2023-08-12 |
human |
| Zhi-Guo Sheng, Wei Huang, Yu-Xiang Liu, Ye Yuan, Ben-Zhan Zh. Ofloxacin induces apoptosis via β1 integrin-EGFR-Rac1-Nox2 pathway in microencapsulated chondrocytes. Toxicology and applied pharmacology. vol 267. issue 1. 2013-03-25. PMID:23274517. |
intracellular reactive oxygen species (ros) significantly increases in a time-dependent manner after exposure to ofloxacin for 12-48 h. furthermore, ofloxacin markedly enhances the level of activated rac1 and epidermal growth factor receptor (egfr) phosphorylation, and its inhibition in turn reduces the ros production, apoptosis and rac1 activation. |
2013-03-25 |
2023-08-12 |
rabbit |
| Zhi-Guo Sheng, Wei Huang, Yu-Xiang Liu, Ye Yuan, Ben-Zhan Zh. Ofloxacin induces apoptosis via β1 integrin-EGFR-Rac1-Nox2 pathway in microencapsulated chondrocytes. Toxicology and applied pharmacology. vol 267. issue 1. 2013-03-25. PMID:23274517. |
silencing nox2, rac1 or supplementing mg(2+) inhibits ros accumulation, apoptosis occurrence and egfr phosphorylation induced by ofloxacin. |
2013-03-25 |
2023-08-12 |
rabbit |
| Junji Kawaguchi, Seiji Adachi, Ichiro Yasuda, Takahiro Yamauchi, Masanori Nakashima, Tomohiko Ohno, Masahito Shimizu, Takashi Yoshioka, Masahiko Itani, Osamu Kozawa, Hisataka Moriwak. Cisplatin and ultra-violet-C synergistically down-regulate receptor tyrosine kinases in human colorectal cancer cells. Molecular cancer. vol 11. 2013-03-22. PMID:22788833. |
whereas we have recently reported that high dose uv-c (200 j/m²) induces colorectal cancer cell proliferation by desensitization of egfr, which leads oncogenic signaling in these cells, in this study we investigated the combination effect of low dose cisplatin (10 μm) and low dose uv-c (10 j/m²) on cell growth and apoptosis in several human colorectal cancer cells, sw480, dld-1, ht29 and hct116. |
2013-03-22 |
2023-08-12 |
human |
| Ling Xu, Ye Zhang, Jing Liu, Jinglei Qu, Xuejun Hu, Fan Zhang, Huachuan Zheng, Xiujuan Qu, Yunpeng Li. TRAIL-activated EGFR by Cbl-b-regulated EGFR redistribution in lipid rafts antagonises TRAIL-induced apoptosis in gastric cancer cells. European journal of cancer (Oxford, England : 1990). vol 48. issue 17. 2013-03-04. PMID:22456178. |
trail-activated egfr by cbl-b-regulated egfr redistribution in lipid rafts antagonises trail-induced apoptosis in gastric cancer cells. |
2013-03-04 |
2023-08-12 |
Not clear |
| Ling Xu, Ye Zhang, Jing Liu, Jinglei Qu, Xuejun Hu, Fan Zhang, Huachuan Zheng, Xiujuan Qu, Yunpeng Li. TRAIL-activated EGFR by Cbl-b-regulated EGFR redistribution in lipid rafts antagonises TRAIL-induced apoptosis in gastric cancer cells. European journal of cancer (Oxford, England : 1990). vol 48. issue 17. 2013-03-04. PMID:22456178. |
either using inhibitors of egfr or depletion of egfr with small interfering rna (sirna) prevented egfr pathway activation, and thus increased trail-induced apoptosis, especially in cbl-b knockdown clones. |
2013-03-04 |
2023-08-12 |
Not clear |
| Ling Xu, Ye Zhang, Jing Liu, Jinglei Qu, Xuejun Hu, Fan Zhang, Huachuan Zheng, Xiujuan Qu, Yunpeng Li. TRAIL-activated EGFR by Cbl-b-regulated EGFR redistribution in lipid rafts antagonises TRAIL-induced apoptosis in gastric cancer cells. European journal of cancer (Oxford, England : 1990). vol 48. issue 17. 2013-03-04. PMID:22456178. |
