| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Siddik Sarkar, Abhijit Mazumdar, Rupesh Dash, Devanand Sarkar, Paul B Fisher, Mahitosh Manda. ZD6474, a dual tyrosine kinase inhibitor of EGFR and VEGFR-2, inhibits MAPK/ERK and AKT/PI3-K and induces apoptosis in breast cancer cells. Cancer biology & therapy. vol 9. issue 8. 2011-01-06. PMID:20139705. |
we hypothesized that inhibition of phosphorylation of the egfr and vegfr by zd6474 would inhibit breast cancer cell proliferation and induce apoptosis. |
2011-01-06 |
2023-08-12 |
human |
| Siddik Sarkar, Abhijit Mazumdar, Rupesh Dash, Devanand Sarkar, Paul B Fisher, Mahitosh Manda. ZD6474 enhances paclitaxel antiproliferative and apoptotic effects in breast carcinoma cells. Journal of cellular physiology. vol 226. issue 2. 2011-01-06. PMID:20665703. |
chemotherapy employing paclitaxel and docetaxel is widely used for treating early-stage breast cancer and metastasis, which is frequently associated with overexpression of epidermal growth factor receptor (egfr) and resistance to apoptosis. |
2011-01-06 |
2023-08-12 |
human |
| Alireza Rezaiemanesh, Jafar Majidi, Behzad Baradaran, Aliakbar Movasaghpour, Ailar Nakhlband, Jaleh Barar, Yadollah Omid. Impacts of anti-EGFR monoclonal antibody in prostate cancer PC3 cells. Human antibodies. vol 19. issue 2-3. 2011-01-06. PMID:20826931. |
semi-quantitative rt-pcr was used to evaluate the expression of egfr and some important apoptosis signaling molecules (e.g., mapk-1, stat-5, akt-1 kinase). |
2011-01-06 |
2023-08-12 |
Not clear |
| Lei Han, An-ling Zhang, Peng Xu, Xiao Yue, Yang Yang, Guang-xiu Wang, Zhi-fan Jia, Pei-yu Pu, Chun-sheng Kan. Combination gene therapy with PTEN and EGFR siRNA suppresses U251 malignant glioma cell growth in vitro and in vivo. Medical oncology (Northwood, London, England). vol 27. issue 3. 2010-12-30. PMID:19728186. |
it was found that down-regulation of egfr expression and up-regulation of pten expression resulted in the suppression of cell proliferation, arrest of cell cycle, reduction in cell invasion and promotion of cell apoptosis in vitro. |
2010-12-30 |
2023-08-12 |
mouse |
| Lara Cattaruzza, Dolores Fregona, Maurizio Mongiat, Luca Ronconi, Ambrogio Fassina, Alfonso Colombatti, Donatella Aldinucc. Antitumor activity of gold(III)-dithiocarbamato derivatives on prostate cancer cells and xenografts. International journal of cancer. vol 128. issue 1. 2010-12-30. PMID:20209498. |
in addition, it induces apoptosis, caspase activation, bcl-2 downregulation and bax upregulation, reduces the expression of the phosphorylated form of the egfr, and it inhibits pc3 cell migration. |
2010-12-30 |
2023-08-12 |
mouse |
| Ching-Ming Chien, Shang-Yu Chang, Kuei-Li Lin, Chien-Chih Chiu, Long-Sen Chang, Shinne-Ren Li. Taiwan cobra cardiotoxin III inhibits Src kinase leading to apoptosis and cell cycle arrest of oral squamous cell carcinoma Ca9-22 cells. Toxicon : official journal of the International Society on Toxinology. vol 56. issue 4. 2010-12-13. PMID:20493203. |
taken together, these results indicate that ctx iii induces apoptosis and s-phase arrest in ca9-22 cells via concomitant inactivation of the src, egfr, stat3, stat5, pi3 k(p110), and akt signaling pathways. |
2010-12-13 |
2023-08-12 |
Not clear |
| Seta A Sarkis, Bashar H Abdullah, Ban A Abdul Majeed, Nazar G Talaban. Immunohistochemical expression of epidermal growth factor receptor (EGFR) in oral squamous cell carcinoma in relation to proliferation, apoptosis, angiogenesis and lymphangiogenesis. Head & neck oncology. vol 2. 2010-11-29. PMID:20579333. |
immunohistochemical expression of epidermal growth factor receptor (egfr) in oral squamous cell carcinoma in relation to proliferation, apoptosis, angiogenesis and lymphangiogenesis. |
2010-11-29 |
2023-08-12 |
Not clear |
