| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Baoming Zhang, Heguang Huang, Jieming Xie, Chunsen Xu, Minghuang Chen, Congfei Wang, Aiqin Yang, Qiang Yi. Cucurmosin induces apoptosis of BxPC-3 human pancreatic cancer cells via inactivation of the EGFR signaling pathway. Oncology reports. vol 27. issue 3. 2012-08-10. PMID:22139427. |
cucurmosin induces apoptosis of bxpc-3 human pancreatic cancer cells via inactivation of the egfr signaling pathway. |
2012-08-10 |
2023-08-12 |
human |
| Jean-Charles Soria, Tony S Mok, Federico Cappuzzo, Pasi A Jänn. EGFR-mutated oncogene-addicted non-small cell lung cancer: current trends and future prospects. Cancer treatment reviews. vol 38. issue 5. 2012-08-08. PMID:22119437. |
non-small cell lung cancer (nsclc) tumours with certain mutations in the epidermal growth factor receptor (egfr) tyrosine kinase have been termed 'oncogene addicted' to reflect their dependence on egfr-mediated pro-survival signalling and their high susceptibility to apoptosis induced by egfr tyrosine kinase inhibitors (egfr-tkis, e.g. |
2012-08-08 |
2023-08-12 |
Not clear |
| M Siegemund, N Pollak, O Seifert, K Wahl, K Hanak, A Vogel, A K Nussler, D Göttsch, S Münkel, H Bantel, R E Kontermann, K Pfizenmaie. Superior antitumoral activity of dimerized targeted single-chain TRAIL fusion proteins under retention of tumor selectivity. Cell death & disease. vol 3. 2012-07-23. PMID:22495350. |
apoptosis induction by a single-chain trail (sctrail) molecule could be enhanced >10-fold by generation of epidermal growth factor receptor (egfr)-specific scfv-sctrail fusion proteins. |
2012-07-23 |
2023-08-12 |
mouse |
| Xinqi Wu, Jun Zhou, Andrew M Rogers, Pasi A Jänne, Elisa Benedettini, Massimo Loda, F Stephen Hod. c-Met, epidermal growth factor receptor, and insulin-like growth factor-1 receptor are important for growth in uveal melanoma and independently contribute to migration and metastatic potential. Melanoma research. vol 22. issue 2. 2012-07-12. PMID:22343486. |
selective inhibitors of egfr and igf-1r decreased proliferation and induced apoptosis in um cells regardless of the expression levels of c-met, egfr, and igf-1r. |
2012-07-12 |
2023-08-12 |
Not clear |
| Roland H Stauber, Shirley K Knauer, Negusse Habtemichael, Carolin Bier, Britta Unruhe, Simona Weisheit, Stephanie Spange, Frank Nonnenmacher, Verena Fetz, Torsten Ginter, Sigrid Reichardt, Claus Liebmann, Günter Schneider, Oliver H Kräme. A combination of a ribonucleotide reductase inhibitor and histone deacetylase inhibitors downregulates EGFR and triggers BIM-dependent apoptosis in head and neck cancer. Oncotarget. vol 3. issue 1. 2012-07-02. PMID:22289787. |
a combination of a ribonucleotide reductase inhibitor and histone deacetylase inhibitors downregulates egfr and triggers bim-dependent apoptosis in head and neck cancer. |
2012-07-02 |
2023-08-12 |
mouse |
| Kunio Okamoto, Isamu Okamoto, Erina Hatashita, Kiyoko Kuwata, Haruka Yamaguchi, Aya Kita, Kentaro Yamanaka, Mayumi Ono, Kazuhiko Nakagaw. Overcoming erlotinib resistance in EGFR mutation-positive non-small cell lung cancer cells by targeting survivin. Molecular cancer therapeutics. vol 11. issue 1. 2012-06-29. PMID:22075159. |
we previously showed that downregulation of the expression of the antiapoptotic protein survivin by egfr-tkis contributes to egfr-tki-induced apoptosis in egfr mutation-positive nsclc cells. |
2012-06-29 |
2023-08-12 |
mouse |
