| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qi Qi, Kunyan He, Min-Heui Yoo, Chi-Bun Chan, Xia Liu, Zhaobin Zhang, Jeffrey J Olson, Ge Xiao, Liya Wang, Hui Mao, Haian Fu, Hui Tao, Suresh S Ramalingam, Shi-Yong Sun, Paul S Mischel, Keqiang Y. Acridine yellow G blocks glioblastoma growth via dual inhibition of epidermal growth factor receptor and protein kinase C kinases. The Journal of biological chemistry. vol 287. issue 9. 2012-04-25. PMID:22215664. |
it dually inhibits egfr and pkcs, resulting in a blockade of mammalian target of rapamycin signaling and cell cycle arrest in the g(1) phase, which leads to activation of apoptosis in the tumors. |
2012-04-25 |
2023-08-12 |
human |
| Tuanlao Wang, Ming Zhang, Zexu Ma, Ke Guo, Vinay Tergaonkar, Qi Zeng, Wanjin Hon. A role of Rab7 in stabilizing EGFR-Her2 and in sustaining Akt survival signal. Journal of cellular physiology. vol 227. issue 6. 2012-04-19. PMID:21928319. |
low concentration of ga (50-100 nm)-induced apoptosis of the rab7 knocked-down cells but not control cells, suggesting that rab7 and hsp90 together contribute to the optimal stability of egfr and her2 as well as to protect cancer cells from apoptosis. |
2012-04-19 |
2023-08-12 |
Not clear |
| William Weidong Du, Burton B Yang, Bing L Yang, Zhaoqun Deng, Ling Fang, Sze Wan Shan, Zina Jeyapalan, Yaou Zhang, Arun Seth, Albert J Ye. Versican G3 domain modulates breast cancer cell apoptosis: a mechanism for breast cancer cell response to chemotherapy and EGFR therapy. PloS one. vol 6. issue 11. 2012-04-10. PMID:22096483. |
versican g3 domain modulates breast cancer cell apoptosis: a mechanism for breast cancer cell response to chemotherapy and egfr therapy. |
2012-04-10 |
2023-08-12 |
cattle |
| Simona Weisheit, Claus Liebman. Allosteric modulation by protein kinase Cε leads to modified responses of EGF receptor towards tyrosine kinase inhibitors. Cellular signalling. vol 24. issue 2. 2012-04-06. PMID:21964064. |
cell cycle and western blot analysis revealed that the gefitinib-induced apoptosis was enhanced whereas the pro-apoptotic effect of lapatinib that requires another egfr conformation was reduced by pkcε. |
2012-04-06 |
2023-08-12 |
Not clear |
| A Martínez-Palacián, G Del Castillo, B Herrera, M Fernández, C Roncero, I Fabregat, A Sánche. EGFR is dispensable for c-Met-mediated proliferation and survival activities in mouse adult liver oval cells. Cellular signalling. vol 24. issue 2. 2012-04-06. PMID:22001397. |
on the other hand, treatment with ag1478, a specific inhibitor of egfr, effectively blocked endogenous and egf-induced proliferation, while increased serum withdrawal and transforming growth factor-beta (tgf-β)-induced apoptosis. |
2012-04-06 |
2023-08-12 |
mouse |
| Xiangbin Xu, Rachel R Steere, Christine A Fedorchuk, Jinjiang Pang, Ji-Yun Lee, Jae Hyang Lim, Haidong Xu, Zhixing K Pan, Sanjay B Maggirwar, Jian-Dong L. Activation of epidermal growth factor receptor is required for NTHi-induced NF-κB-dependent inflammation. PloS one. vol 6. issue 11. 2012-04-02. PMID:22132240. |
epidermal growth factor receptor (egfr) has been shown to play important roles in regulating diverse biological processes, including cell growth, differentiation, apoptosis, adhesion, and migration. |
2012-04-02 |
2023-08-12 |
human |
| Elena B Burova, Irina S Smirnova, Ilya V Gonchar, Alla N Shatrova, Nikolay N Nikolsk. Inhibition of the EGF receptor and ERK1/2 signaling pathways rescues the human epidermoid carcinoma A431 cells from IFNγ-induced apoptosis. Cell cycle (Georgetown, Tex.). vol 10. issue 13. 2012-03-16. PMID:21606674. |