| Adel Badran, Ryutaro Asano, Makoto Nakayama, Yasuhiro Watanabe, Takeshi Nakanishi, Mitsuo Umetsu, Hiroki Hayashi, Yu Katayose, Michiaki Unno, Izumi Kumaga. Target cell-restricted apoptosis induction by 528scFv-TRAIL fusion protein specific for human EGFR and expressed in Escherichia coli. International journal of oncology. vol 36. issue 5. 2010-11-22. PMID:20372797. |
target cell-restricted apoptosis induction by 528scfv-trail fusion protein specific for human egfr and expressed in escherichia coli. |
2010-11-22 |
2023-08-12 |
human |
| Jung-Chen Su, Kuei-Li Lin, Ching-Ming Chien, Pei-Wen Chuang, Long-Sen Chang, Shinne-Ren Li. Concomitant inactivation of the epidermal growth factor receptor, phosphatidylinositol 3-kinase/Akt and Janus tyrosine kinase 2/signal transducer and activator of transcription 3 signalling pathways in cardiotoxin III-treated A549 cells. Clinical and experimental pharmacology & physiology. vol 37. issue 8. 2010-11-22. PMID:20456425. |
together, the results of the present study indicate that ctx iii induces apoptosis in a549 cells by inactivating the egfr, pi3-k/akt and jak2/stat3 signalling pathways. |
2010-11-22 |
2023-08-12 |
human |
| Fusanori Yotsumoto, Eiji Oki, Eriko Tokunaga, Yoshihiko Maehara, Masahide Kuroki, Shingo Miyamot. HB-EGF orchestrates the complex signals involved in triple-negative and trastuzumab-resistant breast cancer. International journal of cancer. vol 127. issue 11. 2010-11-04. PMID:20499311. |
here, we found that heparin-binding epidermal growth factor-like growth factor (hb-egf), a member of the egfr ligands, was predominantly expressed in breast cancer and that treatment with crossreacting material 197 (crm197), a specific inhibitor of hb-egf, blocked erk as well as akt activation via complexes of egfr and unknown growth factor receptors in tnbc or through complexes of egfr and human epidermal growth factor receptor-2 in trastuzumab-resistant breast cancer, caused significant cell apoptosis and inhibited tumor growth. |
2010-11-04 |
2023-08-12 |
human |
| Thaís F G Lucas, Carine Royer, Erica R Siu, Maria Fatima M Lazari, Catarina S Port. Expression and signaling of G protein-coupled estrogen receptor 1 (GPER) in rat sertoli cells. Biology of reproduction. vol 83. issue 2. 2010-10-26. PMID:20445128. |
taken together, these results indicate that in sertoli cells 1) gper-mediated mapk3/1 activation occurs via egfr transactivation through g protein beta gamma subunits that promote src-mediated metalloprotease-dependent release of egfr ligands, which bind to egfr and lead to mapk3/1 phosphorylation; 2) e2-esrs play a role in sertoli cell proliferation; and 3) e2-gper may regulate gene expression involved with apoptosis. |
2010-10-26 |
2023-08-12 |
rat |
| P Smile. [Molecular predictors in head and neck tumours]. Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti. vol 23. issue 4. 2010-10-12. PMID:20806819. |
these markers could be evaluated in every step that is believed to be necessary for the development of a cancer: acquisition of autonomous proliferative signalling (egfr), proliferative activity of tumour cells (dna content, ki-67, mitotic index), inhibition of growth inhibitory signals (bcl-2), apoptosis (p53), immortalization (telomerase), angiogenesis (cd34, vegf) and metastasis (mmp-9, e-cadherin, i-cam aj.). |
2010-10-12 |
2023-08-12 |
Not clear |
| Yanhe Li, Qiang Jia, Junxia Zhang, Lei Han, Desheng Xu, Anling Zhang, Yipei Zhang, Zhiyuan Zhang, Peiyu Pu, Chunsheng Kan. Combination therapy with Gamma Knife radiosurgery and antisense EGFR for malignant glioma in vitro and orthotopic xenografts. Oncology reports. vol 23. issue 6. 2010-09-30. PMID:20428813. |
gkr and down-regulation of egfr expression by antisense egfr resulted in significant suppression of cell proliferation and induction of cell apoptosis in vitro. |