| Kunio Okamoto, Isamu Okamoto, Erina Hatashita, Kiyoko Kuwata, Haruka Yamaguchi, Aya Kita, Kentaro Yamanaka, Mayumi Ono, Kazuhiko Nakagaw. Overcoming erlotinib resistance in EGFR mutation-positive non-small cell lung cancer cells by targeting survivin. Molecular cancer therapeutics. vol 11. issue 1. 2012-06-29. PMID:22075159. |
the egfr-tki erlotinib did not affect survivin expression or induce apoptosis in egfr mutation-positive nsclc cells with pten loss. |
2012-06-29 |
2023-08-12 |
mouse |
| Kunio Okamoto, Isamu Okamoto, Erina Hatashita, Kiyoko Kuwata, Haruka Yamaguchi, Aya Kita, Kentaro Yamanaka, Mayumi Ono, Kazuhiko Nakagaw. Overcoming erlotinib resistance in EGFR mutation-positive non-small cell lung cancer cells by targeting survivin. Molecular cancer therapeutics. vol 11. issue 1. 2012-06-29. PMID:22075159. |
these results thus indicate that persistent activation of signaling by the akt-survivin pathway induced by pten loss underlies a mechanism of resistance to erlotinib-induced apoptosis in egfr mutation-positive nsclc. |
2012-06-29 |
2023-08-12 |
mouse |
| Jill Wykosky, Tim Fenton, Frank Furnari, Webster K Cavene. Therapeutic targeting of epidermal growth factor receptor in human cancer: successes and limitations. Chinese journal of cancer. vol 30. issue 1. 2012-05-24. PMID:21192840. |
targeted inhibition of egfr activity suppresses signal transduction pathways which control tumor cell growth, proliferation, and resistance to apoptosis. |
2012-05-24 |
2023-08-12 |
human |
| S Giunta, A Castorina, S Scuderi, C Patti, V D'Agat. Epidermal growth factor receptor (EGFR) and neuregulin (Neu) activation in human airway epithelial cells exposed to nickel acetate. Toxicology in vitro : an international journal published in association with BIBRA. vol 26. issue 2. 2012-05-22. PMID:22210268. |
conversely, beas-2b cells exposed to equivalent concentrations of ni(2+) did not show evident signs of apoptosis and dna damage, hence showing increased expression and phosphorylation of both egfr and neu, increased bcl-2 and reduced bax expression. |
2012-05-22 |
2023-08-12 |
human |
| Shailendra Kumar Maurya, Asit Rai, Nagendra Kumar Rai, Shreekant Deshpande, Rajeev Jain, Mohana Krishna Reddy Mudiam, Yenamandra S Prabhakar, Sanghamitra Bandyopadhya. Cypermethrin induces astrocyte apoptosis by the disruption of the autocrine/paracrine mode of epidermal growth factor receptor signaling. Toxicological sciences : an official journal of the Society of Toxicology. vol 125. issue 2. 2012-05-17. PMID:22048644. |
likewise, cypermethrin caused irreversible suppression in the basal egfr levels, which induced apoptosis in astrocytes. |
2012-05-17 |
2023-08-12 |
rat |
| Shailendra Kumar Maurya, Asit Rai, Nagendra Kumar Rai, Shreekant Deshpande, Rajeev Jain, Mohana Krishna Reddy Mudiam, Yenamandra S Prabhakar, Sanghamitra Bandyopadhya. Cypermethrin induces astrocyte apoptosis by the disruption of the autocrine/paracrine mode of epidermal growth factor receptor signaling. Toxicological sciences : an official journal of the Society of Toxicology. vol 125. issue 2. 2012-05-17. PMID:22048644. |
together, these data demonstrate that cypermethrin induces astrocyte apoptosis by disrupting the autocrine/paracrine mode of hb-egf-egfr signaling at two levels, irreversible loss of basal egfr and downregulation of hb-egf. |
2012-05-17 |
2023-08-12 |
rat |
| Jamie S Rush, Leslie M Quinalty, Luke Engelman, David M Sherry, Brian P Ceres. Endosomal accumulation of the activated epidermal growth factor receptor (EGFR) induces apoptosis. The Journal of biological chemistry. vol 287. issue 1. 2012-05-08. PMID:22102283. |
