| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexander Hoellein, Anja Pickhard, Fabienne von Keitz, Stephanie Schoeffmann, Guido Piontek, Martina Rudelius, Anja Baumgart, Stefan Wagenpfeil, Christian Peschel, Tobias Dechow, Henning Bier, Ulrich Kelle. Aurora kinase inhibition overcomes cetuximab resistance in squamous cell cancer of the head and neck. Oncotarget. vol 2. issue 8. 2012-01-23. PMID:21865609. |
treating scchn cell lines with a pan-aurora kinase inhibitor resulted in defective cytokinesis, polyploidy and apoptosis, which was effective irrespective of the egfr status. |
2012-01-23 |
2023-08-12 |
Not clear |
| Alexander Hoellein, Anja Pickhard, Fabienne von Keitz, Stephanie Schoeffmann, Guido Piontek, Martina Rudelius, Anja Baumgart, Stefan Wagenpfeil, Christian Peschel, Tobias Dechow, Henning Bier, Ulrich Kelle. Aurora kinase inhibition overcomes cetuximab resistance in squamous cell cancer of the head and neck. Oncotarget. vol 2. issue 8. 2012-01-23. PMID:21865609. |
our results demonstrate that combined targeting of egfr and aurora kinases represents a therapeutic means to activate cell cycle checkpoints and apoptosis in scchn. |
2012-01-23 |
2023-08-12 |
Not clear |
| Eva Karamitopoulou, Inti Zlobec, Ioannis Panayiotides, Efstratios S Patsouris, George Peros, George Rallis, Christos Lapas, Petros Karakitsos, Luigi M Terracciano, Alessandro Lugl. Systematic analysis of proteins from different signaling pathways in the tumor center and the invasive front of colorectal cancer. Human pathology. vol 42. issue 12. 2012-01-09. PMID:21664646. |
twenty proteins from different signaling pathways (epidermal growth factor receptor [egfr], phosphorylated extracellular signal regulated kinase [perk], receptor for hyalouronic acid mediated motility [rhamm], raf-1 kinase inhibitor protein [rkip], β-catenin, e-cadherin, phosphorylated ak transforming [pakt], p16, p21, ki-67, b-cell lymphoma-2 [bcl2], vascular endothelial growth factor, apoptosis protease activating factor 1 [apaf-1], mucin1 [muc1], ephrin b2 receptor [ephb2], matrix metalloproteinase 7 [mmp7], phosphorylated mothers against decapentaplegic 2 [psmad2], caudal type homeobox transcription factor 2 [cdx2], laminin5γ2, and mammalian sterile 20-like kinase 1 [mst1]) involved in colorectal cancer progression were studied immunohistochemically on 220 well-characterized patients using a multiple-punch tissue microarray including 437 and 430 samples from the tumor center and the invasive front, respectively. |
2012-01-09 |
2023-08-12 |
Not clear |
| Greta Garrido, Ailem Rabasa, Belinda Sánchez, María Victoria López, Rances Blanco, Armando López, Diana Rosa Hernández, Rolando Pérez, Luis Enrique Fernánde. Induction of immunogenic apoptosis by blockade of epidermal growth factor receptor activation with a specific antibody. Journal of immunology (Baltimore, Md. : 1950). vol 187. issue 10. 2012-01-09. PMID:21984704. |
egfr blocking by 7a7 not only prompted a higher proapoptotic effect on tumor metastases compared with ag1478, but also was able to induce apoptosis with immunogenic potential in an fc-independent manner. |
2012-01-09 |
2023-08-12 |
mouse |
| Greta Garrido, Ailem Rabasa, Belinda Sánchez, María Victoria López, Rances Blanco, Armando López, Diana Rosa Hernández, Rolando Pérez, Luis Enrique Fernánde. Induction of immunogenic apoptosis by blockade of epidermal growth factor receptor activation with a specific antibody. Journal of immunology (Baltimore, Md. : 1950). vol 187. issue 10. 2012-01-09. PMID:21984704. |
this is the first report, to our knowledge, of a tumor-specific ctl response generated by ab-mediated egfr inhibition, suggesting an important contribution of immunogenic apoptosis to this effect. |
2012-01-09 |
2023-08-12 |
mouse |
| Jixia Li, Yeon-Yong Cho, Alyssa Langfald, Andria Carper, Ronald A Lubet, Clinton J Grubbs, Marna E Ericson, Ann M Bod. Lapatinib, a preventive/therapeutic agent against mammary cancer, suppresses RTK-mediated signaling through multiple signaling pathways. Cancer prevention research (Philadelphia, Pa.). vol 4. issue 8. 2012-01-05. PMID:21791570. |