taken together, trail-induced egfr activation through cbl-b-regulated egfr redistribution in lipid rafts antagonised trail-induced apoptosis. |
2013-03-04 |
2023-08-12 |
Not clear |
| Subhasis Das, Kaushik Kumar Dey, Rashmi Bharti, Sujata MaitiChoudhury, Sukumar Maiti, Mahitosh Manda. PKI 166 induced redox signalling and apoptosis through activation of p53, MAP kinase and caspase pathway in epidermoid carcinoma. Journal of experimental therapeutics & oncology. vol 10. issue 2. 2013-02-07. PMID:23350354. |
pki 166 is used to determine the effects of redox sensitive inhibition of egfr, metastasis and apoptosis in epidermoid carcinoma. |
2013-02-07 |
2023-08-12 |
Not clear |
| Fei Xu, Ying Tian, Yan Huang, Ling-Ling Zhang, Zheng-Zheng Guo, Jia-Jia Huang, Tong-Yu Li. EGFR inhibitors sensitize non-small cell lung cancer cells to TRAIL-induced apoptosis. Chinese journal of cancer. vol 30. issue 10. 2013-01-31. PMID:21959047. |
egfr inhibitors sensitize non-small cell lung cancer cells to trail-induced apoptosis. |
2013-01-31 |
2023-08-12 |
mouse |
| Fei Xu, Ying Tian, Yan Huang, Ling-Ling Zhang, Zheng-Zheng Guo, Jia-Jia Huang, Tong-Yu Li. EGFR inhibitors sensitize non-small cell lung cancer cells to TRAIL-induced apoptosis. Chinese journal of cancer. vol 30. issue 10. 2013-01-31. PMID:21959047. |
in vitro, compared to single reagent, adtrail combined with egfr inhibitors reduced proliferation and enhanced apoptosis in h460, a549, and sw1573 cell lines. |
2013-01-31 |
2023-08-12 |
mouse |
| Georgeta Afrem, S S Mogoantă, F A Secureanu, A Olaru, Carmen Neamţu, B D Totolici, M Ionilă, Stefania Crăiţoi. Study of molecular prognostic factors Bcl-2 and EGFR in rectal mucinous carcinomas. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 53. issue 2. 2013-01-28. PMID:22732796. |
thus, we immunohistochemically assessed the degree of apoptosis of tumor cells in mucinous rectal carcinomas using the bcl-2 marker, and tumor aggressiveness using the egfr responsiveness. |
2013-01-28 |
2023-08-12 |
Not clear |
| Chang-Fu Qin, Kun Hao, Xiao-Dong Tian, Xue-Hai Xie, Yin-Mo Yan. Combined effects of EGFR and Hedgehog signaling pathway inhibition on the proliferation and apoptosis of pancreatic cancer cells. Oncology reports. vol 28. issue 2. 2013-01-24. PMID:22581058. |
combined effects of egfr and hedgehog signaling pathway inhibition on the proliferation and apoptosis of pancreatic cancer cells. |
2013-01-24 |
2023-08-12 |
human |
| Chang-Fu Qin, Kun Hao, Xiao-Dong Tian, Xue-Hai Xie, Yin-Mo Yan. Combined effects of EGFR and Hedgehog signaling pathway inhibition on the proliferation and apoptosis of pancreatic cancer cells. Oncology reports. vol 28. issue 2. 2013-01-24. PMID:22581058. |
in the present study, we established a new experimental model to investigate the effects of egfr targeting by rnai, and the synergistic actions between the hedgehog (hh) and egfr signaling pathways on the proliferation and apoptosis in pancreatic cancer cells. |
2013-01-24 |
2023-08-12 |
human |
| Chang-Fu Qin, Kun Hao, Xiao-Dong Tian, Xue-Hai Xie, Yin-Mo Yan. Combined effects of EGFR and Hedgehog signaling pathway inhibition on the proliferation and apoptosis of pancreatic cancer cells. Oncology reports. vol 28. issue 2. 2013-01-24. PMID:22581058. |