endosomal accumulation of the activated epidermal growth factor receptor (egfr) induces apoptosis. |
2012-05-08 |
2023-08-12 |
Not clear |
| Jamie S Rush, Leslie M Quinalty, Luke Engelman, David M Sherry, Brian P Ceres. Endosomal accumulation of the activated epidermal growth factor receptor (EGFR) induces apoptosis. The Journal of biological chemistry. vol 287. issue 1. 2012-05-08. PMID:22102283. |
in mda-mb-468 cells, cell surface egf receptors (egfrs) promote cell growth, whereas intracellular egfrs induce apoptosis, making these cells an excellent model for studying the endocytic regulation of egfr signaling. |
2012-05-08 |
2023-08-12 |
Not clear |
| Jamie S Rush, Leslie M Quinalty, Luke Engelman, David M Sherry, Brian P Ceres. Endosomal accumulation of the activated epidermal growth factor receptor (EGFR) induces apoptosis. The Journal of biological chemistry. vol 287. issue 1. 2012-05-08. PMID:22102283. |
to determine whether perturbation of egfr trafficking is sufficient to cause apoptosis, we used pharmacological and biochemical strategies to disrupt egfr endocytic trafficking in hela cells, which do not undergo egf-dependent apoptosis. |
2012-05-08 |
2023-08-12 |
Not clear |
| Jamie S Rush, Leslie M Quinalty, Luke Engelman, David M Sherry, Brian P Ceres. Endosomal accumulation of the activated epidermal growth factor receptor (EGFR) induces apoptosis. The Journal of biological chemistry. vol 287. issue 1. 2012-05-08. PMID:22102283. |
these data demonstrate that egfr-mediated apoptosis is initiated by the activated egfr from the limiting membrane of the endosome. |
2012-05-08 |
2023-08-12 |
Not clear |
| Huan-Qiu Li, Dong-Dong Li, Xiang Lu, Yun-Yun Xu, Hai-Liang Zh. Design and synthesis of 4,6-substituted-(diaphenylamino)quinazolines as potent EGFR inhibitors with antitumor activity. Bioorganic & medicinal chemistry. vol 20. issue 1. 2012-05-08. PMID:22112541. |
especially, 4-((4-(3-bromophenylamino)quinazolin-6-ylamino)methyl)phenol (5b), showed the most potent inhibitory activity (ic(50)=0.28μm for hep g2, ic(50)=0.59μm for a16-f10 and ic(50)=0.87μm for egfr) and effectively induces apoptosis in a dose-dependent manner in the hep g2 cell line. |
2012-05-08 |
2023-08-12 |
Not clear |
| Prabodh K Kandala, Stephen E Wright, Sanjay K Srivastav. Blocking epidermal growth factor receptor activation by 3,3'-diindolylmethane suppresses ovarian tumor growth in vitro and in vivo. The Journal of pharmacology and experimental therapeutics. vol 341. issue 1. 2012-05-04. PMID:22205686. |
epidermal growth factor treatment significantly blocked the dim-mediated inhibition of egfr activation and apoptosis in both skov-3 and ovcar-3 cells. |
2012-05-04 |
2023-08-12 |
human |
| Tian Li, Yuebo Yang, Xiaomao Li, Chengfang Xu, Lirong Men. EGFR- and AKT-mediated reduction in PTEN expression contributes to tyrphostin resistance and is reversed by mTOR inhibition in endometrial cancer cells. Molecular and cellular biochemistry. vol 361. issue 1-2. 2012-04-27. PMID:21952748. |
cell apoptosis and the cell cycle were studied, and activation of egfr, akt, and p70s6 were detected by western blot analysis. |
2012-04-27 |
2023-08-12 |
Not clear |
| Woody Han, Hui-Wen L. Landscape of EGFR signaling network in human cancers: biology and therapeutic response in relation to receptor subcellular locations. Cancer letters. vol 318. issue 2. 2012-04-27. PMID:22261334. |
the role of mitochondrial egfr remains poorly understood but it appears to regulate apoptosis and autophagy. |
2012-04-27 |
2023-08-12 |
human |