these results combined with immunoreactivity data indicated that, in addition to egfr and her2, lapatinib treatment was associated with changes in a number of other signaling molecules, including igf-1r, akt, and downstream targets such as gsk3, p27, p53, and cyclin d1 presumably leading to impaired proliferation, apoptosis, or cell-cycle arrest. |
2012-01-05 |
2023-08-12 |
human |
| Shyhmin Huang, Sergio Benavente, Eric A Armstrong, Chunrong Li, Deric L Wheeler, Paul M Harar. p53 modulates acquired resistance to EGFR inhibitors and radiation. Cancer research. vol 71. issue 22. 2011-12-27. PMID:22068033. |
further studies indicate that p53 may enhance sensitivity to egfr inhibitors and radiation via induction of cell-cycle arrest, apoptosis, and dna damage repair. |
2011-12-27 |
2023-08-12 |
human |
| Tongrui Liu, Rami Yacoub, LaTonia D Taliaferro-Smith, Shi-Yong Sun, Tisheeka R Graham, Ryan Dolan, Christine Lobo, Mourad Tighiouart, Lily Yang, Amy Adams, Ruth M O'Rega. Combinatorial effects of lapatinib and rapamycin in triple-negative breast cancer cells. Molecular cancer therapeutics. vol 10. issue 8. 2011-12-19. PMID:21690228. |
the combination of egfr and mtor inhibition resulted in increased apoptosis in some, but not all, triple-negative cell lines, and these apoptotic effects correlated with a decrease in activated eukaryotic translation initiation factor (eif4e). |
2011-12-19 |
2023-08-12 |
Not clear |
| Meng Wang, Fabian Morsbach, David Sander, Liliana Gheorghiu, Akash Nanda, Cyril Benes, Malte Kriegs, Mechthild Krause, Ekkehard Dikomey, Michael Baumann, Jochen Dahm-Daphi, Jeffrey Settleman, Henning Willer. EGF receptor inhibition radiosensitizes NSCLC cells by inducing senescence in cells sustaining DNA double-strand breaks. Cancer research. vol 71. issue 19. 2011-12-13. PMID:21852385. |
unexpectedly, egfr inhibition led to pronounced cellular senescence but not apoptosis of irradiated cells, both in vitro and in vivo. |
2011-12-13 |
2023-08-12 |
Not clear |
| Yi-Chieh Nancy Du, Chen-Kung Chou, David S Klimstra, Harold Varmu. Receptor for hyaluronan-mediated motility isoform B promotes liver metastasis in a mouse model of multistep tumorigenesis and a tail vein assay for metastasis. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 40. 2011-12-13. PMID:21940500. |
in initial efforts to identify signaling pathways activated by rhamm(b), we found that rhamm(b) induced phosphorylation of epidermal growth factor receptor (egfr), erk1/2, and stat3 and conferred susceptibility to apoptosis after treatment with an egfr inhibitor, gefitinib. |
2011-12-13 |
2023-08-12 |
mouse |
| Yumin Dai, Shelly Hogan, Eva M Schmelz, Young H Ju, Corene Canning, Kequan Zho. Selective growth inhibition of human breast cancer cells by graviola fruit extract in vitro and in vivo involving downregulation of EGFR expression. Nutrition and cancer. vol 63. issue 5. 2011-12-12. PMID:21767082. |
gfe significantly downregulated egfr mrna expression, arrested cell cycle in the g0/g1 phase, and induced apoptosis in mda-mb-468 cells. |
2011-12-12 |
2023-08-12 |
mouse |
| Thamara J Abouantoun, Tobey J MacDonal. Imatinib blocks migration and invasion of medulloblastoma cells by concurrently inhibiting activation of platelet-derived growth factor receptor and transactivation of epidermal growth factor receptor. Molecular cancer therapeutics. vol 8. issue 5. 2011-11-22. PMID:19417143. |
imatinib treatment also induced daoy cell apoptosis at 72 h and inhibited daoy and d556 cell proliferation at 48 h. sirna silencing of pdgfrb similarly inhibited signaling, migration, and survival and both sirna and imatinib treatment inhibited pdgf-bb-mediated egfr transactivation, indicating that the effects of imatinib treatment are specific to pdgfrb target inhibition. |
2011-11-22 |
2023-08-12 |
human |
| Laia Caja, Patricia Sancho, Esther Bertran, Isabel Fabrega. Dissecting the effect of targeting the epidermal growth factor receptor on TGF-β-induced-apoptosis in human hepatocellular carcinoma cells. Journal of hepatology. vol 55. issue 2. 2011-11-21. PMID:21147185. |