we investigated a role for the egfr and erk1/2 mapk signaling pathways in ifnγ-induced apoptosis of a431 cells. |
2012-03-16 |
2023-08-12 |
human |
| Elena B Burova, Irina S Smirnova, Ilya V Gonchar, Alla N Shatrova, Nikolay N Nikolsk. Inhibition of the EGF receptor and ERK1/2 signaling pathways rescues the human epidermoid carcinoma A431 cells from IFNγ-induced apoptosis. Cell cycle (Georgetown, Tex.). vol 10. issue 13. 2012-03-16. PMID:21606674. |
even though egfr tyrosine kinase inhibitor ag1478 also rescued a431 cells from ifnγ-induced apoptosis, unlike mek1/2 inhibitors, it initiated g 1 arrest. |
2012-03-16 |
2023-08-12 |
human |
| Elena B Burova, Irina S Smirnova, Ilya V Gonchar, Alla N Shatrova, Nikolay N Nikolsk. Inhibition of the EGF receptor and ERK1/2 signaling pathways rescues the human epidermoid carcinoma A431 cells from IFNγ-induced apoptosis. Cell cycle (Georgetown, Tex.). vol 10. issue 13. 2012-03-16. PMID:21606674. |
together, these results suggest that sustained inhibition of both egfr and erk1/2 leads to significant protection of the cells from ifnγ-induced apoptosis, indicating important roles for the egfr tyrosine kinase and erk1/2 map-kinases in regulating a431 cell death. |
2012-03-16 |
2023-08-12 |
human |
| Kuo-Li Chen, Wun-Shaing Wayne Chang, Chun Hei Antonio Cheung, Chun-Cheng Lin, Chien-Chang Huang, Yung-Ning Yang, Chang-Po Kuo, Ching-Chuan Kuo, Yi-Hsun Chang, Ko-Jiunn Liu, Ching-Ming Wu, Jang-Yang Chan. Targeting cathepsin S induces tumor cell autophagy via the EGFR-ERK signaling pathway. Cancer letters. vol 317. issue 1. 2012-03-15. PMID:22101325. |
in this study, we demonstrated that targeting cathepsin s by either specific small molecular inhibitors or cathepsin s sirna induced autophagy and subsequent apoptosis in human cancer cells, and the induction of autophagy was dependent on the phosphorylation of egfr and activation of the egfr-related erk/mapk-signaling pathway. |
2012-03-15 |
2023-08-12 |
human |
| Gisela Paul, Ronald R Marchelletta, Declan F McCole, Kim E Barret. Interferon-γ alters downstream signaling originating from epidermal growth factor receptor in intestinal epithelial cells: functional consequences for ion transport. The Journal of biological chemistry. vol 287. issue 3. 2012-03-05. PMID:22069319. |
the epidermal growth factor receptor (egfr) regulates many cellular functions, such as proliferation, apoptosis, and ion transport. |
2012-03-05 |
2023-08-12 |
mouse |
| Roland Reinehr, Dieter Häussinge. CD95 death receptor and epidermal growth factor receptor (EGFR) in liver cell apoptosis and regeneration. Archives of biochemistry and biophysics. vol 518. issue 1. 2012-03-05. PMID:22182753. |
cd95 death receptor and epidermal growth factor receptor (egfr) in liver cell apoptosis and regeneration. |
2012-03-05 |
2023-08-12 |
Not clear |
| David Matallanas, David Romano, Fahd Al-Mulla, Eric O'Neill, Waleed Al-Ali, Piero Crespo, Brendan Doyle, Colin Nixon, Owen Sansom, Matthias Drosten, Mariano Barbacid, Walter Kolc. Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras. Molecular cell. vol 44. issue 6. 2012-02-24. PMID:22195963. |
however, mutant ras also stimulates autocrine activation of the egf receptor (egfr) which counteracts mutant k-ras-induced apoptosis. |
2012-02-24 |
2023-08-12 |
mouse |
| Qi-Jia Yu, Zi-Yue Li, Shun Yao, Miao Ming, Shu-Ya Wang, Bo Liu, Jin-Ku Ba. In silico analysis of molecular mechanisms of Galanthus nivalis agglutinin-related lectin-induced cancer cell death from carbohydrate-binding motif evolution hypothesis. Applied biochemistry and biotechnology. vol 165. issue 3-4. 2012-02-23. PMID:21748493. |