2010-09-30 |
2023-08-12 |
human |
| Jyoti Nautiyal, Yingjie Yu, Amro Aboukameel, Shailender S Kanwar, Jayanta K Das, Jianhua Du, Bhaumik B Patel, Fazlul H Sarkar, Arun K Rishi, Ramzi M Mohammad, Adhip P N Majumda. ErbB-inhibitory protein: a modified ectodomain of epidermal growth factor receptor synergizes with dasatinib to inhibit growth of breast cancer cells. Molecular cancer therapeutics. vol 9. issue 6. 2010-09-16. PMID:20515951. |
many solid tumors, including breast cancer, show increased activation of several growth factor receptors, specifically epidermal growth factor receptor (egfr) and its family members as well as c-src, a nonreceptor tyrosine kinase that promotes proliferation, inhibits apoptosis, and induces metastasis. |
2010-09-16 |
2023-08-12 |
mouse |
| Jyoti Nautiyal, Yingjie Yu, Amro Aboukameel, Shailender S Kanwar, Jayanta K Das, Jianhua Du, Bhaumik B Patel, Fazlul H Sarkar, Arun K Rishi, Ramzi M Mohammad, Adhip P N Majumda. ErbB-inhibitory protein: a modified ectodomain of epidermal growth factor receptor synergizes with dasatinib to inhibit growth of breast cancer cells. Molecular cancer therapeutics. vol 9. issue 6. 2010-09-16. PMID:20515951. |
in egfr-overexpressing mda-mb-468 cells, the combination, but not monotherapy, markedly stimulated apoptosis mediated by caspase-9 and caspase-8 and attenuated activation of egfr and src as well as tyrosine kinase activity. |
2010-09-16 |
2023-08-12 |
mouse |
| Brian M Howard, Demirkan B Gursel, Anne-Marie Bleau, Robel T Beyene, Eric C Holland, John A Boockva. EGFR signaling is differentially activated in patient-derived glioblastoma stem cells. Journal of experimental therapeutics & oncology. vol 8. issue 3. 2010-09-09. PMID:20734923. |
inhibition of egfr signaling by ag1478 increased gsc senescence and apoptosis, likely via inhibition of akt and activation of gsk3beta. |
2010-09-09 |
2023-08-12 |
Not clear |
| Ning Kang, Jing-Hai Zhang, Feng Qiu, Shin-Ichi Tashiro, Satoshi Onodera, Takashi Ikejim. Inhibition of EGFR signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways. Cancer letters. vol 294. issue 2. 2010-09-07. PMID:20202741. |
inhibition of egfr signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways. |
2010-09-07 |
2023-08-12 |
human |
| Aditya Murthy, Virginie Defamie, David S Smookler, Marco A Di Grappa, Keisuke Horiuchi, Massimo Federici, Maria Sibilia, Carl P Blobel, Rama Khokh. Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice. The Journal of clinical investigation. vol 120. issue 8. 2010-09-02. PMID:20628198. |
ectodomain shedding of egfr ligands and tnfr1 dictates hepatocyte apoptosis during fulminant hepatitis in mice. |
2010-09-02 |
2023-08-12 |
mouse |
| Aditya Murthy, Virginie Defamie, David S Smookler, Marco A Di Grappa, Keisuke Horiuchi, Massimo Federici, Maria Sibilia, Carl P Blobel, Rama Khokh. Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice. The Journal of clinical investigation. vol 120. issue 8. 2010-09-02. PMID:20628198. |
loss of timp3 enhanced metalloproteinase-dependent egfr signaling due to increased release of the egfr ligands tgf-alpha, amphiregulin, and hb-egf, while depletion of shed amphiregulin resensitized timp3-/- hepatocytes to apoptosis. |
2010-09-02 |
2023-08-12 |
mouse |
| S Wang, X Huang, C-K Lee, B Li. Elevated expression of erbB3 confers paclitaxel resistance in erbB2-overexpressing breast cancer cells via upregulation of Survivin. Oncogene. vol 29. issue 29. 2010-08-27. PMID:20498641. |
the overexpression of exogenous erbb3 via either stable or transient transfection in erbb2-overexpressing, but not epidermal growth factor receptor (egfr)-expressing, breast cancer cells significantly decreases paclitaxel-induced growth inhibition and apoptosis. |
2010-08-27 |
2023-08-12 |
Not clear |