transforming growth factor-beta (tgf-β) induces apoptosis in hepatocytes, a process that is inhibited by the epidermal growth factor receptor (egfr) pathway. |
2011-11-21 |
2023-08-12 |
human |
| Olivier Nolan-Stevaux, Morgan C Truitt, Jessica C Pahler, Peter Olson, Cristina Guinto, David C Lee, Douglas Hanaha. Differential contribution to neuroendocrine tumorigenesis of parallel egfr signaling in cancer cells and pericytes. Genes & cancer. vol 1. issue 2. 2011-11-10. PMID:20975924. |
upon treatment of rt2 mice with egfr inhibitors, pnet tumors harboring wild-type, nonamplified alleles of egfr grow at a markedly reduced rate and display a significant increase in tumor cell apoptosis, as well as reduced neovascularization. |
2011-11-10 |
2023-08-12 |
mouse |
| J Bolnick, L Albitar, L L Laidler, R Abdullah, K K Lesli. Blocking Epidermal Growth Factor Receptor Signaling in HTR-8/SVneo First Trimester Trophoblast Cells Results in Dephosphorylation of PKBα/AKT and Induces Apoptosis. Obstetrics and gynecology international. vol 2011. 2011-11-10. PMID:21876698. |
egf- and iressa-(gefitinib, zd1839, an inhibitor of egfr) treated htr-8/svneo cells were subjected to immunoblotting and flow cytometry to confirm the phosphoprotein screen and to assess the effects of egf versus iressa on cell cycle and apoptosis. |
2011-11-10 |
2023-08-12 |
Not clear |
| Brian P Ceresa, Phillip A Vanlandingha. Molecular Mechanisms that Regulate Epidermal Growth Factor Receptor Inactivation. Clinical medicine. Oncology. vol 2. 2011-11-10. PMID:21892266. |
the activated egfr regulates diverse cell fates such as growth, proliferation, differentiation, migration, and apoptosis. |
2011-11-10 |
2023-08-12 |
Not clear |
| Kousaku Mimura, Koji Kono, Takanori Maruyama, Mitsuaki Watanabe, Shinichiro Izawa, Shugo Shiba, Yoshiki Mizukami, Yoshihiko Kawaguchi, Masayuki Inoue, Tetsuo Kono, Aniruddha Choudhury, Rolf Kiessling, Hideki Fuji. Lapatinib inhibits receptor phosphorylation and cell growth and enhances antibody-dependent cellular cytotoxicity of EGFR- and HER2-overexpressing esophageal cancer cell lines. International journal of cancer. vol 129. issue 10. 2011-11-04. PMID:21207425. |
lapatinib also inhibited cell proliferation, induced apoptosis and caused the surface accumulation of her2 and egfr in escc cell lines. |
2011-11-04 |
2023-08-12 |
Not clear |
| J Tupper, M R Crompton, A J Harve. Breast tumor kinase (Brk/PTK6) plays a role in the differentiation of primary keratinocytes. Archives of dermatological research. vol 303. issue 4. 2011-10-21. PMID:21240512. |
decreasing brk protein levels lead to an increase in the number of cells with a permeable plasma membrane, a decrease in epidermal growth factor receptor (egfr) and a parallel increase in keratin 10 levels, but classical markers of apoptosis or terminal differentiation are not affected. |
2011-10-21 |
2023-08-12 |
human |
| Deborah French, Andrew Smith, Martin P Powers, Alan H B W. KRAS mutation detection in colorectal cancer by a commercially available gene chip array compares well with Sanger sequencing. Clinica chimica acta; international journal of clinical chemistry. vol 412. issue 17-18. 2011-10-18. PMID:21575616. |
binding of a ligand to the epidermal growth factor receptor (egfr) stimulates various intracellular signaling pathways resulting in cell cycle progression, proliferation, angiogenesis and apoptosis inhibition. |
2011-10-18 |
2023-08-12 |
human |
| Zhiwei Yu, Binbin Cui, Yinghu Jin, Haipeng Chen, Xishan Wan. Novel irreversible EGFR tyrosine kinase inhibitor 324674 sensitizes human colon carcinoma HT29 and SW480 cells to apoptosis by blocking the EGFR pathway. Biochemical and biophysical research communications. vol 411. issue 4. 2011-10-14. PMID:21782788. |
novel irreversible egfr tyrosine kinase inhibitor 324674 sensitizes human colon carcinoma ht29 and sw480 cells to apoptosis by blocking the egfr pathway. |
2011-10-14 |
2023-08-12 |
human |