subsequently, we indicated that some sugar-containing receptors such as tnfr1, egfr, hsp90, and hsp70 could block downstream anti-apoptotic or survival signaling pathways, which, in turn, resulted in tumor cell apoptosis. |
2012-02-23 |
2023-08-12 |
Not clear |
| A Bergamaschi, B S Katzenellenboge. Tamoxifen downregulation of miR-451 increases 14-3-3ζ and promotes breast cancer cell survival and endocrine resistance. Oncogene. vol 31. issue 1. 2012-02-21. PMID:21666713. |
increasing the level of mir-451 by overexpression, which decreased 14-3-3ζ, suppressed cell proliferation and colony formation, markedly reduced activation of her2, egfr and mapk signaling, increased apoptosis, and, importantly, restored the growth-inhibitory effectiveness of serms in endocrine-resistant cells. |
2012-02-21 |
2023-08-12 |
Not clear |
| D G Powe, M J Voss, H O Habashy, K S Zänker, A R Green, I O Ellis, F Entschlade. Alpha- and beta-adrenergic receptor (AR) protein expression is associated with poor clinical outcome in breast cancer: an immunohistochemical study. Breast cancer research and treatment. vol 130. issue 2. 2012-02-08. PMID:21298476. |
strong α1b expression occurred in large high grade (p < 0.0001), her2+ (p < 0.0001) or basal-like (ck5/6, p = 0.0005; ck14, p = 0.0001; egfr, p = 0.003) cancers, showing increased proliferation (mib1, p = 0.002), decreased apoptosis (bcl2, p < 0.0001) and poor npi membership (p = 0.001). |
2012-02-08 |
2023-08-12 |
Not clear |
| Hidenori Fukuoka, Odelia Cooper, Anat Ben-Shlomo, Adam Mamelak, Song-Guang Ren, Dave Bruyette, Shlomo Melme. EGFR as a therapeutic target for human, canine, and mouse ACTH-secreting pituitary adenomas. The Journal of clinical investigation. vol 121. issue 12. 2012-01-31. PMID:22105169. |
blocking egfr activity with gefitinib, an egfr tyrosine kinase inhibitor, attenuated pomc expression, inhibited corticotroph tumor cell proliferation, and induced apoptosis. |
2012-01-31 |
2023-08-12 |
mouse |
| Toni M Brand, Emily F Dunn, Mari Iida, Rebecca A Myers, Kellie T Kostopoulos, Chunrong Li, Chimera R Peet, Deric L Wheele. Erlotinib is a viable treatment for tumors with acquired resistance to cetuximab. Cancer biology & therapy. vol 12. issue 5. 2012-01-26. PMID:21725209. |
in vitro, erlotinib was able to decrease signaling through the egfr axis, decrease cellular proliferation, and induce apoptosis. |
2012-01-26 |
2023-08-12 |
mouse |
| Norma O'Donovan, Annette T Byrne, Aisling E O'Connor, Sharon McGee, William M Gallagher, John Crow. Synergistic interaction between trastuzumab and EGFR/HER-2 tyrosine kinase inhibitors in HER-2 positive breast cancer cells. Investigational new drugs. vol 29. issue 5. 2012-01-24. PMID:20229355. |
trastuzumab (10 nm) and gefitinib (5 µm) induced apoptosis comparable to lapatinib alone (0.75 µm), suggesting that inhibition of both egfr and her-2 may be required to induce apoptosis in these cells. |
2012-01-24 |
2023-08-12 |
Not clear |
| Vivian Wai Yan Lui, Cecilia Pik Yuk Lau, Kakiu Ho, Margaret Heung Ling Ng, Suk Hang Cheng, Sai-Wah Tsao, Chi Man Tsang, Kenny Ieng Kit Lei, Anthony Tc Chan, Tony Shu Kam Mo. Anti-invasion, anti-proliferation and anoikis-sensitization activities of lapatinib in nasopharyngeal carcinoma cells. Investigational new drugs. vol 29. issue 6. 2012-01-23. PMID:20571878. |
sensitizing cancer cells to detachment-induced apoptosis) in human cancer cells overexpressing both egfr and her-2 (hk1-lmp1 and hk1). |
2012-01-23 |
2023-08-12 |
human |