the effects of egfr rnai and hh inhibition on cell proliferation and apoptosis were explored in vitro and in vivo. |
2013-01-24 |
2023-08-12 |
human |
| Chang-Fu Qin, Kun Hao, Xiao-Dong Tian, Xue-Hai Xie, Yin-Mo Yan. Combined effects of EGFR and Hedgehog signaling pathway inhibition on the proliferation and apoptosis of pancreatic cancer cells. Oncology reports. vol 28. issue 2. 2013-01-24. PMID:22581058. |
we observed that egfr rnai notably inhibited cell proliferation and colony formation, induced apoptosis and markedly decreased xenograft tumor growth. |
2013-01-24 |
2023-08-12 |
human |
| Reba Mustafi, Urszula Dougherty, Hardik Shah, Hooman Dehghan, Ariel Gliksberg, Jiang Wu, Hongyan Zhu, Loren Joseph, John Hart, Caroline Dive, Alessandro Fichera, David Threadgill, Marc Bissonnett. Both stromal cell and colonocyte epidermal growth factor receptors control HCT116 colon cancer cell growth in tumor xenografts. Carcinogenesis. vol 33. issue 10. 2013-01-18. PMID:22791816. |
tumor xenografts in egfr(velvet/+) mice were significantly smaller than tumors in egfr(+/+) mice, with decreased proliferation (ki67) and increased apoptosis (cleaved caspase-3) in cancer cells and decreased stromal blood vessels. |
2013-01-18 |
2023-08-12 |
mouse |
| Kazunori Yamaguchi, Kazuhiro Shiozaki, Setsuko Moriya, Koichi Koseki, Tadashi Wada, Hiroo Tateno, Ikuro Sato, Masahide Asano, Yoichiro Iwakura, Taeko Miyag. Reduced susceptibility to colitis-associated colon carcinogenesis in mice lacking plasma membrane-associated sialidase. PloS one. vol 7. issue 7. 2013-01-16. PMID:22815940. |
the small interfering rna-mediated knock-down of neu3 in cancer cell lines, but not in normal cell-derived primary cultures, downregulates egfr signaling and induces apoptosis. |
2013-01-16 |
2023-08-12 |
mouse |
| Lingxiang Liu, Xiaoyan Shao, Wen Gao, Zhi Zhang, Ping Liu, Rongsheng Wang, Puwen Huang, Yongmei Yin, Yongqian Sh. MicroRNA-133b inhibits the growth of non-small-cell lung cancer by targeting the epidermal growth factor receptor. The FEBS journal. vol 279. issue 20. 2013-01-10. PMID:22883469. |
moreover, mir-133b transfection may modulate apoptosis, invasion and sensitivity to egfr-tki through the egfr signaling pathways, especially in egfr-addicted nsclc cells. |
2013-01-10 |
2023-08-12 |
Not clear |
| Ting Gui, Keng She. The epidermal growth factor receptor as a therapeutic target in epithelial ovarian cancer. Cancer epidemiology. vol 36. issue 5. 2013-01-04. PMID:22818908. |
the epidermal growth factor receptor (egfr) is overexpressed in 30-98% of epithelial ovarian carcinoma (eoc), and the signaling cascades activated are related with cell proliferation, migration and invasion, and angiogenesis, as well as resistance to cell apoptosis. |
2013-01-04 |
2023-08-12 |
Not clear |
| Héctor Herranz, Xin Hong, Stephen M Cohe. Mutual repression by bantam miRNA and Capicua links the EGFR/MAPK and Hippo pathways in growth control. Current biology : CB. vol 22. issue 8. 2012-12-07. PMID:22445297. |
the epidermal growth factor receptor (egfr) and hippo signaling pathways control cell proliferation and apoptosis to promote tissue growth during development. |
2012-12-07 |
2023-08-12 |
Not clear |